YPR140W / TAZ1

Lyso-phosphatidylcholine acyltransferase, required for normal phospholipid content of mitochondrial membranes; may remodel acyl groups of cardiolipin in the inner membrane; human ortholog tafazzin is implicated in Barth syndrome

Zygosity: Homozygous strain
fixedexpanded
Profile for YPR140W / TAZ1

Click on Significant Values for Screen Details ID:SGTC_52|Compound:0329-0193|FD-Score:3.73|P-value:6.60E-5 ID:SGTC_135|Compound:0933-0004|FD-Score:3.83|P-value:4.19E-5 ID:SGTC_219|Compound:mitoxanthrone|FD-Score:3.75|P-value:5.98E-5 ID:SGTC_335|Compound:4077-0256|FD-Score:3.05|P-value:8.86E-4 ID:SGTC_479|Compound:n-linoleoylglycine|FD-Score:-3.18|P-value:4.97E-4 ID:SGTC_516|Compound:3992-2719|FD-Score:-3.02|P-value:8.87E-4 ID:SGTC_522|Compound:1273-0010|FD-Score:4.03|P-value:1.79E-5 ID:SGTC_677|Compound:0929-0063|FD-Score:-3.43|P-value:1.93E-4 ID:SGTC_746|Compound:1095-0025|FD-Score:-3.08|P-value:7.11E-4 ID:SGTC_789|Compound:1309-1135|FD-Score:3.76|P-value:5.71E-5 ID:SGTC_809|Compound:3998-0021|FD-Score:3.66|P-value:8.75E-5 ID:SGTC_823|Compound:0417-1665|FD-Score:3.09|P-value:7.76E-4 ID:SGTC_869|Compound:0564-0080|FD-Score:3.27|P-value:4.04E-4 ID:SGTC_939|Compound:1165-0479|FD-Score:3.17|P-value:5.74E-4 ID:SGTC_990|Compound:3985-0011|FD-Score:3.41|P-value:2.35E-4 ID:SGTC_1180|Compound:1193-0155|FD-Score:3.49|P-value:1.75E-4 ID:SGTC_1700|Compound:st030840|FD-Score:-3.93|P-value:2.39E-5 ID:SGTC_1705|Compound:st027868|FD-Score:-4.01|P-value:1.65E-5 ID:SGTC_1857|Compound:st056007|FD-Score:3.59|P-value:1.16E-4 ID:SGTC_1916|Compound:st067606|FD-Score:-3.65|P-value:7.95E-5 ID:SGTC_2107|Compound:5363541|FD-Score:-3.40|P-value:2.17E-4 ID:SGTC_2123|Compound:5259487|FD-Score:-3.62|P-value:8.81E-5 ID:SGTC_2124|Compound:5246320|FD-Score:4.06|P-value:1.58E-5 ID:SGTC_2244|Compound:6635614|FD-Score:3.21|P-value:4.94E-4 ID:SGTC_2271|Compound:7849410|FD-Score:3.39|P-value:2.53E-4 ID:SGTC_2689|Compound:tacrolimus|FD-Score:-3.20|P-value:4.60E-4 ID:SGTC_2693|Compound:st077581|FD-Score:-6.65|P-value:3.27E-12 ID:SGTC_2762|Compound:leflunomide|FD-Score:5.15|P-value:6.09E-8 ID:SGTC_2853|Compound:9015042|FD-Score:3.69|P-value:7.59E-5 ID:SGTC_3211|Compound:9128781|FD-Score:3.43|P-value:2.18E-4 ID:SGTC_3342|Compound:9147791|FD-Score:-3.13|P-value:5.98E-4 ID:SGTC_52|Compound:0329-0193|FD-Score:3.73|P-value:6.60E-5 ID:SGTC_135|Compound:0933-0004|FD-Score:3.83|P-value:4.19E-5 ID:SGTC_219|Compound:mitoxanthrone|FD-Score:3.75|P-value:5.98E-5 ID:SGTC_335|Compound:4077-0256|FD-Score:3.05|P-value:8.86E-4 ID:SGTC_479|Compound:n-linoleoylglycine|FD-Score:-3.18|P-value:4.97E-4 ID:SGTC_516|Compound:3992-2719|FD-Score:-3.02|P-value:8.87E-4 ID:SGTC_522|Compound:1273-0010|FD-Score:4.03|P-value:1.79E-5 ID:SGTC_677|Compound:0929-0063|FD-Score:-3.43|P-value:1.93E-4 ID:SGTC_746|Compound:1095-0025|FD-Score:-3.08|P-value:7.11E-4 ID:SGTC_789|Compound:1309-1135|FD-Score:3.76|P-value:5.71E-5 ID:SGTC_809|Compound:3998-0021|FD-Score:3.66|P-value:8.75E-5 ID:SGTC_823|Compound:0417-1665|FD-Score:3.09|P-value:7.76E-4 ID:SGTC_869|Compound:0564-0080|FD-Score:3.27|P-value:4.04E-4 ID:SGTC_939|Compound:1165-0479|FD-Score:3.17|P-value:5.74E-4 ID:SGTC_990|Compound:3985-0011|FD-Score:3.41|P-value:2.35E-4 ID:SGTC_1180|Compound:1193-0155|FD-Score:3.49|P-value:1.75E-4 ID:SGTC_1700|Compound:st030840|FD-Score:-3.93|P-value:2.39E-5 ID:SGTC_1705|Compound:st027868|FD-Score:-4.01|P-value:1.65E-5 ID:SGTC_1857|Compound:st056007|FD-Score:3.59|P-value:1.16E-4 ID:SGTC_1916|Compound:st067606|FD-Score:-3.65|P-value:7.95E-5 ID:SGTC_2107|Compound:5363541|FD-Score:-3.40|P-value:2.17E-4 ID:SGTC_2123|Compound:5259487|FD-Score:-3.62|P-value:8.81E-5 ID:SGTC_2124|Compound:5246320|FD-Score:4.06|P-value:1.58E-5 ID:SGTC_2244|Compound:6635614|FD-Score:3.21|P-value:4.94E-4 ID:SGTC_2271|Compound:7849410|FD-Score:3.39|P-value:2.53E-4 ID:SGTC_2689|Compound:tacrolimus|FD-Score:-3.20|P-value:4.60E-4 ID:SGTC_2693|Compound:st077581|FD-Score:-6.65|P-value:3.27E-12 ID:SGTC_2762|Compound:leflunomide|FD-Score:5.15|P-value:6.09E-8 ID:SGTC_2853|Compound:9015042|FD-Score:3.69|P-value:7.59E-5 ID:SGTC_3211|Compound:9128781|FD-Score:3.43|P-value:2.18E-4 ID:SGTC_3342|Compound:9147791|FD-Score:-3.13|P-value:5.98E-4

Top fitness defect scores for YPR140W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2762 leflunomide 5.15 42.1 µM 6.09E-8 9 1.30E-7
2 SGTC_2124 5246320 4.06 200.0 µM 1.58E-5 heme biosynthesis & mitochondrial translocase 18 2.50E-5
3 SGTC_522 1273-0010 4.03 11.6 µM 1.79E-5 60S ribosome export 23 2.83E-5
4 SGTC_135 0933-0004 3.83 26.4 µM 4.19E-5 60S ribosome export 29 6.33E-5
5 SGTC_789 1309-1135 3.76 70.6 µM 5.71E-5 ERG2 37 8.49E-5
6 SGTC_219 mitoxanthrone 3.75 164.4 µM 5.98E-5 DNA intercalators 57 8.85E-5
7 SGTC_52 0329-0193 3.73 875.0 nM 6.60E-5 TSC3-RPN4 43 9.73E-5
8 SGTC_2853 9015042 3.69 58.4 µM 7.59E-5 33 1.11E-4
9 SGTC_809 3998-0021 3.66 90.0 µM 8.75E-5 RNA processing & uracil transport 16 1.27E-4
10 SGTC_1857 st056007 3.59 79.3 µM 1.16E-4 12 1.66E-4
11 SGTC_1180 1193-0155 3.49 285.0 µM 1.75E-4 26 2.46E-4
12 SGTC_3211 9128781 3.43 49.5 µM 2.18E-4 93 3.02E-4
13 SGTC_990 3985-0011 3.41 41.3 µM 2.35E-4 amide catabolism 32 3.25E-4
14 SGTC_2271 7849410 3.39 118.6 µM 2.53E-4 22 3.48E-4
15 SGTC_869 0564-0080 3.27 44.1 µM 4.04E-4 42 5.43E-4
16 SGTC_2244 6635614 3.21 200.0 µM 4.94E-4 14 6.58E-4
17 SGTC_939 1165-0479 3.17 45.3 µM 5.74E-4 73 7.58E-4
18 SGTC_823 0417-1665 3.09 178.0 µM 7.76E-4 69 0.00101
19 SGTC_335 4077-0256 3.05 27.6 µM 8.86E-4 41 0.00115
20 SGTC_992 3909-8734 3.01 162.0 µM 0.00101 59 0.00130

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.156 1.23E-19 YEL040W UTR2 hom Chitin transglycosylase that functions in the transfer of chitin to beta(1-6) and beta(1-3) glucans in the cell wall; similar to and functionally redundant with Crh1; glycosylphosphatidylinositol (GPI)-anchored protein localized to bud neck
0.129 5.38E-14 YJR067C YAE1 het Protein that forms a complex with Lto1p and Rli1p; essential for growth under standard (aerobic) conditions but not under anaerobic conditions; may have a role in protection of ribosomal assembly and function from damage due to reactive oxygen species
0.129 6.42E-14 YLR280C_d YLR280C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.122 1.12E-12 YGR110W CLD1 hom Mitochondrial cardiolipin-specific phospholipase; functions upstream of Taz1p to generate monolyso-cardiolipin; transcription increases upon genotoxic stress; involved in restricting Ty1 transposition; has homology to mammalian CGI-58
0.116 1.67E-11 YNR020C ATP23 hom Putative metalloprotease of the mitochondrial inner membrane, required for processing of Atp6p; has an additional role in assembly of the F0 sector of the F1F0 ATP synthase complex; substrate of the Mia40p-Erv1p disulfide relay system, and folding is assisted by Mia40p
0.113 5.68E-11 YDR164C SEC1 het Sm-like protein involved in docking and fusion of exocytic vesicles; binds to assembled SNARE complexes at the membrane and stimulates membrane fusion; localization to sites of secretion (bud neck and bud tip) is dependent on SNARE function
0.110 1.54E-10 YGL125W MET13 hom Major isozyme of methylenetetrahydrofolate reductase, catalyzes the reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate in the methionine biosynthesis pathway
0.104 1.51E-9 YDR165W TRM82 hom Catalytic subunit of a tRNA methyltransferase complex; Trm8p and Trm82p comprise an enzyme that catalyzes a methyl-transfer from S-adenosyl-l-methionine to the N(7) atom of guanine at position 46 in tRNA; Trm8 lacks catalytic activity if not bound to Trm82p
0.103 2.63E-9 YGL004C RPN14 hom Proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasome regulatory particle (RP); null mutants accumulate ubiquitinated Gcn4p and display decreased 26S proteasome stability; interacts with Rpt5p
0.101 5.41E-9 YER069W ARG5,6 hom Acetylglutamate kinase and N-acetyl-gamma-glutamyl-phosphate reductase; N-acetyl-L-glutamate kinase (NAGK) catalyzes the 2nd and N-acetyl-gamma-glutamyl-phosphate reductase (NAGSA), the 3rd step in arginine biosynthesis; synthesized as a precursor which is processed in the mitochondrion to yield mature NAGK and NAGSA; enzymes form a metabolon complex with Arg2p; NAGK C-terminal domain stabilizes the enzymes, slows catalysis and is involved in feed-back inhibition by arginine
0.098 1.30E-8 YKL201C MNN4 hom Putative positive regulator of mannosylphosphate transferase Mnn6p; involved in mannosylphosphorylation of N-linked oligosaccharides; expression increases in late-logarithmic and stationary growth phases; MNN4 has a paralog, YJR061W, that arose from the whole genome duplication
0.095 3.15E-8 YKL156W RPS27A hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S27, no bacterial homolog; RPS27A has a paralog, RPS27B, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.090 1.64E-7 YLR385C SWC7 hom Protein of unknown function, component of the Swr1p complex that incorporates Htz1p into chromatin
0.089 2.33E-7 YGR096W TPC1 hom Mitochondrial membrane transporter that mediates uptake of the essential cofactor thiamine pyrophosphate (ThPP) into mitochondria; expression appears to be regulated by carbon source; member of the mitochondrial carrier family
0.088 3.22E-7 YDR287W INM2 hom Inositol monophosphatase, involved in biosynthesis of inositol; enzymatic activity requires magnesium ions and is inhibited by lithium and sodium ions; inm1 inm2 double mutant lacks inositol auxotrophy