YPR142C_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RRP15, which is required for ribosomal RNA processing

Zygosity: Heterozygous strain
fixedexpanded
Profile for YPR142C / YPR142C

Click on Significant Values for Screen Details ID:SGTC_68|Compound:0986-0284|FD-Score:3.12|P-value:2.88E-4 ID:SGTC_242|Compound:5hr heat shock (37°C) + 5-fluorouracil|FD-Score:5.68|P-value:1.75E-10 ID:SGTC_305|Compound:1682-2595|FD-Score:5.31|P-value:2.31E-9 ID:SGTC_325|Compound:2810-4341|FD-Score:-2.84|P-value:8.21E-4 ID:SGTC_326|Compound:k292-0812|FD-Score:-2.79|P-value:9.85E-4 ID:SGTC_335|Compound:4077-0256|FD-Score:3.12|P-value:2.93E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:4.14|P-value:2.47E-6 ID:SGTC_361|Compound:000s-0510|FD-Score:4.18|P-value:2.02E-6 ID:SGTC_362|Compound:0310-0100|FD-Score:3.78|P-value:1.50E-5 ID:SGTC_363|Compound:0455-0021|FD-Score:-3.86|P-value:9.68E-6 ID:SGTC_366|Compound:0181-0206|FD-Score:-3.28|P-value:1.39E-4 ID:SGTC_370|Compound:0180-0345|FD-Score:-6.83|P-value:1.97E-14 ID:SGTC_405|Compound:ebelactone b|FD-Score:2.91|P-value:6.72E-4 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:5.32|P-value:2.07E-9 ID:SGTC_431|Compound:k089-0097|FD-Score:2.84|P-value:8.63E-4 ID:SGTC_610|Compound:4215-0184|FD-Score:7.42|P-value:1.23E-16 ID:SGTC_673|Compound:1082-0474|FD-Score:-3.15|P-value:2.42E-4 ID:SGTC_741|Compound:4582-0002|FD-Score:-3.32|P-value:1.17E-4 ID:SGTC_879|Compound:0831-1030|FD-Score:3.08|P-value:3.36E-4 ID:SGTC_1015|Compound:4130-4525|FD-Score:2.82|P-value:9.46E-4 ID:SGTC_1074|Compound:carmofur|FD-Score:8.07|P-value:2.36E-19 ID:SGTC_1077|Compound:5-fluorocytosine|FD-Score:9.81|P-value:1.20E-27 ID:SGTC_1111|Compound:tnp00062|FD-Score:2.83|P-value:8.88E-4 ID:SGTC_1212|Compound:0520-0165|FD-Score:2.90|P-value:6.92E-4 ID:SGTC_1336|Compound:1486-0901|FD-Score:-3.89|P-value:8.09E-6 ID:SGTC_1513|Compound:0337-0559|FD-Score:3.56|P-value:4.32E-5 ID:SGTC_1592|Compound:4',5'-dihydroxyflavone|FD-Score:-3.71|P-value:1.95E-5 ID:SGTC_1698|Compound:5-fluorocytosine|FD-Score:6.96|P-value:7.85E-15 ID:SGTC_1820|Compound:st053765|FD-Score:2.91|P-value:6.57E-4 ID:SGTC_1887|Compound:st057648|FD-Score:2.83|P-value:8.97E-4 ID:SGTC_1889|Compound:st059080|FD-Score:2.87|P-value:7.81E-4 ID:SGTC_1981|Compound:st071826|FD-Score:2.90|P-value:6.99E-4 ID:SGTC_2019|Compound:4016004|FD-Score:3.35|P-value:1.12E-4 ID:SGTC_2042|Compound:p-Dimethylaminoacetophenone|FD-Score:3.07|P-value:3.55E-4 ID:SGTC_2113|Compound:5491891|FD-Score:3.53|P-value:4.94E-5 ID:SGTC_2133|Compound:5320837|FD-Score:3.34|P-value:1.16E-4 ID:SGTC_2160|Compound:5660466|FD-Score:6.18|P-value:4.37E-12 ID:SGTC_2162|Compound:5663267|FD-Score:3.55|P-value:4.41E-5 ID:SGTC_2251|Compound:lansoprazole|FD-Score:3.27|P-value:1.52E-4 ID:SGTC_2359|Compound:9039622|FD-Score:4.02|P-value:4.64E-6 ID:SGTC_2367|Compound:9070478|FD-Score:3.57|P-value:4.00E-5 ID:SGTC_2432|Compound:5630864|FD-Score:-4.40|P-value:5.68E-7 ID:SGTC_2457|Compound:5731572|FD-Score:3.31|P-value:1.29E-4 ID:SGTC_2458|Compound:5808907|FD-Score:3.04|P-value:4.02E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:-2.99|P-value:4.63E-4 ID:SGTC_2495|Compound:cafestol|FD-Score:-3.18|P-value:2.13E-4 ID:SGTC_2504|Compound:purpurogallin|FD-Score:-2.95|P-value:5.33E-4 ID:SGTC_2592|Compound:piperlongumine|FD-Score:3.34|P-value:1.12E-4 ID:SGTC_2593|Compound:nobiletin|FD-Score:4.11|P-value:2.80E-6 ID:SGTC_2594|Compound:a-mangostin|FD-Score:3.68|P-value:2.48E-5 ID:SGTC_2600|Compound:tangeritin|FD-Score:-2.91|P-value:6.27E-4 ID:SGTC_2705|Compound:st078069|FD-Score:-2.89|P-value:6.92E-4 ID:SGTC_2722|Compound:naftopidil|FD-Score:2.99|P-value:4.92E-4 ID:SGTC_2853|Compound:9015042|FD-Score:-3.12|P-value:2.72E-4 ID:SGTC_2854|Compound:9024559|FD-Score:3.85|P-value:1.06E-5 ID:SGTC_2880|Compound:9042983|FD-Score:3.57|P-value:4.15E-5 ID:SGTC_2919|Compound:7978188|FD-Score:-3.29|P-value:1.36E-4 ID:SGTC_2949|Compound:9072542|FD-Score:4.80|P-value:5.99E-8 ID:SGTC_2950|Compound:9072895|FD-Score:3.22|P-value:1.89E-4 ID:SGTC_2952|Compound:9073731|FD-Score:4.85|P-value:4.29E-8 ID:SGTC_2988|Compound:9073640|FD-Score:-3.42|P-value:7.66E-5 ID:SGTC_2995|Compound:9067767|FD-Score:-3.10|P-value:2.96E-4 ID:SGTC_3068|Compound:9116768|FD-Score:-4.22|P-value:1.46E-6 ID:SGTC_3089|Compound:9117425|FD-Score:3.30|P-value:1.34E-4 ID:SGTC_3148|Compound:9097893|FD-Score:3.09|P-value:3.33E-4 ID:SGTC_3170|Compound:9103054|FD-Score:-2.97|P-value:5.07E-4 ID:SGTC_3200|Compound:9114385|FD-Score:-3.17|P-value:2.19E-4 ID:SGTC_3294|Compound:9122953|FD-Score:3.24|P-value:1.78E-4 ID:SGTC_68|Compound:0986-0284|FD-Score:3.12|P-value:2.88E-4 ID:SGTC_242|Compound:5hr heat shock (37°C) + 5-fluorouracil|FD-Score:5.68|P-value:1.75E-10 ID:SGTC_305|Compound:1682-2595|FD-Score:5.31|P-value:2.31E-9 ID:SGTC_325|Compound:2810-4341|FD-Score:-2.84|P-value:8.21E-4 ID:SGTC_326|Compound:k292-0812|FD-Score:-2.79|P-value:9.85E-4 ID:SGTC_335|Compound:4077-0256|FD-Score:3.12|P-value:2.93E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:4.14|P-value:2.47E-6 ID:SGTC_361|Compound:000s-0510|FD-Score:4.18|P-value:2.02E-6 ID:SGTC_362|Compound:0310-0100|FD-Score:3.78|P-value:1.50E-5 ID:SGTC_363|Compound:0455-0021|FD-Score:-3.86|P-value:9.68E-6 ID:SGTC_366|Compound:0181-0206|FD-Score:-3.28|P-value:1.39E-4 ID:SGTC_370|Compound:0180-0345|FD-Score:-6.83|P-value:1.97E-14 ID:SGTC_405|Compound:ebelactone b|FD-Score:2.91|P-value:6.72E-4 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:5.32|P-value:2.07E-9 ID:SGTC_431|Compound:k089-0097|FD-Score:2.84|P-value:8.63E-4 ID:SGTC_610|Compound:4215-0184|FD-Score:7.42|P-value:1.23E-16 ID:SGTC_673|Compound:1082-0474|FD-Score:-3.15|P-value:2.42E-4 ID:SGTC_741|Compound:4582-0002|FD-Score:-3.32|P-value:1.17E-4 ID:SGTC_879|Compound:0831-1030|FD-Score:3.08|P-value:3.36E-4 ID:SGTC_1015|Compound:4130-4525|FD-Score:2.82|P-value:9.46E-4 ID:SGTC_1074|Compound:carmofur|FD-Score:8.07|P-value:2.36E-19 ID:SGTC_1077|Compound:5-fluorocytosine|FD-Score:9.81|P-value:1.20E-27 ID:SGTC_1111|Compound:tnp00062|FD-Score:2.83|P-value:8.88E-4 ID:SGTC_1212|Compound:0520-0165|FD-Score:2.90|P-value:6.92E-4 ID:SGTC_1336|Compound:1486-0901|FD-Score:-3.89|P-value:8.09E-6 ID:SGTC_1513|Compound:0337-0559|FD-Score:3.56|P-value:4.32E-5 ID:SGTC_1592|Compound:4',5'-dihydroxyflavone|FD-Score:-3.71|P-value:1.95E-5 ID:SGTC_1698|Compound:5-fluorocytosine|FD-Score:6.96|P-value:7.85E-15 ID:SGTC_1820|Compound:st053765|FD-Score:2.91|P-value:6.57E-4 ID:SGTC_1887|Compound:st057648|FD-Score:2.83|P-value:8.97E-4 ID:SGTC_1889|Compound:st059080|FD-Score:2.87|P-value:7.81E-4 ID:SGTC_1981|Compound:st071826|FD-Score:2.90|P-value:6.99E-4 ID:SGTC_2019|Compound:4016004|FD-Score:3.35|P-value:1.12E-4 ID:SGTC_2042|Compound:p-Dimethylaminoacetophenone|FD-Score:3.07|P-value:3.55E-4 ID:SGTC_2113|Compound:5491891|FD-Score:3.53|P-value:4.94E-5 ID:SGTC_2133|Compound:5320837|FD-Score:3.34|P-value:1.16E-4 ID:SGTC_2160|Compound:5660466|FD-Score:6.18|P-value:4.37E-12 ID:SGTC_2162|Compound:5663267|FD-Score:3.55|P-value:4.41E-5 ID:SGTC_2251|Compound:lansoprazole|FD-Score:3.27|P-value:1.52E-4 ID:SGTC_2359|Compound:9039622|FD-Score:4.02|P-value:4.64E-6 ID:SGTC_2367|Compound:9070478|FD-Score:3.57|P-value:4.00E-5 ID:SGTC_2432|Compound:5630864|FD-Score:-4.40|P-value:5.68E-7 ID:SGTC_2457|Compound:5731572|FD-Score:3.31|P-value:1.29E-4 ID:SGTC_2458|Compound:5808907|FD-Score:3.04|P-value:4.02E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:-2.99|P-value:4.63E-4 ID:SGTC_2495|Compound:cafestol|FD-Score:-3.18|P-value:2.13E-4 ID:SGTC_2504|Compound:purpurogallin|FD-Score:-2.95|P-value:5.33E-4 ID:SGTC_2592|Compound:piperlongumine|FD-Score:3.34|P-value:1.12E-4 ID:SGTC_2593|Compound:nobiletin|FD-Score:4.11|P-value:2.80E-6 ID:SGTC_2594|Compound:a-mangostin|FD-Score:3.68|P-value:2.48E-5 ID:SGTC_2600|Compound:tangeritin|FD-Score:-2.91|P-value:6.27E-4 ID:SGTC_2705|Compound:st078069|FD-Score:-2.89|P-value:6.92E-4 ID:SGTC_2722|Compound:naftopidil|FD-Score:2.99|P-value:4.92E-4 ID:SGTC_2853|Compound:9015042|FD-Score:-3.12|P-value:2.72E-4 ID:SGTC_2854|Compound:9024559|FD-Score:3.85|P-value:1.06E-5 ID:SGTC_2880|Compound:9042983|FD-Score:3.57|P-value:4.15E-5 ID:SGTC_2919|Compound:7978188|FD-Score:-3.29|P-value:1.36E-4 ID:SGTC_2949|Compound:9072542|FD-Score:4.80|P-value:5.99E-8 ID:SGTC_2950|Compound:9072895|FD-Score:3.22|P-value:1.89E-4 ID:SGTC_2952|Compound:9073731|FD-Score:4.85|P-value:4.29E-8 ID:SGTC_2988|Compound:9073640|FD-Score:-3.42|P-value:7.66E-5 ID:SGTC_2995|Compound:9067767|FD-Score:-3.10|P-value:2.96E-4 ID:SGTC_3068|Compound:9116768|FD-Score:-4.22|P-value:1.46E-6 ID:SGTC_3089|Compound:9117425|FD-Score:3.30|P-value:1.34E-4 ID:SGTC_3148|Compound:9097893|FD-Score:3.09|P-value:3.33E-4 ID:SGTC_3170|Compound:9103054|FD-Score:-2.97|P-value:5.07E-4 ID:SGTC_3200|Compound:9114385|FD-Score:-3.17|P-value:2.19E-4 ID:SGTC_3294|Compound:9122953|FD-Score:3.24|P-value:1.78E-4

Top fitness defect scores for YPR142C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1077 5-fluorocytosine 9.81 377.0 nM 1.20E-27 exosome 6 5.30E-23 1.07
2 SGTC_1074 carmofur 8.07 3.8 µM 2.36E-19 exosome 8 3.39E-16 0.78
3 SGTC_610 4215-0184 7.42 155.0 µM 1.23E-16 exosome 6 5.78E-14 0.34
4 SGTC_1698 5-fluorocytosine 6.96 1.1 µM 7.85E-15 exosome 6 1.76E-12 0.24
5 SGTC_2160 5660466 6.18 132.9 µM 4.37E-12 60S ribosome export 3 3.18E-10 0.18
6 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 5.68 4.6 µM 1.75E-10 heat shock/prefoldin 11 6.63E-9 0.23
7 SGTC_423 5-fluorouracil 5.32 457.0 µM 2.07E-9 exosome 16 5.06E-8 0.56
8 SGTC_305 1682-2595 5.31 20.8 µM 2.31E-9 RNA processing & uracil transport 3 5.55E-8 0.56
9 SGTC_2952 9073731 4.85 13.8 µM 4.29E-8 tubulin folding & SWR complex 7 6.16E-7 0.06
10 SGTC_2949 9072542 4.80 2.2 µM 5.99E-8 TSC3-RPN4 5 8.11E-7 0.02
11 SGTC_361 000s-0510 4.18 1.4 µM 2.02E-6 6 1.48E-5 0.46
12 SGTC_358 0075-0058 4.14 9.4 µM 2.47E-6 1 1.75E-5 0.37
13 SGTC_2593 nobiletin 4.11 86.2 µM 2.80E-6 10 1.94E-5 0.21
14 SGTC_2359 9039622 4.02 200.0 µM 4.64E-6 endomembrane recycling 3 2.95E-5 0.17
15 SGTC_2854 9024559 3.85 71.4 µM 1.06E-5 7 5.83E-5 0.09
16 SGTC_362 0310-0100 3.78 9.0 µM 1.50E-5 RPP1 & pyrimidine depletion 10 7.80E-5 0.03
17 SGTC_2594 a-mangostin 3.68 100.0 µM 2.48E-5 10 1.18E-4 0.20
18 SGTC_2367 9070478 3.57 135.4 µM 4.00E-5 cell wall 13 1.75E-4 0.01
19 SGTC_2880 9042983 3.57 58.4 µM 4.15E-5 fatty acid desaturase (OLE1) 17 1.81E-4 0.01
20 SGTC_1513 0337-0559 3.56 19.0 µM 4.32E-5 10 1.87E-4 0.07

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.461 3.55E-176 YGR195W SKI6 het Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp41p (EXOSC4)
0.396 1.74E-126 YDL111C RRP42 het Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp42p (EXOSC7)
0.369 1.31E-108 YPL044C_d YPL044C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene NOP4/YPL043W
0.327 2.86E-84 YPL043W NOP4 het Nucleolar protein, essential for processing and maturation of 27S pre-rRNA and large ribosomal subunit biogenesis; constituent of 66S pre-ribosomal particles; contains four RNA recognition motifs (RRMs)
0.323 4.92E-82 YOL021C DIS3 het Exosome core complex catalytic subunit; possesses both endonuclease and 3'-5' exonuclease activity; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase R and to human DIS3; protein abundance increases in response to DNA replication stress
0.310 8.38E-76 YGR158C MTR3 het Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hMtr3p (EXOSC6)
0.307 2.36E-74 YPR143W RRP15 het Nucleolar protein, constituent of pre-60S ribosomal particles; required for proper processing of the 27S pre-rRNA at the A3 and B1 sites to yield mature 5.8S and 25S rRNAs
0.279 6.10E-61 YDR280W RRP45 het Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp45p (PM/SCL-75, EXOSC9); protein abundance increases in response to DNA replication stress
0.277 5.94E-60 YKL172W EBP2 het Required for 25S rRNA maturation and 60S ribosomal subunit assembly; localizes to the nucleolus and in foci along nuclear periphery; constituent of 66S pre-ribosomal particles; cooperates with Rrs1p and Mps3p to mediate telomere clustering by binding Sir4p, but is not involved in telomere tethering
0.215 2.34E-36 YKL021C MAK11 het Protein involved in an early, nucleolar step of 60S ribosomal subunit biogenesis; essential for cell growth and replication of killer M1 dsRNA virus; contains four beta-transducin repeats
0.206 1.42E-33 YNL002C RLP7 het Nucleolar protein with similarity to large ribosomal subunit L7 proteins; constituent of 66S pre-ribosomal particles; plays an essential role in processing of precursors to the large ribosomal subunit RNAs
0.206 1.49E-33 YGR095C RRP46 het Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp46p (EXOSC5)
0.201 8.57E-32 YNL232W CSL4 het Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; predicted to contain an S1 RNA binding domain; has similarity to human hCsl4p (EXOSC1)
0.190 1.72E-28 YDR060W MAK21 het Constituent of 66S pre-ribosomal particles, required for large (60S) ribosomal subunit biogenesis; involved in nuclear export of pre-ribosomes; required for maintenance of dsRNA virus; homolog of human CAATT-binding protein
0.179 1.52E-25 YNL061W NOP2 het Probable RNA m(5)C methyltransferase, essential for processing and maturation of 27S pre-rRNA and large ribosomal subunit biogenesis; localized to the nucleolus; constituent of 66S pre-ribosomal particles