YPR143W / RRP15

Nucleolar protein, constituent of pre-60S ribosomal particles; required for proper processing of the 27S pre-rRNA at the A3 and B1 sites to yield mature 5.8S and 25S rRNAs

Zygosity: Heterozygous strain
fixedexpanded
Profile for YPR143W / RRP15

Click on Significant Values for Screen Details ID:SGTC_133|Compound:0724-0033|FD-Score:6.16|P-value:7.35E-10 ID:SGTC_134|Compound:0269-0018|FD-Score:3.94|P-value:5.56E-5 ID:SGTC_138|Compound:0850-0259|FD-Score:9.38|P-value:1.59E-20 ID:SGTC_147|Compound:4466-0538|FD-Score:3.68|P-value:1.52E-4 ID:SGTC_153|Compound:4077-0274|FD-Score:3.45|P-value:3.55E-4 ID:SGTC_157|Compound:1348-1695|FD-Score:-3.30|P-value:5.58E-4 ID:SGTC_164|Compound:4100-3994|FD-Score:3.52|P-value:2.79E-4 ID:SGTC_188|Compound:3229-0966|FD-Score:5.79|P-value:6.49E-9 ID:SGTC_242|Compound:5hr heat shock (37°C) + 5-fluorouracil|FD-Score:5.45|P-value:4.36E-8 ID:SGTC_256|Compound:clotrimazole|FD-Score:3.30|P-value:6.19E-4 ID:SGTC_261|Compound:5-fluorouridine|FD-Score:5.20|P-value:1.68E-7 ID:SGTC_269|Compound:exalamide|FD-Score:3.27|P-value:6.88E-4 ID:SGTC_291|Compound:4130-1278|FD-Score:3.58|P-value:2.23E-4 ID:SGTC_305|Compound:1682-2595|FD-Score:7.13|P-value:1.28E-12 ID:SGTC_351|Compound:caspofungin|FD-Score:5.15|P-value:2.20E-7 ID:SGTC_354|Compound:2783-3500|FD-Score:7.54|P-value:6.46E-14 ID:SGTC_360|Compound:0957-0399|FD-Score:4.69|P-value:2.08E-6 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:12.30|P-value:3.73E-34 ID:SGTC_514|Compound:4466-0038|FD-Score:10.30|P-value:1.45E-24 ID:SGTC_534|Compound:k292-0788|FD-Score:3.97|P-value:5.03E-5 ID:SGTC_610|Compound:4215-0184|FD-Score:6.49|P-value:9.37E-11 ID:SGTC_636|Compound:0kpi-0074|FD-Score:3.21|P-value:8.35E-4 ID:SGTC_666|Compound:0272-0154|FD-Score:4.81|P-value:1.20E-6 ID:SGTC_734|Compound:2023-0417|FD-Score:3.18|P-value:9.31E-4 ID:SGTC_743|Compound:1275-0778|FD-Score:-3.34|P-value:4.91E-4 ID:SGTC_779|Compound:1360-0071|FD-Score:4.43|P-value:6.88E-6 ID:SGTC_863|Compound:0466-0191|FD-Score:8.58|P-value:1.76E-17 ID:SGTC_879|Compound:0831-1030|FD-Score:3.91|P-value:6.32E-5 ID:SGTC_916|Compound:4466-0038|FD-Score:11.10|P-value:7.68E-28 ID:SGTC_964|Compound:1287-0107|FD-Score:3.22|P-value:8.16E-4 ID:SGTC_994|Compound:3910-0338|FD-Score:3.41|P-value:4.19E-4 ID:SGTC_1074|Compound:carmofur|FD-Score:10.30|P-value:2.04E-24 ID:SGTC_1077|Compound:5-fluorocytosine|FD-Score:11.40|P-value:2.89E-29 ID:SGTC_1111|Compound:tnp00062|FD-Score:4.00|P-value:4.44E-5 ID:SGTC_1121|Compound:fusaric acid|FD-Score:-4.29|P-value:1.17E-5 ID:SGTC_1123|Compound:mangostin|FD-Score:-3.77|P-value:9.99E-5 ID:SGTC_1282|Compound:0886-0010|FD-Score:8.91|P-value:1.08E-18 ID:SGTC_1454|Compound:4239-0054|FD-Score:4.81|P-value:1.19E-6 ID:SGTC_1476|Compound:4112-3294|FD-Score:-3.22|P-value:7.42E-4 ID:SGTC_1687|Compound:st020778|FD-Score:4.51|P-value:4.84E-6 ID:SGTC_1698|Compound:5-fluorocytosine|FD-Score:6.01|P-value:1.80E-9 ID:SGTC_1745|Compound:st081495|FD-Score:4.27|P-value:1.38E-5 ID:SGTC_1786|Compound:berberine|FD-Score:-3.19|P-value:8.21E-4 ID:SGTC_1817|Compound:st052116|FD-Score:3.42|P-value:3.99E-4 ID:SGTC_1827|Compound:berberine|FD-Score:-3.26|P-value:6.37E-4 ID:SGTC_1894|Compound:3',6'-dihydroxyflavone|FD-Score:4.12|P-value:2.70E-5 ID:SGTC_1895|Compound:st058434|FD-Score:3.96|P-value:5.19E-5 ID:SGTC_2003|Compound:4023581|FD-Score:4.34|P-value:1.06E-5 ID:SGTC_2007|Compound:4011539|FD-Score:-5.77|P-value:6.31E-9 ID:SGTC_2009|Compound:4012297|FD-Score:-5.85|P-value:4.12E-9 ID:SGTC_2052|Compound:5265182|FD-Score:3.59|P-value:2.15E-4 ID:SGTC_2074|Compound:5212007|FD-Score:3.27|P-value:6.86E-4 ID:SGTC_2137|Compound:5261020|FD-Score:4.63|P-value:2.78E-6 ID:SGTC_2140|Compound:5586273|FD-Score:3.76|P-value:1.15E-4 ID:SGTC_2175|Compound:5807670|FD-Score:3.75|P-value:1.20E-4 ID:SGTC_2584|Compound:androsterone|FD-Score:6.78|P-value:1.42E-11 ID:SGTC_2620|Compound:irigenin|FD-Score:3.21|P-value:8.32E-4 ID:SGTC_2778|Compound:tioconazole|FD-Score:3.65|P-value:1.71E-4 ID:SGTC_2792|Compound:7535235|FD-Score:3.70|P-value:1.41E-4 ID:SGTC_2804|Compound:7954240|FD-Score:-3.21|P-value:7.51E-4 ID:SGTC_2814|Compound:7977482|FD-Score:3.65|P-value:1.75E-4 ID:SGTC_2820|Compound:7989630|FD-Score:3.60|P-value:2.08E-4 ID:SGTC_2827|Compound:7993847|FD-Score:3.82|P-value:9.08E-5 ID:SGTC_2912|Compound:7964298|FD-Score:3.47|P-value:3.34E-4 ID:SGTC_2920|Compound:7982904|FD-Score:3.36|P-value:4.92E-4 ID:SGTC_2939|Compound:9044578|FD-Score:3.76|P-value:1.15E-4 ID:SGTC_3028|Compound:9087778|FD-Score:-3.72|P-value:1.20E-4 ID:SGTC_3058|Compound:9093861|FD-Score:3.90|P-value:6.49E-5 ID:SGTC_3232|Compound:9132874|FD-Score:3.41|P-value:4.09E-4 ID:SGTC_3321|Compound:9137793|FD-Score:3.37|P-value:4.81E-4 ID:SGTC_133|Compound:0724-0033|FD-Score:6.16|P-value:7.35E-10 ID:SGTC_134|Compound:0269-0018|FD-Score:3.94|P-value:5.56E-5 ID:SGTC_138|Compound:0850-0259|FD-Score:9.38|P-value:1.59E-20 ID:SGTC_147|Compound:4466-0538|FD-Score:3.68|P-value:1.52E-4 ID:SGTC_153|Compound:4077-0274|FD-Score:3.45|P-value:3.55E-4 ID:SGTC_157|Compound:1348-1695|FD-Score:-3.30|P-value:5.58E-4 ID:SGTC_164|Compound:4100-3994|FD-Score:3.52|P-value:2.79E-4 ID:SGTC_188|Compound:3229-0966|FD-Score:5.79|P-value:6.49E-9 ID:SGTC_242|Compound:5hr heat shock (37°C) + 5-fluorouracil|FD-Score:5.45|P-value:4.36E-8 ID:SGTC_256|Compound:clotrimazole|FD-Score:3.30|P-value:6.19E-4 ID:SGTC_261|Compound:5-fluorouridine|FD-Score:5.20|P-value:1.68E-7 ID:SGTC_269|Compound:exalamide|FD-Score:3.27|P-value:6.88E-4 ID:SGTC_291|Compound:4130-1278|FD-Score:3.58|P-value:2.23E-4 ID:SGTC_305|Compound:1682-2595|FD-Score:7.13|P-value:1.28E-12 ID:SGTC_351|Compound:caspofungin|FD-Score:5.15|P-value:2.20E-7 ID:SGTC_354|Compound:2783-3500|FD-Score:7.54|P-value:6.46E-14 ID:SGTC_360|Compound:0957-0399|FD-Score:4.69|P-value:2.08E-6 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:12.30|P-value:3.73E-34 ID:SGTC_514|Compound:4466-0038|FD-Score:10.30|P-value:1.45E-24 ID:SGTC_534|Compound:k292-0788|FD-Score:3.97|P-value:5.03E-5 ID:SGTC_610|Compound:4215-0184|FD-Score:6.49|P-value:9.37E-11 ID:SGTC_636|Compound:0kpi-0074|FD-Score:3.21|P-value:8.35E-4 ID:SGTC_666|Compound:0272-0154|FD-Score:4.81|P-value:1.20E-6 ID:SGTC_734|Compound:2023-0417|FD-Score:3.18|P-value:9.31E-4 ID:SGTC_743|Compound:1275-0778|FD-Score:-3.34|P-value:4.91E-4 ID:SGTC_779|Compound:1360-0071|FD-Score:4.43|P-value:6.88E-6 ID:SGTC_863|Compound:0466-0191|FD-Score:8.58|P-value:1.76E-17 ID:SGTC_879|Compound:0831-1030|FD-Score:3.91|P-value:6.32E-5 ID:SGTC_916|Compound:4466-0038|FD-Score:11.10|P-value:7.68E-28 ID:SGTC_964|Compound:1287-0107|FD-Score:3.22|P-value:8.16E-4 ID:SGTC_994|Compound:3910-0338|FD-Score:3.41|P-value:4.19E-4 ID:SGTC_1074|Compound:carmofur|FD-Score:10.30|P-value:2.04E-24 ID:SGTC_1077|Compound:5-fluorocytosine|FD-Score:11.40|P-value:2.89E-29 ID:SGTC_1111|Compound:tnp00062|FD-Score:4.00|P-value:4.44E-5 ID:SGTC_1121|Compound:fusaric acid|FD-Score:-4.29|P-value:1.17E-5 ID:SGTC_1123|Compound:mangostin|FD-Score:-3.77|P-value:9.99E-5 ID:SGTC_1282|Compound:0886-0010|FD-Score:8.91|P-value:1.08E-18 ID:SGTC_1454|Compound:4239-0054|FD-Score:4.81|P-value:1.19E-6 ID:SGTC_1476|Compound:4112-3294|FD-Score:-3.22|P-value:7.42E-4 ID:SGTC_1687|Compound:st020778|FD-Score:4.51|P-value:4.84E-6 ID:SGTC_1698|Compound:5-fluorocytosine|FD-Score:6.01|P-value:1.80E-9 ID:SGTC_1745|Compound:st081495|FD-Score:4.27|P-value:1.38E-5 ID:SGTC_1786|Compound:berberine|FD-Score:-3.19|P-value:8.21E-4 ID:SGTC_1817|Compound:st052116|FD-Score:3.42|P-value:3.99E-4 ID:SGTC_1827|Compound:berberine|FD-Score:-3.26|P-value:6.37E-4 ID:SGTC_1894|Compound:3',6'-dihydroxyflavone|FD-Score:4.12|P-value:2.70E-5 ID:SGTC_1895|Compound:st058434|FD-Score:3.96|P-value:5.19E-5 ID:SGTC_2003|Compound:4023581|FD-Score:4.34|P-value:1.06E-5 ID:SGTC_2007|Compound:4011539|FD-Score:-5.77|P-value:6.31E-9 ID:SGTC_2009|Compound:4012297|FD-Score:-5.85|P-value:4.12E-9 ID:SGTC_2052|Compound:5265182|FD-Score:3.59|P-value:2.15E-4 ID:SGTC_2074|Compound:5212007|FD-Score:3.27|P-value:6.86E-4 ID:SGTC_2137|Compound:5261020|FD-Score:4.63|P-value:2.78E-6 ID:SGTC_2140|Compound:5586273|FD-Score:3.76|P-value:1.15E-4 ID:SGTC_2175|Compound:5807670|FD-Score:3.75|P-value:1.20E-4 ID:SGTC_2584|Compound:androsterone|FD-Score:6.78|P-value:1.42E-11 ID:SGTC_2620|Compound:irigenin|FD-Score:3.21|P-value:8.32E-4 ID:SGTC_2778|Compound:tioconazole|FD-Score:3.65|P-value:1.71E-4 ID:SGTC_2792|Compound:7535235|FD-Score:3.70|P-value:1.41E-4 ID:SGTC_2804|Compound:7954240|FD-Score:-3.21|P-value:7.51E-4 ID:SGTC_2814|Compound:7977482|FD-Score:3.65|P-value:1.75E-4 ID:SGTC_2820|Compound:7989630|FD-Score:3.60|P-value:2.08E-4 ID:SGTC_2827|Compound:7993847|FD-Score:3.82|P-value:9.08E-5 ID:SGTC_2912|Compound:7964298|FD-Score:3.47|P-value:3.34E-4 ID:SGTC_2920|Compound:7982904|FD-Score:3.36|P-value:4.92E-4 ID:SGTC_2939|Compound:9044578|FD-Score:3.76|P-value:1.15E-4 ID:SGTC_3028|Compound:9087778|FD-Score:-3.72|P-value:1.20E-4 ID:SGTC_3058|Compound:9093861|FD-Score:3.90|P-value:6.49E-5 ID:SGTC_3232|Compound:9132874|FD-Score:3.41|P-value:4.09E-4 ID:SGTC_3321|Compound:9137793|FD-Score:3.37|P-value:4.81E-4

Top fitness defect scores for YPR143W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_423 5-fluorouracil 12.30 457.0 µM 3.73E-34 exosome 2 2.73E-35 2.32
2 SGTC_1077 5-fluorocytosine 11.40 377.0 nM 2.89E-29 exosome 4 3.09E-30 1.07
3 SGTC_916 4466-0038 11.10 42.0 nM 7.68E-28 cell wall 4 9.20E-29 0.03
4 SGTC_514 4466-0038 10.30 2.6 nM 1.45E-24 cell wall 2 2.25E-25 0.87
5 SGTC_1074 carmofur 10.30 3.8 µM 2.04E-24 exosome 5 3.19E-25 1.02
6 SGTC_138 0850-0259 9.38 40.9 µM 1.59E-20 cell wall 13 3.39E-21 0.27
7 SGTC_1282 0886-0010 8.91 32.4 µM 1.08E-18 endomembrane recycling 2 2.65E-19 2.94
8 SGTC_863 0466-0191 8.58 129.0 µM 1.76E-17 cell wall 5 4.76E-18 0.20
9 SGTC_354 2783-3500 7.54 4.9 µM 6.46E-14 cell wall 6 2.31E-14 0.26
10 SGTC_305 1682-2595 7.13 20.8 µM 1.28E-12 RNA processing & uracil transport 1 5.10E-13 1.82
11 SGTC_2584 androsterone 6.78 48.7 µM 1.42E-11 cell wall 8 6.13E-12 0.04
12 SGTC_610 4215-0184 6.49 155.0 µM 9.37E-11 exosome 11 4.31E-11 0.12
13 SGTC_133 0724-0033 6.16 378.9 µM 7.35E-10 2 3.63E-10 0.78
14 SGTC_1698 5-fluorocytosine 6.01 1.1 µM 1.80E-9 exosome 9 9.16E-10 0.06
15 SGTC_188 3229-0966 5.79 278.5 µM 6.49E-9 6 3.46E-9 0.02
16 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 5.45 4.6 µM 4.36E-8 heat shock/prefoldin 12 2.48E-8 0.49
17 SGTC_261 5-fluorouridine 5.20 15.4 µM 1.68E-7 exosome 5 1.00E-7 0.15
18 SGTC_351 caspofungin 5.15 25.0 nM 2.20E-7 cell wall 18 1.32E-7 0.28
19 SGTC_1454 4239-0054 4.81 42.6 µM 1.19E-6 4 7.59E-7 0.62
20 SGTC_666 0272-0154 4.81 136.0 µM 1.20E-6 cell wall 9 7.68E-7 0.06

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.380 2.19E-115 YGR195W SKI6 het Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp41p (EXOSC4)
0.346 8.56E-95 YDL111C RRP42 het Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp42p (EXOSC7)
0.325 4.48E-83 YJL099W CHS6 hom Member of the ChAPs (Chs5p-Arf1p-binding proteins) family; part of the exomer complex that mediates export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane; CHS6 has a paralog, BCH2, that arose from the whole genome duplication
0.307 2.36E-74 YPR142C_d YPR142C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RRP15, which is required for ribosomal RNA processing
0.302 1.42E-71 YPL044C_d YPL044C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene NOP4/YPL043W
0.291 1.29E-66 YKL172W EBP2 het Required for 25S rRNA maturation and 60S ribosomal subunit assembly; localizes to the nucleolus and in foci along nuclear periphery; constituent of 66S pre-ribosomal particles; cooperates with Rrs1p and Mps3p to mediate telomere clustering by binding Sir4p, but is not involved in telomere tethering
0.285 9.96E-64 YPL043W NOP4 het Nucleolar protein, essential for processing and maturation of 27S pre-rRNA and large ribosomal subunit biogenesis; constituent of 66S pre-ribosomal particles; contains four RNA recognition motifs (RRMs)
0.282 1.94E-62 YMR124W_p YMR124W_p hom Protein of unknown function; GFP-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; interacts with Crm1p in two-hybrid assay; YMR124W is not an essential gene; predicted to have a role in organelle organization
0.282 2.24E-62 YPL066W RGL1 hom Regulator of Rho1p signaling, cofactor of Tus1p; required for the localization of Tus1p during all phases of cytokinesis; green fluorescent protein (GFP)-fusion protein localizes to the bud neck and cytoplasm; null mutant is viable and exhibits growth defect on a non-fermentable (respiratory) carbon source
0.277 3.34E-60 YOL021C DIS3 het Exosome core complex catalytic subunit; possesses both endonuclease and 3'-5' exonuclease activity; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase R and to human DIS3; protein abundance increases in response to DNA replication stress
0.276 6.49E-60 YGR158C MTR3 het Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hMtr3p (EXOSC6)
0.275 2.79E-59 YBR023C CHS3 hom Chitin synthase III, catalyzes the transfer of N-acetylglucosamine (GlcNAc) to chitin; required for synthesis of the majority of cell wall chitin, the chitin ring during bud emergence, and spore wall chitosan
0.266 2.05E-55 YBL061C SKT5 hom Activator of Chs3p (chitin synthase III) during vegetative growth; recruits Chs3p to the bud neck via interaction with Bni4p; SKT5 has a paralog, SHC1, that arose from the whole genome duplication
0.262 1.80E-53 YDR280W RRP45 het Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp45p (PM/SCL-75, EXOSC9); protein abundance increases in response to DNA replication stress
0.257 9.01E-52 YOL003C PFA4 hom Palmitoyltransferase with autoacylation activity, required for palmitoylation of amino acid permeases containing a C-terminal Phe-Trp-Cys site; required for modification of Chs3p; member of the DHHC family of putative palmitoyltransferases