YPR144C / NOC4

Nucleolar protein, forms a complex with Nop14p that mediates maturation and nuclear export of 40S ribosomal subunits

Zygosity: Heterozygous strain
fixedexpanded
Profile for YPR144C / NOC4

Click on Significant Values for Screen Details ID:SGTC_17|Compound:0960-0276|FD-Score:4.43|P-value:1.24E-5 ID:SGTC_22|Compound:0964-0034|FD-Score:3.57|P-value:3.38E-4 ID:SGTC_69|Compound:0096-0274|FD-Score:-4.00|P-value:6.91E-5 ID:SGTC_74|Compound:000s-0487|FD-Score:4.58|P-value:6.65E-6 ID:SGTC_114|Compound:0364-0001|FD-Score:3.51|P-value:4.23E-4 ID:SGTC_121|Compound:0557-0495|FD-Score:3.41|P-value:5.98E-4 ID:SGTC_279|Compound:1273-0055|FD-Score:-3.27|P-value:9.14E-4 ID:SGTC_284|Compound:0988-0104|FD-Score:-3.69|P-value:2.14E-4 ID:SGTC_533|Compound:1222-0222|FD-Score:5.08|P-value:6.63E-7 ID:SGTC_735|Compound:3076-0345|FD-Score:3.53|P-value:3.89E-4 ID:SGTC_935|Compound:2996-0153|FD-Score:3.38|P-value:6.58E-4 ID:SGTC_937|Compound:3122-0005|FD-Score:5.60|P-value:4.93E-8 ID:SGTC_979|Compound:1426-2828|FD-Score:3.25|P-value:9.94E-4 ID:SGTC_1069|Compound:diphenylcyclopropenone|FD-Score:4.07|P-value:5.30E-5 ID:SGTC_1082|Compound:camptothecin|FD-Score:8.26|P-value:1.94E-15 ID:SGTC_1129|Compound:3453-1384|FD-Score:3.89|P-value:1.09E-4 ID:SGTC_1619|Compound:st003326|FD-Score:-4.38|P-value:1.50E-5 ID:SGTC_1671|Compound:st016596|FD-Score:3.41|P-value:5.97E-4 ID:SGTC_1675|Compound:st018485|FD-Score:-3.30|P-value:8.24E-4 ID:SGTC_1986|Compound:st071812|FD-Score:3.35|P-value:7.15E-4 ID:SGTC_2118|Compound:5526350|FD-Score:-3.78|P-value:1.56E-4 ID:SGTC_2186|Compound:6124449|FD-Score:3.42|P-value:5.65E-4 ID:SGTC_2239|Compound:6685329|FD-Score:3.71|P-value:2.07E-4 ID:SGTC_2245|Compound:6637752|FD-Score:4.44|P-value:1.21E-5 ID:SGTC_2346|Compound:9031566|FD-Score:3.84|P-value:1.32E-4 ID:SGTC_2351|Compound:9026858|FD-Score:3.85|P-value:1.24E-4 ID:SGTC_2352|Compound:9027995|FD-Score:3.34|P-value:7.57E-4 ID:SGTC_2544|Compound:sphondin|FD-Score:6.17|P-value:2.16E-9 ID:SGTC_2553|Compound:4-methylesculetin|FD-Score:4.03|P-value:6.39E-5 ID:SGTC_2561|Compound:acetosyringone|FD-Score:-3.47|P-value:4.68E-4 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:3.75|P-value:1.80E-4 ID:SGTC_2705|Compound:st078069|FD-Score:3.56|P-value:3.61E-4 ID:SGTC_3081|Compound:9117243|FD-Score:-4.17|P-value:3.55E-5 ID:SGTC_3082|Compound:9117008|FD-Score:5.06|P-value:7.51E-7 ID:SGTC_3084|Compound:9116877|FD-Score:3.59|P-value:3.25E-4 ID:SGTC_3095|Compound:9117207|FD-Score:5.84|P-value:1.35E-8 ID:SGTC_3182|Compound:9108849|FD-Score:3.38|P-value:6.55E-4 ID:SGTC_3200|Compound:9114385|FD-Score:4.55|P-value:7.51E-6 ID:SGTC_3245|Compound:9134821|FD-Score:-3.42|P-value:5.53E-4 ID:SGTC_3249|Compound:9135183|FD-Score:-4.75|P-value:2.89E-6 ID:SGTC_3253|Compound:9135987|FD-Score:-3.82|P-value:1.33E-4 ID:SGTC_3254|Compound:9136651|FD-Score:4.02|P-value:6.68E-5 ID:SGTC_3259|Compound:9138485|FD-Score:3.39|P-value:6.32E-4 ID:SGTC_3280|Compound:9140961|FD-Score:-4.53|P-value:7.87E-6 ID:SGTC_3323|Compound:9138564|FD-Score:3.31|P-value:8.30E-4 ID:SGTC_3337|Compound:9144342|FD-Score:-3.41|P-value:5.77E-4 ID:SGTC_17|Compound:0960-0276|FD-Score:4.43|P-value:1.24E-5 ID:SGTC_22|Compound:0964-0034|FD-Score:3.57|P-value:3.38E-4 ID:SGTC_69|Compound:0096-0274|FD-Score:-4.00|P-value:6.91E-5 ID:SGTC_74|Compound:000s-0487|FD-Score:4.58|P-value:6.65E-6 ID:SGTC_114|Compound:0364-0001|FD-Score:3.51|P-value:4.23E-4 ID:SGTC_121|Compound:0557-0495|FD-Score:3.41|P-value:5.98E-4 ID:SGTC_279|Compound:1273-0055|FD-Score:-3.27|P-value:9.14E-4 ID:SGTC_284|Compound:0988-0104|FD-Score:-3.69|P-value:2.14E-4 ID:SGTC_533|Compound:1222-0222|FD-Score:5.08|P-value:6.63E-7 ID:SGTC_735|Compound:3076-0345|FD-Score:3.53|P-value:3.89E-4 ID:SGTC_935|Compound:2996-0153|FD-Score:3.38|P-value:6.58E-4 ID:SGTC_937|Compound:3122-0005|FD-Score:5.60|P-value:4.93E-8 ID:SGTC_979|Compound:1426-2828|FD-Score:3.25|P-value:9.94E-4 ID:SGTC_1069|Compound:diphenylcyclopropenone|FD-Score:4.07|P-value:5.30E-5 ID:SGTC_1082|Compound:camptothecin|FD-Score:8.26|P-value:1.94E-15 ID:SGTC_1129|Compound:3453-1384|FD-Score:3.89|P-value:1.09E-4 ID:SGTC_1619|Compound:st003326|FD-Score:-4.38|P-value:1.50E-5 ID:SGTC_1671|Compound:st016596|FD-Score:3.41|P-value:5.97E-4 ID:SGTC_1675|Compound:st018485|FD-Score:-3.30|P-value:8.24E-4 ID:SGTC_1986|Compound:st071812|FD-Score:3.35|P-value:7.15E-4 ID:SGTC_2118|Compound:5526350|FD-Score:-3.78|P-value:1.56E-4 ID:SGTC_2186|Compound:6124449|FD-Score:3.42|P-value:5.65E-4 ID:SGTC_2239|Compound:6685329|FD-Score:3.71|P-value:2.07E-4 ID:SGTC_2245|Compound:6637752|FD-Score:4.44|P-value:1.21E-5 ID:SGTC_2346|Compound:9031566|FD-Score:3.84|P-value:1.32E-4 ID:SGTC_2351|Compound:9026858|FD-Score:3.85|P-value:1.24E-4 ID:SGTC_2352|Compound:9027995|FD-Score:3.34|P-value:7.57E-4 ID:SGTC_2544|Compound:sphondin|FD-Score:6.17|P-value:2.16E-9 ID:SGTC_2553|Compound:4-methylesculetin|FD-Score:4.03|P-value:6.39E-5 ID:SGTC_2561|Compound:acetosyringone|FD-Score:-3.47|P-value:4.68E-4 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:3.75|P-value:1.80E-4 ID:SGTC_2705|Compound:st078069|FD-Score:3.56|P-value:3.61E-4 ID:SGTC_3081|Compound:9117243|FD-Score:-4.17|P-value:3.55E-5 ID:SGTC_3082|Compound:9117008|FD-Score:5.06|P-value:7.51E-7 ID:SGTC_3084|Compound:9116877|FD-Score:3.59|P-value:3.25E-4 ID:SGTC_3095|Compound:9117207|FD-Score:5.84|P-value:1.35E-8 ID:SGTC_3182|Compound:9108849|FD-Score:3.38|P-value:6.55E-4 ID:SGTC_3200|Compound:9114385|FD-Score:4.55|P-value:7.51E-6 ID:SGTC_3245|Compound:9134821|FD-Score:-3.42|P-value:5.53E-4 ID:SGTC_3249|Compound:9135183|FD-Score:-4.75|P-value:2.89E-6 ID:SGTC_3253|Compound:9135987|FD-Score:-3.82|P-value:1.33E-4 ID:SGTC_3254|Compound:9136651|FD-Score:4.02|P-value:6.68E-5 ID:SGTC_3259|Compound:9138485|FD-Score:3.39|P-value:6.32E-4 ID:SGTC_3280|Compound:9140961|FD-Score:-4.53|P-value:7.87E-6 ID:SGTC_3323|Compound:9138564|FD-Score:3.31|P-value:8.30E-4 ID:SGTC_3337|Compound:9144342|FD-Score:-3.41|P-value:5.77E-4

Top fitness defect scores for YPR144C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature		Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1082 camptothecin 8.26 424.9 nM 1.94E-15 DNA damage response 2 7.56E-17 1.68
2 SGTC_2544 sphondin 6.17 68.5 µM 2.16E-9 RNA pol III & RNase P/MRP 17 3.43E-10 0.41
3 SGTC_3095 9117207 5.84 49.5 µM 1.35E-8 1 2.58E-9 2.14
4 SGTC_937 3122-0005 5.60 46.7 µM 4.93E-8 2 1.07E-8 0.64
5 SGTC_533 1222-0222 5.08 6.7 µM 6.63E-7 PDR1 4 1.87E-7 0.19
6 SGTC_3082 9117008 5.06 49.5 µM 7.51E-7 1 2.14E-7 0.92
7 SGTC_74 000s-0487 4.58 160.3 µM 6.65E-6 1 2.35E-6 0.60
8 SGTC_3200 9114385 4.55 49.5 µM 7.51E-6 9 2.69E-6 0.01
9 SGTC_2245 6637752 4.44 200.0 µM 1.21E-5 3 4.53E-6 0.15
10 SGTC_17 0960-0276 4.43 49.8 µM 1.24E-5 4 4.67E-6 0.47
11 SGTC_1069 diphenylcyclopropenone 4.07 8.5 µM 5.30E-5 8 2.30E-5 0.10
12 SGTC_2553 4-methylesculetin 4.03 85.1 µM 6.39E-5 3 2.83E-5 0.15
13 SGTC_3254 9136651 4.02 49.5 µM 6.68E-5 DNA damage response 5 2.96E-5 0.25
14 SGTC_1129 3453-1384 3.89 223.0 µM 1.09E-4 19 5.07E-5 0.21
15 SGTC_2351 9026858 3.85 72.3 µM 1.24E-4 RNA processing & uracil transport 14 5.84E-5 0.30
16 SGTC_2346 9031566 3.84 143.8 µM 1.32E-4 Golgi 12 6.27E-5 0.14
17 SGTC_2613 3',4'-dimethoxydalbergione 3.75 24.6 µM 1.80E-4 11 8.81E-5 0.12
18 SGTC_2239 6685329 3.71 187.6 µM 2.07E-4 5 1.03E-4 0.14
19 SGTC_3084 9116877 3.59 49.5 µM 3.25E-4 2 1.68E-4 0.52
20 SGTC_22 0964-0034 3.57 14.5 µM 3.38E-4 unfolded protein response 30 1.76E-4 0.04

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.140 4.27E-16 YBR099C_d YBR099C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified gene MMS4
0.125 4.39E-13 YDL059C RAD59 hom Protein involved DNA double-strand break repair; repairs breaks in DNA during vegetative growth via recombination and single-strand annealing; anneals complementary single-stranded DNA; forms nuclear foci upon DNA replication stress; required for loading of Rad52p to DSBs; paralog of Rad52p
0.120 2.90E-12 YBL088C TEL1 hom Protein kinase primarily involved in telomere length regulation; contributes to cell cycle checkpoint control in response to DNA damage; functionally redundant with Mec1p; regulates P-body formation induced by replication stress; homolog of human ataxia-telangiectasia mutated (ATM) gene, the gene responsible for ataxia telangiectasia (AT) (OMIM 607585)
0.118 6.13E-12 YDR386W MUS81 hom Subunit of the structure-specific Mms4p-Mus81p endonuclease that cleaves branched DNA; involved in DNA repair, replication fork stability, and joint molecule formation/resolution during meiotic recombination; helix-hairpin-helix protein; phosphorylation of the non-catalytic subunit Mms4p by Cdc28p and Cdcp during mitotic cell cycle activates the function of Mms4p-Mus81p
0.104 1.70E-9 YLR142W PUT1 hom Proline oxidase, nuclear-encoded mitochondrial protein involved in utilization of proline as sole nitrogen source; PUT1 transcription is induced by Put3p in the presence of proline and the absence of a preferred nitrogen source
0.100 6.60E-9 YKR100C SKG1 hom Transmembrane protein with a role in cell wall polymer composition; localizes on the inner surface of the plasma membrane at the bud and in the daughter cell
0.098 1.43E-8 YJL077W-B_p YJL077W-B_p hom Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
0.097 1.53E-8 YDR076W RAD55 hom Protein that stimulates strand exchange by stabilizing the binding of Rad51p to single-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; forms heterodimer with Rad57p
0.094 5.46E-8 YOR044W IRC23 hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion localizes to the ER; null mutant displays increased levels of spontaneous Rad52p foci; IRC23 has a paralog, BSC2, that arose from the whole genome duplication
0.087 4.22E-7 YPR066W UBA3 hom Protein that acts together with Ula1p to activate Rub1p before its conjugation to proteins (neddylation), which may play a role in protein degradation; GFP-fusion protein localizes to the cytoplasm in a punctate pattern
0.087 4.45E-7 YLR412C-A_p YLR412C-A_p hom Putative protein of unknown function
0.084 1.02E-6 YFR055W_p IRC7_p hom Beta-lyase involved in the production of thiols; null mutant displays increased levels of spontaneous Rad52p foci; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner and by copper levels in a Mac1-dependent manner
0.082 1.98E-6 YER095W RAD51 hom Strand exchange protein, forms a helical filament with DNA that searches for homology; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; homolog of Dmc1p and bacterial RecA protein
0.081 2.88E-6 YPR019W MCM4 het Essential helicase component of heterohexameric MCM2-7 complexes which bind pre-replication complexes on DNA and melt DNA prior to replication; forms an Mcm4p-6p-7p subcomplex; shows nuclear accumulation in G1; homolog of S. pombe Cdc21p
0.078 5.44E-6 YPR172W_p YPR172W_p hom Putative pyridoxal 5'-phosphate synthase; transcriptionally activated by Yrm1p along with genes involved in multidrug resistance; YPR172W has a paralog, YLR456W, that arose from the whole genome duplication