YPR147C_p

Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS

Zygosity: Homozygous strain
fixedexpanded
Profile for YPR147C / YPR147C

Click on Significant Values for Screen Details ID:SGTC_39|Compound:0986-0283|FD-Score:-3.62|P-value:2.99E-4 ID:SGTC_158|Compound:k038-0087|FD-Score:3.35|P-value:6.92E-4 ID:SGTC_434|Compound:1-hexadecyl-2-methylglycero-3 PC|FD-Score:-3.56|P-value:3.67E-4 ID:SGTC_494|Compound:Boc-Gly-Val-Val-CHO|FD-Score:-4.62|P-value:5.67E-6 ID:SGTC_793|Compound:0488-0545|FD-Score:-4.10|P-value:4.95E-5 ID:SGTC_804|Compound:1595-0054|FD-Score:3.99|P-value:7.18E-5 ID:SGTC_1097|Compound:itavastatin|FD-Score:3.80|P-value:1.46E-4 ID:SGTC_1111|Compound:tnp00062|FD-Score:4.67|P-value:4.26E-6 ID:SGTC_1117|Compound:retinoic acid|FD-Score:3.41|P-value:5.75E-4 ID:SGTC_1211|Compound:1056-0033|FD-Score:3.88|P-value:1.07E-4 ID:SGTC_1225|Compound:1216-0074|FD-Score:3.93|P-value:8.97E-5 ID:SGTC_1360|Compound:1598-0022|FD-Score:-4.11|P-value:4.79E-5 ID:SGTC_1520|Compound:flindersine|FD-Score:-6.15|P-value:2.60E-9 ID:SGTC_1527|Compound:coumarin|FD-Score:-3.97|P-value:8.36E-5 ID:SGTC_1733|Compound:st037357|FD-Score:3.85|P-value:1.18E-4 ID:SGTC_1921|Compound:5740136|FD-Score:3.43|P-value:5.30E-4 ID:SGTC_1962|Compound:st076595|FD-Score:-3.47|P-value:5.03E-4 ID:SGTC_1996|Compound:st072960|FD-Score:4.78|P-value:2.54E-6 ID:SGTC_2014|Compound:4013930|FD-Score:3.92|P-value:9.09E-5 ID:SGTC_2020|Compound:4017018|FD-Score:-5.10|P-value:6.33E-7 ID:SGTC_2304|Compound:7443016|FD-Score:3.83|P-value:1.29E-4 ID:SGTC_2315|Compound:7733312|FD-Score:-5.91|P-value:1.02E-8 ID:SGTC_2394|Compound:5221648|FD-Score:4.87|P-value:1.72E-6 ID:SGTC_2407|Compound:paclitaxel|FD-Score:-3.57|P-value:3.54E-4 ID:SGTC_2438|Compound:5259590|FD-Score:4.02|P-value:6.22E-5 ID:SGTC_2503|Compound:beta-caryophyllene alcohol|FD-Score:3.33|P-value:7.52E-4 ID:SGTC_2723|Compound:salbutamol|FD-Score:4.17|P-value:3.50E-5 ID:SGTC_2742|Compound:clothiapine|FD-Score:3.90|P-value:9.87E-5 ID:SGTC_2853|Compound:9015042|FD-Score:4.81|P-value:2.25E-6 ID:SGTC_2917|Compound:7979103|FD-Score:3.39|P-value:6.13E-4 ID:SGTC_2923|Compound:7992654|FD-Score:3.65|P-value:2.50E-4 ID:SGTC_3143|Compound:9086658|FD-Score:3.78|P-value:1.57E-4 ID:SGTC_3145|Compound:9085516|FD-Score:3.40|P-value:5.90E-4 ID:SGTC_3217|Compound:9129673|FD-Score:3.85|P-value:1.18E-4 ID:SGTC_3339|Compound:9145883|FD-Score:3.83|P-value:1.27E-4 ID:SGTC_3350|Compound:9150499|FD-Score:-3.48|P-value:4.85E-4 ID:SGTC_39|Compound:0986-0283|FD-Score:-3.62|P-value:2.99E-4 ID:SGTC_158|Compound:k038-0087|FD-Score:3.35|P-value:6.92E-4 ID:SGTC_434|Compound:1-hexadecyl-2-methylglycero-3 PC|FD-Score:-3.56|P-value:3.67E-4 ID:SGTC_494|Compound:Boc-Gly-Val-Val-CHO|FD-Score:-4.62|P-value:5.67E-6 ID:SGTC_793|Compound:0488-0545|FD-Score:-4.10|P-value:4.95E-5 ID:SGTC_804|Compound:1595-0054|FD-Score:3.99|P-value:7.18E-5 ID:SGTC_1097|Compound:itavastatin|FD-Score:3.80|P-value:1.46E-4 ID:SGTC_1111|Compound:tnp00062|FD-Score:4.67|P-value:4.26E-6 ID:SGTC_1117|Compound:retinoic acid|FD-Score:3.41|P-value:5.75E-4 ID:SGTC_1211|Compound:1056-0033|FD-Score:3.88|P-value:1.07E-4 ID:SGTC_1225|Compound:1216-0074|FD-Score:3.93|P-value:8.97E-5 ID:SGTC_1360|Compound:1598-0022|FD-Score:-4.11|P-value:4.79E-5 ID:SGTC_1520|Compound:flindersine|FD-Score:-6.15|P-value:2.60E-9 ID:SGTC_1527|Compound:coumarin|FD-Score:-3.97|P-value:8.36E-5 ID:SGTC_1733|Compound:st037357|FD-Score:3.85|P-value:1.18E-4 ID:SGTC_1921|Compound:5740136|FD-Score:3.43|P-value:5.30E-4 ID:SGTC_1962|Compound:st076595|FD-Score:-3.47|P-value:5.03E-4 ID:SGTC_1996|Compound:st072960|FD-Score:4.78|P-value:2.54E-6 ID:SGTC_2014|Compound:4013930|FD-Score:3.92|P-value:9.09E-5 ID:SGTC_2020|Compound:4017018|FD-Score:-5.10|P-value:6.33E-7 ID:SGTC_2304|Compound:7443016|FD-Score:3.83|P-value:1.29E-4 ID:SGTC_2315|Compound:7733312|FD-Score:-5.91|P-value:1.02E-8 ID:SGTC_2394|Compound:5221648|FD-Score:4.87|P-value:1.72E-6 ID:SGTC_2407|Compound:paclitaxel|FD-Score:-3.57|P-value:3.54E-4 ID:SGTC_2438|Compound:5259590|FD-Score:4.02|P-value:6.22E-5 ID:SGTC_2503|Compound:beta-caryophyllene alcohol|FD-Score:3.33|P-value:7.52E-4 ID:SGTC_2723|Compound:salbutamol|FD-Score:4.17|P-value:3.50E-5 ID:SGTC_2742|Compound:clothiapine|FD-Score:3.90|P-value:9.87E-5 ID:SGTC_2853|Compound:9015042|FD-Score:4.81|P-value:2.25E-6 ID:SGTC_2917|Compound:7979103|FD-Score:3.39|P-value:6.13E-4 ID:SGTC_2923|Compound:7992654|FD-Score:3.65|P-value:2.50E-4 ID:SGTC_3143|Compound:9086658|FD-Score:3.78|P-value:1.57E-4 ID:SGTC_3145|Compound:9085516|FD-Score:3.40|P-value:5.90E-4 ID:SGTC_3217|Compound:9129673|FD-Score:3.85|P-value:1.18E-4 ID:SGTC_3339|Compound:9145883|FD-Score:3.83|P-value:1.27E-4 ID:SGTC_3350|Compound:9150499|FD-Score:-3.48|P-value:4.85E-4

Top fitness defect scores for YPR147C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2394 5221648 4.87 200.0 µM 1.72E-6 11 5.60E-7
2 SGTC_2853 9015042 4.81 58.4 µM 2.25E-6 13 7.54E-7
3 SGTC_1996 st072960 4.78 66.8 µM 2.54E-6 3 8.62E-7
4 SGTC_1111 tnp00062 4.67 510.7 nM 4.26E-6 5 1.52E-6
5 SGTC_2723 salbutamol 4.17 83.6 µM 3.50E-5 8 1.53E-5
6 SGTC_2438 5259590 4.02 200.0 µM 6.22E-5 16 2.88E-5
7 SGTC_804 1595-0054 3.99 20.9 µM 7.18E-5 sphingolipid biosynthesis & PDR1 35 3.37E-5
8 SGTC_1225 1216-0074 3.93 20.6 µM 8.97E-5 23 4.30E-5
9 SGTC_2014 4013930 3.92 200.0 µM 9.09E-5 31 4.36E-5
10 SGTC_2742 clothiapine 3.90 36.3 µM 9.87E-5 NEO1 11 4.78E-5
11 SGTC_1211 1056-0033 3.88 32.3 µM 1.07E-4 11 5.20E-5
12 SGTC_1733 st037357 3.85 54.9 µM 1.18E-4 60S ribosome export 30 5.82E-5
13 SGTC_3217 9129673 3.85 49.5 µM 1.18E-4 44 5.83E-5
14 SGTC_3339 9145883 3.83 14.9 µM 1.27E-4 15 6.28E-5
15 SGTC_2304 7443016 3.83 91.4 µM 1.29E-4 22 6.41E-5
16 SGTC_1097 itavastatin 3.80 7.2 µM 1.46E-4 azole & statin 25 7.35E-5
17 SGTC_3143 9086658 3.78 49.5 µM 1.57E-4 53 7.94E-5
18 SGTC_2923 7992654 3.65 58.1 µM 2.50E-4 Golgi 38 1.32E-4
19 SGTC_1921 5740136 3.43 50.0 µM 5.30E-4 TRP & mitochondrial translation 79 3.01E-4
20 SGTC_1117 retinoic acid 3.41 1.1 µM 5.75E-4 31 3.29E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.111 1.23E-10 YLR307C-A_p YLR307C-A_p hom Putative protein of unknown function
0.092 1.02E-7 YKR101W SIR1 hom Protein involved in repression of transcription at the silent mating-type loci HML and HMR; recruitment to silent chromatin requires interactions with Orc1p and with Sir4p, through a common Sir1p domain; binds to centromeric chromatin
0.086 6.76E-7 YJR009C TDH2 hom Glyceraldehyde-3-phosphate dehydrogenase, isozyme 2; involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell wall; protein abundance increases in response to DNA replication stress; TDH2 has a paralog, TDH3, that arose from the whole genome duplication
0.083 1.28E-6 YLR263W RED1 hom Protein component of the synaptonemal complex axial elements, involved in chromosome segregation during the first meiotic division; critical for coupling checkpoint signaling to SC formation; interacts with Hop1p, Mec3p and Ddc1p
0.082 1.85E-6 YEL065W SIT1 hom Ferrioxamine B transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; transcription is induced during iron deprivation and diauxic shift; potentially phosphorylated by Cdc28p
0.078 5.69E-6 YLR387C REH1 hom Cytoplasmic 60S subunit biogenesis factor, associates with pre-60S particles; similar to Rei1p and shares partially redundant function in cytoplasmic 60S subunit maturation; contains dispersed C2H2 zinc finger domains
0.076 1.06E-5 YDL243C AAD4 hom Putative aryl-alcohol dehydrogenase; involved in oxidative stress response; similar to P. chrysosporium aryl-alcohol dehydrogenase; expression induced in cells treated with the mycotoxin patulin
0.076 1.17E-5 YOL099C_d YOL099C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene PKH2/YOL100W; may interact with ribosomes
0.073 2.18E-5 YDR131C_p YDR131C_p hom F-box protein, substrate-specific adaptor subunit that recruits substrates to a core ubiquitination complex
0.073 2.33E-5 YPL012W RRP12 het Protein required for export of the ribosomal subunits; associates with the RNA components of the pre-ribosomes; has a role in nuclear import in association with Pse1p; contains HEAT-repeats
0.072 2.62E-5 YDR222W_p YDR222W_p hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
0.072 3.05E-5 YBR199W KTR4 hom Putative mannosyltransferase involved in protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family
0.072 3.14E-5 YNL094W APP1 hom Phosphatidate phosphatase, converts phosphatidate to diacylglycerol; App1p, Pah1p, Dpp1p, and Lpp1p are responsible for all the phosphatidate phosphatase activity; component of cortical actin patches; interacts with components of endocytic pathway
0.069 5.91E-5 YGL230C_p YGL230C_p hom Putative protein of unknown function; non-essential gene
0.069 7.02E-5 YGR242W_d YGR242W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YAP1802/YGR241C