YPR148C

Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern

Zygosity: Homozygous strain
fixedexpanded
Profile for YPR148C / YPR148C

Click on Significant Values for Screen Details ID:SGTC_131|Compound:0141-0277|FD-Score:-3.73|P-value:1.39E-4 ID:SGTC_136|Compound:0097-0015|FD-Score:4.47|P-value:4.02E-6 ID:SGTC_137|Compound:0438-0332|FD-Score:6.10|P-value:6.53E-10 ID:SGTC_139|Compound:0099-0334|FD-Score:5.48|P-value:2.43E-8 ID:SGTC_142|Compound:0335-0849|FD-Score:5.42|P-value:3.38E-8 ID:SGTC_237|Compound:nikkomycin|FD-Score:3.29|P-value:4.81E-4 ID:SGTC_549|Compound:1661-1316|FD-Score:-4.08|P-value:3.44E-5 ID:SGTC_560|Compound:2332-1943|FD-Score:3.12|P-value:8.78E-4 ID:SGTC_795|Compound:0685-0265|FD-Score:4.28|P-value:9.78E-6 ID:SGTC_896|Compound:0964-0007|FD-Score:-3.31|P-value:6.32E-4 ID:SGTC_967|Compound:1306-0166|FD-Score:-3.85|P-value:8.86E-5 ID:SGTC_1078|Compound:idebenone|FD-Score:3.13|P-value:8.40E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:4.54|P-value:2.87E-6 ID:SGTC_1334|Compound:1486-0610|FD-Score:3.23|P-value:6.04E-4 ID:SGTC_1439|Compound:4092-1168|FD-Score:3.10|P-value:9.28E-4 ID:SGTC_1686|Compound:st019653|FD-Score:-3.59|P-value:2.35E-4 ID:SGTC_1707|Compound:st032323|FD-Score:3.19|P-value:6.97E-4 ID:SGTC_2418|Compound:pentamidine|FD-Score:6.91|P-value:3.16E-12 ID:SGTC_2419|Compound:paclitaxel|FD-Score:3.46|P-value:2.68E-4 ID:SGTC_2935|Compound:9038016|FD-Score:-3.76|P-value:1.26E-4 ID:SGTC_2959|Compound:9079155|FD-Score:5.96|P-value:1.48E-9 ID:SGTC_2966|Compound:9084041|FD-Score:3.09|P-value:9.63E-4 ID:SGTC_3255|Compound:9139072|FD-Score:3.26|P-value:5.42E-4 ID:SGTC_3299|Compound:9121982|FD-Score:-3.22|P-value:8.81E-4 ID:SGTC_3307|Compound:9126885|FD-Score:-3.46|P-value:3.83E-4 ID:SGTC_3308|Compound:9128332|FD-Score:-3.44|P-value:4.10E-4 ID:SGTC_131|Compound:0141-0277|FD-Score:-3.73|P-value:1.39E-4 ID:SGTC_136|Compound:0097-0015|FD-Score:4.47|P-value:4.02E-6 ID:SGTC_137|Compound:0438-0332|FD-Score:6.10|P-value:6.53E-10 ID:SGTC_139|Compound:0099-0334|FD-Score:5.48|P-value:2.43E-8 ID:SGTC_142|Compound:0335-0849|FD-Score:5.42|P-value:3.38E-8 ID:SGTC_237|Compound:nikkomycin|FD-Score:3.29|P-value:4.81E-4 ID:SGTC_549|Compound:1661-1316|FD-Score:-4.08|P-value:3.44E-5 ID:SGTC_560|Compound:2332-1943|FD-Score:3.12|P-value:8.78E-4 ID:SGTC_795|Compound:0685-0265|FD-Score:4.28|P-value:9.78E-6 ID:SGTC_896|Compound:0964-0007|FD-Score:-3.31|P-value:6.32E-4 ID:SGTC_967|Compound:1306-0166|FD-Score:-3.85|P-value:8.86E-5 ID:SGTC_1078|Compound:idebenone|FD-Score:3.13|P-value:8.40E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:4.54|P-value:2.87E-6 ID:SGTC_1334|Compound:1486-0610|FD-Score:3.23|P-value:6.04E-4 ID:SGTC_1439|Compound:4092-1168|FD-Score:3.10|P-value:9.28E-4 ID:SGTC_1686|Compound:st019653|FD-Score:-3.59|P-value:2.35E-4 ID:SGTC_1707|Compound:st032323|FD-Score:3.19|P-value:6.97E-4 ID:SGTC_2418|Compound:pentamidine|FD-Score:6.91|P-value:3.16E-12 ID:SGTC_2419|Compound:paclitaxel|FD-Score:3.46|P-value:2.68E-4 ID:SGTC_2935|Compound:9038016|FD-Score:-3.76|P-value:1.26E-4 ID:SGTC_2959|Compound:9079155|FD-Score:5.96|P-value:1.48E-9 ID:SGTC_2966|Compound:9084041|FD-Score:3.09|P-value:9.63E-4 ID:SGTC_3255|Compound:9139072|FD-Score:3.26|P-value:5.42E-4 ID:SGTC_3299|Compound:9121982|FD-Score:-3.22|P-value:8.81E-4 ID:SGTC_3307|Compound:9126885|FD-Score:-3.46|P-value:3.83E-4 ID:SGTC_3308|Compound:9128332|FD-Score:-3.44|P-value:4.10E-4

Top fitness defect scores for YPR148C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2418 pentamidine 6.91 31.7 µM 3.16E-12 mitochondrial processes 10 2.40E-12
2 SGTC_137 0438-0332 6.10 85.4 µM 6.53E-10 ubiquinone biosynthesis & proteasome 62 5.45E-10
3 SGTC_2959 9079155 5.96 11.0 µM 1.48E-9 8 1.26E-9
4 SGTC_139 0099-0334 5.48 718.6 µM 2.43E-8 7 2.16E-8
5 SGTC_142 0335-0849 5.42 62.7 µM 3.38E-8 ubiquinone biosynthesis & proteasome 76 3.02E-8
6 SGTC_1082 camptothecin 4.54 424.9 nM 2.87E-6 DNA damage response 37 2.75E-6
7 SGTC_136 0097-0015 4.47 404.5 µM 4.02E-6 60S ribosome export 9 3.87E-6
8 SGTC_795 0685-0265 4.28 78.0 µM 9.78E-6 excess fatty acid 15 9.54E-6
9 SGTC_2419 paclitaxel 3.46 166.5 µM 2.68E-4 70 2.72E-4
10 SGTC_237 nikkomycin 3.29 200.0 µM 4.81E-4 RSC complex & mRNA processing 37 4.93E-4
11 SGTC_3255 9139072 3.26 49.5 µM 5.42E-4 39 5.56E-4
12 SGTC_1334 1486-0610 3.23 236.0 µM 6.04E-4 60S ribosome export 44 6.20E-4
13 SGTC_1707 st032323 3.19 6.3 µM 6.97E-4 DNA damage response 95 7.17E-4
14 SGTC_1078 idebenone 3.13 36.1 µM 8.40E-4 Golgi 82 8.66E-4
15 SGTC_560 2332-1943 3.12 155.0 µM 8.78E-4 35 9.05E-4
16 SGTC_1439 4092-1168 3.10 46.0 µM 9.28E-4 31 9.57E-4
17 SGTC_2966 9084041 3.09 48.0 µM 9.63E-4 79 9.94E-4
18 SGTC_1048 3161-0300 3.03 24.5 µM 0.00120 57 0.00124
19 SGTC_1930 st074634 3.00 34.3 µM 0.00132 RNA pol III & RNase P/MRP 80 0.00136
20 SGTC_2029 5175081 2.98 200.0 µM 0.00139 66 0.00144

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.236 1.67E-43 YJL193W_p YJL193W_p hom Putative protein of unknown function, predicted to encode a triose phosphate transporter subfamily member based on phylogenetic analysis; similar to YOR307C/SLY41; deletion mutant has a respiratory growth defect
0.201 7.10E-32 YKR018C YKR018C hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; protein abundance increases in response to DNA replication stress; YKR018C has a paralog, IML2, that arose from the whole genome duplication
0.182 2.89E-26 YDL183C YDL183C hom Mitochondrial inner-membrane protein thought to be involved in the formation of an active mitochondrial K+/H+ exchanger (KHE) system; non-essential gene
0.169 7.11E-23 YML034C-A_d YML034C-A_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.161 8.30E-21 YOR254C SEC63 het Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
0.159 1.67E-20 YDL059C RAD59 hom Protein involved DNA double-strand break repair; repairs breaks in DNA during vegetative growth via recombination and single-strand annealing; anneals complementary single-stranded DNA; forms nuclear foci upon DNA replication stress; required for loading of Rad52p to DSBs; paralog of Rad52p
0.158 3.62E-20 YOR165W SEY1 hom Dynamin-like GTPase that mediates homotypic ER fusion; has a role in ER morphology; interacts physically and genetically with Yop1p and Rtn1p; functional ortholog of the human atlastin ATL1, defects in which cause a form of the human disease hereditary spastic paraplegia; homolog of Arabidopsis RHD3
0.155 2.02E-19 YPR065W ROX1 hom Heme-dependent repressor of hypoxic genes; mediates aerobic transcriptional repression of hypoxia induced genes such as COX5b and CYC7; repressor function regulated through decreased promoter occupancy in response to oxidative stress; contains an HMG domain that is responsible for DNA bending activity; involved in the hyperosmotic stress resistance
0.153 5.76E-19 YER012W PRE1 het Beta 4 subunit of the 20S proteasome; localizes to the nucleus throughout the cell cycle
0.147 8.82E-18 YJL155C FBP26 hom Fructose-2,6-bisphosphatase, required for glucose metabolism; protein abundance increases in response to DNA replication stress
0.147 1.46E-17 YML034W SRC1 hom Inner nuclear membrane protein; functions in regulation of subtelomeric genes and is linked to TREX (transcription export) factors; SRC1 produces 2 splice variant proteins with different functions; alternative splicing of SRC1 pre-mRNA is promoted by Hub1p; mutant has aneuploidy tolerance
0.146 1.44E-17 YPR064W_d YPR064W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.143 9.12E-17 YDR086C SSS1 het Subunit of the Sec61p translocation complex (Sec61p-Sss1p-Sbh1p) that forms a channel for passage of secretory proteins through the endoplasmic reticulum membrane, and of the Ssh1p complex (Ssh1p-Sbh2p-Sss1p); interacts with Ost4p and Wbp1p
0.140 3.82E-16 YOR311C DGK1 hom Diacylglycerol kinase, localized to the endoplasmic reticulum (ER); overproduction induces enlargement of ER-like membrane structures and suppresses a temperature-sensitive sly1 mutation; contains a CTP transferase domain
0.139 5.55E-16 YDR386W MUS81 hom Subunit of the structure-specific Mms4p-Mus81p endonuclease that cleaves branched DNA; involved in DNA repair, replication fork stability, and joint molecule formation/resolution during meiotic recombination; helix-hairpin-helix protein; phosphorylation of the non-catalytic subunit Mms4p by Cdc28p and Cdcp during mitotic cell cycle activates the function of Mms4p-Mus81p