YPR149W / NCE102

Protein of unknown function; contains transmembrane domains; involved in secretion of proteins that lack classical secretory signal sequences; component of the detergent-insoluble glycolipid-enriched complexes (DIGs)

Zygosity: Homozygous strain
fixedexpanded
Profile for YPR149W / NCE102

Click on Significant Values for Screen Details ID:SGTC_49|Compound:0717-0965|FD-Score:4.87|P-value:1.04E-7 ID:SGTC_68|Compound:0986-0284|FD-Score:-3.33|P-value:1.90E-4 ID:SGTC_108|Compound:0509-0257|FD-Score:5.25|P-value:1.08E-8 ID:SGTC_123|Compound:0083-0120|FD-Score:-3.28|P-value:2.38E-4 ID:SGTC_146|Compound:3448-8650|FD-Score:-3.93|P-value:1.42E-5 ID:SGTC_394|Compound:menadione|FD-Score:4.40|P-value:1.32E-6 ID:SGTC_408|Compound:cantharidin|FD-Score:3.12|P-value:4.30E-4 ID:SGTC_414|Compound:piperonyl butoxide|FD-Score:3.09|P-value:4.96E-4 ID:SGTC_418|Compound:lividomycin a|FD-Score:3.85|P-value:1.97E-5 ID:SGTC_588|Compound:3970-1144|FD-Score:4.20|P-value:3.80E-6 ID:SGTC_604|Compound:1000-0114|FD-Score:4.01|P-value:9.50E-6 ID:SGTC_720|Compound:r052-1644|FD-Score:-2.90|P-value:9.97E-4 ID:SGTC_834|Compound:0312-0008|FD-Score:4.05|P-value:7.75E-6 ID:SGTC_840|Compound:0245-0196|FD-Score:3.21|P-value:3.11E-4 ID:SGTC_843|Compound:0310-0051|FD-Score:3.43|P-value:1.28E-4 ID:SGTC_990|Compound:3985-0011|FD-Score:3.76|P-value:2.96E-5 ID:SGTC_991|Compound:3996-0057|FD-Score:-3.37|P-value:1.61E-4 ID:SGTC_1205|Compound:4161-2785|FD-Score:3.52|P-value:8.70E-5 ID:SGTC_1401|Compound:3807-4679|FD-Score:-3.59|P-value:6.47E-5 ID:SGTC_1570|Compound:verbenone|FD-Score:3.01|P-value:6.71E-4 ID:SGTC_1638|Compound:st008370|FD-Score:3.56|P-value:7.23E-5 ID:SGTC_1697|Compound:st025554|FD-Score:2.92|P-value:9.11E-4 ID:SGTC_1749|Compound:st037932|FD-Score:3.30|P-value:2.13E-4 ID:SGTC_1752|Compound:st044819|FD-Score:2.99|P-value:7.01E-4 ID:SGTC_1776|Compound:st049249|FD-Score:-3.02|P-value:6.51E-4 ID:SGTC_1796|Compound:st049173|FD-Score:4.98|P-value:5.24E-8 ID:SGTC_1879|Compound:gemcitabine|FD-Score:3.96|P-value:1.20E-5 ID:SGTC_2015|Compound:5119600|FD-Score:3.72|P-value:3.57E-5 ID:SGTC_2037|Compound:5169046|FD-Score:-4.49|P-value:8.42E-7 ID:SGTC_2040|Compound:5100729|FD-Score:-3.03|P-value:6.26E-4 ID:SGTC_2083|Compound:5306046|FD-Score:4.34|P-value:1.80E-6 ID:SGTC_2102|Compound:5377816|FD-Score:2.93|P-value:8.77E-4 ID:SGTC_2164|Compound:5685496|FD-Score:5.61|P-value:1.09E-9 ID:SGTC_2165|Compound:5727197|FD-Score:3.35|P-value:1.72E-4 ID:SGTC_2201|Compound:6605497|FD-Score:2.97|P-value:7.52E-4 ID:SGTC_2305|Compound:7443522|FD-Score:-3.38|P-value:1.55E-4 ID:SGTC_2316|Compound:5844804|FD-Score:-3.22|P-value:3.00E-4 ID:SGTC_2327|Compound:6189656|FD-Score:3.49|P-value:9.80E-5 ID:SGTC_2480|Compound:5767542|FD-Score:-3.73|P-value:3.54E-5 ID:SGTC_2610|Compound:ononetin|FD-Score:3.59|P-value:6.43E-5 ID:SGTC_2629|Compound:bisabolol|FD-Score:3.61|P-value:5.97E-5 ID:SGTC_2694|Compound:st077685|FD-Score:-3.10|P-value:4.69E-4 ID:SGTC_2817|Compound:7995342|FD-Score:3.03|P-value:6.06E-4 ID:SGTC_2829|Compound:7992743|FD-Score:3.25|P-value:2.67E-4 ID:SGTC_2844|Compound:9010103|FD-Score:-3.24|P-value:2.77E-4 ID:SGTC_2907|Compound:7721985|FD-Score:-3.21|P-value:3.07E-4 ID:SGTC_2978|Compound:9011784|FD-Score:-2.93|P-value:8.87E-4 ID:SGTC_2999|Compound:9069765|FD-Score:3.01|P-value:6.57E-4 ID:SGTC_3015|Compound:9080845|FD-Score:-3.26|P-value:2.55E-4 ID:SGTC_3291|Compound:9121177|FD-Score:3.49|P-value:9.90E-5 ID:SGTC_49|Compound:0717-0965|FD-Score:4.87|P-value:1.04E-7 ID:SGTC_68|Compound:0986-0284|FD-Score:-3.33|P-value:1.90E-4 ID:SGTC_108|Compound:0509-0257|FD-Score:5.25|P-value:1.08E-8 ID:SGTC_123|Compound:0083-0120|FD-Score:-3.28|P-value:2.38E-4 ID:SGTC_146|Compound:3448-8650|FD-Score:-3.93|P-value:1.42E-5 ID:SGTC_394|Compound:menadione|FD-Score:4.40|P-value:1.32E-6 ID:SGTC_408|Compound:cantharidin|FD-Score:3.12|P-value:4.30E-4 ID:SGTC_414|Compound:piperonyl butoxide|FD-Score:3.09|P-value:4.96E-4 ID:SGTC_418|Compound:lividomycin a|FD-Score:3.85|P-value:1.97E-5 ID:SGTC_588|Compound:3970-1144|FD-Score:4.20|P-value:3.80E-6 ID:SGTC_604|Compound:1000-0114|FD-Score:4.01|P-value:9.50E-6 ID:SGTC_720|Compound:r052-1644|FD-Score:-2.90|P-value:9.97E-4 ID:SGTC_834|Compound:0312-0008|FD-Score:4.05|P-value:7.75E-6 ID:SGTC_840|Compound:0245-0196|FD-Score:3.21|P-value:3.11E-4 ID:SGTC_843|Compound:0310-0051|FD-Score:3.43|P-value:1.28E-4 ID:SGTC_990|Compound:3985-0011|FD-Score:3.76|P-value:2.96E-5 ID:SGTC_991|Compound:3996-0057|FD-Score:-3.37|P-value:1.61E-4 ID:SGTC_1205|Compound:4161-2785|FD-Score:3.52|P-value:8.70E-5 ID:SGTC_1401|Compound:3807-4679|FD-Score:-3.59|P-value:6.47E-5 ID:SGTC_1570|Compound:verbenone|FD-Score:3.01|P-value:6.71E-4 ID:SGTC_1638|Compound:st008370|FD-Score:3.56|P-value:7.23E-5 ID:SGTC_1697|Compound:st025554|FD-Score:2.92|P-value:9.11E-4 ID:SGTC_1749|Compound:st037932|FD-Score:3.30|P-value:2.13E-4 ID:SGTC_1752|Compound:st044819|FD-Score:2.99|P-value:7.01E-4 ID:SGTC_1776|Compound:st049249|FD-Score:-3.02|P-value:6.51E-4 ID:SGTC_1796|Compound:st049173|FD-Score:4.98|P-value:5.24E-8 ID:SGTC_1879|Compound:gemcitabine|FD-Score:3.96|P-value:1.20E-5 ID:SGTC_2015|Compound:5119600|FD-Score:3.72|P-value:3.57E-5 ID:SGTC_2037|Compound:5169046|FD-Score:-4.49|P-value:8.42E-7 ID:SGTC_2040|Compound:5100729|FD-Score:-3.03|P-value:6.26E-4 ID:SGTC_2083|Compound:5306046|FD-Score:4.34|P-value:1.80E-6 ID:SGTC_2102|Compound:5377816|FD-Score:2.93|P-value:8.77E-4 ID:SGTC_2164|Compound:5685496|FD-Score:5.61|P-value:1.09E-9 ID:SGTC_2165|Compound:5727197|FD-Score:3.35|P-value:1.72E-4 ID:SGTC_2201|Compound:6605497|FD-Score:2.97|P-value:7.52E-4 ID:SGTC_2305|Compound:7443522|FD-Score:-3.38|P-value:1.55E-4 ID:SGTC_2316|Compound:5844804|FD-Score:-3.22|P-value:3.00E-4 ID:SGTC_2327|Compound:6189656|FD-Score:3.49|P-value:9.80E-5 ID:SGTC_2480|Compound:5767542|FD-Score:-3.73|P-value:3.54E-5 ID:SGTC_2610|Compound:ononetin|FD-Score:3.59|P-value:6.43E-5 ID:SGTC_2629|Compound:bisabolol|FD-Score:3.61|P-value:5.97E-5 ID:SGTC_2694|Compound:st077685|FD-Score:-3.10|P-value:4.69E-4 ID:SGTC_2817|Compound:7995342|FD-Score:3.03|P-value:6.06E-4 ID:SGTC_2829|Compound:7992743|FD-Score:3.25|P-value:2.67E-4 ID:SGTC_2844|Compound:9010103|FD-Score:-3.24|P-value:2.77E-4 ID:SGTC_2907|Compound:7721985|FD-Score:-3.21|P-value:3.07E-4 ID:SGTC_2978|Compound:9011784|FD-Score:-2.93|P-value:8.87E-4 ID:SGTC_2999|Compound:9069765|FD-Score:3.01|P-value:6.57E-4 ID:SGTC_3015|Compound:9080845|FD-Score:-3.26|P-value:2.55E-4 ID:SGTC_3291|Compound:9121177|FD-Score:3.49|P-value:9.90E-5

Top fitness defect scores for YPR149W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2164 5685496 5.61 200.0 µM 1.09E-9 6 1.02E-8
2 SGTC_108 0509-0257 5.25 621.1 µM 1.08E-8 20 7.71E-8
3 SGTC_1796 st049173 4.98 110.4 µM 5.24E-8 3 3.10E-7
4 SGTC_49 0717-0965 4.87 32.1 µM 1.04E-7 60S ribosome export 7 5.68E-7
5 SGTC_394 menadione 4.40 8.3 µM 1.32E-6 superoxide 22 5.33E-6
6 SGTC_2083 5306046 4.34 65.9 µM 1.80E-6 17 7.02E-6
7 SGTC_588 3970-1144 4.20 52.9 µM 3.80E-6 22 1.36E-5
8 SGTC_834 0312-0008 4.05 75.7 µM 7.75E-6 NEO1 30 2.56E-5
9 SGTC_604 1000-0114 4.01 314.0 µM 9.50E-6 18 3.06E-5
10 SGTC_1879 gemcitabine 3.96 100.0 µM 1.20E-5 15 3.76E-5
11 SGTC_418 lividomycin a 3.85 100.0 µM 1.97E-5 12 5.83E-5
12 SGTC_990 3985-0011 3.76 41.3 µM 2.96E-5 amide catabolism 26 8.36E-5
13 SGTC_2015 5119600 3.72 184.0 µM 3.57E-5 35 9.86E-5
14 SGTC_2629 bisabolol 3.61 100.0 µM 5.97E-5 30 1.56E-4
15 SGTC_2610 ononetin 3.59 44.2 µM 6.43E-5 58 1.66E-4
16 SGTC_1638 st008370 3.56 60.6 µM 7.23E-5 ergosterol biosynthesis 41 1.84E-4
17 SGTC_1205 4161-2785 3.52 76.0 µM 8.70E-5 48 2.17E-4
18 SGTC_2327 6189656 3.49 200.0 µM 9.80E-5 33 2.41E-4
19 SGTC_3291 9121177 3.49 71.4 µM 9.90E-5 23 2.44E-4
20 SGTC_843 0310-0051 3.43 143.0 µM 1.28E-4 27 3.06E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.126 2.33E-13 YGR126W_p YGR126W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus and is induced in response to the DNA-damaging agent MMS
0.118 6.87E-12 YGR130C YGR130C hom Component of the eisosome with unknown function; GFP-fusion protein localizes to the cytoplasm; specifically phosphorylated in vitro by mammalian diphosphoinositol pentakisphosphate (IP7)
0.108 3.93E-10 YPL149W ATG5 hom Conserved protein involved in autophagy and the Cvt pathway; undergoes conjugation with Atg12p to form a complex involved in Atg8p lipidation; conjugated Atg12p also forms a complex with Atg16p that is essential for autophagosome formation
0.106 7.87E-10 YPR136C_d YPR136C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF RRP9
0.090 1.70E-7 YLR014C PPR1 hom Zinc finger transcription factor containing a Zn(2)-Cys(6) binuclear cluster domain, positively regulates transcription of URA1, URA3, URA4, and URA10, which are involved in de novo pyrimidine biosynthesis, in response to pyrimidine starvation; activity may be modulated by interaction with Tup1p
0.087 3.87E-7 YDR057W YOS9 hom ER quality-control lectin; integral subunit of the HRD ligase; binds to glycans with terminal alpha-1,6 linked mannose on misfolded N-glycosylated proteins and participates in targeting proteins to ERAD; member of the OS-9 protein family
0.079 4.48E-6 YDL241W_p YDL241W_p hom Putative protein of unknown function; YDL241W is not an essential gene
0.077 8.66E-6 YOR038C HIR2 hom Subunit of the HIR complex, a nucleosome assembly complex involved in regulation of histone gene transcription; recruits Swi-Snf complexes to histone gene promoters; promotes heterochromatic gene silencing with Asf1p
0.077 8.77E-6 YMR130W_p YMR130W_p hom Putative protein of unknown function; YMR130W is not an essential gene
0.076 9.84E-6 YER157W COG3 het Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
0.076 1.14E-5 YLR165C PUS5 hom Pseudouridine synthase, catalyzes only the formation of pseudouridine (Psi)-2819 in mitochondrial 21S rRNA; not essential for viability
0.075 1.25E-5 YDR539W FDC1 hom Putative phenylacrylic acid decarboxylase; essential for the decarboxylation of aromatic carboxylic acids to the corresponding vinyl derivatives; homolog of E. coli UbiD; GFP-fusion protein localizes to the cytoplasm
0.073 2.11E-5 YNL131W TOM22 het Component of the TOM (translocase of outer mitochondrial membrane) complex responsible for initial import of mitochondrially directed proteins; acts as a receptor for precursor proteins and mediates interaction between TOM and TIM complexes
0.073 2.19E-5 YBL064C PRX1 hom Mitochondrial peroxiredoxin with thioredoxin peroxidase activity; has a role in reduction of hydroperoxides; reactivation requires Trr2p and glutathione; induced during respiratory growth and oxidative stress; phosphorylated; protein abundance increases in response to DNA replication stress
0.072 3.07E-5 YKR038C KAE1 het Highly conserved ATPase of HSP70/DnaK family; component of the EKC/KEOPS complex with Bud32p, Cgi121p, Pcc1p, and Gon7p; EKC/KEOPS complex is required for t6A tRNA modification and may have roles in telomere maintenance and transcription