YPR150W_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene SUE1/YPR151C

Zygosity: Homozygous strain
fixedexpanded
Profile for YPR150W / YPR150W

Click on Significant Values for Screen Details ID:SGTC_75|Compound:0159-0059|FD-Score:3.42|P-value:1.19E-4 ID:SGTC_160|Compound:3453-0671|FD-Score:2.93|P-value:8.04E-4 ID:SGTC_192|Compound:3455-0609|FD-Score:3.48|P-value:9.07E-5 ID:SGTC_341|Compound:1486-1430|FD-Score:3.81|P-value:2.18E-5 ID:SGTC_366|Compound:0181-0206|FD-Score:-4.32|P-value:3.02E-6 ID:SGTC_449|Compound:xestospongin c|FD-Score:-3.00|P-value:8.92E-4 ID:SGTC_566|Compound:0958-0068|FD-Score:-3.90|P-value:2.31E-5 ID:SGTC_627|Compound:1391-0720|FD-Score:4.45|P-value:9.46E-7 ID:SGTC_633|Compound:0437-0093|FD-Score:3.44|P-value:1.09E-4 ID:SGTC_712|Compound:r015-0009|FD-Score:3.53|P-value:7.52E-5 ID:SGTC_771|Compound:0250-0039|FD-Score:-3.21|P-value:4.14E-4 ID:SGTC_869|Compound:0564-0080|FD-Score:2.92|P-value:8.16E-4 ID:SGTC_878|Compound:0828-0289|FD-Score:-4.54|P-value:9.87E-7 ID:SGTC_1150|Compound:3909-7983|FD-Score:3.51|P-value:8.01E-5 ID:SGTC_1154|Compound:4088-0362|FD-Score:3.41|P-value:1.22E-4 ID:SGTC_1155|Compound:4088-0394|FD-Score:3.67|P-value:4.16E-5 ID:SGTC_1166|Compound:k206-0078|FD-Score:3.52|P-value:7.81E-5 ID:SGTC_1168|Compound:k815-0004|FD-Score:-3.05|P-value:7.53E-4 ID:SGTC_1178|Compound:0988-0033|FD-Score:2.92|P-value:8.21E-4 ID:SGTC_1220|Compound:1838-0075|FD-Score:3.23|P-value:2.59E-4 ID:SGTC_1241|Compound:0364-0022|FD-Score:-4.13|P-value:7.60E-6 ID:SGTC_1243|Compound:0416-0003|FD-Score:-3.41|P-value:1.86E-4 ID:SGTC_1244|Compound:0416-0015|FD-Score:3.65|P-value:4.44E-5 ID:SGTC_1245|Compound:0418-0076|FD-Score:-4.36|P-value:2.52E-6 ID:SGTC_1305|Compound:1181-0477|FD-Score:3.05|P-value:5.18E-4 ID:SGTC_1472|Compound:k841-0093|FD-Score:3.80|P-value:2.27E-5 ID:SGTC_1557|Compound:sumaresinolic acid|FD-Score:-2.97|P-value:9.91E-4 ID:SGTC_1562|Compound:morin hydrate|FD-Score:3.22|P-value:2.64E-4 ID:SGTC_1576|Compound:erythromycin ethylsuccinate|FD-Score:2.90|P-value:8.98E-4 ID:SGTC_1586|Compound:deoxycorticosterone acetate|FD-Score:3.12|P-value:3.93E-4 ID:SGTC_1689|Compound:st020265|FD-Score:3.33|P-value:1.70E-4 ID:SGTC_2004|Compound:4023728|FD-Score:3.38|P-value:1.40E-4 ID:SGTC_2129|Compound:girgensonine|FD-Score:3.63|P-value:4.89E-5 ID:SGTC_2203|Compound:7227154|FD-Score:3.49|P-value:8.67E-5 ID:SGTC_2365|Compound:9042475|FD-Score:-3.38|P-value:2.08E-4 ID:SGTC_2387|Compound:9077560|FD-Score:-3.02|P-value:8.33E-4 ID:SGTC_2395|Compound:5646831|FD-Score:-3.33|P-value:2.59E-4 ID:SGTC_2563|Compound:tomatine|FD-Score:-3.04|P-value:7.67E-4 ID:SGTC_2774|Compound:tamoxifen|FD-Score:4.92|P-value:6.94E-8 ID:SGTC_2829|Compound:7992743|FD-Score:2.98|P-value:6.71E-4 ID:SGTC_3000|Compound:9075062|FD-Score:3.00|P-value:6.17E-4 ID:SGTC_3193|Compound:9111931|FD-Score:-3.08|P-value:6.74E-4 ID:SGTC_75|Compound:0159-0059|FD-Score:3.42|P-value:1.19E-4 ID:SGTC_160|Compound:3453-0671|FD-Score:2.93|P-value:8.04E-4 ID:SGTC_192|Compound:3455-0609|FD-Score:3.48|P-value:9.07E-5 ID:SGTC_341|Compound:1486-1430|FD-Score:3.81|P-value:2.18E-5 ID:SGTC_366|Compound:0181-0206|FD-Score:-4.32|P-value:3.02E-6 ID:SGTC_449|Compound:xestospongin c|FD-Score:-3.00|P-value:8.92E-4 ID:SGTC_566|Compound:0958-0068|FD-Score:-3.90|P-value:2.31E-5 ID:SGTC_627|Compound:1391-0720|FD-Score:4.45|P-value:9.46E-7 ID:SGTC_633|Compound:0437-0093|FD-Score:3.44|P-value:1.09E-4 ID:SGTC_712|Compound:r015-0009|FD-Score:3.53|P-value:7.52E-5 ID:SGTC_771|Compound:0250-0039|FD-Score:-3.21|P-value:4.14E-4 ID:SGTC_869|Compound:0564-0080|FD-Score:2.92|P-value:8.16E-4 ID:SGTC_878|Compound:0828-0289|FD-Score:-4.54|P-value:9.87E-7 ID:SGTC_1150|Compound:3909-7983|FD-Score:3.51|P-value:8.01E-5 ID:SGTC_1154|Compound:4088-0362|FD-Score:3.41|P-value:1.22E-4 ID:SGTC_1155|Compound:4088-0394|FD-Score:3.67|P-value:4.16E-5 ID:SGTC_1166|Compound:k206-0078|FD-Score:3.52|P-value:7.81E-5 ID:SGTC_1168|Compound:k815-0004|FD-Score:-3.05|P-value:7.53E-4 ID:SGTC_1178|Compound:0988-0033|FD-Score:2.92|P-value:8.21E-4 ID:SGTC_1220|Compound:1838-0075|FD-Score:3.23|P-value:2.59E-4 ID:SGTC_1241|Compound:0364-0022|FD-Score:-4.13|P-value:7.60E-6 ID:SGTC_1243|Compound:0416-0003|FD-Score:-3.41|P-value:1.86E-4 ID:SGTC_1244|Compound:0416-0015|FD-Score:3.65|P-value:4.44E-5 ID:SGTC_1245|Compound:0418-0076|FD-Score:-4.36|P-value:2.52E-6 ID:SGTC_1305|Compound:1181-0477|FD-Score:3.05|P-value:5.18E-4 ID:SGTC_1472|Compound:k841-0093|FD-Score:3.80|P-value:2.27E-5 ID:SGTC_1557|Compound:sumaresinolic acid|FD-Score:-2.97|P-value:9.91E-4 ID:SGTC_1562|Compound:morin hydrate|FD-Score:3.22|P-value:2.64E-4 ID:SGTC_1576|Compound:erythromycin ethylsuccinate|FD-Score:2.90|P-value:8.98E-4 ID:SGTC_1586|Compound:deoxycorticosterone acetate|FD-Score:3.12|P-value:3.93E-4 ID:SGTC_1689|Compound:st020265|FD-Score:3.33|P-value:1.70E-4 ID:SGTC_2004|Compound:4023728|FD-Score:3.38|P-value:1.40E-4 ID:SGTC_2129|Compound:girgensonine|FD-Score:3.63|P-value:4.89E-5 ID:SGTC_2203|Compound:7227154|FD-Score:3.49|P-value:8.67E-5 ID:SGTC_2365|Compound:9042475|FD-Score:-3.38|P-value:2.08E-4 ID:SGTC_2387|Compound:9077560|FD-Score:-3.02|P-value:8.33E-4 ID:SGTC_2395|Compound:5646831|FD-Score:-3.33|P-value:2.59E-4 ID:SGTC_2563|Compound:tomatine|FD-Score:-3.04|P-value:7.67E-4 ID:SGTC_2774|Compound:tamoxifen|FD-Score:4.92|P-value:6.94E-8 ID:SGTC_2829|Compound:7992743|FD-Score:2.98|P-value:6.71E-4 ID:SGTC_3000|Compound:9075062|FD-Score:3.00|P-value:6.17E-4 ID:SGTC_3193|Compound:9111931|FD-Score:-3.08|P-value:6.74E-4

Top fitness defect scores for YPR150W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2774 tamoxifen 4.92 10.9 µM 6.94E-8 6 4.27E-7
2 SGTC_627 1391-0720 4.45 175.0 µM 9.46E-7 6 4.33E-6
3 SGTC_341 1486-1430 3.81 230.0 µM 2.18E-5 26 6.98E-5
4 SGTC_1472 k841-0093 3.80 193.0 µM 2.27E-5 21 7.22E-5
5 SGTC_1155 4088-0394 3.67 48.2 µM 4.16E-5 41 1.24E-4
6 SGTC_1244 0416-0015 3.65 52.5 µM 4.44E-5 ERG2 47 1.31E-4
7 SGTC_2129 girgensonine 3.63 121.0 µM 4.89E-5 heme biosynthesis & mitochondrial translocase 40 1.43E-4
8 SGTC_712 r015-0009 3.53 80.6 µM 7.52E-5 30 2.09E-4
9 SGTC_1166 k206-0078 3.52 225.0 µM 7.81E-5 34 2.16E-4
10 SGTC_1150 3909-7983 3.51 10.9 µM 8.01E-5 40 2.21E-4
11 SGTC_2203 7227154 3.49 166.4 µM 8.67E-5 25 2.37E-4
12 SGTC_192 3455-0609 3.48 60.9 µM 9.07E-5 24 2.47E-4
13 SGTC_633 0437-0093 3.44 97.7 µM 1.09E-4 DNA intercalators 27 2.91E-4
14 SGTC_75 0159-0059 3.42 199.0 µM 1.19E-4 fatty acid desaturase (OLE1) 32 3.14E-4
15 SGTC_1154 4088-0362 3.41 150.0 µM 1.22E-4 39 3.20E-4
16 SGTC_2004 4023728 3.38 41.9 µM 1.40E-4 48 3.63E-4
17 SGTC_1689 st020265 3.33 53.5 µM 1.70E-4 30 4.30E-4
18 SGTC_1220 1838-0075 3.23 193.0 µM 2.59E-4 33 6.26E-4
19 SGTC_1562 morin hydrate 3.22 59.1 µM 2.64E-4 42 6.36E-4
20 SGTC_1586 deoxycorticosterone acetate 3.12 53.7 µM 3.93E-4 37 9.04E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.112 7.39E-11 YLR060W FRS1 het Beta subunit of cytoplasmic phenylalanyl-tRNA synthetase, forms a tetramer with Frs2p to generate active enzyme; able to hydrolyze mis-aminoacylated tRNA-Phe, which could contribute to translational quality control
0.099 1.06E-8 YML058W SML1 hom Ribonucleotide reductase inhibitor involved in regulating dNTP production; regulated by Mec1p and Rad53p during DNA damage and S phase
0.098 1.18E-8 YPL210C SRP72 het Core component of the signal recognition particle (SRP) ribonucleoprotein (RNP) complex that functions in targeting nascent secretory proteins to the endoplasmic reticulum (ER) membrane
0.093 7.77E-8 YPL183C RTT10 hom WD40 domain-containing protein involved in endosomal recycling; forms a complex with Rrt2p that functions in the retromer-mediated pathway for recycling internalized cell-surface proteins; evidence it interacts with Trm7p for 2'-O-methylation of N34 of substrate tRNAs; has a role in regulation of Ty1 transposition; human ortholog is WDR6
0.089 2.71E-7 YNL226W_d YNL226W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene JJJ1/YNL227C
0.083 1.31E-6 YKL014C URB1 het Nucleolar protein required for the normal accumulation of 25S and 5.8S rRNAs, associated with the 27SA2 pre-ribosomal particle; proposed to be involved in the biogenesis of the 60S ribosomal subunit
0.081 2.94E-6 YDR421W ARO80 hom Zinc finger transcriptional activator of the Zn2Cys6 family; activates transcription of aromatic amino acid catabolic genes in the presence of aromatic amino acids
0.076 1.03E-5 YER014C-A BUD25 hom Protein involved in bud-site selection; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern
0.074 1.99E-5 YDR527W RBA50 het Protein involved in transcription; interacts with RNA polymerase II subunits Rpb2p, Rpb3, and Rpb11p; has similarity to human RPAP1
0.071 4.03E-5 YML043C RRN11 het Component of the core factor (CF) rDNA transcription factor complex; CF is required for transcription of 35S rRNA genes by RNA polymerase I and is composed of Rrn6p, Rrn7p, and Rrn11p
0.070 5.00E-5 YNL122C_p YNL122C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YNL122C is not an essential gene
0.069 6.85E-5 YBR088C POL30 het Proliferating cell nuclear antigen (PCNA), functions as the sliding clamp for DNA polymerase delta; may function as a docking site for other proteins required for mitotic and meiotic chromosomal DNA replication and for DNA repair
0.068 7.21E-5 YKL196C YKT6 het Vesicle membrane protein (v-SNARE) with acyltransferase activity; involved in trafficking to and within the Golgi, endocytic trafficking to the vacuole, and vacuolar fusion; membrane localization due to prenylation at the carboxy-terminus
0.068 8.75E-5 YER066C-A_d YER066C-A_d hom Dubious open reading frame unlikely to encode a protein, partially overlaps uncharacterized ORF YER067W
0.067 9.19E-5 YHR112C YHR112C hom Protein of unknown function; localizes to the cytoplasm and nucleus; overexpression affects protein trafficking through the endocytic pathway