YPR152C / URN1

Putative protein of unknown function containing WW and FF domains; overexpression causes accumulation of cells in G1 phase

Zygosity: Homozygous strain
fixedexpanded
Profile for YPR152C / URN1

Click on Significant Values for Screen Details ID:SGTC_12|Compound:0849-0099|FD-Score:3.49|P-value:1.72E-4 ID:SGTC_40|Compound:0327-0103|FD-Score:4.64|P-value:9.85E-7 ID:SGTC_294|Compound:k038-0071|FD-Score:3.45|P-value:2.00E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-3.81|P-value:4.64E-5 ID:SGTC_326|Compound:k292-0812|FD-Score:-3.50|P-value:1.62E-4 ID:SGTC_343|Compound:4130-2827|FD-Score:3.24|P-value:4.52E-4 ID:SGTC_345|Compound:1362-0200|FD-Score:-3.61|P-value:1.06E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:3.38|P-value:2.68E-4 ID:SGTC_519|Compound:k048-0011|FD-Score:-3.12|P-value:6.88E-4 ID:SGTC_523|Compound:1934-0222|FD-Score:-3.69|P-value:7.52E-5 ID:SGTC_546|Compound:peri-Naphthalide|FD-Score:-3.73|P-value:6.60E-5 ID:SGTC_550|Compound:4123-0385|FD-Score:3.42|P-value:2.28E-4 ID:SGTC_557|Compound:1315-0110|FD-Score:-3.77|P-value:5.55E-5 ID:SGTC_560|Compound:2332-1943|FD-Score:4.08|P-value:1.43E-5 ID:SGTC_622|Compound:1348-1566|FD-Score:3.02|P-value:9.91E-4 ID:SGTC_644|Compound:1498-1197|FD-Score:4.02|P-value:1.90E-5 ID:SGTC_718|Compound:1130-0073|FD-Score:3.17|P-value:5.82E-4 ID:SGTC_1009|Compound:4106-0057|FD-Score:3.23|P-value:4.61E-4 ID:SGTC_1015|Compound:4130-4525|FD-Score:3.98|P-value:2.28E-5 ID:SGTC_1051|Compound:3253-3903|FD-Score:-3.52|P-value:1.54E-4 ID:SGTC_1071|Compound:trifluoperazine|FD-Score:3.62|P-value:1.02E-4 ID:SGTC_1520|Compound:flindersine|FD-Score:-3.45|P-value:1.99E-4 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:4.17|P-value:9.41E-6 ID:SGTC_1564|Compound:D-Arginine|FD-Score:-3.25|P-value:4.29E-4 ID:SGTC_1633|Compound:st005664|FD-Score:-3.31|P-value:3.40E-4 ID:SGTC_1675|Compound:st018485|FD-Score:3.49|P-value:1.70E-4 ID:SGTC_1760|Compound:st045453|FD-Score:3.05|P-value:8.87E-4 ID:SGTC_1919|Compound:st067113|FD-Score:-3.11|P-value:7.16E-4 ID:SGTC_2058|Compound:5236698|FD-Score:-3.93|P-value:2.81E-5 ID:SGTC_2085|Compound:5307070|FD-Score:4.10|P-value:1.33E-5 ID:SGTC_2088|Compound:5278280|FD-Score:3.22|P-value:4.84E-4 ID:SGTC_2101|Compound:5377231|FD-Score:4.63|P-value:1.03E-6 ID:SGTC_2238|Compound:6671620|FD-Score:-3.26|P-value:4.05E-4 ID:SGTC_2313|Compound:7726885|FD-Score:3.28|P-value:3.92E-4 ID:SGTC_2351|Compound:9026858|FD-Score:-5.83|P-value:1.09E-9 ID:SGTC_2406|Compound:ethylparaben|FD-Score:-3.09|P-value:7.58E-4 ID:SGTC_2413|Compound:inermin|FD-Score:4.01|P-value:1.95E-5 ID:SGTC_2423|Compound:st077119|FD-Score:-3.02|P-value:9.73E-4 ID:SGTC_2429|Compound:5902844|FD-Score:3.29|P-value:3.77E-4 ID:SGTC_2507|Compound:purpurin|FD-Score:-3.14|P-value:6.36E-4 ID:SGTC_2610|Compound:ononetin|FD-Score:4.24|P-value:6.76E-6 ID:SGTC_2622|Compound:2-methoxyxanthone|FD-Score:3.93|P-value:2.80E-5 ID:SGTC_2691|Compound:st077356|FD-Score:3.38|P-value:2.69E-4 ID:SGTC_2788|Compound:5282734|FD-Score:3.66|P-value:8.83E-5 ID:SGTC_2853|Compound:9015042|FD-Score:-4.33|P-value:4.53E-6 ID:SGTC_3213|Compound:9129884|FD-Score:4.82|P-value:3.95E-7 ID:SGTC_3225|Compound:9130819|FD-Score:4.75|P-value:5.52E-7 ID:SGTC_12|Compound:0849-0099|FD-Score:3.49|P-value:1.72E-4 ID:SGTC_40|Compound:0327-0103|FD-Score:4.64|P-value:9.85E-7 ID:SGTC_294|Compound:k038-0071|FD-Score:3.45|P-value:2.00E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-3.81|P-value:4.64E-5 ID:SGTC_326|Compound:k292-0812|FD-Score:-3.50|P-value:1.62E-4 ID:SGTC_343|Compound:4130-2827|FD-Score:3.24|P-value:4.52E-4 ID:SGTC_345|Compound:1362-0200|FD-Score:-3.61|P-value:1.06E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:3.38|P-value:2.68E-4 ID:SGTC_519|Compound:k048-0011|FD-Score:-3.12|P-value:6.88E-4 ID:SGTC_523|Compound:1934-0222|FD-Score:-3.69|P-value:7.52E-5 ID:SGTC_546|Compound:peri-Naphthalide|FD-Score:-3.73|P-value:6.60E-5 ID:SGTC_550|Compound:4123-0385|FD-Score:3.42|P-value:2.28E-4 ID:SGTC_557|Compound:1315-0110|FD-Score:-3.77|P-value:5.55E-5 ID:SGTC_560|Compound:2332-1943|FD-Score:4.08|P-value:1.43E-5 ID:SGTC_622|Compound:1348-1566|FD-Score:3.02|P-value:9.91E-4 ID:SGTC_644|Compound:1498-1197|FD-Score:4.02|P-value:1.90E-5 ID:SGTC_718|Compound:1130-0073|FD-Score:3.17|P-value:5.82E-4 ID:SGTC_1009|Compound:4106-0057|FD-Score:3.23|P-value:4.61E-4 ID:SGTC_1015|Compound:4130-4525|FD-Score:3.98|P-value:2.28E-5 ID:SGTC_1051|Compound:3253-3903|FD-Score:-3.52|P-value:1.54E-4 ID:SGTC_1071|Compound:trifluoperazine|FD-Score:3.62|P-value:1.02E-4 ID:SGTC_1520|Compound:flindersine|FD-Score:-3.45|P-value:1.99E-4 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:4.17|P-value:9.41E-6 ID:SGTC_1564|Compound:D-Arginine|FD-Score:-3.25|P-value:4.29E-4 ID:SGTC_1633|Compound:st005664|FD-Score:-3.31|P-value:3.40E-4 ID:SGTC_1675|Compound:st018485|FD-Score:3.49|P-value:1.70E-4 ID:SGTC_1760|Compound:st045453|FD-Score:3.05|P-value:8.87E-4 ID:SGTC_1919|Compound:st067113|FD-Score:-3.11|P-value:7.16E-4 ID:SGTC_2058|Compound:5236698|FD-Score:-3.93|P-value:2.81E-5 ID:SGTC_2085|Compound:5307070|FD-Score:4.10|P-value:1.33E-5 ID:SGTC_2088|Compound:5278280|FD-Score:3.22|P-value:4.84E-4 ID:SGTC_2101|Compound:5377231|FD-Score:4.63|P-value:1.03E-6 ID:SGTC_2238|Compound:6671620|FD-Score:-3.26|P-value:4.05E-4 ID:SGTC_2313|Compound:7726885|FD-Score:3.28|P-value:3.92E-4 ID:SGTC_2351|Compound:9026858|FD-Score:-5.83|P-value:1.09E-9 ID:SGTC_2406|Compound:ethylparaben|FD-Score:-3.09|P-value:7.58E-4 ID:SGTC_2413|Compound:inermin|FD-Score:4.01|P-value:1.95E-5 ID:SGTC_2423|Compound:st077119|FD-Score:-3.02|P-value:9.73E-4 ID:SGTC_2429|Compound:5902844|FD-Score:3.29|P-value:3.77E-4 ID:SGTC_2507|Compound:purpurin|FD-Score:-3.14|P-value:6.36E-4 ID:SGTC_2610|Compound:ononetin|FD-Score:4.24|P-value:6.76E-6 ID:SGTC_2622|Compound:2-methoxyxanthone|FD-Score:3.93|P-value:2.80E-5 ID:SGTC_2691|Compound:st077356|FD-Score:3.38|P-value:2.69E-4 ID:SGTC_2788|Compound:5282734|FD-Score:3.66|P-value:8.83E-5 ID:SGTC_2853|Compound:9015042|FD-Score:-4.33|P-value:4.53E-6 ID:SGTC_3213|Compound:9129884|FD-Score:4.82|P-value:3.95E-7 ID:SGTC_3225|Compound:9130819|FD-Score:4.75|P-value:5.52E-7

Top fitness defect scores for YPR152C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3213 9129884 4.82 49.5 µM 3.95E-7 8 7.33E-7
2 SGTC_3225 9130819 4.75 49.5 µM 5.52E-7 amide catabolism 13 1.01E-6
3 SGTC_40 0327-0103 4.64 19.8 µM 9.85E-7 14 1.75E-6
4 SGTC_2101 5377231 4.63 179.2 µM 1.03E-6 4 1.82E-6
5 SGTC_2610 ononetin 4.24 44.2 µM 6.76E-6 32 1.10E-5
6 SGTC_1525 8-methoxypsoralen 4.17 92.5 µM 9.41E-6 DNA damage response 24 1.50E-5
7 SGTC_2085 5307070 4.10 144.1 µM 1.33E-5 superoxide 23 2.09E-5
8 SGTC_560 2332-1943 4.08 155.0 µM 1.43E-5 8 2.24E-5
9 SGTC_644 1498-1197 4.02 63.3 µM 1.90E-5 19 2.94E-5
10 SGTC_2413 inermin 4.01 26.1 µM 1.95E-5 50 3.01E-5
11 SGTC_1015 4130-4525 3.98 82.0 µM 2.28E-5 60S ribosome export 20 3.49E-5
12 SGTC_2622 2-methoxyxanthone 3.93 59.9 µM 2.80E-5 21 4.25E-5
13 SGTC_2788 5282734 3.66 71.4 µM 8.83E-5 60 1.27E-4
14 SGTC_1071 trifluoperazine 3.62 6.3 µM 1.02E-4 36 1.46E-4
15 SGTC_1675 st018485 3.49 24.5 µM 1.70E-4 60S ribosome export 44 2.38E-4
16 SGTC_12 0849-0099 3.49 9.3 µM 1.72E-4 31 2.41E-4
17 SGTC_294 k038-0071 3.45 157.0 µM 2.00E-4 ubiquinone biosynthesis & proteasome 80 2.77E-4
18 SGTC_550 4123-0385 3.42 25.7 µM 2.28E-4 TSC3-RPN4 49 3.14E-4
19 SGTC_431 k089-0097 3.38 107.0 µM 2.68E-4 iron homeostasis 68 3.66E-4
20 SGTC_2691 st077356 3.38 60.2 µM 2.69E-4 55 3.68E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.103 1.98E-9 YFL038C YPT1 het Rab family GTPase, involved in the ER-to-Golgi step of the secretory pathway; complex formation with the Rab escort protein Mrs6p is required for prenylation of Ypt1p by protein geranylgeranyltransferase type II (Bet2p-Bet4p)
0.096 2.59E-8 YOL015W IRC10 hom Putative protein of unknown function; null mutant displays increased levels of spontaneous Rad52p foci
0.090 1.64E-7 YJL131C AIM23 hom Mitochondrial translation initiation factor 3 (IF3, mIF3); evolutionarily conserved; binds to E. coli ribosomes in vitro; null mutant displays severe respiratory growth defect and elevated frequency of mitochondrial genome loss
0.089 2.30E-7 YBR221W-A_p YBR221W-A_p hom Putative protein of unknown function; identified by expression profiling and mass spectrometry
0.089 2.50E-7 YLR178C TFS1 hom Protein that interacts with and inhibits carboxypeptidase Y and Ira2p; phosphatidylethanolamine-binding protein (PEBP) family member; targets to vacuolar membranes during stationary phase; acetylated by NatB N-terminal acetyltransferase; protein abundance increases in response to DNA replication stress
0.088 2.89E-7 YPL037C EGD1 hom Subunit beta1 of the nascent polypeptide-associated complex (NAC) involved in protein targeting, associated with cytoplasmic ribosomes; enhances DNA binding of the Gal4p activator; homolog of human BTF3b
0.082 2.14E-6 YOR073W SGO1 hom Component of the spindle checkpoint, involved in sensing lack of tension on mitotic chromosomes; protects centromeric Rec8p at meiosis I; required for accurate chromosomal segregation at meiosis II and for mitotic chromosome stability
0.082 2.20E-6 YPL011C TAF3 het TFIID subunit (47 kDa), involved in promoter binding and RNA polymerase II transcription initiation
0.081 2.38E-6 YOR246C ENV9 hom Protein proposed to be involved in vacuolar functions; mutant shows defect in CPY processing and defects in vacuolar morphology; has similarity to oxidoreductases, found in lipid particles; required for replication of Brome mosaic virus in S. cerevisiae, a model system for studying replication of positive-strand RNA viruses in their natural hosts
0.080 3.17E-6 YER066C-A_d YER066C-A_d hom Dubious open reading frame unlikely to encode a protein, partially overlaps uncharacterized ORF YER067W
0.080 3.21E-6 YPR159C-A_p YPR159C-A_p hom Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
0.080 3.46E-6 YDR089W YDR089W hom Protein of unknown function; deletion confers resistance to nickel; contains an SPX domain, which is found in proteins involved in phosphate homeostasis; relocalizes from vacuole to cytoplasm upon DNA replication stress
0.080 3.57E-6 YPL007C TFC8 het One of six subunits of RNA polymerase III transcription initiation factor complex (TFIIIC); part of TFIIIC TauB domain that binds BoxB promoter sites of tRNA and other genes; linker between TauB and TauA domains; human homolog is TFIIIC-90
0.079 5.05E-6 YBR173C UMP1 hom Short-lived chaperone required for correct maturation of the 20S proteasome; may inhibit premature dimerization of proteasome half-mers; degraded by proteasome upon completion of its assembly
0.076 1.18E-5 YER091C-A_d YER091C-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data