HIPHOP chemogenomics database
YPR152C / URN1 
Putative protein of unknown function containing WW and FF domains; overexpression causes accumulation of cells in G1 phase
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YPR152C deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.103 | 1.98E-9 | YFL038C | YPT1 | het | Rab family GTPase, involved in the ER-to-Golgi step of the secretory pathway; complex formation with the Rab escort protein Mrs6p is required for prenylation of Ypt1p by protein geranylgeranyltransferase type II (Bet2p-Bet4p) |
| 0.096 | 2.59E-8 | YOL015W | IRC10 | hom | Putative protein of unknown function; null mutant displays increased levels of spontaneous Rad52p foci |
| 0.090 | 1.64E-7 | YJL131C | AIM23 | hom | Mitochondrial translation initiation factor 3 (IF3, mIF3); evolutionarily conserved; binds to E. coli ribosomes in vitro; null mutant displays severe respiratory growth defect and elevated frequency of mitochondrial genome loss |
| 0.089 | 2.30E-7 | YBR221W-A_p | YBR221W-A_p | hom | Putative protein of unknown function; identified by expression profiling and mass spectrometry |
| 0.089 | 2.50E-7 | YLR178C | TFS1 | hom | Protein that interacts with and inhibits carboxypeptidase Y and Ira2p; phosphatidylethanolamine-binding protein (PEBP) family member; targets to vacuolar membranes during stationary phase; acetylated by NatB N-terminal acetyltransferase; protein abundance increases in response to DNA replication stress |
| 0.088 | 2.89E-7 | YPL037C | EGD1 | hom | Subunit beta1 of the nascent polypeptide-associated complex (NAC) involved in protein targeting, associated with cytoplasmic ribosomes; enhances DNA binding of the Gal4p activator; homolog of human BTF3b |
| 0.082 | 2.14E-6 | YOR073W | SGO1 | hom | Component of the spindle checkpoint, involved in sensing lack of tension on mitotic chromosomes; protects centromeric Rec8p at meiosis I; required for accurate chromosomal segregation at meiosis II and for mitotic chromosome stability |
| 0.082 | 2.20E-6 | YPL011C | TAF3 | het | TFIID subunit (47 kDa), involved in promoter binding and RNA polymerase II transcription initiation |
| 0.081 | 2.38E-6 | YOR246C | ENV9 | hom | Protein proposed to be involved in vacuolar functions; mutant shows defect in CPY processing and defects in vacuolar morphology; has similarity to oxidoreductases, found in lipid particles; required for replication of Brome mosaic virus in S. cerevisiae, a model system for studying replication of positive-strand RNA viruses in their natural hosts |
| 0.080 | 3.17E-6 | YER066C-A_d | YER066C-A_d | hom | Dubious open reading frame unlikely to encode a protein, partially overlaps uncharacterized ORF YER067W |
| 0.080 | 3.21E-6 | YPR159C-A_p | YPR159C-A_p | hom | Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching |
| 0.080 | 3.46E-6 | YDR089W | YDR089W | hom | Protein of unknown function; deletion confers resistance to nickel; contains an SPX domain, which is found in proteins involved in phosphate homeostasis; relocalizes from vacuole to cytoplasm upon DNA replication stress |
| 0.080 | 3.57E-6 | YPL007C | TFC8 | het | One of six subunits of RNA polymerase III transcription initiation factor complex (TFIIIC); part of TFIIIC TauB domain that binds BoxB promoter sites of tRNA and other genes; linker between TauB and TauA domains; human homolog is TFIIIC-90 |
| 0.079 | 5.05E-6 | YBR173C | UMP1 | hom | Short-lived chaperone required for correct maturation of the 20S proteasome; may inhibit premature dimerization of proteasome half-mers; degraded by proteasome upon completion of its assembly |
| 0.076 | 1.18E-5 | YER091C-A_d | YER091C-A_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data |