YPR153W

Putative protein of unknown function

Zygosity: Homozygous strain
fixedexpanded
Profile for YPR153W / YPR153W

Click on Significant Values for Screen Details ID:SGTC_8|Compound:0354-0001|FD-Score:8.23|P-value:4.67E-19 ID:SGTC_17|Compound:0960-0276|FD-Score:2.98|P-value:6.64E-4 ID:SGTC_18|Compound:0111-0177|FD-Score:3.55|P-value:6.55E-5 ID:SGTC_56|Compound:0957-0365|FD-Score:7.94|P-value:6.70E-18 ID:SGTC_58|Compound:0957-0393|FD-Score:-3.08|P-value:4.83E-4 ID:SGTC_59|Compound:0330-0160|FD-Score:6.46|P-value:1.85E-12 ID:SGTC_87|Compound:0100-0052|FD-Score:8.90|P-value:5.65E-22 ID:SGTC_129|Compound:0088-0017|FD-Score:3.76|P-value:2.62E-5 ID:SGTC_164|Compound:4100-3994|FD-Score:3.35|P-value:1.53E-4 ID:SGTC_178|Compound:4092-0806|FD-Score:-3.05|P-value:5.43E-4 ID:SGTC_306|Compound:1672-3436|FD-Score:3.43|P-value:1.12E-4 ID:SGTC_315|Compound:k915-0449|FD-Score:2.94|P-value:7.80E-4 ID:SGTC_329|Compound:k048-0121|FD-Score:2.99|P-value:6.52E-4 ID:SGTC_467|Compound:ro 31-8220|FD-Score:-3.29|P-value:2.06E-4 ID:SGTC_495|Compound:decylubiquinone|FD-Score:3.53|P-value:7.15E-5 ID:SGTC_542|Compound:3381-0244|FD-Score:5.23|P-value:9.45E-9 ID:SGTC_568|Compound:1193-0097|FD-Score:9.68|P-value:1.20E-25 ID:SGTC_606|Compound:k015-0008|FD-Score:3.10|P-value:4.19E-4 ID:SGTC_623|Compound:k072-0108|FD-Score:3.09|P-value:4.34E-4 ID:SGTC_628|Compound:1636-0253|FD-Score:3.37|P-value:1.42E-4 ID:SGTC_716|Compound:1683-5115|FD-Score:4.00|P-value:8.56E-6 ID:SGTC_718|Compound:1130-0073|FD-Score:3.06|P-value:5.03E-4 ID:SGTC_822|Compound:1487-0950|FD-Score:3.22|P-value:2.60E-4 ID:SGTC_848|Compound:0368-0089|FD-Score:3.39|P-value:1.33E-4 ID:SGTC_874|Compound:0599-0792|FD-Score:3.52|P-value:7.47E-5 ID:SGTC_904|Compound:1141-0088|FD-Score:-3.30|P-value:2.02E-4 ID:SGTC_939|Compound:1165-0479|FD-Score:3.74|P-value:2.91E-5 ID:SGTC_947|Compound:3447-0010|FD-Score:-5.38|P-value:3.78E-9 ID:SGTC_988|Compound:1497-1057|FD-Score:3.05|P-value:5.12E-4 ID:SGTC_1035|Compound:k081-0041|FD-Score:3.00|P-value:6.17E-4 ID:SGTC_1093|Compound:fluphenazine|FD-Score:3.33|P-value:1.68E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:4.76|P-value:1.51E-7 ID:SGTC_1184|Compound:1269-1718|FD-Score:3.49|P-value:8.80E-5 ID:SGTC_1537|Compound:2',6'-dihydroxyflavanone|FD-Score:-3.77|P-value:2.60E-5 ID:SGTC_1720|Compound:st037298|FD-Score:2.91|P-value:8.68E-4 ID:SGTC_1750|Compound:st081859|FD-Score:26.30|P-value:4.19E-176 ID:SGTC_1889|Compound:st059080|FD-Score:4.32|P-value:1.67E-6 ID:SGTC_1994|Compound:st072947|FD-Score:3.09|P-value:4.45E-4 ID:SGTC_1995|Compound:st072814|FD-Score:4.64|P-value:3.01E-7 ID:SGTC_2088|Compound:5278280|FD-Score:3.44|P-value:1.07E-4 ID:SGTC_2093|Compound:5331342|FD-Score:3.09|P-value:4.44E-4 ID:SGTC_2314|Compound:7727897|FD-Score:-4.36|P-value:1.42E-6 ID:SGTC_2341|Compound:7987486|FD-Score:6.99|P-value:2.86E-14 ID:SGTC_2362|Compound:9071156|FD-Score:3.96|P-value:1.02E-5 ID:SGTC_2395|Compound:5646831|FD-Score:3.27|P-value:2.17E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:4.56|P-value:4.69E-7 ID:SGTC_2407|Compound:paclitaxel|FD-Score:3.44|P-value:1.08E-4 ID:SGTC_2412|Compound:st077135|FD-Score:4.57|P-value:4.38E-7 ID:SGTC_2415|Compound:st077333|FD-Score:3.37|P-value:1.45E-4 ID:SGTC_2425|Compound:5628681|FD-Score:3.04|P-value:5.33E-4 ID:SGTC_2583|Compound:asiatic acid|FD-Score:3.69|P-value:3.63E-5 ID:SGTC_2859|Compound:9028643|FD-Score:2.97|P-value:6.92E-4 ID:SGTC_3018|Compound:9082602|FD-Score:2.92|P-value:8.41E-4 ID:SGTC_3030|Compound:9087619|FD-Score:3.49|P-value:8.63E-5 ID:SGTC_3221|Compound:9128209|FD-Score:-3.23|P-value:2.69E-4 ID:SGTC_3314|Compound:9135860|FD-Score:3.26|P-value:2.29E-4 ID:SGTC_8|Compound:0354-0001|FD-Score:8.23|P-value:4.67E-19 ID:SGTC_17|Compound:0960-0276|FD-Score:2.98|P-value:6.64E-4 ID:SGTC_18|Compound:0111-0177|FD-Score:3.55|P-value:6.55E-5 ID:SGTC_56|Compound:0957-0365|FD-Score:7.94|P-value:6.70E-18 ID:SGTC_58|Compound:0957-0393|FD-Score:-3.08|P-value:4.83E-4 ID:SGTC_59|Compound:0330-0160|FD-Score:6.46|P-value:1.85E-12 ID:SGTC_87|Compound:0100-0052|FD-Score:8.90|P-value:5.65E-22 ID:SGTC_129|Compound:0088-0017|FD-Score:3.76|P-value:2.62E-5 ID:SGTC_164|Compound:4100-3994|FD-Score:3.35|P-value:1.53E-4 ID:SGTC_178|Compound:4092-0806|FD-Score:-3.05|P-value:5.43E-4 ID:SGTC_306|Compound:1672-3436|FD-Score:3.43|P-value:1.12E-4 ID:SGTC_315|Compound:k915-0449|FD-Score:2.94|P-value:7.80E-4 ID:SGTC_329|Compound:k048-0121|FD-Score:2.99|P-value:6.52E-4 ID:SGTC_467|Compound:ro 31-8220|FD-Score:-3.29|P-value:2.06E-4 ID:SGTC_495|Compound:decylubiquinone|FD-Score:3.53|P-value:7.15E-5 ID:SGTC_542|Compound:3381-0244|FD-Score:5.23|P-value:9.45E-9 ID:SGTC_568|Compound:1193-0097|FD-Score:9.68|P-value:1.20E-25 ID:SGTC_606|Compound:k015-0008|FD-Score:3.10|P-value:4.19E-4 ID:SGTC_623|Compound:k072-0108|FD-Score:3.09|P-value:4.34E-4 ID:SGTC_628|Compound:1636-0253|FD-Score:3.37|P-value:1.42E-4 ID:SGTC_716|Compound:1683-5115|FD-Score:4.00|P-value:8.56E-6 ID:SGTC_718|Compound:1130-0073|FD-Score:3.06|P-value:5.03E-4 ID:SGTC_822|Compound:1487-0950|FD-Score:3.22|P-value:2.60E-4 ID:SGTC_848|Compound:0368-0089|FD-Score:3.39|P-value:1.33E-4 ID:SGTC_874|Compound:0599-0792|FD-Score:3.52|P-value:7.47E-5 ID:SGTC_904|Compound:1141-0088|FD-Score:-3.30|P-value:2.02E-4 ID:SGTC_939|Compound:1165-0479|FD-Score:3.74|P-value:2.91E-5 ID:SGTC_947|Compound:3447-0010|FD-Score:-5.38|P-value:3.78E-9 ID:SGTC_988|Compound:1497-1057|FD-Score:3.05|P-value:5.12E-4 ID:SGTC_1035|Compound:k081-0041|FD-Score:3.00|P-value:6.17E-4 ID:SGTC_1093|Compound:fluphenazine|FD-Score:3.33|P-value:1.68E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:4.76|P-value:1.51E-7 ID:SGTC_1184|Compound:1269-1718|FD-Score:3.49|P-value:8.80E-5 ID:SGTC_1537|Compound:2',6'-dihydroxyflavanone|FD-Score:-3.77|P-value:2.60E-5 ID:SGTC_1720|Compound:st037298|FD-Score:2.91|P-value:8.68E-4 ID:SGTC_1750|Compound:st081859|FD-Score:26.30|P-value:4.19E-176 ID:SGTC_1889|Compound:st059080|FD-Score:4.32|P-value:1.67E-6 ID:SGTC_1994|Compound:st072947|FD-Score:3.09|P-value:4.45E-4 ID:SGTC_1995|Compound:st072814|FD-Score:4.64|P-value:3.01E-7 ID:SGTC_2088|Compound:5278280|FD-Score:3.44|P-value:1.07E-4 ID:SGTC_2093|Compound:5331342|FD-Score:3.09|P-value:4.44E-4 ID:SGTC_2314|Compound:7727897|FD-Score:-4.36|P-value:1.42E-6 ID:SGTC_2341|Compound:7987486|FD-Score:6.99|P-value:2.86E-14 ID:SGTC_2362|Compound:9071156|FD-Score:3.96|P-value:1.02E-5 ID:SGTC_2395|Compound:5646831|FD-Score:3.27|P-value:2.17E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:4.56|P-value:4.69E-7 ID:SGTC_2407|Compound:paclitaxel|FD-Score:3.44|P-value:1.08E-4 ID:SGTC_2412|Compound:st077135|FD-Score:4.57|P-value:4.38E-7 ID:SGTC_2415|Compound:st077333|FD-Score:3.37|P-value:1.45E-4 ID:SGTC_2425|Compound:5628681|FD-Score:3.04|P-value:5.33E-4 ID:SGTC_2583|Compound:asiatic acid|FD-Score:3.69|P-value:3.63E-5 ID:SGTC_2859|Compound:9028643|FD-Score:2.97|P-value:6.92E-4 ID:SGTC_3018|Compound:9082602|FD-Score:2.92|P-value:8.41E-4 ID:SGTC_3030|Compound:9087619|FD-Score:3.49|P-value:8.63E-5 ID:SGTC_3221|Compound:9128209|FD-Score:-3.23|P-value:2.69E-4 ID:SGTC_3314|Compound:9135860|FD-Score:3.26|P-value:2.29E-4

Top fitness defect scores for YPR153W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1750 st081859 26.30 2.4 µM 4.19E-176 endomembrane recycling 7 7.79E-153
2 SGTC_568 1193-0097 9.68 7.5 µM 1.20E-25 ERAD & cell cycle 26 1.87E-22
3 SGTC_87 0100-0052 8.90 35.5 µM 5.65E-22 11 2.86E-19
4 SGTC_8 0354-0001 8.23 70.0 µM 4.67E-19 8 9.71E-17
5 SGTC_56 0957-0365 7.94 83.2 µM 6.70E-18 Golgi 11 9.79E-16
6 SGTC_2341 7987486 6.99 176.7 µM 2.86E-14 2 1.38E-12
7 SGTC_59 0330-0160 6.46 1.3 µM 1.85E-12 31 5.17E-11
8 SGTC_542 3381-0244 5.23 89.3 µM 9.45E-9 17 8.59E-8
9 SGTC_1161 k007-0610 4.76 110.0 µM 1.51E-7 ERAD & cell cycle 86 9.54E-7
10 SGTC_1995 st072814 4.64 61.1 µM 3.01E-7 5 1.74E-6
11 SGTC_2412 st077135 4.57 33.4 µM 4.38E-7 12 2.42E-6
12 SGTC_2405 ticlatone 4.56 3.5 µM 4.69E-7 48 2.56E-6
13 SGTC_1889 st059080 4.32 5.2 µM 1.67E-6 12 7.73E-6
14 SGTC_716 1683-5115 4.00 658.0 µM 8.56E-6 19 3.21E-5
15 SGTC_2362 9071156 3.96 126.0 µM 1.02E-5 10 3.75E-5
16 SGTC_129 0088-0017 3.76 176.6 µM 2.62E-5 70 8.51E-5
17 SGTC_939 1165-0479 3.74 45.3 µM 2.91E-5 36 9.32E-5
18 SGTC_2583 asiatic acid 3.69 100.0 µM 3.63E-5 44 1.13E-4
19 SGTC_18 0111-0177 3.55 500.0 nM 6.55E-5 87 1.89E-4
20 SGTC_495 decylubiquinone 3.53 155.0 µM 7.15E-5 copper-dependent oxidative stress 38 2.04E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.721 0 YMR126C_p DLT1_p hom Protein of unknown function, mutant sensitive to 6-azauracil (6AU) and mycophenolic acid (MPA)
0.519 6.48E-231 YPL077C_p YPL077C_p hom Putative protein of unknown function; regulates PIS1 expression; mutant displays spore wall assembly defect in ether sensitivity screen; YPL077C is not an essential gene; YPL077C has a paralog, YBR197C, that arose from the whole genome duplication
0.497 1.22E-208 YKL098W MTC2 hom Protein of unknown function; mtc2 is synthetically sick with cdc13-1
0.483 9.58E-196 YBR255W MTC4 hom Protein of unknown function, required for normal growth rate at 15 degrees C; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; mtc4 is synthetically sick with cdc13-1
0.435 3.61E-155 YPR029C APL4 hom Gamma-adaptin, large subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in vesicle mediated transport
0.378 1.55E-114 YML072C TCB3 hom Cortical ER protein involved in ER-plasma membrane tethering; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; localized to the bud via specific mRNA transport; non-tagged protein detected in a phosphorylated state in mitochondria; C-termini of Tcb1p, Tcb2p and Tcb3p interact
0.346 7.47E-95 YCL046W_d YCL046W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YCL045C
0.336 1.58E-89 YLR087C CSF1 hom Protein required for fermentation at low temperature; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.274 1.15E-58 YJR088C EMC2 hom Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; homologous to worm Y57G7A.10/EMC-2, fly CG17556, human TTC35
0.256 2.42E-51 YMR007W_d YMR007W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.254 1.99E-50 YHR151C MTC6 hom Protein of unknown function; mtc6 is synthetically sick with cdc13-1
0.253 3.29E-50 YLR169W_d YLR169W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.249 1.56E-48 YBR197C YBR197C hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YBR197C is not an essential gene; relative distribution to the nucleus increases upon DNA replication stress; YBR197C has a paralog, YPL077C, that arose from the whole genome duplication
0.245 7.06E-47 YGR202C PCT1 hom Cholinephosphate cytidylyltransferase; a rate-determining enzyme of the CDP-choline pathway for phosphatidylcholine synthesis, inhibited by Sec14p, activated upon lipid-binding; contains an element within the regulatory domain involved in both silencing and activation of enzymatic activity
0.242 6.87E-46 YKL136W_d YKL136W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF APL2/YKL135C