YPR154W / PIN3

Protein that induces appearance of [PIN+] prion when overproduced

Zygosity: Homozygous strain
fixedexpanded
Profile for YPR154W / PIN3

Click on Significant Values for Screen Details ID:SGTC_135|Compound:0933-0004|FD-Score:4.04|P-value:5.28E-5 ID:SGTC_164|Compound:4100-3994|FD-Score:4.22|P-value:2.58E-5 ID:SGTC_378|Compound:3970-0959|FD-Score:3.48|P-value:4.08E-4 ID:SGTC_385|Compound:1494-0393|FD-Score:3.94|P-value:7.66E-5 ID:SGTC_419|Compound:nsc-638432|FD-Score:4.54|P-value:6.56E-6 ID:SGTC_559|Compound:1550-0661|FD-Score:3.62|P-value:2.50E-4 ID:SGTC_798|Compound:1287-0182|FD-Score:4.84|P-value:1.71E-6 ID:SGTC_802|Compound:4112-3352|FD-Score:-3.87|P-value:1.12E-4 ID:SGTC_948|Compound:3448-0295|FD-Score:3.55|P-value:3.24E-4 ID:SGTC_954|Compound:1189-0853|FD-Score:-3.58|P-value:3.14E-4 ID:SGTC_956|Compound:1185-0240|FD-Score:3.88|P-value:9.66E-5 ID:SGTC_967|Compound:1306-0166|FD-Score:4.91|P-value:1.22E-6 ID:SGTC_1021|Compound:4476-0760|FD-Score:3.26|P-value:8.53E-4 ID:SGTC_1113|Compound:artemisinin|FD-Score:3.54|P-value:3.36E-4 ID:SGTC_1117|Compound:retinoic acid|FD-Score:3.77|P-value:1.45E-4 ID:SGTC_1397|Compound:3532-0190|FD-Score:3.51|P-value:3.75E-4 ID:SGTC_1521|Compound:st012942|FD-Score:3.59|P-value:2.79E-4 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:3.88|P-value:9.75E-5 ID:SGTC_1579|Compound:chlormadinone acetate|FD-Score:4.63|P-value:4.39E-6 ID:SGTC_1584|Compound:6-fluoro-dl-tryptophan|FD-Score:-4.31|P-value:1.92E-5 ID:SGTC_1811|Compound:st050069|FD-Score:4.16|P-value:3.25E-5 ID:SGTC_1832|Compound:st054113|FD-Score:4.02|P-value:5.61E-5 ID:SGTC_1846|Compound:st056244|FD-Score:5.51|P-value:6.33E-8 ID:SGTC_2002|Compound:4023503|FD-Score:3.60|P-value:2.70E-4 ID:SGTC_2004|Compound:4023728|FD-Score:4.86|P-value:1.54E-6 ID:SGTC_2058|Compound:5236698|FD-Score:-3.39|P-value:6.09E-4 ID:SGTC_2166|Compound:5933061|FD-Score:4.53|P-value:6.85E-6 ID:SGTC_2203|Compound:7227154|FD-Score:-3.81|P-value:1.36E-4 ID:SGTC_2327|Compound:6189656|FD-Score:3.32|P-value:7.21E-4 ID:SGTC_2346|Compound:9031566|FD-Score:3.69|P-value:1.98E-4 ID:SGTC_2512|Compound:diallyl trisulfide|FD-Score:-3.54|P-value:3.59E-4 ID:SGTC_2518|Compound:prenyletin|FD-Score:3.80|P-value:1.31E-4 ID:SGTC_2520|Compound:obtusaquinone|FD-Score:3.25|P-value:8.99E-4 ID:SGTC_2521|Compound:angolensin|FD-Score:-3.46|P-value:4.85E-4 ID:SGTC_2525|Compound:harmine|FD-Score:3.42|P-value:5.16E-4 ID:SGTC_2695|Compound:st077686|FD-Score:-4.01|P-value:6.55E-5 ID:SGTC_3100|Compound:9120536|FD-Score:4.10|P-value:4.06E-5 ID:SGTC_3228|Compound:9131799|FD-Score:-3.78|P-value:1.57E-4 ID:SGTC_3320|Compound:9137005|FD-Score:3.27|P-value:8.39E-4 ID:SGTC_3333|Compound:9141820|FD-Score:-3.29|P-value:8.35E-4 ID:SGTC_135|Compound:0933-0004|FD-Score:4.04|P-value:5.28E-5 ID:SGTC_164|Compound:4100-3994|FD-Score:4.22|P-value:2.58E-5 ID:SGTC_378|Compound:3970-0959|FD-Score:3.48|P-value:4.08E-4 ID:SGTC_385|Compound:1494-0393|FD-Score:3.94|P-value:7.66E-5 ID:SGTC_419|Compound:nsc-638432|FD-Score:4.54|P-value:6.56E-6 ID:SGTC_559|Compound:1550-0661|FD-Score:3.62|P-value:2.50E-4 ID:SGTC_798|Compound:1287-0182|FD-Score:4.84|P-value:1.71E-6 ID:SGTC_802|Compound:4112-3352|FD-Score:-3.87|P-value:1.12E-4 ID:SGTC_948|Compound:3448-0295|FD-Score:3.55|P-value:3.24E-4 ID:SGTC_954|Compound:1189-0853|FD-Score:-3.58|P-value:3.14E-4 ID:SGTC_956|Compound:1185-0240|FD-Score:3.88|P-value:9.66E-5 ID:SGTC_967|Compound:1306-0166|FD-Score:4.91|P-value:1.22E-6 ID:SGTC_1021|Compound:4476-0760|FD-Score:3.26|P-value:8.53E-4 ID:SGTC_1113|Compound:artemisinin|FD-Score:3.54|P-value:3.36E-4 ID:SGTC_1117|Compound:retinoic acid|FD-Score:3.77|P-value:1.45E-4 ID:SGTC_1397|Compound:3532-0190|FD-Score:3.51|P-value:3.75E-4 ID:SGTC_1521|Compound:st012942|FD-Score:3.59|P-value:2.79E-4 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:3.88|P-value:9.75E-5 ID:SGTC_1579|Compound:chlormadinone acetate|FD-Score:4.63|P-value:4.39E-6 ID:SGTC_1584|Compound:6-fluoro-dl-tryptophan|FD-Score:-4.31|P-value:1.92E-5 ID:SGTC_1811|Compound:st050069|FD-Score:4.16|P-value:3.25E-5 ID:SGTC_1832|Compound:st054113|FD-Score:4.02|P-value:5.61E-5 ID:SGTC_1846|Compound:st056244|FD-Score:5.51|P-value:6.33E-8 ID:SGTC_2002|Compound:4023503|FD-Score:3.60|P-value:2.70E-4 ID:SGTC_2004|Compound:4023728|FD-Score:4.86|P-value:1.54E-6 ID:SGTC_2058|Compound:5236698|FD-Score:-3.39|P-value:6.09E-4 ID:SGTC_2166|Compound:5933061|FD-Score:4.53|P-value:6.85E-6 ID:SGTC_2203|Compound:7227154|FD-Score:-3.81|P-value:1.36E-4 ID:SGTC_2327|Compound:6189656|FD-Score:3.32|P-value:7.21E-4 ID:SGTC_2346|Compound:9031566|FD-Score:3.69|P-value:1.98E-4 ID:SGTC_2512|Compound:diallyl trisulfide|FD-Score:-3.54|P-value:3.59E-4 ID:SGTC_2518|Compound:prenyletin|FD-Score:3.80|P-value:1.31E-4 ID:SGTC_2520|Compound:obtusaquinone|FD-Score:3.25|P-value:8.99E-4 ID:SGTC_2521|Compound:angolensin|FD-Score:-3.46|P-value:4.85E-4 ID:SGTC_2525|Compound:harmine|FD-Score:3.42|P-value:5.16E-4 ID:SGTC_2695|Compound:st077686|FD-Score:-4.01|P-value:6.55E-5 ID:SGTC_3100|Compound:9120536|FD-Score:4.10|P-value:4.06E-5 ID:SGTC_3228|Compound:9131799|FD-Score:-3.78|P-value:1.57E-4 ID:SGTC_3320|Compound:9137005|FD-Score:3.27|P-value:8.39E-4 ID:SGTC_3333|Compound:9141820|FD-Score:-3.29|P-value:8.35E-4

Top fitness defect scores for YPR154W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1846 st056244 5.51 14.8 µM 6.33E-8 6 1.83E-8
2 SGTC_967 1306-0166 4.91 352.0 µM 1.22E-6 14 4.54E-7
3 SGTC_2004 4023728 4.86 41.9 µM 1.54E-6 14 5.82E-7
4 SGTC_798 1287-0182 4.84 476.0 µM 1.71E-6 10 6.56E-7
5 SGTC_1579 chlormadinone acetate 4.63 49.4 µM 4.39E-6 3 1.82E-6
6 SGTC_419 nsc-638432 4.54 893.0 µM 6.56E-6 DNA damage response 5 2.81E-6
7 SGTC_2166 5933061 4.53 31.5 µM 6.85E-6 tubulin folding & SWR complex 25 2.95E-6
8 SGTC_164 4100-3994 4.22 89.6 µM 2.58E-5 22 1.24E-5
9 SGTC_1811 st050069 4.16 61.5 µM 3.25E-5 3 1.60E-5
10 SGTC_3100 9120536 4.10 49.5 µM 4.06E-5 10 2.03E-5
11 SGTC_135 0933-0004 4.04 26.4 µM 5.28E-5 60S ribosome export 23 2.70E-5
12 SGTC_1832 st054113 4.02 55.0 µM 5.61E-5 5 2.88E-5
13 SGTC_385 1494-0393 3.94 12.4 µM 7.66E-5 25 4.03E-5
14 SGTC_956 1185-0240 3.88 191.0 µM 9.66E-5 24 5.19E-5
15 SGTC_1525 8-methoxypsoralen 3.88 92.5 µM 9.75E-5 DNA damage response 34 5.24E-5
16 SGTC_2518 prenyletin 3.80 46.3 µM 1.31E-4 14 7.23E-5
17 SGTC_1117 retinoic acid 3.77 1.1 µM 1.45E-4 18 8.05E-5
18 SGTC_2346 9031566 3.69 143.8 µM 1.98E-4 Golgi 27 1.13E-4
19 SGTC_559 1550-0661 3.62 158.0 µM 2.50E-4 13 1.45E-4
20 SGTC_2002 4023503 3.60 131.0 µM 2.70E-4 mitochondrial processes 46 1.58E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.134 6.61E-15 YML058W SML1 hom Ribonucleotide reductase inhibitor involved in regulating dNTP production; regulated by Mec1p and Rad53p during DNA damage and S phase
0.107 4.70E-10 YPL110C GDE1 hom Glycerophosphocholine (GroPCho) phosphodiesterase; hydrolyzes GroPCho to choline and glycerolphosphate, for use as a phosphate source and as a precursor for phosphocholine synthesis; may interact with ribosomes
0.106 8.28E-10 YJL203W PRP21 het Subunit of the SF3a splicing factor complex, required for spliceosome assembly
0.104 1.77E-9 YNL088W TOP2 het Topoisomerase II, relieves torsional strain in DNA by cleaving and re-sealing the phosphodiester backbone of both positively and negatively supercoiled DNA; cleaves complementary strands; localizes to axial cores in meiosis; required for replication slow zone (RSZ) breakage following Mec1p inactivation
0.102 3.21E-9 YMR092C AIP1 hom Actin cortical patch component; interacts with the actin depolymerizing factor cofilin; required to restrict cofilin localization to cortical patches; contains WD repeats; protein increases in abundance and relocalizes from cytoplasm to plasma membrane upon DNA replication stress
0.100 7.46E-9 YOL032W OPI10 hom Protein with a possible role in phospholipid biosynthesis; null mutant displays an inositol-excreting phenotype that is suppressed by exogenous choline; protein abundance increases in response to DNA replication stress
0.091 1.16E-7 YDR527W RBA50 het Protein involved in transcription; interacts with RNA polymerase II subunits Rpb2p, Rpb3, and Rpb11p; has similarity to human RPAP1
0.090 1.53E-7 YNL057W_d YNL057W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.087 4.86E-7 YLR132C USB1 het Putative phosphodiesterase specific for U6 snRNA 3' end modification; trims the 3' poly(u) tract to leave a terminal 3' phosphate; human homolog, hUSB1 (aka C16orf57) produces a 2',3' cyclic phosphate; mutations in hUSB1 are associated with a rare skin condition (OMIM 604173); essential protein that localizes to the nucleus and mitochondria; overexpression suppresses the respiratory defects of oxa1 and mtf2 mutants
0.080 3.42E-6 YNR046W TRM112 het Protein involved in methylation of tRNA, rRNA, and translation factors; subunit of tRNA methyltransferase (MTase) complexes in combination with Trm9p and Trm11p; interacts with and stabilizes 18S rRNA methyltransferase Bud23p; subunit of complex with Mtq2p that methylates Sup45p (eRF1) in the ternary complex eRF1-eRF3-GTP; deletion confers resistance to zymocin; relative distribution to the nucleus increases upon DNA replication stress
0.078 5.51E-6 YOR262W GPN2 het Putative GTPase with a role in biogenesis of RNA pol II and polIII; may be involved in assembly of RNA polymerases II and III and in their transport into the nucleus; contains a Gly-Pro-Asn motif in the G domain; similar to Npa3p and Gpn3p; highly conserved across species and homologous to human gene GPN2/ATPBD1B; required for establishment of sister chromatid cohesion
0.077 7.76E-6 YKR039W GAP1 hom General amino acid permease; Gap1p senses the presence of amino acid substrates to regulate localization to the plasma membrane when needed; essential for invasive growth
0.076 1.14E-5 YLR042C_p YLR042C_p hom Protein of unknown function; localizes to the cytoplasm; YLL042C is not an essential gene
0.075 1.23E-5 YGR213C RTA1 hom Protein involved in 7-aminocholesterol resistance; has seven potential membrane-spanning regions; expression is induced under both low-heme and low-oxygen conditions; member of the fungal lipid-translocating exporter (LTE) family of protein
0.075 1.50E-5 YDR438W THI74 hom Mitochondrial transporter repressible by thiamine; THI74 has a paralog, YML018C, that arose from the whole genome duplication