YPR155C / NCA2

Protein involved in regulation of mitochondrial expression of subunits 6 (Atp6p) and 8 (Atp8p) of the Fo-F1 ATP synthase; functions with Nca3p

Zygosity: Homozygous strain
fixedexpanded
Profile for YPR155C / NCA2

Click on Significant Values for Screen Details ID:SGTC_399|Compound:oxolinic acid|FD-Score:-3.08|P-value:4.08E-4 ID:SGTC_400|Compound:oxethazaine|FD-Score:-5.64|P-value:4.22E-10 ID:SGTC_414|Compound:piperonyl butoxide|FD-Score:-4.27|P-value:1.69E-6 ID:SGTC_506|Compound:n9-isopropylolomoucine|FD-Score:3.22|P-value:2.26E-4 ID:SGTC_561|Compound:1550-0330|FD-Score:3.14|P-value:3.18E-4 ID:SGTC_594|Compound:1487-1584|FD-Score:3.79|P-value:1.90E-5 ID:SGTC_620|Compound:0109-0052|FD-Score:3.44|P-value:9.12E-5 ID:SGTC_704|Compound:1310-0270|FD-Score:2.86|P-value:9.35E-4 ID:SGTC_769|Compound:0302-0231|FD-Score:3.35|P-value:1.33E-4 ID:SGTC_785|Compound:1270-0111|FD-Score:-4.18|P-value:2.77E-6 ID:SGTC_786|Compound:4544-0069|FD-Score:3.08|P-value:4.05E-4 ID:SGTC_859|Compound:0439-0102|FD-Score:3.65|P-value:3.49E-5 ID:SGTC_910|Compound:3454-3003|FD-Score:3.13|P-value:3.29E-4 ID:SGTC_1227|Compound:3909-8010|FD-Score:3.02|P-value:4.99E-4 ID:SGTC_1407|Compound:3909-7909|FD-Score:2.97|P-value:6.14E-4 ID:SGTC_1413|Compound:3910-0535|FD-Score:2.97|P-value:6.10E-4 ID:SGTC_1426|Compound:4048-4480|FD-Score:2.96|P-value:6.48E-4 ID:SGTC_1427|Compound:4048-4900|FD-Score:3.08|P-value:3.96E-4 ID:SGTC_1479|Compound:0549-0158|FD-Score:3.59|P-value:4.60E-5 ID:SGTC_1485|Compound:3909-9022|FD-Score:4.21|P-value:2.27E-6 ID:SGTC_1547|Compound:harmine|FD-Score:3.11|P-value:3.63E-4 ID:SGTC_1653|Compound:st012112|FD-Score:-3.27|P-value:1.92E-4 ID:SGTC_1677|Compound:st019204|FD-Score:3.18|P-value:2.72E-4 ID:SGTC_1834|Compound:st055981|FD-Score:-3.49|P-value:7.51E-5 ID:SGTC_2019|Compound:4016004|FD-Score:3.15|P-value:3.05E-4 ID:SGTC_2025|Compound:5147754|FD-Score:2.87|P-value:8.84E-4 ID:SGTC_2043|Compound:5101342|FD-Score:3.12|P-value:3.45E-4 ID:SGTC_2050|Compound:5263056|FD-Score:2.88|P-value:8.60E-4 ID:SGTC_2051|Compound:5263410|FD-Score:-3.26|P-value:1.97E-4 ID:SGTC_2054|Compound:5233173|FD-Score:-5.23|P-value:6.50E-9 ID:SGTC_2059|Compound:5238311|FD-Score:-3.49|P-value:7.33E-5 ID:SGTC_2087|Compound:5276107|FD-Score:-3.32|P-value:1.56E-4 ID:SGTC_2422|Compound:chlorphenesin carbamate|FD-Score:3.07|P-value:4.16E-4 ID:SGTC_2462|Compound:5162487|FD-Score:3.20|P-value:2.53E-4 ID:SGTC_2529|Compound:gangaleoidin|FD-Score:-3.38|P-value:1.21E-4 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:3.93|P-value:9.28E-6 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:2.97|P-value:6.23E-4 ID:SGTC_2798|Compound:7813637|FD-Score:4.44|P-value:6.98E-7 ID:SGTC_2822|Compound:7994718|FD-Score:3.08|P-value:3.97E-4 ID:SGTC_2954|Compound:9074818|FD-Score:2.96|P-value:6.38E-4 ID:SGTC_2962|Compound:9082311|FD-Score:-4.20|P-value:2.45E-6 ID:SGTC_3026|Compound:9090633|FD-Score:3.66|P-value:3.37E-5 ID:SGTC_3028|Compound:9087778|FD-Score:3.06|P-value:4.41E-4 ID:SGTC_3030|Compound:9087619|FD-Score:3.27|P-value:1.88E-4 ID:SGTC_3087|Compound:9117406|FD-Score:3.32|P-value:1.53E-4 ID:SGTC_3344|Compound:9148862|FD-Score:4.79|P-value:9.41E-8 ID:SGTC_3351|Compound:9150312|FD-Score:3.06|P-value:4.36E-4 ID:SGTC_399|Compound:oxolinic acid|FD-Score:-3.08|P-value:4.08E-4 ID:SGTC_400|Compound:oxethazaine|FD-Score:-5.64|P-value:4.22E-10 ID:SGTC_414|Compound:piperonyl butoxide|FD-Score:-4.27|P-value:1.69E-6 ID:SGTC_506|Compound:n9-isopropylolomoucine|FD-Score:3.22|P-value:2.26E-4 ID:SGTC_561|Compound:1550-0330|FD-Score:3.14|P-value:3.18E-4 ID:SGTC_594|Compound:1487-1584|FD-Score:3.79|P-value:1.90E-5 ID:SGTC_620|Compound:0109-0052|FD-Score:3.44|P-value:9.12E-5 ID:SGTC_704|Compound:1310-0270|FD-Score:2.86|P-value:9.35E-4 ID:SGTC_769|Compound:0302-0231|FD-Score:3.35|P-value:1.33E-4 ID:SGTC_785|Compound:1270-0111|FD-Score:-4.18|P-value:2.77E-6 ID:SGTC_786|Compound:4544-0069|FD-Score:3.08|P-value:4.05E-4 ID:SGTC_859|Compound:0439-0102|FD-Score:3.65|P-value:3.49E-5 ID:SGTC_910|Compound:3454-3003|FD-Score:3.13|P-value:3.29E-4 ID:SGTC_1227|Compound:3909-8010|FD-Score:3.02|P-value:4.99E-4 ID:SGTC_1407|Compound:3909-7909|FD-Score:2.97|P-value:6.14E-4 ID:SGTC_1413|Compound:3910-0535|FD-Score:2.97|P-value:6.10E-4 ID:SGTC_1426|Compound:4048-4480|FD-Score:2.96|P-value:6.48E-4 ID:SGTC_1427|Compound:4048-4900|FD-Score:3.08|P-value:3.96E-4 ID:SGTC_1479|Compound:0549-0158|FD-Score:3.59|P-value:4.60E-5 ID:SGTC_1485|Compound:3909-9022|FD-Score:4.21|P-value:2.27E-6 ID:SGTC_1547|Compound:harmine|FD-Score:3.11|P-value:3.63E-4 ID:SGTC_1653|Compound:st012112|FD-Score:-3.27|P-value:1.92E-4 ID:SGTC_1677|Compound:st019204|FD-Score:3.18|P-value:2.72E-4 ID:SGTC_1834|Compound:st055981|FD-Score:-3.49|P-value:7.51E-5 ID:SGTC_2019|Compound:4016004|FD-Score:3.15|P-value:3.05E-4 ID:SGTC_2025|Compound:5147754|FD-Score:2.87|P-value:8.84E-4 ID:SGTC_2043|Compound:5101342|FD-Score:3.12|P-value:3.45E-4 ID:SGTC_2050|Compound:5263056|FD-Score:2.88|P-value:8.60E-4 ID:SGTC_2051|Compound:5263410|FD-Score:-3.26|P-value:1.97E-4 ID:SGTC_2054|Compound:5233173|FD-Score:-5.23|P-value:6.50E-9 ID:SGTC_2059|Compound:5238311|FD-Score:-3.49|P-value:7.33E-5 ID:SGTC_2087|Compound:5276107|FD-Score:-3.32|P-value:1.56E-4 ID:SGTC_2422|Compound:chlorphenesin carbamate|FD-Score:3.07|P-value:4.16E-4 ID:SGTC_2462|Compound:5162487|FD-Score:3.20|P-value:2.53E-4 ID:SGTC_2529|Compound:gangaleoidin|FD-Score:-3.38|P-value:1.21E-4 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:3.93|P-value:9.28E-6 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:2.97|P-value:6.23E-4 ID:SGTC_2798|Compound:7813637|FD-Score:4.44|P-value:6.98E-7 ID:SGTC_2822|Compound:7994718|FD-Score:3.08|P-value:3.97E-4 ID:SGTC_2954|Compound:9074818|FD-Score:2.96|P-value:6.38E-4 ID:SGTC_2962|Compound:9082311|FD-Score:-4.20|P-value:2.45E-6 ID:SGTC_3026|Compound:9090633|FD-Score:3.66|P-value:3.37E-5 ID:SGTC_3028|Compound:9087778|FD-Score:3.06|P-value:4.41E-4 ID:SGTC_3030|Compound:9087619|FD-Score:3.27|P-value:1.88E-4 ID:SGTC_3087|Compound:9117406|FD-Score:3.32|P-value:1.53E-4 ID:SGTC_3344|Compound:9148862|FD-Score:4.79|P-value:9.41E-8 ID:SGTC_3351|Compound:9150312|FD-Score:3.06|P-value:4.36E-4

Top fitness defect scores for YPR155C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3344 9148862 4.79 3.9 µM 9.41E-8 4 8.37E-7
2 SGTC_2798 7813637 4.44 45.5 µM 6.98E-7 21 4.60E-6
3 SGTC_1485 3909-9022 4.21 254.0 µM 2.27E-6 RPP1 & pyrimidine depletion 3 1.25E-5
4 SGTC_2627 acetyl isogambogic acid 3.93 100.0 µM 9.28E-6 TSC3-RPN4 43 4.16E-5
5 SGTC_594 1487-1584 3.79 10.8 µM 1.90E-5 30 7.66E-5
6 SGTC_3026 9090633 3.66 49.5 µM 3.37E-5 33 1.25E-4
7 SGTC_859 0439-0102 3.65 54.6 µM 3.49E-5 redox potentiating 20 1.29E-4
8 SGTC_1479 0549-0158 3.59 134.0 µM 4.60E-5 42 1.63E-4
9 SGTC_620 0109-0052 3.44 432.0 µM 9.12E-5 33 2.92E-4
10 SGTC_769 0302-0231 3.35 76.0 µM 1.33E-4 79 4.03E-4
11 SGTC_3087 9117406 3.32 49.5 µM 1.53E-4 39 4.54E-4
12 SGTC_3030 9087619 3.27 49.5 µM 1.88E-4 33 5.41E-4
13 SGTC_506 n9-isopropylolomoucine 3.22 153.0 µM 2.26E-4 31 6.35E-4
14 SGTC_2462 5162487 3.20 171.8 µM 2.53E-4 38 6.97E-4
15 SGTC_1677 st019204 3.18 53.9 µM 2.72E-4 53 7.41E-4
16 SGTC_2019 4016004 3.15 108.0 µM 3.05E-4 65 8.19E-4
17 SGTC_561 1550-0330 3.14 72.9 µM 3.18E-4 36 8.47E-4
18 SGTC_910 3454-3003 3.13 490.0 µM 3.29E-4 53 8.72E-4
19 SGTC_2043 5101342 3.12 149.0 µM 3.45E-4 SWF1 & branched chain AA biosynthesis 50 9.10E-4
20 SGTC_1547 harmine 3.11 94.2 µM 3.63E-4 ergosterol biosynthesis 90 9.50E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.097 1.55E-8 YDL149W ATG9 hom Transmembrane protein involved in forming Cvt and autophagic vesicles; cycles between the phagophore assembly site (PAS) and other cytosolic punctate structures, not found in autophagosomes; may be involved in membrane delivery to the PAS
0.096 2.61E-8 YNL066W SUN4 hom Cell wall protein related to glucanases, possibly involved in cell wall septation; member of the SUN family
0.096 2.97E-8 YOR304W ISW2 hom ATP-dependent DNA translocase involved in chromatin remodeling; ATPase component that, with Itc1p, forms a complex required for repression of a-specific genes, INO1, and early meiotic genes during mitotic growth
0.094 4.58E-8 YDR119W_p VBA4_p hom Protein of unknown function with proposed role as a basic amino acid permease based on phylogeny; GFP-fusion protein localizes to vacuolar membrane; physical interaction with Atg27p suggests a possible role in autophagy; non-essential gene
0.092 9.64E-8 YDR397C NCB2 het Subunit of a heterodimeric NC2 transcription regulator complex with Bur6p; complex binds to TBP and can repress transcription by preventing preinitiation complex assembly or stimulate activated transcription; homologous to human NC2beta
0.088 2.91E-7 YDR365C ESF1 het Nucleolar protein involved in pre-rRNA processing; depletion causes severely decreased 18S rRNA levels
0.087 4.14E-7 YEL028W_d YEL028W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.086 6.99E-7 YER009W NTF2 het Nuclear envelope protein, interacts with GDP-bound Gsp1p and with proteins of the nuclear pore to transport Gsp1p into the nucleus where it is an essential player in nucleocytoplasmic transport
0.085 7.75E-7 YDL164C CDC9 het DNA ligase found in the nucleus and mitochondria, an essential enzyme that joins Okazaki fragments during DNA replication; also acts in nucleotide excision repair, base excision repair, and recombination
0.082 1.87E-6 YNL298W CLA4 hom Cdc42p-activated signal transducing kinase of the PAK (p21-activated kinase) family, along with Ste20p and Skm1p; involved in septin ring assembly, vacuole inheritance, cytokinesis, sterol uptake regulation; phosphorylates Cdc3p and Cdc10p
0.082 2.00E-6 YGL221C NIF3 hom Protein of unknown function, similar to Listeria monocytogenes major sigma factor (rpoD gene product); the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.081 2.52E-6 YDR037W KRS1 het Lysyl-tRNA synthetase
0.079 4.84E-6 YHR117W TOM71 hom Mitochondrial outer membrane protein; probable minor component of the TOM (translocase of outer membrane) complex responsible for recognition and import of mitochondrially directed proteins; TOM71 has a paralog, TOM70, that arose from the whole genome duplication
0.079 5.12E-6 YMR115W MGR3 hom Subunit of the mitochondrial (mt) i-AAA protease supercomplex, which degrades misfolded mitochondrial proteins; forms a subcomplex with Mgr1p that binds to substrates to facilitate proteolysis; required for growth of cells lacking mtDNA
0.072 3.14E-5 YHL017W_p YHL017W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein co-localizes with clathrin-coated vesicles; YHL017W has a paralog, PTM1, that arose from the whole genome duplication