YPR156C / TPO3

Polyamine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; specific for spermine; localizes to the plasma membrane; TPO3 has a paralog, TPO2, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YPR156C / TPO3

Click on Significant Values for Screen Details ID:SGTC_39|Compound:0986-0283|FD-Score:3.79|P-value:2.04E-5 ID:SGTC_49|Compound:0717-0965|FD-Score:3.08|P-value:4.27E-4 ID:SGTC_70|Compound:0141-0289|FD-Score:-3.13|P-value:3.39E-4 ID:SGTC_127|Compound:0180-0333|FD-Score:-3.22|P-value:2.38E-4 ID:SGTC_177|Compound:1327-0068|FD-Score:-3.63|P-value:4.22E-5 ID:SGTC_184|Compound:1494-0393|FD-Score:3.65|P-value:3.90E-5 ID:SGTC_251|Compound:melphalan|FD-Score:4.48|P-value:5.96E-7 ID:SGTC_275|Compound:trichlorophene|FD-Score:-3.58|P-value:5.22E-5 ID:SGTC_523|Compound:1934-0222|FD-Score:3.77|P-value:2.25E-5 ID:SGTC_531|Compound:3788-1495|FD-Score:-3.19|P-value:2.71E-4 ID:SGTC_542|Compound:3381-0244|FD-Score:-3.61|P-value:4.60E-5 ID:SGTC_570|Compound:0987-0065|FD-Score:3.47|P-value:8.43E-5 ID:SGTC_747|Compound:3448-8087|FD-Score:3.48|P-value:8.31E-5 ID:SGTC_971|Compound:1315-0384|FD-Score:3.07|P-value:4.46E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:-4.81|P-value:9.01E-8 ID:SGTC_1130|Compound:3454-2858|FD-Score:3.19|P-value:2.78E-4 ID:SGTC_1182|Compound:1222-0449|FD-Score:-3.22|P-value:2.43E-4 ID:SGTC_1201|Compound:1889-3372|FD-Score:3.09|P-value:4.04E-4 ID:SGTC_1202|Compound:1988-0068|FD-Score:2.94|P-value:7.27E-4 ID:SGTC_1233|Compound:0325-0408|FD-Score:3.11|P-value:3.80E-4 ID:SGTC_1253|Compound:0550-0034|FD-Score:-3.05|P-value:4.75E-4 ID:SGTC_1255|Compound:0566-0045|FD-Score:3.07|P-value:4.44E-4 ID:SGTC_1340|Compound:1486-1359|FD-Score:3.05|P-value:4.77E-4 ID:SGTC_1387|Compound:3342-1166|FD-Score:-3.75|P-value:2.45E-5 ID:SGTC_1392|Compound:3455-1037|FD-Score:-4.19|P-value:2.81E-6 ID:SGTC_1461|Compound:k072-0203|FD-Score:3.19|P-value:2.73E-4 ID:SGTC_1468|Compound:k284-1086|FD-Score:2.90|P-value:8.37E-4 ID:SGTC_1577|Compound:3(2'-chlorophenyl)-7-ethoxycoumarin|FD-Score:3.38|P-value:1.22E-4 ID:SGTC_2003|Compound:4023581|FD-Score:3.43|P-value:9.91E-5 ID:SGTC_2113|Compound:5491891|FD-Score:3.05|P-value:4.79E-4 ID:SGTC_2122|Compound:5258151|FD-Score:3.33|P-value:1.56E-4 ID:SGTC_2139|Compound:5578692|FD-Score:4.57|P-value:3.66E-7 ID:SGTC_2163|Compound:5671233|FD-Score:-2.86|P-value:9.75E-4 ID:SGTC_2191|Compound:5911152|FD-Score:4.06|P-value:5.49E-6 ID:SGTC_2454|Compound:5-benzylidenerhodanine|FD-Score:3.01|P-value:5.57E-4 ID:SGTC_2563|Compound:tomatine|FD-Score:-3.86|P-value:1.44E-5 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:-4.79|P-value:1.02E-7 ID:SGTC_2575|Compound:plumbagin|FD-Score:-2.89|P-value:8.66E-4 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:-3.07|P-value:4.41E-4 ID:SGTC_2581|Compound:avocatin a|FD-Score:3.43|P-value:1.02E-4 ID:SGTC_2687|Compound:chenodiol|FD-Score:5.31|P-value:4.25E-9 ID:SGTC_2692|Compound:st077426|FD-Score:6.07|P-value:2.39E-11 ID:SGTC_2985|Compound:9022375|FD-Score:2.94|P-value:7.35E-4 ID:SGTC_2986|Compound:9022445|FD-Score:3.05|P-value:4.81E-4 ID:SGTC_3000|Compound:9075062|FD-Score:-2.91|P-value:8.00E-4 ID:SGTC_3009|Compound:9080819|FD-Score:3.46|P-value:8.94E-5 ID:SGTC_3081|Compound:9117243|FD-Score:3.53|P-value:6.42E-5 ID:SGTC_3146|Compound:9095609|FD-Score:2.92|P-value:7.70E-4 ID:SGTC_3316|Compound:9136639|FD-Score:-3.27|P-value:1.95E-4 ID:SGTC_3317|Compound:9138495|FD-Score:-3.02|P-value:5.30E-4 ID:SGTC_39|Compound:0986-0283|FD-Score:3.79|P-value:2.04E-5 ID:SGTC_49|Compound:0717-0965|FD-Score:3.08|P-value:4.27E-4 ID:SGTC_70|Compound:0141-0289|FD-Score:-3.13|P-value:3.39E-4 ID:SGTC_127|Compound:0180-0333|FD-Score:-3.22|P-value:2.38E-4 ID:SGTC_177|Compound:1327-0068|FD-Score:-3.63|P-value:4.22E-5 ID:SGTC_184|Compound:1494-0393|FD-Score:3.65|P-value:3.90E-5 ID:SGTC_251|Compound:melphalan|FD-Score:4.48|P-value:5.96E-7 ID:SGTC_275|Compound:trichlorophene|FD-Score:-3.58|P-value:5.22E-5 ID:SGTC_523|Compound:1934-0222|FD-Score:3.77|P-value:2.25E-5 ID:SGTC_531|Compound:3788-1495|FD-Score:-3.19|P-value:2.71E-4 ID:SGTC_542|Compound:3381-0244|FD-Score:-3.61|P-value:4.60E-5 ID:SGTC_570|Compound:0987-0065|FD-Score:3.47|P-value:8.43E-5 ID:SGTC_747|Compound:3448-8087|FD-Score:3.48|P-value:8.31E-5 ID:SGTC_971|Compound:1315-0384|FD-Score:3.07|P-value:4.46E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:-4.81|P-value:9.01E-8 ID:SGTC_1130|Compound:3454-2858|FD-Score:3.19|P-value:2.78E-4 ID:SGTC_1182|Compound:1222-0449|FD-Score:-3.22|P-value:2.43E-4 ID:SGTC_1201|Compound:1889-3372|FD-Score:3.09|P-value:4.04E-4 ID:SGTC_1202|Compound:1988-0068|FD-Score:2.94|P-value:7.27E-4 ID:SGTC_1233|Compound:0325-0408|FD-Score:3.11|P-value:3.80E-4 ID:SGTC_1253|Compound:0550-0034|FD-Score:-3.05|P-value:4.75E-4 ID:SGTC_1255|Compound:0566-0045|FD-Score:3.07|P-value:4.44E-4 ID:SGTC_1340|Compound:1486-1359|FD-Score:3.05|P-value:4.77E-4 ID:SGTC_1387|Compound:3342-1166|FD-Score:-3.75|P-value:2.45E-5 ID:SGTC_1392|Compound:3455-1037|FD-Score:-4.19|P-value:2.81E-6 ID:SGTC_1461|Compound:k072-0203|FD-Score:3.19|P-value:2.73E-4 ID:SGTC_1468|Compound:k284-1086|FD-Score:2.90|P-value:8.37E-4 ID:SGTC_1577|Compound:3(2'-chlorophenyl)-7-ethoxycoumarin|FD-Score:3.38|P-value:1.22E-4 ID:SGTC_2003|Compound:4023581|FD-Score:3.43|P-value:9.91E-5 ID:SGTC_2113|Compound:5491891|FD-Score:3.05|P-value:4.79E-4 ID:SGTC_2122|Compound:5258151|FD-Score:3.33|P-value:1.56E-4 ID:SGTC_2139|Compound:5578692|FD-Score:4.57|P-value:3.66E-7 ID:SGTC_2163|Compound:5671233|FD-Score:-2.86|P-value:9.75E-4 ID:SGTC_2191|Compound:5911152|FD-Score:4.06|P-value:5.49E-6 ID:SGTC_2454|Compound:5-benzylidenerhodanine|FD-Score:3.01|P-value:5.57E-4 ID:SGTC_2563|Compound:tomatine|FD-Score:-3.86|P-value:1.44E-5 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:-4.79|P-value:1.02E-7 ID:SGTC_2575|Compound:plumbagin|FD-Score:-2.89|P-value:8.66E-4 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:-3.07|P-value:4.41E-4 ID:SGTC_2581|Compound:avocatin a|FD-Score:3.43|P-value:1.02E-4 ID:SGTC_2687|Compound:chenodiol|FD-Score:5.31|P-value:4.25E-9 ID:SGTC_2692|Compound:st077426|FD-Score:6.07|P-value:2.39E-11 ID:SGTC_2985|Compound:9022375|FD-Score:2.94|P-value:7.35E-4 ID:SGTC_2986|Compound:9022445|FD-Score:3.05|P-value:4.81E-4 ID:SGTC_3000|Compound:9075062|FD-Score:-2.91|P-value:8.00E-4 ID:SGTC_3009|Compound:9080819|FD-Score:3.46|P-value:8.94E-5 ID:SGTC_3081|Compound:9117243|FD-Score:3.53|P-value:6.42E-5 ID:SGTC_3146|Compound:9095609|FD-Score:2.92|P-value:7.70E-4 ID:SGTC_3316|Compound:9136639|FD-Score:-3.27|P-value:1.95E-4 ID:SGTC_3317|Compound:9138495|FD-Score:-3.02|P-value:5.30E-4

Top fitness defect scores for YPR156C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2692 st077426 6.07 47.7 µM 2.39E-11 4 6.40E-10
2 SGTC_2687 chenodiol 5.31 100.0 µM 4.25E-9 5 5.36E-8
3 SGTC_2139 5578692 4.57 56.5 µM 3.66E-7 superoxide 11 2.43E-6
4 SGTC_251 melphalan 4.48 456.5 µM 5.96E-7 DNA damage response 12 3.69E-6
5 SGTC_2191 5911152 4.06 200.0 µM 5.49E-6 12 2.48E-5
6 SGTC_39 0986-0283 3.79 58.4 µM 2.04E-5 calcium & mitochondrial duress 43 7.65E-5
7 SGTC_523 1934-0222 3.77 13.7 µM 2.25E-5 35 8.32E-5
8 SGTC_184 1494-0393 3.65 24.7 µM 3.90E-5 72 1.33E-4
9 SGTC_3081 9117243 3.53 49.5 µM 6.42E-5 fatty acid desaturase (OLE1) 31 2.05E-4
10 SGTC_747 3448-8087 3.48 38.7 µM 8.31E-5 40 2.55E-4
11 SGTC_570 0987-0065 3.47 62.6 µM 8.43E-5 60S ribosome export 14 2.58E-4
12 SGTC_3009 9080819 3.46 71.4 µM 8.94E-5 28 2.72E-4
13 SGTC_2003 4023581 3.43 200.0 µM 9.91E-5 cell wall signaling 52 2.97E-4
14 SGTC_2581 avocatin a 3.43 64.0 µM 1.02E-4 sphingolipid biosynthesis & PDR1 70 3.06E-4
15 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 3.38 66.5 µM 1.22E-4 27 3.56E-4
16 SGTC_2122 5258151 3.33 111.7 µM 1.56E-4 44 4.39E-4
17 SGTC_1461 k072-0203 3.19 53.8 µM 2.73E-4 39 7.11E-4
18 SGTC_1130 3454-2858 3.19 15.9 µM 2.78E-4 NEO1 127 7.21E-4
19 SGTC_1233 0325-0408 3.11 14.2 µM 3.80E-4 51 9.44E-4
20 SGTC_1201 1889-3372 3.09 45.9 µM 4.04E-4 Golgi 30 9.94E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.127 1.33E-13 YML116W ATR1 hom Multidrug efflux pump of the major facilitator superfamily; required for resistance to aminotriazole and 4-nitroquinoline-N-oxide; ATR1 has a paralog, YMR279C, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.112 6.61E-11 YER023W PRO3 het Delta 1-pyrroline-5-carboxylate reductase, catalyzes the last step in proline biosynthesis
0.091 1.36E-7 YLR023C IZH3 hom Membrane protein involved in zinc ion homeostasis, member of the four-protein IZH family, expression induced by zinc deficiency; deletion reduces sensitivity to elevated zinc and shortens lag phase, overexpression reduces Zap1p activity
0.091 1.50E-7 YKL197C PEX1 hom AAA-peroxin that heterodimerizes with AAA-peroxin Pex6p and participates in the recycling of peroxisomal signal receptor Pex5p from the peroxisomal membrane to the cystosol; induced by oleic acid and upregulated during anaerobiosis
0.088 2.88E-7 YIR012W SQT1 het Protein involved in 60S ribosomal subunit assembly or modification; contains multiple WD repeats; interacts with Qsr1p in a two-hybrid assay; protein abundance increases in response to DNA replication stress
0.087 4.95E-7 YJL208C NUC1 hom Major mitochondrial nuclease, has RNAse and DNA endo- and exonucleolytic activities; has roles in mitochondrial recombination, apoptosis and maintenance of polyploidy
0.087 4.96E-7 YMR013C SEC59 het Dolichol kinase, catalyzes the terminal step in dolichyl monophosphate (Dol-P) biosynthesis; required for viability and for normal rates of lipid intermediate synthesis and protein N-glycosylation
0.081 2.37E-6 YMR322C_p SNO4_p hom Possible chaperone and cysteine protease, similar to bacterial Hsp31 and yeast Hsp31p, Hsp32p, and Hsp33p; DJ-1/ThiJ/PfpI superfamily member; predicted involvement in pyridoxine metabolism; induced by mild heat stress and copper deprivation
0.080 3.61E-6 YOR242C SSP2 hom Sporulation specific protein that localizes to the spore wall; required for sporulation at a point after meiosis II and during spore wall formation; SSP2 expression is induced midway in meiosis
0.078 6.99E-6 YOL037C_d YOL037C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YOL036W
0.076 1.10E-5 YMR028W TAP42 het Essential protein involved in the TOR signaling pathway; physically associates with the protein phosphatase 2A and the SIT4 protein phosphatase catalytic subunits
0.075 1.26E-5 YHR160C PEX18 hom Peroxin required for targeting of peroxisomal matrix proteins containing PTS2; interacts with Pex7p; partially redundant with Pex21p
0.074 1.63E-5 YMR195W ICY1 hom Protein of unknown function, required for viability in rich media of cells lacking mitochondrial DNA; mutants have an invasive growth defect with elongated morphology; induced by amino acid starvation
0.074 1.71E-5 YKL064W MNR2 hom Vacuolar membrane protein required for magnesium homeostasis; putative magnesium transporter; has similarity to Alr1p and Alr2p, which mediate influx of Mg2+ and other divalent cations
0.074 1.90E-5 YPL091W GLR1 hom Cytosolic and mitochondrial glutathione oxidoreductase; converts oxidized glutathione to reduced glutathione; mitochondrial but not cytosolic form has a role in resistance to hyperoxia; protein abundance increases in response to DNA replication stress