YPR157W_p / TDA6

Putative protein of unknown function; induced by treatment with 8-methoxypsoralen and UVA irradiation; null mutant is sensitive to expression of the top1-T722A allele

Zygosity: Homozygous strain
fixedexpanded
Profile for YPR157W / TDA6

Click on Significant Values for Screen Details ID:SGTC_105|Compound:0111-0055|FD-Score:3.46|P-value:4.79E-4 ID:SGTC_106|Compound:0092-0003|FD-Score:3.93|P-value:9.29E-5 ID:SGTC_373|Compound:0844-0104|FD-Score:-4.34|P-value:2.57E-5 ID:SGTC_450|Compound:aminopyrene|FD-Score:-3.33|P-value:9.80E-4 ID:SGTC_541|Compound:4513-1321|FD-Score:3.67|P-value:2.31E-4 ID:SGTC_737|Compound:1950-0117|FD-Score:-4.31|P-value:2.95E-5 ID:SGTC_751|Compound:0833-0568|FD-Score:-3.72|P-value:2.65E-4 ID:SGTC_796|Compound:1234-0020|FD-Score:3.44|P-value:5.11E-4 ID:SGTC_1030|Compound:k029-0042|FD-Score:3.81|P-value:1.43E-4 ID:SGTC_1032|Compound:k061-1018|FD-Score:-4.26|P-value:3.66E-5 ID:SGTC_1126|Compound:isoteolin|FD-Score:3.27|P-value:9.14E-4 ID:SGTC_1205|Compound:4161-2785|FD-Score:-4.28|P-value:3.32E-5 ID:SGTC_1213|Compound:1315-0166|FD-Score:-3.48|P-value:5.97E-4 ID:SGTC_1372|Compound:2752-0194|FD-Score:3.34|P-value:7.28E-4 ID:SGTC_1387|Compound:3342-1166|FD-Score:3.36|P-value:6.78E-4 ID:SGTC_1409|Compound:3909-8004|FD-Score:3.56|P-value:3.43E-4 ID:SGTC_1610|Compound:st001799|FD-Score:3.42|P-value:5.45E-4 ID:SGTC_1611|Compound:st001856|FD-Score:4.34|P-value:1.83E-5 ID:SGTC_1613|Compound:st002381|FD-Score:3.29|P-value:8.51E-4 ID:SGTC_1619|Compound:st003326|FD-Score:-3.99|P-value:1.02E-4 ID:SGTC_1632|Compound:st005650|FD-Score:3.28|P-value:8.76E-4 ID:SGTC_1713|Compound:st033146|FD-Score:3.59|P-value:3.16E-4 ID:SGTC_1714|Compound:st033236|FD-Score:3.54|P-value:3.68E-4 ID:SGTC_1728|Compound:st035614|FD-Score:-3.55|P-value:4.84E-4 ID:SGTC_1947|Compound:st076332|FD-Score:3.85|P-value:1.25E-4 ID:SGTC_2054|Compound:5233173|FD-Score:3.84|P-value:1.29E-4 ID:SGTC_2130|Compound:NSC 7|FD-Score:-3.44|P-value:7.00E-4 ID:SGTC_2367|Compound:9070478|FD-Score:3.97|P-value:7.88E-5 ID:SGTC_2368|Compound:9071271|FD-Score:3.54|P-value:3.66E-4 ID:SGTC_2455|Compound:5377712|FD-Score:4.50|P-value:9.31E-6 ID:SGTC_2465|Compound:5809242|FD-Score:3.53|P-value:3.84E-4 ID:SGTC_2468|Compound:5987765|FD-Score:5.88|P-value:1.24E-8 ID:SGTC_2470|Compound:5664817|FD-Score:5.21|P-value:3.79E-7 ID:SGTC_2471|Compound:5466956|FD-Score:4.26|P-value:2.53E-5 ID:SGTC_2488|Compound:5268135|FD-Score:-3.58|P-value:4.35E-4 ID:SGTC_2593|Compound:nobiletin|FD-Score:3.32|P-value:7.81E-4 ID:SGTC_2798|Compound:7813637|FD-Score:4.05|P-value:5.74E-5 ID:SGTC_2804|Compound:7954240|FD-Score:3.70|P-value:2.08E-4 ID:SGTC_2850|Compound:9015429|FD-Score:4.79|P-value:2.64E-6 ID:SGTC_2955|Compound:9076254|FD-Score:-3.54|P-value:4.96E-4 ID:SGTC_2963|Compound:9082507|FD-Score:5.35|P-value:1.88E-7 ID:SGTC_3089|Compound:9117425|FD-Score:5.08|P-value:6.85E-7 ID:SGTC_3126|Compound:9127922|FD-Score:3.72|P-value:1.95E-4 ID:SGTC_3140|Compound:9094243|FD-Score:4.00|P-value:7.07E-5 ID:SGTC_3234|Compound:9132280|FD-Score:4.22|P-value:2.92E-5 ID:SGTC_105|Compound:0111-0055|FD-Score:3.46|P-value:4.79E-4 ID:SGTC_106|Compound:0092-0003|FD-Score:3.93|P-value:9.29E-5 ID:SGTC_373|Compound:0844-0104|FD-Score:-4.34|P-value:2.57E-5 ID:SGTC_450|Compound:aminopyrene|FD-Score:-3.33|P-value:9.80E-4 ID:SGTC_541|Compound:4513-1321|FD-Score:3.67|P-value:2.31E-4 ID:SGTC_737|Compound:1950-0117|FD-Score:-4.31|P-value:2.95E-5 ID:SGTC_751|Compound:0833-0568|FD-Score:-3.72|P-value:2.65E-4 ID:SGTC_796|Compound:1234-0020|FD-Score:3.44|P-value:5.11E-4 ID:SGTC_1030|Compound:k029-0042|FD-Score:3.81|P-value:1.43E-4 ID:SGTC_1032|Compound:k061-1018|FD-Score:-4.26|P-value:3.66E-5 ID:SGTC_1126|Compound:isoteolin|FD-Score:3.27|P-value:9.14E-4 ID:SGTC_1205|Compound:4161-2785|FD-Score:-4.28|P-value:3.32E-5 ID:SGTC_1213|Compound:1315-0166|FD-Score:-3.48|P-value:5.97E-4 ID:SGTC_1372|Compound:2752-0194|FD-Score:3.34|P-value:7.28E-4 ID:SGTC_1387|Compound:3342-1166|FD-Score:3.36|P-value:6.78E-4 ID:SGTC_1409|Compound:3909-8004|FD-Score:3.56|P-value:3.43E-4 ID:SGTC_1610|Compound:st001799|FD-Score:3.42|P-value:5.45E-4 ID:SGTC_1611|Compound:st001856|FD-Score:4.34|P-value:1.83E-5 ID:SGTC_1613|Compound:st002381|FD-Score:3.29|P-value:8.51E-4 ID:SGTC_1619|Compound:st003326|FD-Score:-3.99|P-value:1.02E-4 ID:SGTC_1632|Compound:st005650|FD-Score:3.28|P-value:8.76E-4 ID:SGTC_1713|Compound:st033146|FD-Score:3.59|P-value:3.16E-4 ID:SGTC_1714|Compound:st033236|FD-Score:3.54|P-value:3.68E-4 ID:SGTC_1728|Compound:st035614|FD-Score:-3.55|P-value:4.84E-4 ID:SGTC_1947|Compound:st076332|FD-Score:3.85|P-value:1.25E-4 ID:SGTC_2054|Compound:5233173|FD-Score:3.84|P-value:1.29E-4 ID:SGTC_2130|Compound:NSC 7|FD-Score:-3.44|P-value:7.00E-4 ID:SGTC_2367|Compound:9070478|FD-Score:3.97|P-value:7.88E-5 ID:SGTC_2368|Compound:9071271|FD-Score:3.54|P-value:3.66E-4 ID:SGTC_2455|Compound:5377712|FD-Score:4.50|P-value:9.31E-6 ID:SGTC_2465|Compound:5809242|FD-Score:3.53|P-value:3.84E-4 ID:SGTC_2468|Compound:5987765|FD-Score:5.88|P-value:1.24E-8 ID:SGTC_2470|Compound:5664817|FD-Score:5.21|P-value:3.79E-7 ID:SGTC_2471|Compound:5466956|FD-Score:4.26|P-value:2.53E-5 ID:SGTC_2488|Compound:5268135|FD-Score:-3.58|P-value:4.35E-4 ID:SGTC_2593|Compound:nobiletin|FD-Score:3.32|P-value:7.81E-4 ID:SGTC_2798|Compound:7813637|FD-Score:4.05|P-value:5.74E-5 ID:SGTC_2804|Compound:7954240|FD-Score:3.70|P-value:2.08E-4 ID:SGTC_2850|Compound:9015429|FD-Score:4.79|P-value:2.64E-6 ID:SGTC_2955|Compound:9076254|FD-Score:-3.54|P-value:4.96E-4 ID:SGTC_2963|Compound:9082507|FD-Score:5.35|P-value:1.88E-7 ID:SGTC_3089|Compound:9117425|FD-Score:5.08|P-value:6.85E-7 ID:SGTC_3126|Compound:9127922|FD-Score:3.72|P-value:1.95E-4 ID:SGTC_3140|Compound:9094243|FD-Score:4.00|P-value:7.07E-5 ID:SGTC_3234|Compound:9132280|FD-Score:4.22|P-value:2.92E-5

Top fitness defect scores for YPR157W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2468 5987765 5.88 72.9 µM 1.24E-8 2 2.10E-9
2 SGTC_2963 9082507 5.35 9.0 µM 1.88E-7 8 4.37E-8
3 SGTC_2470 5664817 5.21 21.7 µM 3.79E-7 3 9.52E-8
4 SGTC_3089 9117425 5.08 49.5 µM 6.85E-7 7 1.84E-7
5 SGTC_2850 9015429 4.79 58.4 µM 2.64E-6 5 8.26E-7
6 SGTC_2455 5377712 4.50 9.8 µM 9.31E-6 14 3.36E-6
7 SGTC_1611 st001856 4.34 99.4 µM 1.83E-5 10 7.14E-6
8 SGTC_2471 5466956 4.26 24.8 µM 2.53E-5 mitochondrial processes 8 1.02E-5
9 SGTC_3234 9132280 4.22 49.5 µM 2.92E-5 12 1.20E-5
10 SGTC_2798 7813637 4.05 45.5 µM 5.74E-5 29 2.54E-5
11 SGTC_3140 9094243 4.00 49.5 µM 7.07E-5 22 3.20E-5
12 SGTC_2367 9070478 3.97 135.4 µM 7.88E-5 cell wall 31 3.60E-5
13 SGTC_106 0092-0003 3.93 11.6 µM 9.29E-5 copper-dependent oxidative stress 18 4.33E-5
14 SGTC_1947 st076332 3.85 61.6 µM 1.25E-4 14 5.99E-5
15 SGTC_2054 5233173 3.84 129.0 µM 1.29E-4 mitochondrial response to ROS 58 6.24E-5
16 SGTC_1030 k029-0042 3.81 36.7 µM 1.43E-4 TSC3-RPN4 30 7.01E-5
17 SGTC_3126 9127922 3.72 49.5 µM 1.95E-4 fatty acid desaturase (OLE1) 43 9.85E-5
18 SGTC_2804 7954240 3.70 19.5 µM 2.08E-4 44 1.06E-4
19 SGTC_541 4513-1321 3.67 94.0 µM 2.31E-4 27 1.19E-4
20 SGTC_1713 st033146 3.59 12.8 µM 3.16E-4 39 1.68E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.109 2.21E-10 YGL171W ROK1 het RNA-dependent ATPase; involved in pre-rRNA processing at sites A0, A1, and A2, and in control of cell cycle progression; contains two upstream open reading frames (uORFs) in 5' untranslated region which regulate translation
0.104 1.41E-9 YPL007C TFC8 het One of six subunits of RNA polymerase III transcription initiation factor complex (TFIIIC); part of TFIIIC TauB domain that binds BoxB promoter sites of tRNA and other genes; linker between TauB and TauA domains; human homolog is TFIIIC-90
0.093 6.97E-8 YMR113W FOL3 het Dihydrofolate synthetase, involved in folic acid biosynthesis; catalyzes the conversion of dihydropteroate to dihydrofolate in folate coenzyme biosynthesis
0.082 1.71E-6 YGR036C CAX4 hom Dolichyl pyrophosphate (Dol-P-P) phosphatase with a luminally oriented active site in the ER, cleaves the anhydride linkage in Dol-P-P, required for Dol-P-P-linked oligosaccharide intermediate synthesis and protein N-glycosylation
0.082 2.06E-6 YPL086C ELP3 hom Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; exhibits histone acetyltransferase activity that is directed to histones H3 and H4; disruption confers resistance to K. lactis zymotoxin
0.081 2.50E-6 YBR105C VID24 hom GID Complex regulatory subunit; binds GID Complex in response to glucose through interactions with complex member Vid28p; regulates fructose-1,6-bisphosphatase (FBPase) targeting to the vacuole; promotes proteasome-dependent catabolite degradation of FBPase; peripheral membrane protein located at Vid (vacuole import and degradation) vesicles
0.075 1.23E-5 YBL100W-C_p YBL100W-C_p hom Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
0.071 3.70E-5 YGR201C_p YGR201C_p hom Putative protein of unknown function
0.070 5.44E-5 YKL206C ADD66 hom Protein involved in 20S proteasome assembly; forms a heterodimer with Pba1p that binds to proteasome precursors; similar to human PAC2 constituent of the PAC1-PAC2 complex involved in proteasome assembly
0.069 6.23E-5 YAL030W SNC1 hom Vesicle membrane receptor protein (v-SNARE); involved in the fusion between Golgi-derived secretory vesicles with the plasma membrane; proposed to be involved in endocytosis; member of the synaptobrevin/VAMP family of R-type v-SNARE proteins; SNC1 has a paralog, SNC2, that arose from the whole genome duplication
0.069 6.63E-5 YPL266W DIM1 het Essential 18S rRNA dimethylase (dimethyladenosine transferase), responsible for conserved m6(2)Am6(2)A dimethylation in 3'-terminal loop of 18S rRNA, part of 90S and 40S pre-particles in nucleolus, involved in pre-ribosomal RNA processing
0.065 1.74E-4 YOR360C PDE2 hom High-affinity cyclic AMP phosphodiesterase, component of the cAMP-dependent protein kinase signaling system, protects the cell from extracellular cAMP, contains readthrough motif surrounding termination codon
0.065 1.81E-4 YHR198C AIM18 hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays elevated frequency of mitochondrial genome loss
0.063 2.33E-4 YPL083C SEN54 het Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p
0.063 2.36E-4 YDR314C RAD34 hom Protein involved in nucleotide excision repair (NER); homologous to RAD4