YPR158W / CUR1

Sorting factor, central regulator of spatial protein quality control; physically and functionally interacts with chaperones to promote sorting and deposition of misfolded proteins into cytosolic compartments; involved in destabilization of [URE3] prions; CUR1 has a paralog, BTN2, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YPR158W / CUR1

Click on Significant Values for Screen Details ID:SGTC_93|Compound:0109-0045|FD-Score:3.47|P-value:4.16E-4 ID:SGTC_95|Compound:0471-0001|FD-Score:3.78|P-value:1.32E-4 ID:SGTC_202|Compound:3594-0513|FD-Score:4.74|P-value:2.22E-6 ID:SGTC_256|Compound:clotrimazole|FD-Score:3.37|P-value:5.86E-4 ID:SGTC_380|Compound:3970-0968|FD-Score:3.45|P-value:4.37E-4 ID:SGTC_455|Compound:paf C-16|FD-Score:4.04|P-value:4.82E-5 ID:SGTC_494|Compound:Boc-Gly-Val-Val-CHO|FD-Score:3.32|P-value:6.85E-4 ID:SGTC_590|Compound:k048-0076|FD-Score:-3.20|P-value:7.35E-4 ID:SGTC_596|Compound:1155-0152|FD-Score:4.03|P-value:4.97E-5 ID:SGTC_760|Compound:0568-0725|FD-Score:-4.27|P-value:1.21E-5 ID:SGTC_765|Compound:1319-0117|FD-Score:4.33|P-value:1.39E-5 ID:SGTC_819|Compound:1013-0258|FD-Score:4.39|P-value:1.09E-5 ID:SGTC_822|Compound:1487-0950|FD-Score:3.63|P-value:2.30E-4 ID:SGTC_904|Compound:1141-0088|FD-Score:3.84|P-value:1.04E-4 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:3.89|P-value:8.53E-5 ID:SGTC_920|Compound:mycophenolic acid|FD-Score:3.73|P-value:1.58E-4 ID:SGTC_939|Compound:1165-0479|FD-Score:3.35|P-value:6.26E-4 ID:SGTC_951|Compound:1171-0579|FD-Score:5.64|P-value:2.34E-8 ID:SGTC_1016|Compound:4226-1401|FD-Score:-3.19|P-value:7.68E-4 ID:SGTC_1152|Compound:3909-8331|FD-Score:3.40|P-value:5.25E-4 ID:SGTC_1215|Compound:3852-0577|FD-Score:3.31|P-value:7.05E-4 ID:SGTC_1360|Compound:1598-0022|FD-Score:4.49|P-value:7.15E-6 ID:SGTC_1495|Compound:4469-0029|FD-Score:3.78|P-value:1.33E-4 ID:SGTC_1530|Compound:rhein|FD-Score:3.70|P-value:1.76E-4 ID:SGTC_1564|Compound:D-Arginine|FD-Score:4.75|P-value:2.18E-6 ID:SGTC_1647|Compound:st011722|FD-Score:-3.29|P-value:5.40E-4 ID:SGTC_1668|Compound:st014914|FD-Score:3.52|P-value:3.48E-4 ID:SGTC_1703|Compound:st026983|FD-Score:4.25|P-value:1.98E-5 ID:SGTC_1706|Compound:st031321|FD-Score:4.76|P-value:2.00E-6 ID:SGTC_1773|Compound:st048542|FD-Score:3.50|P-value:3.74E-4 ID:SGTC_1877|Compound:wortmannin|FD-Score:3.28|P-value:7.77E-4 ID:SGTC_1952|Compound:st077036|FD-Score:3.34|P-value:6.43E-4 ID:SGTC_1985|Compound:st071382|FD-Score:3.69|P-value:1.87E-4 ID:SGTC_1998|Compound:st075797|FD-Score:3.67|P-value:1.97E-4 ID:SGTC_2135|Compound:5326629|FD-Score:3.35|P-value:6.21E-4 ID:SGTC_2221|Compound:6807166|FD-Score:4.01|P-value:5.35E-5 ID:SGTC_2356|Compound:9061756|FD-Score:3.48|P-value:3.97E-4 ID:SGTC_2386|Compound:9075165|FD-Score:3.41|P-value:5.14E-4 ID:SGTC_2387|Compound:9077560|FD-Score:3.81|P-value:1.19E-4 ID:SGTC_2585|Compound:alliin|FD-Score:3.25|P-value:8.84E-4 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:-4.85|P-value:8.47E-7 ID:SGTC_2783|Compound:7738165|FD-Score:3.80|P-value:1.23E-4 ID:SGTC_2809|Compound:7964133|FD-Score:3.73|P-value:1.57E-4 ID:SGTC_2892|Compound:9047358|FD-Score:3.38|P-value:5.71E-4 ID:SGTC_2899|Compound:9053889|FD-Score:3.77|P-value:1.35E-4 ID:SGTC_2929|Compound:9013348|FD-Score:-4.51|P-value:4.20E-6 ID:SGTC_2937|Compound:9044753|FD-Score:4.32|P-value:1.49E-5 ID:SGTC_2942|Compound:9052777|FD-Score:-3.57|P-value:2.02E-4 ID:SGTC_2968|Compound:9090663|FD-Score:4.96|P-value:7.92E-7 ID:SGTC_2985|Compound:9022375|FD-Score:3.41|P-value:5.02E-4 ID:SGTC_3028|Compound:9087778|FD-Score:-3.29|P-value:5.37E-4 ID:SGTC_3030|Compound:9087619|FD-Score:-3.71|P-value:1.20E-4 ID:SGTC_3040|Compound:9091894|FD-Score:4.71|P-value:2.55E-6 ID:SGTC_3118|Compound:9124250|FD-Score:4.65|P-value:3.48E-6 ID:SGTC_3146|Compound:9095609|FD-Score:3.36|P-value:6.04E-4 ID:SGTC_3238|Compound:9133470|FD-Score:-3.32|P-value:4.91E-4 ID:SGTC_3318|Compound:9139014|FD-Score:4.14|P-value:3.17E-5 ID:SGTC_93|Compound:0109-0045|FD-Score:3.47|P-value:4.16E-4 ID:SGTC_95|Compound:0471-0001|FD-Score:3.78|P-value:1.32E-4 ID:SGTC_202|Compound:3594-0513|FD-Score:4.74|P-value:2.22E-6 ID:SGTC_256|Compound:clotrimazole|FD-Score:3.37|P-value:5.86E-4 ID:SGTC_380|Compound:3970-0968|FD-Score:3.45|P-value:4.37E-4 ID:SGTC_455|Compound:paf C-16|FD-Score:4.04|P-value:4.82E-5 ID:SGTC_494|Compound:Boc-Gly-Val-Val-CHO|FD-Score:3.32|P-value:6.85E-4 ID:SGTC_590|Compound:k048-0076|FD-Score:-3.20|P-value:7.35E-4 ID:SGTC_596|Compound:1155-0152|FD-Score:4.03|P-value:4.97E-5 ID:SGTC_760|Compound:0568-0725|FD-Score:-4.27|P-value:1.21E-5 ID:SGTC_765|Compound:1319-0117|FD-Score:4.33|P-value:1.39E-5 ID:SGTC_819|Compound:1013-0258|FD-Score:4.39|P-value:1.09E-5 ID:SGTC_822|Compound:1487-0950|FD-Score:3.63|P-value:2.30E-4 ID:SGTC_904|Compound:1141-0088|FD-Score:3.84|P-value:1.04E-4 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:3.89|P-value:8.53E-5 ID:SGTC_920|Compound:mycophenolic acid|FD-Score:3.73|P-value:1.58E-4 ID:SGTC_939|Compound:1165-0479|FD-Score:3.35|P-value:6.26E-4 ID:SGTC_951|Compound:1171-0579|FD-Score:5.64|P-value:2.34E-8 ID:SGTC_1016|Compound:4226-1401|FD-Score:-3.19|P-value:7.68E-4 ID:SGTC_1152|Compound:3909-8331|FD-Score:3.40|P-value:5.25E-4 ID:SGTC_1215|Compound:3852-0577|FD-Score:3.31|P-value:7.05E-4 ID:SGTC_1360|Compound:1598-0022|FD-Score:4.49|P-value:7.15E-6 ID:SGTC_1495|Compound:4469-0029|FD-Score:3.78|P-value:1.33E-4 ID:SGTC_1530|Compound:rhein|FD-Score:3.70|P-value:1.76E-4 ID:SGTC_1564|Compound:D-Arginine|FD-Score:4.75|P-value:2.18E-6 ID:SGTC_1647|Compound:st011722|FD-Score:-3.29|P-value:5.40E-4 ID:SGTC_1668|Compound:st014914|FD-Score:3.52|P-value:3.48E-4 ID:SGTC_1703|Compound:st026983|FD-Score:4.25|P-value:1.98E-5 ID:SGTC_1706|Compound:st031321|FD-Score:4.76|P-value:2.00E-6 ID:SGTC_1773|Compound:st048542|FD-Score:3.50|P-value:3.74E-4 ID:SGTC_1877|Compound:wortmannin|FD-Score:3.28|P-value:7.77E-4 ID:SGTC_1952|Compound:st077036|FD-Score:3.34|P-value:6.43E-4 ID:SGTC_1985|Compound:st071382|FD-Score:3.69|P-value:1.87E-4 ID:SGTC_1998|Compound:st075797|FD-Score:3.67|P-value:1.97E-4 ID:SGTC_2135|Compound:5326629|FD-Score:3.35|P-value:6.21E-4 ID:SGTC_2221|Compound:6807166|FD-Score:4.01|P-value:5.35E-5 ID:SGTC_2356|Compound:9061756|FD-Score:3.48|P-value:3.97E-4 ID:SGTC_2386|Compound:9075165|FD-Score:3.41|P-value:5.14E-4 ID:SGTC_2387|Compound:9077560|FD-Score:3.81|P-value:1.19E-4 ID:SGTC_2585|Compound:alliin|FD-Score:3.25|P-value:8.84E-4 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:-4.85|P-value:8.47E-7 ID:SGTC_2783|Compound:7738165|FD-Score:3.80|P-value:1.23E-4 ID:SGTC_2809|Compound:7964133|FD-Score:3.73|P-value:1.57E-4 ID:SGTC_2892|Compound:9047358|FD-Score:3.38|P-value:5.71E-4 ID:SGTC_2899|Compound:9053889|FD-Score:3.77|P-value:1.35E-4 ID:SGTC_2929|Compound:9013348|FD-Score:-4.51|P-value:4.20E-6 ID:SGTC_2937|Compound:9044753|FD-Score:4.32|P-value:1.49E-5 ID:SGTC_2942|Compound:9052777|FD-Score:-3.57|P-value:2.02E-4 ID:SGTC_2968|Compound:9090663|FD-Score:4.96|P-value:7.92E-7 ID:SGTC_2985|Compound:9022375|FD-Score:3.41|P-value:5.02E-4 ID:SGTC_3028|Compound:9087778|FD-Score:-3.29|P-value:5.37E-4 ID:SGTC_3030|Compound:9087619|FD-Score:-3.71|P-value:1.20E-4 ID:SGTC_3040|Compound:9091894|FD-Score:4.71|P-value:2.55E-6 ID:SGTC_3118|Compound:9124250|FD-Score:4.65|P-value:3.48E-6 ID:SGTC_3146|Compound:9095609|FD-Score:3.36|P-value:6.04E-4 ID:SGTC_3238|Compound:9133470|FD-Score:-3.32|P-value:4.91E-4 ID:SGTC_3318|Compound:9139014|FD-Score:4.14|P-value:3.17E-5

Top fitness defect scores for YPR158W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_951 1171-0579 5.64 82.7 µM 2.34E-8 cell wall 38 8.74E-9
2 SGTC_2968 9090663 4.96 33.4 µM 7.92E-7 15 3.57E-7
3 SGTC_1706 st031321 4.76 10.0 µM 2.00E-6 TSC3-RPN4 8 9.46E-7
4 SGTC_1564 D-Arginine 4.75 115.0 µM 2.18E-6 15 1.04E-6
5 SGTC_202 3594-0513 4.74 34.8 µM 2.22E-6 PDR1 5 1.06E-6
6 SGTC_3040 9091894 4.71 49.5 µM 2.55E-6 DNA intercalators 12 1.22E-6
7 SGTC_3118 9124250 4.65 49.5 µM 3.48E-6 7 1.70E-6
8 SGTC_1360 1598-0022 4.49 39.8 µM 7.15E-6 ERG2 20 3.62E-6
9 SGTC_819 1013-0258 4.39 27.7 µM 1.09E-5 28 5.66E-6
10 SGTC_765 1319-0117 4.33 244.0 µM 1.39E-5 60S ribosome export 6 7.30E-6
11 SGTC_2937 9044753 4.32 11.3 µM 1.49E-5 60S ribosome export 26 7.87E-6
12 SGTC_1703 st026983 4.25 48.3 µM 1.98E-5 6 1.06E-5
13 SGTC_3318 9139014 4.14 38.6 µM 3.17E-5 10 1.74E-5
14 SGTC_455 paf C-16 4.04 10.0 µM 4.82E-5 31 2.71E-5
15 SGTC_596 1155-0152 4.03 116.0 µM 4.97E-5 TRP & mitochondrial translation 35 2.80E-5
16 SGTC_2221 6807166 4.01 181.1 µM 5.35E-5 5 3.03E-5
17 SGTC_915 methyl methanesulfonate (MMS) 3.89 110.0 mM 8.53E-5 DNA damage response 46 4.95E-5
18 SGTC_904 1141-0088 3.84 396.0 µM 1.04E-4 13 6.12E-5
19 SGTC_2387 9077560 3.81 195.1 µM 1.19E-4 21 7.04E-5
20 SGTC_2783 7738165 3.80 71.4 µM 1.23E-4 34 7.26E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.088 3.14E-7 YDL223C HBT1 hom Substrate of the Hub1p ubiquitin-like protein that localizes to the shmoo tip (mating projection); mutants are defective for mating projection formation, thereby implicating Hbt1p in polarized cell morphogenesis
0.088 3.41E-7 YML058W-A HUG1 hom Protein involved in the Mec1p-mediated checkpoint pathway; transcription is induced by DNA damage; protein abundance increases in response to DNA replication stress
0.087 5.07E-7 YJL009W_d YJL009W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps CCT8/YJL008C, a verified gene encoding a subunit of the cytosolic chaperonin Cct ring complex
0.082 1.87E-6 YDL092W SRP14 het Signal recognition particle (SRP) subunit, interacts with the RNA component of SRP to form the Alu domain, which is the region of SRP responsible for arrest of nascent chain elongation during membrane targeting; homolog of mammalian SRP14
0.073 2.45E-5 YIL014W MNT3 hom Alpha-1,3-mannosyltransferase, adds the fourth and fifth alpha-1,3-linked mannose residues to O-linked glycans during protein O-glycosylation
0.071 3.91E-5 YJR001W AVT1 hom Vacuolar transporter, imports large neutral amino acids into the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters
0.069 5.89E-5 YKL167C MRP49 hom Mitochondrial ribosomal protein of the large subunit, not essential for mitochondrial translation
0.068 7.29E-5 YOR009W TIR4 hom Cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; expressed under anaerobic conditions and required for anaerobic growth; transcription is also induced by cold shock
0.068 8.70E-5 YLR335W NUP2 hom Nucleoporin involved in nucleocytoplasmic transport, binds to either the nucleoplasmic or cytoplasmic faces of the nuclear pore complex depending on Ran-GTP levels; also has a role in chromatin organization
0.067 9.21E-5 YLR133W CKI1 hom Choline kinase; catalyzes the first step in phosphatidylcholine synthesis via the CDP-choline (Kennedy pathway); exhibits some ethanolamine kinase activity contributing to phosphatidylethanolamine synthesis via the CDP-ethanolamine pathway; CKI1 has a paralog, EKI1, that arose from the whole genome duplication
0.066 1.44E-4 YGL150C INO80 het ATPase and nucleosome spacing factor, subunit of complex containing actin and actin-related proteins that has chromatin remodeling activity and 3' to 5' DNA helicase activity in vitro; has a role in modulating stress gene transcription
0.065 1.61E-4 YKL077W_p YKL077W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole
0.065 1.71E-4 YJL025W RRN7 het Component of the core factor (CF) rDNA transcription factor complex; CF is required for transcription of 35S rRNA genes by RNA polymerase I and is composed of Rrn6p, Rrn7p, and Rrn11p
0.065 1.73E-4 YDR362C TFC6 het One of six subunits of RNA polymerase III transcription initiation factor complex (TFIIIC); part of TFIIIC TauB domain that binds BoxB promoter sites of tRNA and other genes; cooperates with Tfc3p in DNA binding; human homolog is TFIIIC-110
0.064 2.22E-4 YGR156W PTI1 het Essential protein that is a component of CPF (cleavage and polyadenylation factor); involved in 3' end formation of snoRNA and mRNA; interacts directly with Pta1p; has similarity to mammalian Cleavage-Stimulation Factor CstF-64