YPR161C / SGV1

Cyclin (Bur2p)-dependent protein kinase that functions in transcriptional regulation; phosphorylates the carboxy-terminal domain of Rpo21p and the C-terminal repeat domain of Spt5p; regulated by Cak1p; similar to metazoan CDK9 proteins

Zygosity: Heterozygous strain
fixedexpanded
Profile for YPR161C / SGV1

Click on Significant Values for Screen Details ID:SGTC_3|Compound:0833-0587|FD-Score:4.24|P-value:1.76E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:5.56|P-value:2.86E-8 ID:SGTC_61|Compound:0978-8327|FD-Score:-3.76|P-value:1.17E-4 ID:SGTC_227|Compound:fluconazole|FD-Score:3.96|P-value:5.67E-5 ID:SGTC_374|Compound:0880-0231|FD-Score:3.97|P-value:5.53E-5 ID:SGTC_431|Compound:k089-0097|FD-Score:6.18|P-value:8.50E-10 ID:SGTC_444|Compound:curcumin|FD-Score:4.01|P-value:4.69E-5 ID:SGTC_475|Compound:α-linolenic acid|FD-Score:-3.70|P-value:1.46E-4 ID:SGTC_547|Compound:1120-0019|FD-Score:-4.06|P-value:3.52E-5 ID:SGTC_701|Compound:4424-0219|FD-Score:3.59|P-value:2.33E-4 ID:SGTC_733|Compound:4069-0007|FD-Score:3.83|P-value:9.41E-5 ID:SGTC_780|Compound:0109-0199|FD-Score:3.30|P-value:6.52E-4 ID:SGTC_839|Compound:0122-0028|FD-Score:3.98|P-value:5.17E-5 ID:SGTC_849|Compound:0386-0493|FD-Score:3.41|P-value:4.38E-4 ID:SGTC_886|Compound:0866-0150|FD-Score:3.48|P-value:3.47E-4 ID:SGTC_925|Compound:2064-1272|FD-Score:7.75|P-value:2.06E-14 ID:SGTC_1020|Compound:4335-0961|FD-Score:3.58|P-value:2.38E-4 ID:SGTC_1050|Compound:3232-1156|FD-Score:3.25|P-value:7.69E-4 ID:SGTC_1201|Compound:1889-3372|FD-Score:-3.37|P-value:4.85E-4 ID:SGTC_1213|Compound:1315-0166|FD-Score:3.30|P-value:6.47E-4 ID:SGTC_1241|Compound:0364-0022|FD-Score:3.41|P-value:4.50E-4 ID:SGTC_1356|Compound:1502-0781|FD-Score:3.69|P-value:1.64E-4 ID:SGTC_1388|Compound:3346-4487|FD-Score:3.36|P-value:5.21E-4 ID:SGTC_1426|Compound:4048-4480|FD-Score:3.86|P-value:8.47E-5 ID:SGTC_1435|Compound:4092-0789|FD-Score:3.62|P-value:2.13E-4 ID:SGTC_1473|Compound:k844-0725|FD-Score:-3.33|P-value:5.61E-4 ID:SGTC_1615|Compound:st002656|FD-Score:3.53|P-value:2.88E-4 ID:SGTC_1616|Compound:st002734|FD-Score:5.97|P-value:2.87E-9 ID:SGTC_1912|Compound:st060209|FD-Score:3.34|P-value:5.69E-4 ID:SGTC_1915|Compound:st067105|FD-Score:7.30|P-value:5.37E-13 ID:SGTC_1917|Compound:st066507|FD-Score:4.80|P-value:1.41E-6 ID:SGTC_1955|Compound:wogonin|FD-Score:3.69|P-value:1.63E-4 ID:SGTC_1983|Compound:st071813|FD-Score:3.61|P-value:2.14E-4 ID:SGTC_2003|Compound:4023581|FD-Score:3.24|P-value:7.97E-4 ID:SGTC_2023|Compound:5144124|FD-Score:4.16|P-value:2.47E-5 ID:SGTC_2041|Compound:5107442|FD-Score:3.46|P-value:3.67E-4 ID:SGTC_2156|Compound:5649887|FD-Score:-3.18|P-value:9.45E-4 ID:SGTC_2200|Compound:6600604|FD-Score:3.37|P-value:5.17E-4 ID:SGTC_2254|Compound:7938975|FD-Score:3.26|P-value:7.33E-4 ID:SGTC_2259|Compound:7964009|FD-Score:-3.88|P-value:7.25E-5 ID:SGTC_2276|Compound:7947513|FD-Score:3.93|P-value:6.41E-5 ID:SGTC_2301|Compound:7769476|FD-Score:11.00|P-value:3.81E-27 ID:SGTC_2331|Compound:7980721|FD-Score:-3.76|P-value:1.18E-4 ID:SGTC_2333|Compound:9017922|FD-Score:5.78|P-value:8.54E-9 ID:SGTC_2387|Compound:9077560|FD-Score:3.41|P-value:4.51E-4 ID:SGTC_2436|Compound:5633522|FD-Score:3.50|P-value:3.21E-4 ID:SGTC_2440|Compound:5628896|FD-Score:-3.18|P-value:9.30E-4 ID:SGTC_2441|Compound:5730946|FD-Score:5.17|P-value:2.30E-7 ID:SGTC_2489|Compound:cantharidin|FD-Score:3.31|P-value:6.26E-4 ID:SGTC_2593|Compound:nobiletin|FD-Score:4.77|P-value:1.65E-6 ID:SGTC_2596|Compound:sinensetin|FD-Score:-3.36|P-value:5.00E-4 ID:SGTC_2662|Compound:daunorubicin|FD-Score:3.79|P-value:1.09E-4 ID:SGTC_2675|Compound:theaflavin digallate|FD-Score:3.33|P-value:5.77E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:3.92|P-value:6.75E-5 ID:SGTC_2785|Compound:7756463|FD-Score:-3.44|P-value:3.87E-4 ID:SGTC_2786|Compound:7743617|FD-Score:3.45|P-value:3.91E-4 ID:SGTC_2788|Compound:5282734|FD-Score:-7.90|P-value:5.86E-15 ID:SGTC_2790|Compound:5423970|FD-Score:-3.32|P-value:5.73E-4 ID:SGTC_2864|Compound:9034755|FD-Score:-3.31|P-value:6.06E-4 ID:SGTC_2925|Compound:9010536|FD-Score:-4.85|P-value:1.06E-6 ID:SGTC_3114|Compound:9122766|FD-Score:3.25|P-value:7.68E-4 ID:SGTC_3140|Compound:9094243|FD-Score:-4.12|P-value:2.75E-5 ID:SGTC_3141|Compound:9094609|FD-Score:-5.26|P-value:1.35E-7 ID:SGTC_3142|Compound:9086498|FD-Score:-13.10|P-value:7.09E-38 ID:SGTC_3145|Compound:9085516|FD-Score:-3.21|P-value:8.38E-4 ID:SGTC_3304|Compound:9125678|FD-Score:3.57|P-value:2.52E-4 ID:SGTC_3|Compound:0833-0587|FD-Score:4.24|P-value:1.76E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:5.56|P-value:2.86E-8 ID:SGTC_61|Compound:0978-8327|FD-Score:-3.76|P-value:1.17E-4 ID:SGTC_227|Compound:fluconazole|FD-Score:3.96|P-value:5.67E-5 ID:SGTC_374|Compound:0880-0231|FD-Score:3.97|P-value:5.53E-5 ID:SGTC_431|Compound:k089-0097|FD-Score:6.18|P-value:8.50E-10 ID:SGTC_444|Compound:curcumin|FD-Score:4.01|P-value:4.69E-5 ID:SGTC_475|Compound:α-linolenic acid|FD-Score:-3.70|P-value:1.46E-4 ID:SGTC_547|Compound:1120-0019|FD-Score:-4.06|P-value:3.52E-5 ID:SGTC_701|Compound:4424-0219|FD-Score:3.59|P-value:2.33E-4 ID:SGTC_733|Compound:4069-0007|FD-Score:3.83|P-value:9.41E-5 ID:SGTC_780|Compound:0109-0199|FD-Score:3.30|P-value:6.52E-4 ID:SGTC_839|Compound:0122-0028|FD-Score:3.98|P-value:5.17E-5 ID:SGTC_849|Compound:0386-0493|FD-Score:3.41|P-value:4.38E-4 ID:SGTC_886|Compound:0866-0150|FD-Score:3.48|P-value:3.47E-4 ID:SGTC_925|Compound:2064-1272|FD-Score:7.75|P-value:2.06E-14 ID:SGTC_1020|Compound:4335-0961|FD-Score:3.58|P-value:2.38E-4 ID:SGTC_1050|Compound:3232-1156|FD-Score:3.25|P-value:7.69E-4 ID:SGTC_1201|Compound:1889-3372|FD-Score:-3.37|P-value:4.85E-4 ID:SGTC_1213|Compound:1315-0166|FD-Score:3.30|P-value:6.47E-4 ID:SGTC_1241|Compound:0364-0022|FD-Score:3.41|P-value:4.50E-4 ID:SGTC_1356|Compound:1502-0781|FD-Score:3.69|P-value:1.64E-4 ID:SGTC_1388|Compound:3346-4487|FD-Score:3.36|P-value:5.21E-4 ID:SGTC_1426|Compound:4048-4480|FD-Score:3.86|P-value:8.47E-5 ID:SGTC_1435|Compound:4092-0789|FD-Score:3.62|P-value:2.13E-4 ID:SGTC_1473|Compound:k844-0725|FD-Score:-3.33|P-value:5.61E-4 ID:SGTC_1615|Compound:st002656|FD-Score:3.53|P-value:2.88E-4 ID:SGTC_1616|Compound:st002734|FD-Score:5.97|P-value:2.87E-9 ID:SGTC_1912|Compound:st060209|FD-Score:3.34|P-value:5.69E-4 ID:SGTC_1915|Compound:st067105|FD-Score:7.30|P-value:5.37E-13 ID:SGTC_1917|Compound:st066507|FD-Score:4.80|P-value:1.41E-6 ID:SGTC_1955|Compound:wogonin|FD-Score:3.69|P-value:1.63E-4 ID:SGTC_1983|Compound:st071813|FD-Score:3.61|P-value:2.14E-4 ID:SGTC_2003|Compound:4023581|FD-Score:3.24|P-value:7.97E-4 ID:SGTC_2023|Compound:5144124|FD-Score:4.16|P-value:2.47E-5 ID:SGTC_2041|Compound:5107442|FD-Score:3.46|P-value:3.67E-4 ID:SGTC_2156|Compound:5649887|FD-Score:-3.18|P-value:9.45E-4 ID:SGTC_2200|Compound:6600604|FD-Score:3.37|P-value:5.17E-4 ID:SGTC_2254|Compound:7938975|FD-Score:3.26|P-value:7.33E-4 ID:SGTC_2259|Compound:7964009|FD-Score:-3.88|P-value:7.25E-5 ID:SGTC_2276|Compound:7947513|FD-Score:3.93|P-value:6.41E-5 ID:SGTC_2301|Compound:7769476|FD-Score:11.00|P-value:3.81E-27 ID:SGTC_2331|Compound:7980721|FD-Score:-3.76|P-value:1.18E-4 ID:SGTC_2333|Compound:9017922|FD-Score:5.78|P-value:8.54E-9 ID:SGTC_2387|Compound:9077560|FD-Score:3.41|P-value:4.51E-4 ID:SGTC_2436|Compound:5633522|FD-Score:3.50|P-value:3.21E-4 ID:SGTC_2440|Compound:5628896|FD-Score:-3.18|P-value:9.30E-4 ID:SGTC_2441|Compound:5730946|FD-Score:5.17|P-value:2.30E-7 ID:SGTC_2489|Compound:cantharidin|FD-Score:3.31|P-value:6.26E-4 ID:SGTC_2593|Compound:nobiletin|FD-Score:4.77|P-value:1.65E-6 ID:SGTC_2596|Compound:sinensetin|FD-Score:-3.36|P-value:5.00E-4 ID:SGTC_2662|Compound:daunorubicin|FD-Score:3.79|P-value:1.09E-4 ID:SGTC_2675|Compound:theaflavin digallate|FD-Score:3.33|P-value:5.77E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:3.92|P-value:6.75E-5 ID:SGTC_2785|Compound:7756463|FD-Score:-3.44|P-value:3.87E-4 ID:SGTC_2786|Compound:7743617|FD-Score:3.45|P-value:3.91E-4 ID:SGTC_2788|Compound:5282734|FD-Score:-7.90|P-value:5.86E-15 ID:SGTC_2790|Compound:5423970|FD-Score:-3.32|P-value:5.73E-4 ID:SGTC_2864|Compound:9034755|FD-Score:-3.31|P-value:6.06E-4 ID:SGTC_2925|Compound:9010536|FD-Score:-4.85|P-value:1.06E-6 ID:SGTC_3114|Compound:9122766|FD-Score:3.25|P-value:7.68E-4 ID:SGTC_3140|Compound:9094243|FD-Score:-4.12|P-value:2.75E-5 ID:SGTC_3141|Compound:9094609|FD-Score:-5.26|P-value:1.35E-7 ID:SGTC_3142|Compound:9086498|FD-Score:-13.10|P-value:7.09E-38 ID:SGTC_3145|Compound:9085516|FD-Score:-3.21|P-value:8.38E-4 ID:SGTC_3304|Compound:9125678|FD-Score:3.57|P-value:2.52E-4

Top fitness defect scores for YPR161C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2301 7769476 11.00 200.0 µM 3.81E-27 1 2.08E-28 2.54
2 SGTC_925 2064-1272 7.75 59.6 µM 2.06E-14 1 4.73E-15 1.97
3 SGTC_1915 st067105 7.30 30.6 µM 5.37E-13 RNA pol III & RNase P/MRP 15 1.45E-13 0.53
4 SGTC_431 k089-0097 6.18 107.0 µM 8.50E-10 iron homeostasis 4 3.29E-10 0.72
5 SGTC_1616 st002734 5.97 56.1 µM 2.87E-9 2 1.18E-9 0.76
6 SGTC_2333 9017922 5.78 200.0 µM 8.54E-9 1 3.69E-9 0.81
7 SGTC_58 0957-0393 5.56 9.0 µM 2.86E-8 cell wall 31 1.31E-8 0.08
8 SGTC_2441 5730946 5.17 39.1 µM 2.30E-7 1 1.17E-7 1.20
9 SGTC_1917 st066507 4.80 28.5 µM 1.41E-6 Golgi 3 7.85E-7 0.36
10 SGTC_2593 nobiletin 4.77 86.2 µM 1.65E-6 4 9.22E-7 0.07
11 SGTC_3 0833-0587 4.24 95.6 µM 1.76E-5 redox potentiating 13 1.10E-5 0.12
12 SGTC_2023 5144124 4.16 124.0 µM 2.47E-5 5 1.57E-5 0.32
13 SGTC_444 curcumin 4.01 90.4 µM 4.69E-5 iron homeostasis 14 3.08E-5 0.02
14 SGTC_839 0122-0028 3.98 230.0 µM 5.17E-5 RSC complex & mRNA processing 38 3.41E-5 0.14
15 SGTC_374 0880-0231 3.97 82.3 µM 5.53E-5 iron homeostasis 8 3.66E-5 0.15
16 SGTC_227 fluconazole 3.96 33.5 µM 5.67E-5 azole & statin 48 3.76E-5 0.06
17 SGTC_2276 7947513 3.93 42.1 µM 6.41E-5 5 4.27E-5 0.27
18 SGTC_2679 rapamycin 3.92 1.0 nM 6.75E-5 54 4.51E-5 0.04
19 SGTC_1426 4048-4480 3.86 71.7 µM 8.47E-5 60S ribosome export 4 5.72E-5 0.51
20 SGTC_733 4069-0007 3.83 56.1 µM 9.41E-5 ERAD & cell cycle 22 6.38E-5 0.15

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.133 8.93E-15 YFL002C SPB4 het Putative ATP-dependent RNA helicase, nucleolar protein required for synthesis of 60S ribosomal subunits at a late step in the pathway; sediments with 66S pre-ribosomes in sucrose gradients
0.119 4.79E-12 YLR310C CDC25 het Membrane bound guanine nucleotide exchange factor (GEF or GDP-release factor); indirectly regulates adenylate cyclase through activation of Ras1p and Ras2p by stimulating the exchange of GDP for GTP; required for progression through G1
0.106 6.52E-10 YPR116W RRG8 hom Putative protein of unknown function, required for mitochondrial genome maintenance; null mutation results in a decrease in plasma membrane electron transport
0.105 1.08E-9 YGL169W SUA5 het Single-stranded telomeric DNA-binding protein, required for normal telomere length; null mutant lacks N6-threonylcarbamoyl adenosine (t6A) modification in the anticodon loop of ANN-decoding tRNA; member of conserved YrdC/Sua5 family
0.105 1.12E-9 YDR205W MSC2 hom Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids
0.104 1.58E-9 YPR104C FHL1 het Regulator of ribosomal protein (RP) transcription; has forkhead associated domain that binds phosphorylated proteins; recruits coactivator Ifh1p or corepressor Crf1p to RP gene promoters; also has forkhead DNA-binding domain though in vitro DNA binding assays give inconsistent results; computational analyses suggest it binds DNA directly at highly active RP genes and indirectly through Rap1p motifs at others; suppresses RNA pol III and splicing factor prp4 mutants
0.104 1.74E-9 YDR225W HTA1 hom Histone H2A, core histone protein required for chromatin assembly and chromosome function; one of two nearly identical subtypes (see also HTA2); DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair; acetylated by Nat4p
0.103 2.12E-9 YBL026W LSM2 het Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress
0.101 4.99E-9 YBR091C TIM12 het Essential protein of the inner mitochondrial membrane, peripherally localized; component of the TIM22 complex, which is a twin-pore translocase that mediates insertion of numerous multispanning inner membrane proteins
0.101 5.41E-9 YLR321C SFH1 het Component of the RSC chromatin remodeling complex; essential gene required for cell cycle progression and maintenance of proper ploidy; phosphorylated in the G1 phase of the cell cycle; Snf5p paralog
0.101 5.46E-9 YER165W PAB1 het Poly(A) binding protein, part of the 3'-end RNA-processing complex, mediates interactions between the 5' cap structure and the 3' mRNA poly(A) tail, involved in control of poly(A) tail length, interacts with translation factor eIF-4G
0.092 8.24E-8 YGL263W COS12 hom Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins
0.091 1.13E-7 YOR231W MKK1 hom MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p; MKK1 has a paralog, MKK2, that arose from the whole genome duplication
0.091 1.29E-7 YNR016C ACC1 het Acetyl-CoA carboxylase, biotin containing enzyme; catalyzes the carboxylation of cytosolic acetyl-CoA to form malonyl-CoA and regulates histone acetylation by regulating the availablity of acetyl-CoA; required for de novo biosynthesis of long-chain fatty acids;
0.091 1.48E-7 YBR120C CBP6 hom Mitochondrial protein required for translation of the COB mRNA; forms a complex with Cbp3p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex