HIPHOP chemogenomics database
YPR162C / ORC4 
Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing
Zygosity: Heterozygous strain
fixedexpanded
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Top fitness defect scores for YPR162C deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.083 | 1.33E-6 | YNL245C | CWC25 | het | Splicing factor required for the first step of pre-mRNA splicing; binding to the spliceosome requires Prp2p and Yju2p; heat-stable protein; has similarity to S. pombe Cwf25p |
| 0.078 | 5.92E-6 | YER180C | ISC10 | hom | Protein required for sporulation, transcript is induced 7.5 hours after induction of meiosis, expected to play significant role in the formation of reproductive cells |
| 0.076 | 1.06E-5 | YGL062W | PYC1 | hom | Pyruvate carboxylase isoform; cytoplasmic enzyme that converts pyruvate to oxaloacetate; differentially regulated than isoform Pyc2p; mutations in the human homolog are associated with lactic acidosis; PYC1 has a paralog, PYC2, that arose from the whole genome duplication |
| 0.076 | 1.18E-5 | YDL215C | GDH2 | hom | NAD(+)-dependent glutamate dehydrogenase, degrades glutamate to ammonia and alpha-ketoglutarate; expression sensitive to nitrogen catabolite repression and intracellular ammonia levels |
| 0.075 | 1.38E-5 | YMR283C | RIT1 | hom | 2'-O-ribosyl phosphate transferase, modifies the initiator methionine tRNA at position 64 to distinguish it from elongator methionine tRNA |
| 0.073 | 2.29E-5 | YGR047C | TFC4 | het | One of six subunits of the RNA polymerase III transcription initiation factor complex (TFIIIC); part of the TauA domain of TFIIIC that binds BoxA DNA promoter sites of tRNA and similar genes; has TPR motifs; human homolog is TFIIIC-102 |
| 0.070 | 4.53E-5 | YPR026W | ATH1 | hom | Acid trehalase required for utilization of extracellular trehalose |
| 0.069 | 5.82E-5 | YDR071C | PAA1 | hom | Polyamine acetyltransferase; acetylates polyamines (e.g. putrescine, spermidine, spermine) and also aralkylamines (e.g. tryptamine, phenylethylamine); may be involved in transcription and/or DNA replication |
| 0.067 | 9.28E-5 | YBR161W | CSH1 | hom | Mannosylinositol phosphorylceramide (MIPC) synthase catalytic subunit; forms a complex with regulatory subunit Csg2p; function in sphingolipid biosynthesis is overlapping with that of Sur1p; CSH1 has a paralog, SUR1, that arose from the whole genome duplication |
| 0.067 | 9.50E-5 | YHL016C | DUR3 | hom | Plasma membrane transporter for both urea and polyamines, expression is highly sensitive to nitrogen catabolite repression and induced by allophanate, the last intermediate of the allantoin degradative pathway |
| 0.067 | 1.10E-4 | YAL067C | SEO1 | hom | Putative permease, member of the allantoate transporter subfamily of the major facilitator superfamily; mutation confers resistance to ethionine sulfoxide |
| 0.065 | 1.61E-4 | YOL085C_d | YOL085C_d | hom | Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the dubious gene YOL085W-A |
| 0.065 | 1.63E-4 | YCL038C | ATG22 | hom | Vacuolar integral membrane protein required for efflux of amino acids during autophagic body breakdown in the vacuole; null mutation causes a gradual loss of viability during starvation |
| 0.064 | 2.04E-4 | YMR310C_p | YMR310C_p | hom | Putative S-adenosylmethionine-dependent methyltransferase; predicted to be involved in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YMR310C is not an essential gene |
| 0.063 | 2.44E-4 | YLR146C | SPE4 | hom | Spermine synthase, required for the biosynthesis of spermine and also involved in biosynthesis of pantothenic acid |