YPR162C / ORC4

Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing

Zygosity: Heterozygous strain
fixedexpanded
Profile for YPR162C / ORC4

Click on Significant Values for Screen Details ID:SGTC_75|Compound:0159-0059|FD-Score:5.27|P-value:1.88E-7 ID:SGTC_356|Compound:1634-0012|FD-Score:-3.30|P-value:6.80E-4 ID:SGTC_359|Compound:0081-0058|FD-Score:-4.71|P-value:2.56E-6 ID:SGTC_372|Compound:0155-0182|FD-Score:3.58|P-value:2.77E-4 ID:SGTC_375|Compound:3970-0961|FD-Score:4.32|P-value:1.54E-5 ID:SGTC_376|Compound:3970-0862|FD-Score:-3.55|P-value:2.90E-4 ID:SGTC_392|Compound:N-ethylmaleimide|FD-Score:-3.88|P-value:8.61E-5 ID:SGTC_430|Compound:0958-0115|FD-Score:3.37|P-value:5.93E-4 ID:SGTC_661|Compound:1304-0007|FD-Score:3.61|P-value:2.48E-4 ID:SGTC_761|Compound:k216-0224|FD-Score:3.77|P-value:1.38E-4 ID:SGTC_865|Compound:0488-0499|FD-Score:4.21|P-value:2.47E-5 ID:SGTC_884|Compound:0851-0618|FD-Score:3.26|P-value:8.53E-4 ID:SGTC_899|Compound:1083-0020|FD-Score:5.15|P-value:3.40E-7 ID:SGTC_903|Compound:1134-0042|FD-Score:-3.19|P-value:9.97E-4 ID:SGTC_974|Compound:1326-0144|FD-Score:3.53|P-value:3.31E-4 ID:SGTC_1053|Compound:3366-3204|FD-Score:4.17|P-value:2.87E-5 ID:SGTC_1054|Compound:3429-0080|FD-Score:3.39|P-value:5.49E-4 ID:SGTC_1228|Compound:0124-0032|FD-Score:-3.39|P-value:5.02E-4 ID:SGTC_1240|Compound:0356-0016|FD-Score:3.90|P-value:8.53E-5 ID:SGTC_1271|Compound:0832-2808|FD-Score:3.52|P-value:3.51E-4 ID:SGTC_1290|Compound:0986-0249|FD-Score:3.52|P-value:3.49E-4 ID:SGTC_1404|Compound:3909-7820|FD-Score:3.23|P-value:9.38E-4 ID:SGTC_1530|Compound:rhein|FD-Score:-4.82|P-value:1.50E-6 ID:SGTC_1538|Compound:2',3',6-trimethoxyflavanone|FD-Score:4.73|P-value:2.60E-6 ID:SGTC_1678|Compound:st019265|FD-Score:3.70|P-value:1.80E-4 ID:SGTC_1722|Compound:st034304|FD-Score:3.34|P-value:6.50E-4 ID:SGTC_2019|Compound:4016004|FD-Score:-7.71|P-value:4.28E-14 ID:SGTC_2330|Compound:7979373|FD-Score:5.16|P-value:3.17E-7 ID:SGTC_2462|Compound:5162487|FD-Score:-3.21|P-value:9.19E-4 ID:SGTC_2515|Compound:chrysin|FD-Score:-3.92|P-value:7.27E-5 ID:SGTC_2544|Compound:sphondin|FD-Score:-3.50|P-value:3.50E-4 ID:SGTC_2587|Compound:piperic acid|FD-Score:3.66|P-value:2.07E-4 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:3.24|P-value:9.11E-4 ID:SGTC_2596|Compound:sinensetin|FD-Score:-4.82|P-value:1.52E-6 ID:SGTC_2763|Compound:lisinopril|FD-Score:3.72|P-value:1.66E-4 ID:SGTC_2769|Compound:toremifene|FD-Score:4.14|P-value:3.34E-5 ID:SGTC_2771|Compound:fluoxetine|FD-Score:-5.03|P-value:5.60E-7 ID:SGTC_2775|Compound:cyproheptadine|FD-Score:3.69|P-value:1.88E-4 ID:SGTC_2777|Compound:climbazole|FD-Score:3.25|P-value:8.71E-4 ID:SGTC_2786|Compound:7743617|FD-Score:3.87|P-value:9.54E-5 ID:SGTC_2821|Compound:7996764|FD-Score:-4.05|P-value:4.40E-5 ID:SGTC_2989|Compound:9073649|FD-Score:4.56|P-value:5.46E-6 ID:SGTC_2998|Compound:9066762|FD-Score:-4.09|P-value:3.67E-5 ID:SGTC_3050|Compound:9093513|FD-Score:-3.70|P-value:1.68E-4 ID:SGTC_3055|Compound:9094636|FD-Score:4.05|P-value:4.68E-5 ID:SGTC_3065|Compound:9113888|FD-Score:3.42|P-value:5.00E-4 ID:SGTC_3066|Compound:9117245|FD-Score:-3.95|P-value:6.62E-5 ID:SGTC_3147|Compound:9097027|FD-Score:3.44|P-value:4.52E-4 ID:SGTC_3188|Compound:9110789|FD-Score:-3.99|P-value:5.61E-5 ID:SGTC_3189|Compound:9110682|FD-Score:-4.21|P-value:2.26E-5 ID:SGTC_3195|Compound:9113082|FD-Score:3.29|P-value:7.63E-4 ID:SGTC_3201|Compound:9113999|FD-Score:4.44|P-value:9.52E-6 ID:SGTC_3224|Compound:9130643|FD-Score:3.72|P-value:1.68E-4 ID:SGTC_3262|Compound:9137218|FD-Score:-4.37|P-value:1.13E-5 ID:SGTC_3263|Compound:9137018|FD-Score:-7.32|P-value:6.84E-13 ID:SGTC_3278|Compound:9139605|FD-Score:-3.23|P-value:8.76E-4 ID:SGTC_3281|Compound:9140613|FD-Score:6.63|P-value:7.73E-11 ID:SGTC_75|Compound:0159-0059|FD-Score:5.27|P-value:1.88E-7 ID:SGTC_356|Compound:1634-0012|FD-Score:-3.30|P-value:6.80E-4 ID:SGTC_359|Compound:0081-0058|FD-Score:-4.71|P-value:2.56E-6 ID:SGTC_372|Compound:0155-0182|FD-Score:3.58|P-value:2.77E-4 ID:SGTC_375|Compound:3970-0961|FD-Score:4.32|P-value:1.54E-5 ID:SGTC_376|Compound:3970-0862|FD-Score:-3.55|P-value:2.90E-4 ID:SGTC_392|Compound:N-ethylmaleimide|FD-Score:-3.88|P-value:8.61E-5 ID:SGTC_430|Compound:0958-0115|FD-Score:3.37|P-value:5.93E-4 ID:SGTC_661|Compound:1304-0007|FD-Score:3.61|P-value:2.48E-4 ID:SGTC_761|Compound:k216-0224|FD-Score:3.77|P-value:1.38E-4 ID:SGTC_865|Compound:0488-0499|FD-Score:4.21|P-value:2.47E-5 ID:SGTC_884|Compound:0851-0618|FD-Score:3.26|P-value:8.53E-4 ID:SGTC_899|Compound:1083-0020|FD-Score:5.15|P-value:3.40E-7 ID:SGTC_903|Compound:1134-0042|FD-Score:-3.19|P-value:9.97E-4 ID:SGTC_974|Compound:1326-0144|FD-Score:3.53|P-value:3.31E-4 ID:SGTC_1053|Compound:3366-3204|FD-Score:4.17|P-value:2.87E-5 ID:SGTC_1054|Compound:3429-0080|FD-Score:3.39|P-value:5.49E-4 ID:SGTC_1228|Compound:0124-0032|FD-Score:-3.39|P-value:5.02E-4 ID:SGTC_1240|Compound:0356-0016|FD-Score:3.90|P-value:8.53E-5 ID:SGTC_1271|Compound:0832-2808|FD-Score:3.52|P-value:3.51E-4 ID:SGTC_1290|Compound:0986-0249|FD-Score:3.52|P-value:3.49E-4 ID:SGTC_1404|Compound:3909-7820|FD-Score:3.23|P-value:9.38E-4 ID:SGTC_1530|Compound:rhein|FD-Score:-4.82|P-value:1.50E-6 ID:SGTC_1538|Compound:2',3',6-trimethoxyflavanone|FD-Score:4.73|P-value:2.60E-6 ID:SGTC_1678|Compound:st019265|FD-Score:3.70|P-value:1.80E-4 ID:SGTC_1722|Compound:st034304|FD-Score:3.34|P-value:6.50E-4 ID:SGTC_2019|Compound:4016004|FD-Score:-7.71|P-value:4.28E-14 ID:SGTC_2330|Compound:7979373|FD-Score:5.16|P-value:3.17E-7 ID:SGTC_2462|Compound:5162487|FD-Score:-3.21|P-value:9.19E-4 ID:SGTC_2515|Compound:chrysin|FD-Score:-3.92|P-value:7.27E-5 ID:SGTC_2544|Compound:sphondin|FD-Score:-3.50|P-value:3.50E-4 ID:SGTC_2587|Compound:piperic acid|FD-Score:3.66|P-value:2.07E-4 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:3.24|P-value:9.11E-4 ID:SGTC_2596|Compound:sinensetin|FD-Score:-4.82|P-value:1.52E-6 ID:SGTC_2763|Compound:lisinopril|FD-Score:3.72|P-value:1.66E-4 ID:SGTC_2769|Compound:toremifene|FD-Score:4.14|P-value:3.34E-5 ID:SGTC_2771|Compound:fluoxetine|FD-Score:-5.03|P-value:5.60E-7 ID:SGTC_2775|Compound:cyproheptadine|FD-Score:3.69|P-value:1.88E-4 ID:SGTC_2777|Compound:climbazole|FD-Score:3.25|P-value:8.71E-4 ID:SGTC_2786|Compound:7743617|FD-Score:3.87|P-value:9.54E-5 ID:SGTC_2821|Compound:7996764|FD-Score:-4.05|P-value:4.40E-5 ID:SGTC_2989|Compound:9073649|FD-Score:4.56|P-value:5.46E-6 ID:SGTC_2998|Compound:9066762|FD-Score:-4.09|P-value:3.67E-5 ID:SGTC_3050|Compound:9093513|FD-Score:-3.70|P-value:1.68E-4 ID:SGTC_3055|Compound:9094636|FD-Score:4.05|P-value:4.68E-5 ID:SGTC_3065|Compound:9113888|FD-Score:3.42|P-value:5.00E-4 ID:SGTC_3066|Compound:9117245|FD-Score:-3.95|P-value:6.62E-5 ID:SGTC_3147|Compound:9097027|FD-Score:3.44|P-value:4.52E-4 ID:SGTC_3188|Compound:9110789|FD-Score:-3.99|P-value:5.61E-5 ID:SGTC_3189|Compound:9110682|FD-Score:-4.21|P-value:2.26E-5 ID:SGTC_3195|Compound:9113082|FD-Score:3.29|P-value:7.63E-4 ID:SGTC_3201|Compound:9113999|FD-Score:4.44|P-value:9.52E-6 ID:SGTC_3224|Compound:9130643|FD-Score:3.72|P-value:1.68E-4 ID:SGTC_3262|Compound:9137218|FD-Score:-4.37|P-value:1.13E-5 ID:SGTC_3263|Compound:9137018|FD-Score:-7.32|P-value:6.84E-13 ID:SGTC_3278|Compound:9139605|FD-Score:-3.23|P-value:8.76E-4 ID:SGTC_3281|Compound:9140613|FD-Score:6.63|P-value:7.73E-11

Top fitness defect scores for YPR162C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_3281 9140613 6.63 49.5 µM 7.73E-11 RPP1 & pyrimidine depletion 2 1.63E-11 1.88
2 SGTC_75 0159-0059 5.27 199.0 µM 1.88E-7 fatty acid desaturase (OLE1) 3 6.88E-8 0.77
3 SGTC_2330 7979373 5.16 200.0 µM 3.17E-7 60S ribosome export 4 1.21E-7 0.01
4 SGTC_899 1083-0020 5.15 478.0 µM 3.40E-7 1 1.30E-7 1.47
5 SGTC_1538 2',3',6-trimethoxyflavanone 4.73 63.6 µM 2.60E-6 2 1.15E-6 1.10
6 SGTC_2989 9073649 4.56 71.4 µM 5.46E-6 4 2.54E-6 0.45
7 SGTC_3201 9113999 4.44 49.5 µM 9.52E-6 5 4.60E-6 0.44
8 SGTC_375 3970-0961 4.32 9.3 µM 1.54E-5 tubulin folding & SWR complex 7 7.72E-6 0.01
9 SGTC_865 0488-0499 4.21 301.0 µM 2.47E-5 1 1.28E-5 0.33
10 SGTC_1053 3366-3204 4.17 134.0 µM 2.87E-5 cell wall 7 1.50E-5 0.32
11 SGTC_2769 toremifene 4.14 3.7 µM 3.34E-5 4 1.76E-5 0.14
12 SGTC_3055 9094636 4.05 49.5 µM 4.68E-5 6 2.53E-5 0.01
13 SGTC_1240 0356-0016 3.90 42.1 µM 8.53E-5 mitochondrial response to ROS 6 4.81E-5 0.03
14 SGTC_2786 7743617 3.87 45.5 µM 9.54E-5 8 5.42E-5 0.05
15 SGTC_761 k216-0224 3.77 480.0 µM 1.38E-4 6 8.01E-5 0.11
16 SGTC_2763 lisinopril 3.72 49.3 µM 1.66E-4 5 9.80E-5 0.52
17 SGTC_3224 9130643 3.72 49.5 µM 1.68E-4 RPP1 & pyrimidine depletion 9 9.89E-5 0.07
18 SGTC_1678 st019265 3.70 80.2 µM 1.80E-4 60S ribosome export 5 1.07E-4 0.02
19 SGTC_2775 cyproheptadine 3.69 69.6 µM 1.88E-4 5 1.12E-4 0.40
20 SGTC_2587 piperic acid 3.66 92.2 µM 2.07E-4 6 1.24E-4 0.01

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.083 1.33E-6 YNL245C CWC25 het Splicing factor required for the first step of pre-mRNA splicing; binding to the spliceosome requires Prp2p and Yju2p; heat-stable protein; has similarity to S. pombe Cwf25p
0.078 5.92E-6 YER180C ISC10 hom Protein required for sporulation, transcript is induced 7.5 hours after induction of meiosis, expected to play significant role in the formation of reproductive cells
0.076 1.06E-5 YGL062W PYC1 hom Pyruvate carboxylase isoform; cytoplasmic enzyme that converts pyruvate to oxaloacetate; differentially regulated than isoform Pyc2p; mutations in the human homolog are associated with lactic acidosis; PYC1 has a paralog, PYC2, that arose from the whole genome duplication
0.076 1.18E-5 YDL215C GDH2 hom NAD(+)-dependent glutamate dehydrogenase, degrades glutamate to ammonia and alpha-ketoglutarate; expression sensitive to nitrogen catabolite repression and intracellular ammonia levels
0.075 1.38E-5 YMR283C RIT1 hom 2'-O-ribosyl phosphate transferase, modifies the initiator methionine tRNA at position 64 to distinguish it from elongator methionine tRNA
0.073 2.29E-5 YGR047C TFC4 het One of six subunits of the RNA polymerase III transcription initiation factor complex (TFIIIC); part of the TauA domain of TFIIIC that binds BoxA DNA promoter sites of tRNA and similar genes; has TPR motifs; human homolog is TFIIIC-102
0.070 4.53E-5 YPR026W ATH1 hom Acid trehalase required for utilization of extracellular trehalose
0.069 5.82E-5 YDR071C PAA1 hom Polyamine acetyltransferase; acetylates polyamines (e.g. putrescine, spermidine, spermine) and also aralkylamines (e.g. tryptamine, phenylethylamine); may be involved in transcription and/or DNA replication
0.067 9.28E-5 YBR161W CSH1 hom Mannosylinositol phosphorylceramide (MIPC) synthase catalytic subunit; forms a complex with regulatory subunit Csg2p; function in sphingolipid biosynthesis is overlapping with that of Sur1p; CSH1 has a paralog, SUR1, that arose from the whole genome duplication
0.067 9.50E-5 YHL016C DUR3 hom Plasma membrane transporter for both urea and polyamines, expression is highly sensitive to nitrogen catabolite repression and induced by allophanate, the last intermediate of the allantoin degradative pathway
0.067 1.10E-4 YAL067C SEO1 hom Putative permease, member of the allantoate transporter subfamily of the major facilitator superfamily; mutation confers resistance to ethionine sulfoxide
0.065 1.61E-4 YOL085C_d YOL085C_d hom Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the dubious gene YOL085W-A
0.065 1.63E-4 YCL038C ATG22 hom Vacuolar integral membrane protein required for efflux of amino acids during autophagic body breakdown in the vacuole; null mutation causes a gradual loss of viability during starvation
0.064 2.04E-4 YMR310C_p YMR310C_p hom Putative S-adenosylmethionine-dependent methyltransferase; predicted to be involved in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YMR310C is not an essential gene
0.063 2.44E-4 YLR146C SPE4 hom Spermine synthase, required for the biosynthesis of spermine and also involved in biosynthesis of pantothenic acid