YPR164W / MMS1

Subunit of an E3 ubiquitin ligase complex involved in replication repair; stabilizes protein components of the replication fork such as the fork-pausing complex and leading strand polymerase, preventing fork collapse and promoting efficient recovery during replication stress; regulates Ty1 transposition; involved with Rtt101p in nonfunctional rRNA decay

Zygosity: Homozygous strain
fixedexpanded
Profile for YPR164W / MMS1

Click on Significant Values for Screen Details ID:SGTC_18|Compound:0111-0177|FD-Score:3.70|P-value:1.12E-4 ID:SGTC_95|Compound:0471-0001|FD-Score:4.90|P-value:5.04E-7 ID:SGTC_99|Compound:0109-0120|FD-Score:4.14|P-value:1.82E-5 ID:SGTC_163|Compound:1327-0036|FD-Score:3.47|P-value:2.72E-4 ID:SGTC_203|Compound:k066-0004|FD-Score:3.76|P-value:8.85E-5 ID:SGTC_208|Compound:k072-0098|FD-Score:5.60|P-value:1.13E-8 ID:SGTC_218|Compound:alverine citrate|FD-Score:4.11|P-value:2.01E-5 ID:SGTC_235|Compound:0330-0087|FD-Score:3.95|P-value:4.08E-5 ID:SGTC_307|Compound:1501-1223|FD-Score:3.28|P-value:5.41E-4 ID:SGTC_351|Compound:caspofungin|FD-Score:3.60|P-value:1.65E-4 ID:SGTC_356|Compound:1634-0012|FD-Score:4.67|P-value:1.54E-6 ID:SGTC_381|Compound:3461-2219|FD-Score:5.81|P-value:3.26E-9 ID:SGTC_493|Compound:zm226600|FD-Score:3.36|P-value:4.01E-4 ID:SGTC_530|Compound:4358-1714|FD-Score:-3.55|P-value:1.78E-4 ID:SGTC_534|Compound:k292-0788|FD-Score:-3.50|P-value:2.16E-4 ID:SGTC_566|Compound:0958-0068|FD-Score:3.35|P-value:4.22E-4 ID:SGTC_611|Compound:3453-1652|FD-Score:3.79|P-value:7.72E-5 ID:SGTC_621|Compound:3584-0052|FD-Score:6.68|P-value:1.25E-11 ID:SGTC_787|Compound:4152-0075|FD-Score:4.56|P-value:2.67E-6 ID:SGTC_886|Compound:0866-0150|FD-Score:4.71|P-value:1.29E-6 ID:SGTC_1239|Compound:0337-0584|FD-Score:4.90|P-value:4.84E-7 ID:SGTC_1245|Compound:0418-0076|FD-Score:3.35|P-value:4.20E-4 ID:SGTC_1314|Compound:1222-0010|FD-Score:3.36|P-value:3.94E-4 ID:SGTC_1316|Compound:1272-0050|FD-Score:3.76|P-value:8.76E-5 ID:SGTC_1357|Compound:1503-1303|FD-Score:5.59|P-value:1.14E-8 ID:SGTC_1367|Compound:1812-0510|FD-Score:-3.14|P-value:7.88E-4 ID:SGTC_1654|Compound:st012436|FD-Score:3.28|P-value:5.36E-4 ID:SGTC_1854|Compound:st056233|FD-Score:4.58|P-value:2.34E-6 ID:SGTC_1920|Compound:st075728|FD-Score:-3.17|P-value:7.30E-4 ID:SGTC_1937|Compound:st074714|FD-Score:3.31|P-value:4.74E-4 ID:SGTC_2021|Compound:4019055|FD-Score:-3.25|P-value:5.47E-4 ID:SGTC_2050|Compound:5263056|FD-Score:-3.16|P-value:7.57E-4 ID:SGTC_2127|Compound:5253358|FD-Score:3.20|P-value:6.95E-4 ID:SGTC_2189|Compound:6047310|FD-Score:4.77|P-value:9.44E-7 ID:SGTC_2247|Compound:cerulenin|FD-Score:4.63|P-value:1.86E-6 ID:SGTC_2248|Compound:tofa|FD-Score:3.64|P-value:1.43E-4 ID:SGTC_2294|Compound:7971431|FD-Score:5.57|P-value:1.27E-8 ID:SGTC_2325|Compound:6158266|FD-Score:3.15|P-value:8.29E-4 ID:SGTC_2341|Compound:7987486|FD-Score:4.73|P-value:1.13E-6 ID:SGTC_2342|Compound:7990637|FD-Score:4.91|P-value:4.72E-7 ID:SGTC_2344|Compound:7990960|FD-Score:4.98|P-value:3.24E-7 ID:SGTC_2356|Compound:9061756|FD-Score:3.30|P-value:4.99E-4 ID:SGTC_2378|Compound:9074213|FD-Score:3.75|P-value:9.04E-5 ID:SGTC_2427|Compound:5545055|FD-Score:3.12|P-value:9.37E-4 ID:SGTC_2552|Compound:juarezic acid|FD-Score:3.60|P-value:1.65E-4 ID:SGTC_2554|Compound:13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one|FD-Score:3.49|P-value:2.51E-4 ID:SGTC_2643|Compound:anethole|FD-Score:4.22|P-value:1.27E-5 ID:SGTC_2649|Compound:anisomycin|FD-Score:3.69|P-value:1.16E-4 ID:SGTC_2718|Compound:lomofungin|FD-Score:3.26|P-value:5.74E-4 ID:SGTC_2724|Compound:maprotiline|FD-Score:3.26|P-value:5.70E-4 ID:SGTC_2851|Compound:9015922|FD-Score:-3.22|P-value:6.09E-4 ID:SGTC_2957|Compound:9076800|FD-Score:-3.28|P-value:4.84E-4 ID:SGTC_2969|Compound:9091408|FD-Score:3.22|P-value:6.51E-4 ID:SGTC_3174|Compound:9107204|FD-Score:3.80|P-value:7.33E-5 ID:SGTC_3211|Compound:9128781|FD-Score:3.92|P-value:4.63E-5 ID:SGTC_3279|Compound:9140807|FD-Score:3.25|P-value:5.84E-4 ID:SGTC_18|Compound:0111-0177|FD-Score:3.70|P-value:1.12E-4 ID:SGTC_95|Compound:0471-0001|FD-Score:4.90|P-value:5.04E-7 ID:SGTC_99|Compound:0109-0120|FD-Score:4.14|P-value:1.82E-5 ID:SGTC_163|Compound:1327-0036|FD-Score:3.47|P-value:2.72E-4 ID:SGTC_203|Compound:k066-0004|FD-Score:3.76|P-value:8.85E-5 ID:SGTC_208|Compound:k072-0098|FD-Score:5.60|P-value:1.13E-8 ID:SGTC_218|Compound:alverine citrate|FD-Score:4.11|P-value:2.01E-5 ID:SGTC_235|Compound:0330-0087|FD-Score:3.95|P-value:4.08E-5 ID:SGTC_307|Compound:1501-1223|FD-Score:3.28|P-value:5.41E-4 ID:SGTC_351|Compound:caspofungin|FD-Score:3.60|P-value:1.65E-4 ID:SGTC_356|Compound:1634-0012|FD-Score:4.67|P-value:1.54E-6 ID:SGTC_381|Compound:3461-2219|FD-Score:5.81|P-value:3.26E-9 ID:SGTC_493|Compound:zm226600|FD-Score:3.36|P-value:4.01E-4 ID:SGTC_530|Compound:4358-1714|FD-Score:-3.55|P-value:1.78E-4 ID:SGTC_534|Compound:k292-0788|FD-Score:-3.50|P-value:2.16E-4 ID:SGTC_566|Compound:0958-0068|FD-Score:3.35|P-value:4.22E-4 ID:SGTC_611|Compound:3453-1652|FD-Score:3.79|P-value:7.72E-5 ID:SGTC_621|Compound:3584-0052|FD-Score:6.68|P-value:1.25E-11 ID:SGTC_787|Compound:4152-0075|FD-Score:4.56|P-value:2.67E-6 ID:SGTC_886|Compound:0866-0150|FD-Score:4.71|P-value:1.29E-6 ID:SGTC_1239|Compound:0337-0584|FD-Score:4.90|P-value:4.84E-7 ID:SGTC_1245|Compound:0418-0076|FD-Score:3.35|P-value:4.20E-4 ID:SGTC_1314|Compound:1222-0010|FD-Score:3.36|P-value:3.94E-4 ID:SGTC_1316|Compound:1272-0050|FD-Score:3.76|P-value:8.76E-5 ID:SGTC_1357|Compound:1503-1303|FD-Score:5.59|P-value:1.14E-8 ID:SGTC_1367|Compound:1812-0510|FD-Score:-3.14|P-value:7.88E-4 ID:SGTC_1654|Compound:st012436|FD-Score:3.28|P-value:5.36E-4 ID:SGTC_1854|Compound:st056233|FD-Score:4.58|P-value:2.34E-6 ID:SGTC_1920|Compound:st075728|FD-Score:-3.17|P-value:7.30E-4 ID:SGTC_1937|Compound:st074714|FD-Score:3.31|P-value:4.74E-4 ID:SGTC_2021|Compound:4019055|FD-Score:-3.25|P-value:5.47E-4 ID:SGTC_2050|Compound:5263056|FD-Score:-3.16|P-value:7.57E-4 ID:SGTC_2127|Compound:5253358|FD-Score:3.20|P-value:6.95E-4 ID:SGTC_2189|Compound:6047310|FD-Score:4.77|P-value:9.44E-7 ID:SGTC_2247|Compound:cerulenin|FD-Score:4.63|P-value:1.86E-6 ID:SGTC_2248|Compound:tofa|FD-Score:3.64|P-value:1.43E-4 ID:SGTC_2294|Compound:7971431|FD-Score:5.57|P-value:1.27E-8 ID:SGTC_2325|Compound:6158266|FD-Score:3.15|P-value:8.29E-4 ID:SGTC_2341|Compound:7987486|FD-Score:4.73|P-value:1.13E-6 ID:SGTC_2342|Compound:7990637|FD-Score:4.91|P-value:4.72E-7 ID:SGTC_2344|Compound:7990960|FD-Score:4.98|P-value:3.24E-7 ID:SGTC_2356|Compound:9061756|FD-Score:3.30|P-value:4.99E-4 ID:SGTC_2378|Compound:9074213|FD-Score:3.75|P-value:9.04E-5 ID:SGTC_2427|Compound:5545055|FD-Score:3.12|P-value:9.37E-4 ID:SGTC_2552|Compound:juarezic acid|FD-Score:3.60|P-value:1.65E-4 ID:SGTC_2554|Compound:13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one|FD-Score:3.49|P-value:2.51E-4 ID:SGTC_2643|Compound:anethole|FD-Score:4.22|P-value:1.27E-5 ID:SGTC_2649|Compound:anisomycin|FD-Score:3.69|P-value:1.16E-4 ID:SGTC_2718|Compound:lomofungin|FD-Score:3.26|P-value:5.74E-4 ID:SGTC_2724|Compound:maprotiline|FD-Score:3.26|P-value:5.70E-4 ID:SGTC_2851|Compound:9015922|FD-Score:-3.22|P-value:6.09E-4 ID:SGTC_2957|Compound:9076800|FD-Score:-3.28|P-value:4.84E-4 ID:SGTC_2969|Compound:9091408|FD-Score:3.22|P-value:6.51E-4 ID:SGTC_3174|Compound:9107204|FD-Score:3.80|P-value:7.33E-5 ID:SGTC_3211|Compound:9128781|FD-Score:3.92|P-value:4.63E-5 ID:SGTC_3279|Compound:9140807|FD-Score:3.25|P-value:5.84E-4

Top fitness defect scores for YPR164W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_621 3584-0052 6.68 32.1 µM 1.25E-11 4 1.22E-11
2 SGTC_381 3461-2219 5.81 42.7 µM 3.26E-9 copper-dependent oxidative stress 4 3.18E-9
3 SGTC_208 k072-0098 5.60 12.4 µM 1.13E-8 heme biosynthesis & mitochondrial translocase 15 1.10E-8
4 SGTC_1357 1503-1303 5.59 39.5 µM 1.14E-8 8 1.12E-8
5 SGTC_2294 7971431 5.57 200.0 µM 1.27E-8 3 1.24E-8
6 SGTC_2344 7990960 4.98 77.0 µM 3.24E-7 14 3.15E-7
7 SGTC_2342 7990637 4.91 118.9 µM 4.72E-7 RNA processing & uracil transport 16 4.59E-7
8 SGTC_1239 0337-0584 4.90 35.4 µM 4.84E-7 unfolded protein response 28 4.71E-7
9 SGTC_95 0471-0001 4.90 561.1 µM 5.04E-7 11 4.90E-7
10 SGTC_2189 6047310 4.77 154.4 µM 9.44E-7 RPP1 & pyrimidine depletion 8 9.18E-7
11 SGTC_2341 7987486 4.73 176.7 µM 1.13E-6 8 1.10E-6
12 SGTC_886 0866-0150 4.71 153.0 µM 1.29E-6 9 1.25E-6
13 SGTC_356 1634-0012 4.67 32.5 µM 1.54E-6 13 1.50E-6
14 SGTC_2247 cerulenin 4.63 830.0 nM 1.86E-6 8 1.81E-6
15 SGTC_1854 st056233 4.58 32.9 µM 2.34E-6 amide catabolism 11 2.28E-6
16 SGTC_787 4152-0075 4.56 138.0 µM 2.67E-6 12 2.60E-6
17 SGTC_2643 anethole 4.22 100.0 µM 1.27E-5 10 1.24E-5
18 SGTC_99 0109-0120 4.14 622.8 µM 1.82E-5 12 1.77E-5
19 SGTC_218 alverine citrate 4.11 93.8 µM 2.01E-5 fatty acid desaturase (OLE1) 27 1.95E-5
20 SGTC_235 0330-0087 3.95 5.0 mM 4.08E-5 TSC3-RPN4 22 3.97E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.115 2.26E-11 YML130C ERO1 het Thiol oxidase required for oxidative protein folding in the ER; essential for maintaining proper redox balance in ER; feedback regulation of Ero1p occurs via reduction and oxidation of Ero1p regulatory bonds; reduced Pdi1p activates Ero1p by direct reduction of Ero1p regulatory bonds; depletion of thiol substrates and accumulation of oxidized Pdi1p results in inactivation of Ero1p by both Pdi1p-mediated oxidation and autonomous oxidation of Ero1p regulatory bonds
0.098 1.39E-8 YFL032W_d YFL032W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene HAC1/YFL031W; YFL032W is not an essential gene
0.088 3.13E-7 YPL034W_p YPL034W_p hom Putative protein of unknown function; YPL034W is not essential gene
0.087 4.67E-7 YLR327C TMA10 hom Protein of unknown function that associates with ribosomes; putative homolog of the F1F0-ATPase synthase regulator Stf2p; protein abundance increases in response to DNA replication stress
0.082 2.21E-6 YMR216C SKY1 hom SR protein kinase (SRPK) involved in regulating proteins involved in mRNA metabolism and cation homeostasis; similar to human SRPK1
0.079 4.87E-6 YPL063W TIM50 het Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); acts as receptor for the TIM23 complex guiding incoming precursors from the TOM complex; may control the gating of the Tim23p-Tim17p channel
0.077 8.27E-6 YLR147C SMD3 het Core Sm protein Sm D3; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm D3
0.075 1.27E-5 YDL229W SSB1 hom Cytoplasmic ATPase that is a ribosome-associated molecular chaperone; functions with J-protein partner Zuo1p; may be involved in folding of newly-made polypeptide chains; member of the HSP70 family; interacts with phosphatase subunit Reg1p; SSB1 has a paralog, SSB2, that arose from the whole genome duplication
0.075 1.55E-5 YPL098C MGR2 hom Subunit of the TIM23 translocase complex; acts to couple Tim21p with the core Tim23 translocase; absolutely required for mitochondrial import of presequence-containing proteins at elevated temperature; required for viability of cells lacking the mitochondrial genome (petite-negative phenotype)
0.074 1.59E-5 YGR009C SEC9 het t-SNARE protein important for fusion of secretory vesicles with the plasma membrane; similar to but not functionally redundant with Spo20p; SNAP-25 homolog
0.074 1.82E-5 YLR282C_d YLR282C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; deletion mutation confers an increase in Ty1 transposition
0.074 1.92E-5 YMR207C HFA1 hom Mitochondrial acetyl-coenzyme A carboxylase; catalyzes the production of malonyl-CoA in mitochondrial fatty acid biosynthesis; relocalizes from mitochondrion to cytoplasm upon DNA replication stress
0.073 2.51E-5 YKL119C VPH2 hom Integral membrane protein required for vacuolar H+-ATPase (V-ATPase) function, although not an actual component of the V-ATPase complex; functions in the assembly of the V-ATPase; localized to the endoplasmic reticulum (ER)
0.067 9.84E-5 YOL013W-A_p YOL013W-A_p hom Putative protein of unknown function; identified by SAGE
0.066 1.44E-4 YDR252W BTT1 hom Beta3 subunit of the heterotrimeric nascent polypeptide-associated complex which binds ribosomes via its beta-subunits in close proximity to nascent polypeptides; interacts with Caf130p of the CCR4-NOT complex; similar to human BTF3