YPR166C / MRP2

Mitochondrial ribosomal protein of the small subunit

Zygosity: Homozygous strain
fixedexpanded
Profile for YPR166C / MRP2

Click on Significant Values for Screen Details ID:SGTC_10|Compound:0279-0212|FD-Score:4.03|P-value:1.61E-4 ID:SGTC_70|Compound:0141-0289|FD-Score:9.75|P-value:1.47E-18 ID:SGTC_119|Compound:0121-0043|FD-Score:4.55|P-value:2.42E-5 ID:SGTC_134|Compound:0269-0018|FD-Score:4.18|P-value:9.30E-5 ID:SGTC_168|Compound:3970-0862|FD-Score:3.61|P-value:6.36E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:8.18|P-value:1.34E-13 ID:SGTC_236|Compound:1509-0011|FD-Score:20.70|P-value:4.37E-77 ID:SGTC_275|Compound:trichlorophene|FD-Score:15.90|P-value:2.95E-46 ID:SGTC_293|Compound:4049-0273|FD-Score:-3.98|P-value:1.84E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:-3.47|P-value:9.61E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:5.09|P-value:2.75E-6 ID:SGTC_314|Compound:1671-0008|FD-Score:3.65|P-value:5.53E-4 ID:SGTC_386|Compound:1509-0011|FD-Score:8.27|P-value:7.38E-14 ID:SGTC_431|Compound:k089-0097|FD-Score:-3.60|P-value:6.43E-4 ID:SGTC_444|Compound:curcumin|FD-Score:-4.74|P-value:1.15E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-7.23|P-value:5.21E-11 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:-4.53|P-value:2.54E-5 ID:SGTC_462|Compound:ag-879|FD-Score:3.71|P-value:4.55E-4 ID:SGTC_503|Compound:tyrphostin 8|FD-Score:4.14|P-value:1.09E-4 ID:SGTC_748|Compound:0136-0228|FD-Score:4.82|P-value:8.34E-6 ID:SGTC_767|Compound:0929-0023|FD-Score:3.73|P-value:4.25E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:9.10|P-value:2.16E-16 ID:SGTC_920|Compound:mycophenolic acid|FD-Score:3.50|P-value:8.90E-4 ID:SGTC_966|Compound:1300-0360|FD-Score:4.57|P-value:2.21E-5 ID:SGTC_1047|Compound:2043-3044|FD-Score:-4.17|P-value:9.56E-5 ID:SGTC_1048|Compound:3161-0300|FD-Score:-5.36|P-value:8.25E-7 ID:SGTC_1188|Compound:1403-0014|FD-Score:4.75|P-value:1.07E-5 ID:SGTC_1247|Compound:0448-0043|FD-Score:3.59|P-value:6.60E-4 ID:SGTC_1621|Compound:st003705|FD-Score:4.14|P-value:1.09E-4 ID:SGTC_1623|Compound:st003709|FD-Score:3.93|P-value:2.19E-4 ID:SGTC_1635|Compound:st007035|FD-Score:4.56|P-value:2.32E-5 ID:SGTC_1658|Compound:st012944|FD-Score:-4.09|P-value:1.29E-4 ID:SGTC_1703|Compound:st026983|FD-Score:3.55|P-value:7.48E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:-3.66|P-value:5.27E-4 ID:SGTC_1742|Compound:st038235|FD-Score:4.96|P-value:4.62E-6 ID:SGTC_1787|Compound:fluconazole|FD-Score:-5.17|P-value:1.89E-6 ID:SGTC_1872|Compound:amphotericin b|FD-Score:-3.58|P-value:6.79E-4 ID:SGTC_1882|Compound:5615643|FD-Score:7.44|P-value:1.50E-11 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:7.39|P-value:1.98E-11 ID:SGTC_1884|Compound:5633444|FD-Score:-3.62|P-value:6.11E-4 ID:SGTC_1886|Compound:st057356|FD-Score:-3.57|P-value:7.10E-4 ID:SGTC_1889|Compound:st059080|FD-Score:3.96|P-value:2.04E-4 ID:SGTC_1906|Compound:st060206|FD-Score:4.93|P-value:5.30E-6 ID:SGTC_1921|Compound:5740136|FD-Score:4.19|P-value:9.03E-5 ID:SGTC_1922|Compound:5578187|FD-Score:3.65|P-value:5.57E-4 ID:SGTC_2009|Compound:4012297|FD-Score:-5.41|P-value:6.53E-7 ID:SGTC_2021|Compound:4019055|FD-Score:-3.83|P-value:3.07E-4 ID:SGTC_2167|Compound:5876490|FD-Score:-6.03|P-value:3.54E-8 ID:SGTC_2183|Compound:6420625|FD-Score:5.74|P-value:1.45E-7 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:5.38|P-value:7.70E-7 ID:SGTC_2398|Compound:5228213|FD-Score:-4.19|P-value:9.04E-5 ID:SGTC_2419|Compound:paclitaxel|FD-Score:3.83|P-value:3.12E-4 ID:SGTC_2489|Compound:cantharidin|FD-Score:-3.48|P-value:9.19E-4 ID:SGTC_2501|Compound:sodium tetradecyl sulfate|FD-Score:3.96|P-value:2.04E-4 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:5.76|P-value:1.35E-7 ID:SGTC_2651|Compound:1327-0036|FD-Score:-3.83|P-value:3.03E-4 ID:SGTC_2784|Compound:7567673|FD-Score:-4.80|P-value:8.83E-6 ID:SGTC_3239|Compound:9133757|FD-Score:4.78|P-value:9.87E-6 ID:SGTC_10|Compound:0279-0212|FD-Score:4.03|P-value:1.61E-4 ID:SGTC_70|Compound:0141-0289|FD-Score:9.75|P-value:1.47E-18 ID:SGTC_119|Compound:0121-0043|FD-Score:4.55|P-value:2.42E-5 ID:SGTC_134|Compound:0269-0018|FD-Score:4.18|P-value:9.30E-5 ID:SGTC_168|Compound:3970-0862|FD-Score:3.61|P-value:6.36E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:8.18|P-value:1.34E-13 ID:SGTC_236|Compound:1509-0011|FD-Score:20.70|P-value:4.37E-77 ID:SGTC_275|Compound:trichlorophene|FD-Score:15.90|P-value:2.95E-46 ID:SGTC_293|Compound:4049-0273|FD-Score:-3.98|P-value:1.84E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:-3.47|P-value:9.61E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:5.09|P-value:2.75E-6 ID:SGTC_314|Compound:1671-0008|FD-Score:3.65|P-value:5.53E-4 ID:SGTC_386|Compound:1509-0011|FD-Score:8.27|P-value:7.38E-14 ID:SGTC_431|Compound:k089-0097|FD-Score:-3.60|P-value:6.43E-4 ID:SGTC_444|Compound:curcumin|FD-Score:-4.74|P-value:1.15E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-7.23|P-value:5.21E-11 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:-4.53|P-value:2.54E-5 ID:SGTC_462|Compound:ag-879|FD-Score:3.71|P-value:4.55E-4 ID:SGTC_503|Compound:tyrphostin 8|FD-Score:4.14|P-value:1.09E-4 ID:SGTC_748|Compound:0136-0228|FD-Score:4.82|P-value:8.34E-6 ID:SGTC_767|Compound:0929-0023|FD-Score:3.73|P-value:4.25E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:9.10|P-value:2.16E-16 ID:SGTC_920|Compound:mycophenolic acid|FD-Score:3.50|P-value:8.90E-4 ID:SGTC_966|Compound:1300-0360|FD-Score:4.57|P-value:2.21E-5 ID:SGTC_1047|Compound:2043-3044|FD-Score:-4.17|P-value:9.56E-5 ID:SGTC_1048|Compound:3161-0300|FD-Score:-5.36|P-value:8.25E-7 ID:SGTC_1188|Compound:1403-0014|FD-Score:4.75|P-value:1.07E-5 ID:SGTC_1247|Compound:0448-0043|FD-Score:3.59|P-value:6.60E-4 ID:SGTC_1621|Compound:st003705|FD-Score:4.14|P-value:1.09E-4 ID:SGTC_1623|Compound:st003709|FD-Score:3.93|P-value:2.19E-4 ID:SGTC_1635|Compound:st007035|FD-Score:4.56|P-value:2.32E-5 ID:SGTC_1658|Compound:st012944|FD-Score:-4.09|P-value:1.29E-4 ID:SGTC_1703|Compound:st026983|FD-Score:3.55|P-value:7.48E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:-3.66|P-value:5.27E-4 ID:SGTC_1742|Compound:st038235|FD-Score:4.96|P-value:4.62E-6 ID:SGTC_1787|Compound:fluconazole|FD-Score:-5.17|P-value:1.89E-6 ID:SGTC_1872|Compound:amphotericin b|FD-Score:-3.58|P-value:6.79E-4 ID:SGTC_1882|Compound:5615643|FD-Score:7.44|P-value:1.50E-11 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:7.39|P-value:1.98E-11 ID:SGTC_1884|Compound:5633444|FD-Score:-3.62|P-value:6.11E-4 ID:SGTC_1886|Compound:st057356|FD-Score:-3.57|P-value:7.10E-4 ID:SGTC_1889|Compound:st059080|FD-Score:3.96|P-value:2.04E-4 ID:SGTC_1906|Compound:st060206|FD-Score:4.93|P-value:5.30E-6 ID:SGTC_1921|Compound:5740136|FD-Score:4.19|P-value:9.03E-5 ID:SGTC_1922|Compound:5578187|FD-Score:3.65|P-value:5.57E-4 ID:SGTC_2009|Compound:4012297|FD-Score:-5.41|P-value:6.53E-7 ID:SGTC_2021|Compound:4019055|FD-Score:-3.83|P-value:3.07E-4 ID:SGTC_2167|Compound:5876490|FD-Score:-6.03|P-value:3.54E-8 ID:SGTC_2183|Compound:6420625|FD-Score:5.74|P-value:1.45E-7 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:5.38|P-value:7.70E-7 ID:SGTC_2398|Compound:5228213|FD-Score:-4.19|P-value:9.04E-5 ID:SGTC_2419|Compound:paclitaxel|FD-Score:3.83|P-value:3.12E-4 ID:SGTC_2489|Compound:cantharidin|FD-Score:-3.48|P-value:9.19E-4 ID:SGTC_2501|Compound:sodium tetradecyl sulfate|FD-Score:3.96|P-value:2.04E-4 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:5.76|P-value:1.35E-7 ID:SGTC_2651|Compound:1327-0036|FD-Score:-3.83|P-value:3.03E-4 ID:SGTC_2784|Compound:7567673|FD-Score:-4.80|P-value:8.83E-6 ID:SGTC_3239|Compound:9133757|FD-Score:4.78|P-value:9.87E-6

Top fitness defect scores for YPR166C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_236 1509-0011 20.70 5.3 µM 4.37E-77 49 6.15E-96
2 SGTC_275 trichlorophene 15.90 5.7 µM 2.95E-46 mitochondrial stress 7 2.23E-57
3 SGTC_70 0141-0289 9.75 43.3 µM 1.47E-18 mitochondrial stress 19 9.22E-23
4 SGTC_908 3448-7491 9.10 47.7 µM 2.16E-16 mitochondrial stress 12 4.70E-20
5 SGTC_386 1509-0011 8.27 3.1 µM 7.38E-14 59 6.80E-17
6 SGTC_173 1273-0061 8.18 2.7 µM 1.34E-13 mitochondrial stress 62 1.44E-16
7 SGTC_1882 5615643 7.44 20.0 µM 1.50E-11 TRP & mitochondrial translation 11 5.13E-14
8 SGTC_1883 5-benzylidenerhodanine 7.39 20.0 µM 1.98E-11 TRP & mitochondrial translation 13 7.25E-14
9 SGTC_2598 perillyl alcohol 5.76 100.0 µM 1.35E-7 7 4.33E-9
10 SGTC_2183 6420625 5.74 130.5 µM 1.45E-7 mitochondrial processes 16 4.72E-9
11 SGTC_2232 chlorophetanol 5.38 41.5 µM 7.70E-7 TRP & mitochondrial translation 59 3.76E-8
12 SGTC_310 1273-0058 5.09 1.1 µM 2.75E-6 mitochondrial stress 180 1.83E-7
13 SGTC_1742 st038235 4.96 28.9 µM 4.62E-6 mitochondrial stress 77 3.49E-7
14 SGTC_1906 st060206 4.93 94.7 µM 5.30E-6 9 4.14E-7
15 SGTC_748 0136-0228 4.82 77.9 µM 8.34E-6 redox potentiating 49 7.25E-7
16 SGTC_3239 9133757 4.78 49.5 µM 9.87E-6 1 8.94E-7
17 SGTC_1188 1403-0014 4.75 4.6 µM 1.07E-5 mitochondrial stress 32 9.93E-7
18 SGTC_966 1300-0360 4.57 30.2 µM 2.21E-5 heme requiring 14 2.43E-6
19 SGTC_1635 st007035 4.56 42.4 µM 2.32E-5 181 2.58E-6
20 SGTC_119 0121-0043 4.55 24.8 µM 2.42E-5 mitochondrial stress 74 2.72E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.615 0 YNL252C MRPL17 hom Mitochondrial ribosomal protein of the large subunit
0.612 0 YDR518W EUG1 hom Protein disulfide isomerase of the endoplasmic reticulum lumen; EUG1 has a paralog, PDI1, that arose from the whole genome duplication; function overlaps with that of Pdi1p; may interact with nascent polypeptides in the ER
0.600 0 YJL023C PET130 hom Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.579 4.52E-299 YOR330C MIP1 hom Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit
0.570 5.22E-288 YDR462W MRPL28 hom Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress
0.569 1.87E-287 YGR220C MRPL9 hom Mitochondrial ribosomal protein of the large subunit
0.566 6.34E-284 YCR024C SLM5 hom Mitochondrial asparaginyl-tRNA synthetase
0.555 3.20E-270 YDR237W MRPL7 hom Mitochondrial ribosomal protein of the large subunit; MRPL7 produces both YmL5 and YmL7, which are two different modified forms of the same protein
0.544 3.72E-258 YDR533C HSP31 hom Possible chaperone and cysteine protease; has similarity to E. coli Hsp31; member of the DJ-1/ThiJ/PfpI superfamily, which includes human DJ-1 involved in Parkinson's disease; exists as a dimer and contains a putative metal-binding site; protein abundance increases in response to DNA replication stress
0.528 1.59E-240 YOR158W PET123 hom Mitochondrial ribosomal protein of the small subunit; PET123 exhibits genetic interactions with PET122, which encodes a COX3 mRNA-specific translational activator
0.521 1.62E-232 YKL068W-A_p YKL068W-A_p hom Putative protein of unknown function; identified by homology to Ashbya gossypii
0.519 1.93E-231 YNL184C_p YNL184C_p hom Protein of unknown function; expressed at both mRNA and protein levels
0.519 5.19E-231 YNL213C RRG9 hom Protein of unknown function; null mutant lacks mitochondrial DNA and cannot grow on glycerol; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.518 8.44E-230 YGL064C MRH4 hom Mitochondrial ATP-dependent RNA helicase of the DEAD-box family, plays an essential role in mitochondrial function
0.512 1.45E-223 YDR079W PET100 hom Chaperone that specifically facilitates the assembly of cytochrome c oxidase, integral to the mitochondrial inner membrane; interacts with a subcomplex of subunits VII, VIIa, and VIII (Cox7p, Cox9p, and Cox8p) but not with the holoenzyme