YPR169W / JIP5

Essential protein required for biogenesis of the large ribosomal subunit; interacts with proteins involved in RNA processing, ribosome biogenesis, ubiquitination and demethylation; similar to WDR55, a human WD repeat protein

Zygosity: Heterozygous strain
fixedexpanded
Profile for YPR169W / JIP5

Click on Significant Values for Screen Details ID:SGTC_51|Compound:1013-0126|FD-Score:3.25|P-value:9.76E-4 ID:SGTC_141|Compound:0443-0274|FD-Score:-4.78|P-value:3.58E-6 ID:SGTC_186|Compound:3455-3465|FD-Score:3.24|P-value:9.94E-4 ID:SGTC_208|Compound:k072-0098|FD-Score:5.23|P-value:3.26E-7 ID:SGTC_213|Compound:1246-0773|FD-Score:3.50|P-value:4.29E-4 ID:SGTC_251|Compound:melphalan|FD-Score:4.82|P-value:2.25E-6 ID:SGTC_287|Compound:k060-0039|FD-Score:3.59|P-value:3.06E-4 ID:SGTC_304|Compound:1310-0298|FD-Score:3.27|P-value:9.06E-4 ID:SGTC_412|Compound:gemfibrozil|FD-Score:3.39|P-value:6.23E-4 ID:SGTC_801|Compound:0866-0028|FD-Score:-3.83|P-value:1.66E-4 ID:SGTC_896|Compound:0964-0007|FD-Score:4.63|P-value:5.30E-6 ID:SGTC_929|Compound:2805-0021|FD-Score:3.50|P-value:4.26E-4 ID:SGTC_961|Compound:1252-1571|FD-Score:3.51|P-value:4.04E-4 ID:SGTC_1112|Compound:tnp00069|FD-Score:-9.07|P-value:6.44E-18 ID:SGTC_1129|Compound:3453-1384|FD-Score:5.02|P-value:9.00E-7 ID:SGTC_1375|Compound:2910-0797|FD-Score:3.61|P-value:2.95E-4 ID:SGTC_1388|Compound:3346-4487|FD-Score:3.34|P-value:7.13E-4 ID:SGTC_1413|Compound:3910-0535|FD-Score:3.49|P-value:4.42E-4 ID:SGTC_1435|Compound:4092-0789|FD-Score:3.64|P-value:2.61E-4 ID:SGTC_1531|Compound:st059297|FD-Score:-3.34|P-value:8.88E-4 ID:SGTC_1570|Compound:verbenone|FD-Score:4.79|P-value:2.67E-6 ID:SGTC_1720|Compound:st037298|FD-Score:3.44|P-value:5.25E-4 ID:SGTC_1816|Compound:st051957|FD-Score:3.37|P-value:6.64E-4 ID:SGTC_1889|Compound:st059080|FD-Score:5.10|P-value:6.31E-7 ID:SGTC_1910|Compound:st062352|FD-Score:3.67|P-value:2.33E-4 ID:SGTC_1955|Compound:wogonin|FD-Score:4.09|P-value:5.01E-5 ID:SGTC_1984|Compound:st072354|FD-Score:-4.28|P-value:2.92E-5 ID:SGTC_1994|Compound:st072947|FD-Score:3.83|P-value:1.32E-4 ID:SGTC_2025|Compound:5147754|FD-Score:-3.44|P-value:6.37E-4 ID:SGTC_2045|Compound:5106652|FD-Score:-3.57|P-value:4.07E-4 ID:SGTC_2054|Compound:5233173|FD-Score:-4.21|P-value:3.91E-5 ID:SGTC_2080|Compound:5212524|FD-Score:4.14|P-value:4.13E-5 ID:SGTC_2101|Compound:5377231|FD-Score:3.97|P-value:7.80E-5 ID:SGTC_2121|Compound:5257820|FD-Score:-3.70|P-value:2.60E-4 ID:SGTC_2306|Compound:7482397|FD-Score:4.65|P-value:4.90E-6 ID:SGTC_2351|Compound:9026858|FD-Score:-4.71|P-value:4.93E-6 ID:SGTC_2589|Compound:lobaric acid|FD-Score:3.31|P-value:7.92E-4 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:-4.21|P-value:3.95E-5 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:3.29|P-value:8.56E-4 ID:SGTC_2787|Compound:5284540|FD-Score:3.62|P-value:2.85E-4 ID:SGTC_2791|Compound:5663188|FD-Score:-3.84|P-value:1.59E-4 ID:SGTC_2848|Compound:9016370|FD-Score:-3.39|P-value:7.50E-4 ID:SGTC_2931|Compound:9014674|FD-Score:8.17|P-value:4.70E-15 ID:SGTC_2936|Compound:9038235|FD-Score:3.35|P-value:7.01E-4 ID:SGTC_2968|Compound:9090663|FD-Score:5.96|P-value:7.62E-9 ID:SGTC_3285|Compound:9112818|FD-Score:3.88|P-value:1.11E-4 ID:SGTC_3320|Compound:9137005|FD-Score:3.46|P-value:4.83E-4 ID:SGTC_51|Compound:1013-0126|FD-Score:3.25|P-value:9.76E-4 ID:SGTC_141|Compound:0443-0274|FD-Score:-4.78|P-value:3.58E-6 ID:SGTC_186|Compound:3455-3465|FD-Score:3.24|P-value:9.94E-4 ID:SGTC_208|Compound:k072-0098|FD-Score:5.23|P-value:3.26E-7 ID:SGTC_213|Compound:1246-0773|FD-Score:3.50|P-value:4.29E-4 ID:SGTC_251|Compound:melphalan|FD-Score:4.82|P-value:2.25E-6 ID:SGTC_287|Compound:k060-0039|FD-Score:3.59|P-value:3.06E-4 ID:SGTC_304|Compound:1310-0298|FD-Score:3.27|P-value:9.06E-4 ID:SGTC_412|Compound:gemfibrozil|FD-Score:3.39|P-value:6.23E-4 ID:SGTC_801|Compound:0866-0028|FD-Score:-3.83|P-value:1.66E-4 ID:SGTC_896|Compound:0964-0007|FD-Score:4.63|P-value:5.30E-6 ID:SGTC_929|Compound:2805-0021|FD-Score:3.50|P-value:4.26E-4 ID:SGTC_961|Compound:1252-1571|FD-Score:3.51|P-value:4.04E-4 ID:SGTC_1112|Compound:tnp00069|FD-Score:-9.07|P-value:6.44E-18 ID:SGTC_1129|Compound:3453-1384|FD-Score:5.02|P-value:9.00E-7 ID:SGTC_1375|Compound:2910-0797|FD-Score:3.61|P-value:2.95E-4 ID:SGTC_1388|Compound:3346-4487|FD-Score:3.34|P-value:7.13E-4 ID:SGTC_1413|Compound:3910-0535|FD-Score:3.49|P-value:4.42E-4 ID:SGTC_1435|Compound:4092-0789|FD-Score:3.64|P-value:2.61E-4 ID:SGTC_1531|Compound:st059297|FD-Score:-3.34|P-value:8.88E-4 ID:SGTC_1570|Compound:verbenone|FD-Score:4.79|P-value:2.67E-6 ID:SGTC_1720|Compound:st037298|FD-Score:3.44|P-value:5.25E-4 ID:SGTC_1816|Compound:st051957|FD-Score:3.37|P-value:6.64E-4 ID:SGTC_1889|Compound:st059080|FD-Score:5.10|P-value:6.31E-7 ID:SGTC_1910|Compound:st062352|FD-Score:3.67|P-value:2.33E-4 ID:SGTC_1955|Compound:wogonin|FD-Score:4.09|P-value:5.01E-5 ID:SGTC_1984|Compound:st072354|FD-Score:-4.28|P-value:2.92E-5 ID:SGTC_1994|Compound:st072947|FD-Score:3.83|P-value:1.32E-4 ID:SGTC_2025|Compound:5147754|FD-Score:-3.44|P-value:6.37E-4 ID:SGTC_2045|Compound:5106652|FD-Score:-3.57|P-value:4.07E-4 ID:SGTC_2054|Compound:5233173|FD-Score:-4.21|P-value:3.91E-5 ID:SGTC_2080|Compound:5212524|FD-Score:4.14|P-value:4.13E-5 ID:SGTC_2101|Compound:5377231|FD-Score:3.97|P-value:7.80E-5 ID:SGTC_2121|Compound:5257820|FD-Score:-3.70|P-value:2.60E-4 ID:SGTC_2306|Compound:7482397|FD-Score:4.65|P-value:4.90E-6 ID:SGTC_2351|Compound:9026858|FD-Score:-4.71|P-value:4.93E-6 ID:SGTC_2589|Compound:lobaric acid|FD-Score:3.31|P-value:7.92E-4 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:-4.21|P-value:3.95E-5 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:3.29|P-value:8.56E-4 ID:SGTC_2787|Compound:5284540|FD-Score:3.62|P-value:2.85E-4 ID:SGTC_2791|Compound:5663188|FD-Score:-3.84|P-value:1.59E-4 ID:SGTC_2848|Compound:9016370|FD-Score:-3.39|P-value:7.50E-4 ID:SGTC_2931|Compound:9014674|FD-Score:8.17|P-value:4.70E-15 ID:SGTC_2936|Compound:9038235|FD-Score:3.35|P-value:7.01E-4 ID:SGTC_2968|Compound:9090663|FD-Score:5.96|P-value:7.62E-9 ID:SGTC_3285|Compound:9112818|FD-Score:3.88|P-value:1.11E-4 ID:SGTC_3320|Compound:9137005|FD-Score:3.46|P-value:4.83E-4

Top fitness defect scores for YPR169W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2931 9014674 8.17 55.7 µM 4.70E-15 1 1.57E-16 2.99
2 SGTC_2968 9090663 5.96 33.4 µM 7.62E-9 4 1.28E-9 0.54
3 SGTC_208 k072-0098 5.23 12.4 µM 3.26E-7 heme biosynthesis & mitochondrial translocase 11 8.28E-8 0.08
4 SGTC_1889 st059080 5.10 5.2 µM 6.31E-7 2 1.72E-7 0.95
5 SGTC_1129 3453-1384 5.02 223.0 µM 9.00E-7 9 2.56E-7 0.12
6 SGTC_251 melphalan 4.82 456.5 µM 2.25E-6 DNA damage response 1 7.07E-7 0.80
7 SGTC_1570 verbenone 4.79 133.0 µM 2.67E-6 1 8.55E-7 0.50
8 SGTC_2306 7482397 4.65 179.5 µM 4.90E-6 RPP1 & pyrimidine depletion 6 1.67E-6 0.12
9 SGTC_896 0964-0007 4.63 44.5 µM 5.30E-6 3 1.82E-6 0.29
10 SGTC_2080 5212524 4.14 12.4 µM 4.13E-5 copper-dependent oxidative stress 7 1.77E-5 0.12
11 SGTC_1955 wogonin 4.09 32.4 µM 5.01E-5 2 2.20E-5 0.20
12 SGTC_2101 5377231 3.97 179.2 µM 7.80E-5 4 3.58E-5 0.11
13 SGTC_3285 9112818 3.88 20.9 µM 1.11E-4 cell wall 15 5.27E-5 0.02
14 SGTC_1994 st072947 3.83 40.9 µM 1.32E-4 8 6.41E-5 0.15
15 SGTC_1910 st062352 3.67 60.4 µM 2.33E-4 4 1.20E-4 0.24
16 SGTC_1435 4092-0789 3.64 56.7 µM 2.61E-4 plasma membrane duress 7 1.36E-4 0.03
17 SGTC_2787 5284540 3.62 71.4 µM 2.85E-4 12 1.50E-4 0.19
18 SGTC_1375 2910-0797 3.61 186.0 µM 2.95E-4 7 1.56E-4 0.35
19 SGTC_287 k060-0039 3.59 29.6 µM 3.06E-4 12 1.62E-4 0.04
20 SGTC_961 1252-1571 3.51 372.0 µM 4.04E-4 9 2.21E-4 0.02

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.106 7.60E-10 YPR177C_d YPR177C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the 5' end of the essential PRP4 gene encoding a component of the U4/U6-U5 snRNP complex
0.101 4.88E-9 YDL010W GRX6 hom Cis-golgi localized monothiol glutaredoxin, binds Fe-S cluster; more similar in activity to dithiol than other monothiol glutaredoxins; involved in the oxidative stress response; GRX6 has a paralog, GRX7, that arose from the whole genome duplication
0.099 8.15E-9 YJL130C URA2 hom Bifunctional carbamoylphosphate synthetase (CPSase)-aspartate transcarbamylase (ATCase), catalyzes the first two enzymatic steps in the de novo biosynthesis of pyrimidines; both activities are subject to feedback inhibition by UTP
0.094 4.84E-8 YIL161W_p YIL161W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; mRNA is enriched in Scp160p-associated mRNPs; YIL161W is a non-essential gene
0.092 1.06E-7 YOR159C SME1 het Core Sm protein Sm E; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm E
0.090 1.74E-7 YML021C UNG1 hom Uracil-DNA glycosylase, required for repair of uracil in DNA formed by spontaneous cytosine deamination, not required for strand-specific mismatch repair, cell-cycle regulated, expressed in late G1, localizes to mitochondria and nucleus
0.086 5.74E-7 YER159C BUR6 het Subunit of a heterodimeric NC2 transcription regulator complex with Ncb2p; complex binds to TBP and can repress transcription by preventing preinitiation complex assembly or stimulate activated transcription; homologous to human NC2alpha
0.084 9.84E-7 YIL063C YRB2 het Protein of unknown function involved in nuclear processes of the Ran-GTPase cycle; involved in nuclear protein export; contains Ran Binding Domain and FxFG repeats; interacts with Srm1p, GTP-Gsp1p, Rna1p and Crm1p; is not essential
0.084 1.00E-6 YLR276C DBP9 het DEAD-box protein required for 27S rRNA processing; exhibits DNA, RNA and DNA/RNA helicase activities; ATPase activity shows preference for DNA over RNA; DNA helicase activity abolished by mutation in RNA-binding domain
0.077 7.40E-6 YMR301C ATM1 het Mitochondrial inner membrane ATP-binding cassette (ABC) transporter, exports mitochondrially synthesized precursors of iron-sulfur (Fe/S) clusters to the cytosol
0.076 1.18E-5 YKL036C_d YKL036C_d het Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the essential gene UGP1 gene and uncharacterized ORF YKL037W
0.075 1.21E-5 YHR110W ERP5 hom Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport
0.075 1.45E-5 YDL060W TSR1 het Protein required for processing of 20S pre-rRNA in the cytoplasm; associates with pre-40S ribosomal particles; inhibits the premature association of 60S subunits with assembling 40S subunits in the cytoplasm; similar to Bms1p; relocalizes from nucleus to cytoplasm upon DNA replication stress
0.075 1.50E-5 YDR163W CWC15 hom Non-essential protein involved in pre-mRNA splicing, component of a complex containing Cef1p; has similarity to S. pombe Cwf15p
0.075 1.50E-5 YER171W RAD3 het 5' to 3' DNA helicase; involved in nucleotide excision repair and transcription; subunit of RNA polII initiation factor TFIIH and of Nucleotide Excision Repair Factor 3 (NEF3); homolog of human XPD protein; mutant has aneuploidy tolerance; protein abundance increases in response to DNA replication stress