HIPHOP chemogenomics database

YPR170C_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORFs YPR169W-A and YPR170W-B

Zygosity: Homozygous strain

fixedexpanded
Profile for YPR170C / YPR170C

Click on Significant Values for Screen Details

Top fitness defect scores for YPR170C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_515	4092-1064	8.66	102.0 µM	8.05E-15	plasma membrane duress	15	2.29E-18
2	SGTC_1921	5740136	8.13	50.0 µM	3.11E-13	TRP & mitochondrial translation	3	2.22E-16
3	SGTC_2370	9071495	6.41	200.0 µM	7.74E-9	mitochondrial processes	6	7.18E-11
4	SGTC_2786	7743617	5.98	45.5 µM	6.99E-8		3	1.14E-9
5	SGTC_1348	1493-0373	5.38	93.8 µM	1.13E-6		5	3.73E-8
6	SGTC_2824	7998404	5.37	52.0 µM	1.20E-6		10	4.02E-8
7	SGTC_137	0438-0332	5.07	85.4 µM	4.23E-6	ubiquinone biosynthesis & proteasome	75	1.96E-7
8	SGTC_569	4130-2812	5.05	160.0 µM	4.58E-6	amide catabolism	3	2.16E-7
9	SGTC_1047	2043-3044	5.03	82.0 µM	5.14E-6		15	2.50E-7
10	SGTC_1281	0884-0031	4.99	11.8 µM	5.89E-6	fatty acid desaturase (OLE1)	12	2.97E-7
11	SGTC_1515	3460-0031	4.99	42.1 µM	5.93E-6	DNA intercalators	6	3.00E-7
12	SGTC_2343	7990716	4.94	14.8 µM	7.37E-6		7	3.93E-7
13	SGTC_1385	3091-4834	4.72	14.1 µM	1.75E-5	RPP1 & pyrimidine depletion	5	1.16E-6
14	SGTC_2917	7979103	4.63	53.8 µM	2.46E-5		14	1.79E-6
15	SGTC_2783	7738165	4.49	71.4 µM	4.30E-5		20	3.61E-6
16	SGTC_2020	4017018	4.45	200.0 µM	4.90E-5		9	4.25E-6
17	SGTC_2558	carylophyllene oxide	4.43	100.0 µM	5.27E-5		5	4.66E-6
18	SGTC_2334	9017922	4.40	200.0 µM	5.97E-5		15	5.45E-6
19	SGTC_2336	9001819	4.34	198.7 µM	7.41E-5	heme biosynthesis & mitochondrial translocase	39	7.15E-6
20	SGTC_1377	2944-0135	4.33	198.0 µM	7.59E-5	calcium & mitochondrial duress	25	7.37E-6

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.110	1.72E-10	YEL065W	SIT1	hom	Ferrioxamine B transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; transcription is induced during iron deprivation and diauxic shift; potentially phosphorylated by Cdc28p
0.101	3.92E-9	YNL228W_d	YNL228W_d	hom	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; almost completely overlaps ORF YNL227C/JJJ1
0.100	6.12E-9	YJR067C	YAE1	het	Protein that forms a complex with Lto1p and Rli1p; essential for growth under standard (aerobic) conditions but not under anaerobic conditions; may have a role in protection of ribosomal assembly and function from damage due to reactive oxygen species
0.096	3.02E-8	YKR015C_p	YKR015C_p	hom	Putative protein of unknown function
0.086	6.67E-7	YKL173W	SNU114	het	GTPase component of U5 snRNP involved in mRNA splicing via spliceosome; binds directly to U5 snRNA; proposed to be involved in conformational changes of the spliceosome; similarity to ribosomal translocation factor EF-2
0.085	8.50E-7	YNL188W	KAR1	het	Essential protein involved in karyogamy during mating and in spindle pole body duplication during mitosis, localizes to the half-bridge of the spindle pole body, interacts with Spc72p during karyogamy, also interacts with Cdc31p
0.085	9.14E-7	YGR110W	CLD1	hom	Mitochondrial cardiolipin-specific phospholipase; functions upstream of Taz1p to generate monolyso-cardiolipin; transcription increases upon genotoxic stress; involved in restricting Ty1 transposition; has homology to mammalian CGI-58
0.083	1.63E-6	YKL156W	RPS27A	hom	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S27, no bacterial homolog; RPS27A has a paralog, RPS27B, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.082	2.02E-6	YHR072W	ERG7	het	Lanosterol synthase, an essential enzyme that catalyzes the cyclization of squalene 2,3-epoxide, a step in ergosterol biosynthesis
0.081	2.91E-6	YHR203C	RPS4B	hom	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S4, no bacterial homolog; RPS4B has a paralog, RPS4A, that arose from the whole genome duplication
0.081	2.92E-6	YOR165W	SEY1	hom	Dynamin-like GTPase that mediates homotypic ER fusion; has a role in ER morphology; interacts physically and genetically with Yop1p and Rtn1p; functional ortholog of the human atlastin ATL1, defects in which cause a form of the human disease hereditary spastic paraplegia; homolog of Arabidopsis RHD3
0.080	3.51E-6	YJL001W	PRE3	het	Beta 1 subunit of the 20S proteasome, responsible for cleavage after acidic residues in peptides
0.080	3.51E-6	YPL182C_d	YPL182C_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene CTI6/YPL181W
0.079	4.72E-6	YLR099C	ICT1	hom	Lysophosphatidic acid acyltransferase; responsible for enhanced phospholipid synthesis during organic solvent stress; null displays increased sensitivity to Calcofluor white; highly expressed during organic solvent stress; ICT1 has a paralog, ECM18, that arose from the whole genome duplication
0.076	1.04E-5	YDR238C	SEC26	het	Essential beta-coat protein of the COPI coatomer, involved in ER-to-Golgi protein trafficking and maintenance of normal ER morphology; shares 43% sequence identity with mammalian beta-coat protein (beta-COP)