YPR170C_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORFs YPR169W-A and YPR170W-B

Zygosity: Homozygous strain
fixedexpanded
Profile for YPR170C / YPR170C

Click on Significant Values for Screen Details ID:SGTC_137|Compound:0438-0332|FD-Score:5.07|P-value:4.23E-6 ID:SGTC_207|Compound:4185-0010|FD-Score:3.56|P-value:9.92E-4 ID:SGTC_515|Compound:4092-1064|FD-Score:8.66|P-value:8.05E-15 ID:SGTC_520|Compound:3584-0023|FD-Score:-3.50|P-value:5.80E-4 ID:SGTC_521|Compound:r062-0005|FD-Score:3.58|P-value:9.21E-4 ID:SGTC_555|Compound:4296-0685|FD-Score:3.82|P-value:4.41E-4 ID:SGTC_565|Compound:1418-0001|FD-Score:-4.42|P-value:2.28E-5 ID:SGTC_567|Compound:1080-0542|FD-Score:3.75|P-value:5.53E-4 ID:SGTC_569|Compound:4130-2812|FD-Score:5.05|P-value:4.58E-6 ID:SGTC_917|Compound:harmaline|FD-Score:3.56|P-value:9.94E-4 ID:SGTC_1047|Compound:2043-3044|FD-Score:5.03|P-value:5.14E-6 ID:SGTC_1050|Compound:3232-1156|FD-Score:3.63|P-value:7.93E-4 ID:SGTC_1238|Compound:0333-0287|FD-Score:4.07|P-value:1.93E-4 ID:SGTC_1281|Compound:0884-0031|FD-Score:4.99|P-value:5.89E-6 ID:SGTC_1348|Compound:1493-0373|FD-Score:5.38|P-value:1.13E-6 ID:SGTC_1377|Compound:2944-0135|FD-Score:4.33|P-value:7.59E-5 ID:SGTC_1385|Compound:3091-4834|FD-Score:4.72|P-value:1.75E-5 ID:SGTC_1449|Compound:4112-4002|FD-Score:3.69|P-value:6.70E-4 ID:SGTC_1458|Compound:k015-0034|FD-Score:4.21|P-value:1.17E-4 ID:SGTC_1515|Compound:3460-0031|FD-Score:4.99|P-value:5.93E-6 ID:SGTC_1713|Compound:st033146|FD-Score:4.32|P-value:7.96E-5 ID:SGTC_1735|Compound:st034310|FD-Score:4.08|P-value:1.84E-4 ID:SGTC_1813|Compound:st051246|FD-Score:3.90|P-value:3.33E-4 ID:SGTC_1921|Compound:5740136|FD-Score:8.13|P-value:3.11E-13 ID:SGTC_2020|Compound:4017018|FD-Score:4.45|P-value:4.90E-5 ID:SGTC_2130|Compound:NSC 7|FD-Score:-3.51|P-value:5.55E-4 ID:SGTC_2331|Compound:7980721|FD-Score:-3.39|P-value:8.17E-4 ID:SGTC_2334|Compound:9017922|FD-Score:4.40|P-value:5.97E-5 ID:SGTC_2336|Compound:9001819|FD-Score:4.34|P-value:7.41E-5 ID:SGTC_2343|Compound:7990716|FD-Score:4.94|P-value:7.37E-6 ID:SGTC_2370|Compound:9071495|FD-Score:6.41|P-value:7.74E-9 ID:SGTC_2377|Compound:9073351|FD-Score:3.96|P-value:2.75E-4 ID:SGTC_2390|Compound:9097792|FD-Score:3.57|P-value:9.56E-4 ID:SGTC_2558|Compound:carylophyllene oxide|FD-Score:4.43|P-value:5.27E-5 ID:SGTC_2620|Compound:irigenin|FD-Score:-4.76|P-value:5.86E-6 ID:SGTC_2649|Compound:anisomycin|FD-Score:3.59|P-value:8.98E-4 ID:SGTC_2693|Compound:st077581|FD-Score:-6.10|P-value:1.20E-8 ID:SGTC_2763|Compound:lisinopril|FD-Score:-3.88|P-value:1.63E-4 ID:SGTC_2783|Compound:7738165|FD-Score:4.49|P-value:4.30E-5 ID:SGTC_2786|Compound:7743617|FD-Score:5.98|P-value:6.99E-8 ID:SGTC_2791|Compound:5663188|FD-Score:-4.43|P-value:2.19E-5 ID:SGTC_2822|Compound:7994718|FD-Score:4.02|P-value:2.29E-4 ID:SGTC_2824|Compound:7998404|FD-Score:5.37|P-value:1.20E-6 ID:SGTC_2917|Compound:7979103|FD-Score:4.63|P-value:2.46E-5 ID:SGTC_3058|Compound:9093861|FD-Score:-4.06|P-value:8.95E-5 ID:SGTC_3263|Compound:9137018|FD-Score:4.05|P-value:2.03E-4 ID:SGTC_3268|Compound:9137683|FD-Score:3.73|P-value:5.80E-4 ID:SGTC_3303|Compound:9125618|FD-Score:-4.56|P-value:1.36E-5 ID:SGTC_3306|Compound:9127676|FD-Score:-3.94|P-value:1.34E-4 ID:SGTC_3309|Compound:9129340|FD-Score:-4.19|P-value:5.53E-5 ID:SGTC_137|Compound:0438-0332|FD-Score:5.07|P-value:4.23E-6 ID:SGTC_207|Compound:4185-0010|FD-Score:3.56|P-value:9.92E-4 ID:SGTC_515|Compound:4092-1064|FD-Score:8.66|P-value:8.05E-15 ID:SGTC_520|Compound:3584-0023|FD-Score:-3.50|P-value:5.80E-4 ID:SGTC_521|Compound:r062-0005|FD-Score:3.58|P-value:9.21E-4 ID:SGTC_555|Compound:4296-0685|FD-Score:3.82|P-value:4.41E-4 ID:SGTC_565|Compound:1418-0001|FD-Score:-4.42|P-value:2.28E-5 ID:SGTC_567|Compound:1080-0542|FD-Score:3.75|P-value:5.53E-4 ID:SGTC_569|Compound:4130-2812|FD-Score:5.05|P-value:4.58E-6 ID:SGTC_917|Compound:harmaline|FD-Score:3.56|P-value:9.94E-4 ID:SGTC_1047|Compound:2043-3044|FD-Score:5.03|P-value:5.14E-6 ID:SGTC_1050|Compound:3232-1156|FD-Score:3.63|P-value:7.93E-4 ID:SGTC_1238|Compound:0333-0287|FD-Score:4.07|P-value:1.93E-4 ID:SGTC_1281|Compound:0884-0031|FD-Score:4.99|P-value:5.89E-6 ID:SGTC_1348|Compound:1493-0373|FD-Score:5.38|P-value:1.13E-6 ID:SGTC_1377|Compound:2944-0135|FD-Score:4.33|P-value:7.59E-5 ID:SGTC_1385|Compound:3091-4834|FD-Score:4.72|P-value:1.75E-5 ID:SGTC_1449|Compound:4112-4002|FD-Score:3.69|P-value:6.70E-4 ID:SGTC_1458|Compound:k015-0034|FD-Score:4.21|P-value:1.17E-4 ID:SGTC_1515|Compound:3460-0031|FD-Score:4.99|P-value:5.93E-6 ID:SGTC_1713|Compound:st033146|FD-Score:4.32|P-value:7.96E-5 ID:SGTC_1735|Compound:st034310|FD-Score:4.08|P-value:1.84E-4 ID:SGTC_1813|Compound:st051246|FD-Score:3.90|P-value:3.33E-4 ID:SGTC_1921|Compound:5740136|FD-Score:8.13|P-value:3.11E-13 ID:SGTC_2020|Compound:4017018|FD-Score:4.45|P-value:4.90E-5 ID:SGTC_2130|Compound:NSC 7|FD-Score:-3.51|P-value:5.55E-4 ID:SGTC_2331|Compound:7980721|FD-Score:-3.39|P-value:8.17E-4 ID:SGTC_2334|Compound:9017922|FD-Score:4.40|P-value:5.97E-5 ID:SGTC_2336|Compound:9001819|FD-Score:4.34|P-value:7.41E-5 ID:SGTC_2343|Compound:7990716|FD-Score:4.94|P-value:7.37E-6 ID:SGTC_2370|Compound:9071495|FD-Score:6.41|P-value:7.74E-9 ID:SGTC_2377|Compound:9073351|FD-Score:3.96|P-value:2.75E-4 ID:SGTC_2390|Compound:9097792|FD-Score:3.57|P-value:9.56E-4 ID:SGTC_2558|Compound:carylophyllene oxide|FD-Score:4.43|P-value:5.27E-5 ID:SGTC_2620|Compound:irigenin|FD-Score:-4.76|P-value:5.86E-6 ID:SGTC_2649|Compound:anisomycin|FD-Score:3.59|P-value:8.98E-4 ID:SGTC_2693|Compound:st077581|FD-Score:-6.10|P-value:1.20E-8 ID:SGTC_2763|Compound:lisinopril|FD-Score:-3.88|P-value:1.63E-4 ID:SGTC_2783|Compound:7738165|FD-Score:4.49|P-value:4.30E-5 ID:SGTC_2786|Compound:7743617|FD-Score:5.98|P-value:6.99E-8 ID:SGTC_2791|Compound:5663188|FD-Score:-4.43|P-value:2.19E-5 ID:SGTC_2822|Compound:7994718|FD-Score:4.02|P-value:2.29E-4 ID:SGTC_2824|Compound:7998404|FD-Score:5.37|P-value:1.20E-6 ID:SGTC_2917|Compound:7979103|FD-Score:4.63|P-value:2.46E-5 ID:SGTC_3058|Compound:9093861|FD-Score:-4.06|P-value:8.95E-5 ID:SGTC_3263|Compound:9137018|FD-Score:4.05|P-value:2.03E-4 ID:SGTC_3268|Compound:9137683|FD-Score:3.73|P-value:5.80E-4 ID:SGTC_3303|Compound:9125618|FD-Score:-4.56|P-value:1.36E-5 ID:SGTC_3306|Compound:9127676|FD-Score:-3.94|P-value:1.34E-4 ID:SGTC_3309|Compound:9129340|FD-Score:-4.19|P-value:5.53E-5

Top fitness defect scores for YPR170C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_515 4092-1064 8.66 102.0 µM 8.05E-15 plasma membrane duress 15 2.29E-18
2 SGTC_1921 5740136 8.13 50.0 µM 3.11E-13 TRP & mitochondrial translation 3 2.22E-16
3 SGTC_2370 9071495 6.41 200.0 µM 7.74E-9 mitochondrial processes 6 7.18E-11
4 SGTC_2786 7743617 5.98 45.5 µM 6.99E-8 3 1.14E-9
5 SGTC_1348 1493-0373 5.38 93.8 µM 1.13E-6 5 3.73E-8
6 SGTC_2824 7998404 5.37 52.0 µM 1.20E-6 10 4.02E-8
7 SGTC_137 0438-0332 5.07 85.4 µM 4.23E-6 ubiquinone biosynthesis & proteasome 75 1.96E-7
8 SGTC_569 4130-2812 5.05 160.0 µM 4.58E-6 amide catabolism 3 2.16E-7
9 SGTC_1047 2043-3044 5.03 82.0 µM 5.14E-6 15 2.50E-7
10 SGTC_1281 0884-0031 4.99 11.8 µM 5.89E-6 fatty acid desaturase (OLE1) 12 2.97E-7
11 SGTC_1515 3460-0031 4.99 42.1 µM 5.93E-6 DNA intercalators 6 3.00E-7
12 SGTC_2343 7990716 4.94 14.8 µM 7.37E-6 7 3.93E-7
13 SGTC_1385 3091-4834 4.72 14.1 µM 1.75E-5 RPP1 & pyrimidine depletion 5 1.16E-6
14 SGTC_2917 7979103 4.63 53.8 µM 2.46E-5 14 1.79E-6
15 SGTC_2783 7738165 4.49 71.4 µM 4.30E-5 20 3.61E-6
16 SGTC_2020 4017018 4.45 200.0 µM 4.90E-5 9 4.25E-6
17 SGTC_2558 carylophyllene oxide 4.43 100.0 µM 5.27E-5 5 4.66E-6
18 SGTC_2334 9017922 4.40 200.0 µM 5.97E-5 15 5.45E-6
19 SGTC_2336 9001819 4.34 198.7 µM 7.41E-5 heme biosynthesis & mitochondrial translocase 39 7.15E-6
20 SGTC_1377 2944-0135 4.33 198.0 µM 7.59E-5 calcium & mitochondrial duress 25 7.37E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.110 1.72E-10 YEL065W SIT1 hom Ferrioxamine B transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; transcription is induced during iron deprivation and diauxic shift; potentially phosphorylated by Cdc28p
0.101 3.92E-9 YNL228W_d YNL228W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; almost completely overlaps ORF YNL227C/JJJ1
0.100 6.12E-9 YJR067C YAE1 het Protein that forms a complex with Lto1p and Rli1p; essential for growth under standard (aerobic) conditions but not under anaerobic conditions; may have a role in protection of ribosomal assembly and function from damage due to reactive oxygen species
0.096 3.02E-8 YKR015C_p YKR015C_p hom Putative protein of unknown function
0.086 6.67E-7 YKL173W SNU114 het GTPase component of U5 snRNP involved in mRNA splicing via spliceosome; binds directly to U5 snRNA; proposed to be involved in conformational changes of the spliceosome; similarity to ribosomal translocation factor EF-2
0.085 8.50E-7 YNL188W KAR1 het Essential protein involved in karyogamy during mating and in spindle pole body duplication during mitosis, localizes to the half-bridge of the spindle pole body, interacts with Spc72p during karyogamy, also interacts with Cdc31p
0.085 9.14E-7 YGR110W CLD1 hom Mitochondrial cardiolipin-specific phospholipase; functions upstream of Taz1p to generate monolyso-cardiolipin; transcription increases upon genotoxic stress; involved in restricting Ty1 transposition; has homology to mammalian CGI-58
0.083 1.63E-6 YKL156W RPS27A hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S27, no bacterial homolog; RPS27A has a paralog, RPS27B, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.082 2.02E-6 YHR072W ERG7 het Lanosterol synthase, an essential enzyme that catalyzes the cyclization of squalene 2,3-epoxide, a step in ergosterol biosynthesis
0.081 2.91E-6 YHR203C RPS4B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S4, no bacterial homolog; RPS4B has a paralog, RPS4A, that arose from the whole genome duplication
0.081 2.92E-6 YOR165W SEY1 hom Dynamin-like GTPase that mediates homotypic ER fusion; has a role in ER morphology; interacts physically and genetically with Yop1p and Rtn1p; functional ortholog of the human atlastin ATL1, defects in which cause a form of the human disease hereditary spastic paraplegia; homolog of Arabidopsis RHD3
0.080 3.51E-6 YJL001W PRE3 het Beta 1 subunit of the 20S proteasome, responsible for cleavage after acidic residues in peptides
0.080 3.51E-6 YPL182C_d YPL182C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene CTI6/YPL181W
0.079 4.72E-6 YLR099C ICT1 hom Lysophosphatidic acid acyltransferase; responsible for enhanced phospholipid synthesis during organic solvent stress; null displays increased sensitivity to Calcofluor white; highly expressed during organic solvent stress; ICT1 has a paralog, ECM18, that arose from the whole genome duplication
0.076 1.04E-5 YDR238C SEC26 het Essential beta-coat protein of the COPI coatomer, involved in ER-to-Golgi protein trafficking and maintenance of normal ER morphology; shares 43% sequence identity with mammalian beta-coat protein (beta-COP)