YPR171W / BSP1

Adapter that links synaptojanins Inp52p and Inp53p to the cortical actin cytoskeleton

Zygosity: Homozygous strain
fixedexpanded
Profile for YPR171W / BSP1

Click on Significant Values for Screen Details ID:SGTC_61|Compound:0978-8327|FD-Score:-3.28|P-value:5.08E-4 ID:SGTC_121|Compound:0557-0495|FD-Score:-3.71|P-value:1.02E-4 ID:SGTC_128|Compound:0906-2981|FD-Score:4.73|P-value:1.19E-6 ID:SGTC_133|Compound:0724-0033|FD-Score:-3.12|P-value:9.06E-4 ID:SGTC_183|Compound:3914-0051|FD-Score:3.92|P-value:4.79E-5 ID:SGTC_206|Compound:4546-0025|FD-Score:3.17|P-value:8.04E-4 ID:SGTC_318|Compound:1488-0629|FD-Score:3.24|P-value:6.27E-4 ID:SGTC_365|Compound:0121-0052|FD-Score:3.45|P-value:2.94E-4 ID:SGTC_518|Compound:1021-0119|FD-Score:4.20|P-value:1.46E-5 ID:SGTC_599|Compound:1935-0052|FD-Score:4.48|P-value:3.96E-6 ID:SGTC_623|Compound:k072-0108|FD-Score:3.68|P-value:1.24E-4 ID:SGTC_806|Compound:3966-4455|FD-Score:3.61|P-value:1.64E-4 ID:SGTC_962|Compound:1254-0300|FD-Score:4.24|P-value:1.22E-5 ID:SGTC_1009|Compound:4106-0057|FD-Score:4.12|P-value:2.00E-5 ID:SGTC_1013|Compound:4112-3890|FD-Score:4.89|P-value:5.56E-7 ID:SGTC_1014|Compound:4130-3005|FD-Score:3.42|P-value:3.33E-4 ID:SGTC_1016|Compound:4226-1401|FD-Score:-4.04|P-value:2.68E-5 ID:SGTC_1099|Compound:5-nonyloxytryptamine|FD-Score:3.57|P-value:1.88E-4 ID:SGTC_1152|Compound:3909-8331|FD-Score:3.41|P-value:3.45E-4 ID:SGTC_1171|Compound:0368-0077|FD-Score:-3.20|P-value:6.77E-4 ID:SGTC_1358|Compound:1509-0022|FD-Score:4.06|P-value:2.66E-5 ID:SGTC_1372|Compound:2752-0194|FD-Score:-3.39|P-value:3.43E-4 ID:SGTC_1648|Compound:st011736|FD-Score:3.41|P-value:3.42E-4 ID:SGTC_1731|Compound:st035964|FD-Score:3.21|P-value:7.03E-4 ID:SGTC_1747|Compound:st037496|FD-Score:-5.06|P-value:2.11E-7 ID:SGTC_1792|Compound:st045773|FD-Score:3.60|P-value:1.66E-4 ID:SGTC_1823|Compound:3-hydroxy-2-naphthoic acid|FD-Score:3.24|P-value:6.20E-4 ID:SGTC_1851|Compound:st056236|FD-Score:3.44|P-value:3.04E-4 ID:SGTC_1853|Compound:st056710|FD-Score:4.04|P-value:2.89E-5 ID:SGTC_1854|Compound:st056233|FD-Score:3.35|P-value:4.21E-4 ID:SGTC_1954|Compound:st077032|FD-Score:3.14|P-value:8.73E-4 ID:SGTC_2033|Compound:5192550|FD-Score:3.16|P-value:8.31E-4 ID:SGTC_2149|Compound:5554786|FD-Score:-3.23|P-value:6.22E-4 ID:SGTC_2154|Compound:5570129|FD-Score:4.50|P-value:3.71E-6 ID:SGTC_2165|Compound:5727197|FD-Score:6.55|P-value:3.20E-11 ID:SGTC_2285|Compound:7945142|FD-Score:3.51|P-value:2.33E-4 ID:SGTC_2396|Compound:5342950|FD-Score:3.85|P-value:6.33E-5 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:4.37|P-value:6.74E-6 ID:SGTC_2472|Compound:5377652|FD-Score:4.84|P-value:7.08E-7 ID:SGTC_2549|Compound:cedrol|FD-Score:-3.54|P-value:1.97E-4 ID:SGTC_2780|Compound:5215298|FD-Score:4.49|P-value:3.79E-6 ID:SGTC_2795|Compound:7780010|FD-Score:3.60|P-value:1.69E-4 ID:SGTC_2796|Compound:7949634|FD-Score:3.69|P-value:1.19E-4 ID:SGTC_2872|Compound:9044037|FD-Score:4.02|P-value:3.05E-5 ID:SGTC_2992|Compound:9074591|FD-Score:3.33|P-value:4.63E-4 ID:SGTC_2998|Compound:9066762|FD-Score:4.10|P-value:2.20E-5 ID:SGTC_3067|Compound:9117431|FD-Score:3.50|P-value:2.42E-4 ID:SGTC_3098|Compound:9119039|FD-Score:4.62|P-value:2.05E-6 ID:SGTC_3151|Compound:9099821|FD-Score:-3.41|P-value:3.25E-4 ID:SGTC_3202|Compound:9113761|FD-Score:5.32|P-value:5.71E-8 ID:SGTC_3206|Compound:9114350|FD-Score:3.57|P-value:1.87E-4 ID:SGTC_3356|Compound:9151811|FD-Score:3.77|P-value:8.74E-5 ID:SGTC_61|Compound:0978-8327|FD-Score:-3.28|P-value:5.08E-4 ID:SGTC_121|Compound:0557-0495|FD-Score:-3.71|P-value:1.02E-4 ID:SGTC_128|Compound:0906-2981|FD-Score:4.73|P-value:1.19E-6 ID:SGTC_133|Compound:0724-0033|FD-Score:-3.12|P-value:9.06E-4 ID:SGTC_183|Compound:3914-0051|FD-Score:3.92|P-value:4.79E-5 ID:SGTC_206|Compound:4546-0025|FD-Score:3.17|P-value:8.04E-4 ID:SGTC_318|Compound:1488-0629|FD-Score:3.24|P-value:6.27E-4 ID:SGTC_365|Compound:0121-0052|FD-Score:3.45|P-value:2.94E-4 ID:SGTC_518|Compound:1021-0119|FD-Score:4.20|P-value:1.46E-5 ID:SGTC_599|Compound:1935-0052|FD-Score:4.48|P-value:3.96E-6 ID:SGTC_623|Compound:k072-0108|FD-Score:3.68|P-value:1.24E-4 ID:SGTC_806|Compound:3966-4455|FD-Score:3.61|P-value:1.64E-4 ID:SGTC_962|Compound:1254-0300|FD-Score:4.24|P-value:1.22E-5 ID:SGTC_1009|Compound:4106-0057|FD-Score:4.12|P-value:2.00E-5 ID:SGTC_1013|Compound:4112-3890|FD-Score:4.89|P-value:5.56E-7 ID:SGTC_1014|Compound:4130-3005|FD-Score:3.42|P-value:3.33E-4 ID:SGTC_1016|Compound:4226-1401|FD-Score:-4.04|P-value:2.68E-5 ID:SGTC_1099|Compound:5-nonyloxytryptamine|FD-Score:3.57|P-value:1.88E-4 ID:SGTC_1152|Compound:3909-8331|FD-Score:3.41|P-value:3.45E-4 ID:SGTC_1171|Compound:0368-0077|FD-Score:-3.20|P-value:6.77E-4 ID:SGTC_1358|Compound:1509-0022|FD-Score:4.06|P-value:2.66E-5 ID:SGTC_1372|Compound:2752-0194|FD-Score:-3.39|P-value:3.43E-4 ID:SGTC_1648|Compound:st011736|FD-Score:3.41|P-value:3.42E-4 ID:SGTC_1731|Compound:st035964|FD-Score:3.21|P-value:7.03E-4 ID:SGTC_1747|Compound:st037496|FD-Score:-5.06|P-value:2.11E-7 ID:SGTC_1792|Compound:st045773|FD-Score:3.60|P-value:1.66E-4 ID:SGTC_1823|Compound:3-hydroxy-2-naphthoic acid|FD-Score:3.24|P-value:6.20E-4 ID:SGTC_1851|Compound:st056236|FD-Score:3.44|P-value:3.04E-4 ID:SGTC_1853|Compound:st056710|FD-Score:4.04|P-value:2.89E-5 ID:SGTC_1854|Compound:st056233|FD-Score:3.35|P-value:4.21E-4 ID:SGTC_1954|Compound:st077032|FD-Score:3.14|P-value:8.73E-4 ID:SGTC_2033|Compound:5192550|FD-Score:3.16|P-value:8.31E-4 ID:SGTC_2149|Compound:5554786|FD-Score:-3.23|P-value:6.22E-4 ID:SGTC_2154|Compound:5570129|FD-Score:4.50|P-value:3.71E-6 ID:SGTC_2165|Compound:5727197|FD-Score:6.55|P-value:3.20E-11 ID:SGTC_2285|Compound:7945142|FD-Score:3.51|P-value:2.33E-4 ID:SGTC_2396|Compound:5342950|FD-Score:3.85|P-value:6.33E-5 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:4.37|P-value:6.74E-6 ID:SGTC_2472|Compound:5377652|FD-Score:4.84|P-value:7.08E-7 ID:SGTC_2549|Compound:cedrol|FD-Score:-3.54|P-value:1.97E-4 ID:SGTC_2780|Compound:5215298|FD-Score:4.49|P-value:3.79E-6 ID:SGTC_2795|Compound:7780010|FD-Score:3.60|P-value:1.69E-4 ID:SGTC_2796|Compound:7949634|FD-Score:3.69|P-value:1.19E-4 ID:SGTC_2872|Compound:9044037|FD-Score:4.02|P-value:3.05E-5 ID:SGTC_2992|Compound:9074591|FD-Score:3.33|P-value:4.63E-4 ID:SGTC_2998|Compound:9066762|FD-Score:4.10|P-value:2.20E-5 ID:SGTC_3067|Compound:9117431|FD-Score:3.50|P-value:2.42E-4 ID:SGTC_3098|Compound:9119039|FD-Score:4.62|P-value:2.05E-6 ID:SGTC_3151|Compound:9099821|FD-Score:-3.41|P-value:3.25E-4 ID:SGTC_3202|Compound:9113761|FD-Score:5.32|P-value:5.71E-8 ID:SGTC_3206|Compound:9114350|FD-Score:3.57|P-value:1.87E-4 ID:SGTC_3356|Compound:9151811|FD-Score:3.77|P-value:8.74E-5

Top fitness defect scores for YPR171W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2165 5727197 6.55 32.1 µM 3.20E-11 7 2.82E-11
2 SGTC_3202 9113761 5.32 49.5 µM 5.71E-8 16 5.20E-8
3 SGTC_1013 4112-3890 4.89 241.0 µM 5.56E-7 TSC3-RPN4 17 5.12E-7
4 SGTC_2472 5377652 4.84 49.4 µM 7.08E-7 TRP & mitochondrial translation 34 6.53E-7
5 SGTC_128 0906-2981 4.73 13.4 µM 1.19E-6 4 1.10E-6
6 SGTC_3098 9119039 4.62 49.5 µM 2.05E-6 Golgi 25 1.90E-6
7 SGTC_2154 5570129 4.50 200.0 µM 3.71E-6 3 3.44E-6
8 SGTC_2780 5215298 4.49 71.4 µM 3.79E-6 25 3.52E-6
9 SGTC_599 1935-0052 4.48 86.5 µM 3.96E-6 10 3.68E-6
10 SGTC_2410 aloe-emodin-8-o-glycoside 4.37 46.3 µM 6.74E-6 mitochondrial processes 19 6.28E-6
11 SGTC_962 1254-0300 4.24 21.5 µM 1.22E-5 17 1.14E-5
12 SGTC_518 1021-0119 4.20 62.6 µM 1.46E-5 ERG2 29 1.36E-5
13 SGTC_1009 4106-0057 4.12 9.9 µM 2.00E-5 9 1.88E-5
14 SGTC_2998 9066762 4.10 71.4 µM 2.20E-5 RPP1 & pyrimidine depletion 23 2.07E-5
15 SGTC_1358 1509-0022 4.06 2.5 µM 2.66E-5 7 2.50E-5
16 SGTC_1853 st056710 4.04 91.2 µM 2.89E-5 amide catabolism 22 2.71E-5
17 SGTC_2872 9044037 4.02 26.0 µM 3.05E-5 1 2.87E-5
18 SGTC_183 3914-0051 3.92 30.6 µM 4.79E-5 60S ribosome export 24 4.51E-5
19 SGTC_2396 5342950 3.85 42.8 µM 6.33E-5 RSC complex & mRNA processing 46 5.96E-5
20 SGTC_3356 9151811 3.77 4.5 µM 8.74E-5 cell wall 25 8.25E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.128 1.31E-13 YOR291W YPK9 hom Vacuolar protein with a possible role in sequestering heavy metals; has similarity to the type V P-type ATPase Spf1p; homolog of human ATP13A2 (PARK9), mutations in which are associated with Parkinson disease and Kufor-Rakeb syndrome
0.113 5.60E-11 YML026C RPS18B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S18 and bacterial S13; RPS18B has a paralog, RPS18A, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.099 1.09E-8 YGL262W_p YGL262W_p hom Putative protein of unknown function; null mutant displays elevated sensitivity to expression of a mutant huntingtin fragment or of alpha-synuclein; YGL262W is not an essential gene
0.094 5.28E-8 YDR043C NRG1 hom Transcriptional repressor; recruits the Cyc8p-Tup1p complex to promoters; mediates glucose repression and negatively regulates a variety of processes including filamentous growth and alkaline pH response; NRG1 has a paralog, NRG2, that arose from the whole genome duplication
0.091 1.23E-7 YNL306W MRPS18 het Mitochondrial ribosomal protein of the small subunit; essential for viability, unlike most other mitoribosomal proteins
0.087 4.30E-7 YPR017C DSS4 hom Guanine nucleotide dissociation stimulator for Sec4p, functions in the post-Golgi secretory pathway; binds zinc, found both on membranes and in the cytosol
0.082 2.00E-6 YLR084C RAX2 hom N-glycosylated protein involved in the maintenance of bud site selection during bipolar budding; localization requires Rax1p; RAX2 mRNA stability is regulated by Mpt5p
0.081 2.36E-6 YOL078W AVO1 het Component of a membrane-bound complex containing the Tor2p kinase and other proteins, which may have a role in regulation of cell growth
0.080 3.32E-6 YNL326C PFA3 hom Palmitoyltransferase for Vac8p, required for vacuolar membrane fusion; contains an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain; autoacylates; required for vacuolar integrity under stress conditions
0.079 4.30E-6 YGL126W SCS3 hom Protein required for inositol prototrophy; required for normal ER membrane biosynthesis; ortholog of the FIT family of proteins involved in triglyceride droplet biosynthesis and homologous to human FIT2; disputed role in the synthesis of inositol phospholipids from inositol
0.078 6.05E-6 YIR001C SGN1 hom Cytoplasmic RNA-binding protein, contains an RNA recognition motif (RRM); may have a role in mRNA translation, as suggested by genetic interactions with genes encoding proteins involved in translational initiation
0.074 1.81E-5 YNL091W NST1 hom Protein of unknown function, mediates sensitivity to salt stress; interacts physically with the splicing factor Msl1p and also displays genetic interaction with MSL1
0.072 2.85E-5 YPL075W GCR1 het Transcriptional activator of genes involved in glycolysis; DNA-binding protein that interacts and functions with the transcriptional activator Gcr2p
0.072 2.93E-5 YLR151C PCD1 hom Peroxisomal pyrophosphatase with specificity for coenzyme A and CoA derivatives, may function to remove potentially toxic oxidized CoA disulfide from peroxisomes to maintain the capacity for beta-oxidation of fatty acids; nudix hydrolase family member
0.072 3.26E-5 YLR175W CBF5 het Pseudouridine synthase catalytic subunit of box H/ACA small nucleolar ribonucleoprotein particles (snoRNPs), acts on both large and small rRNAs and on snRNA U2; mutations in human ortholog dyskerin cause the disorder dyskeratosis congenita