YPR172W_p

Putative pyridoxal 5'-phosphate synthase; transcriptionally activated by Yrm1p along with genes involved in multidrug resistance; YPR172W has a paralog, YLR456W, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YPR172W / YPR172W

Click on Significant Values for Screen Details ID:SGTC_66|Compound:0109-0187|FD-Score:-4.87|P-value:1.68E-7 ID:SGTC_69|Compound:0096-0274|FD-Score:-5.01|P-value:7.72E-8 ID:SGTC_74|Compound:000s-0487|FD-Score:3.70|P-value:6.03E-5 ID:SGTC_94|Compound:0334-0113|FD-Score:3.62|P-value:8.64E-5 ID:SGTC_109|Compound:0132-0036|FD-Score:-3.02|P-value:7.55E-4 ID:SGTC_168|Compound:3970-0862|FD-Score:-3.47|P-value:1.33E-4 ID:SGTC_206|Compound:4546-0025|FD-Score:-3.35|P-value:2.13E-4 ID:SGTC_337|Compound:1315-0038|FD-Score:3.01|P-value:9.09E-4 ID:SGTC_338|Compound:4055-0136|FD-Score:3.69|P-value:6.33E-5 ID:SGTC_578|Compound:3460-0051|FD-Score:3.43|P-value:1.86E-4 ID:SGTC_766|Compound:1391-0721|FD-Score:3.00|P-value:9.16E-4 ID:SGTC_1071|Compound:trifluoperazine|FD-Score:3.06|P-value:7.35E-4 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:4.27|P-value:4.50E-6 ID:SGTC_1250|Compound:0485-0349|FD-Score:4.14|P-value:8.50E-6 ID:SGTC_1293|Compound:1000-1278|FD-Score:2.99|P-value:9.68E-4 ID:SGTC_1324|Compound:1418-0026|FD-Score:3.60|P-value:9.04E-5 ID:SGTC_1381|Compound:2324-0066|FD-Score:3.32|P-value:2.81E-4 ID:SGTC_1435|Compound:4092-0789|FD-Score:3.72|P-value:5.50E-5 ID:SGTC_1527|Compound:coumarin|FD-Score:3.30|P-value:3.06E-4 ID:SGTC_1735|Compound:st034310|FD-Score:-3.13|P-value:4.99E-4 ID:SGTC_1854|Compound:st056233|FD-Score:3.58|P-value:9.86E-5 ID:SGTC_1859|Compound:st055998|FD-Score:3.43|P-value:1.83E-4 ID:SGTC_1923|Compound:st058458|FD-Score:4.11|P-value:9.83E-6 ID:SGTC_1980|Compound:st071811|FD-Score:3.06|P-value:7.49E-4 ID:SGTC_2181|Compound:6316240|FD-Score:6.25|P-value:3.75E-11 ID:SGTC_2221|Compound:6807166|FD-Score:3.86|P-value:3.07E-5 ID:SGTC_2286|Compound:7945697|FD-Score:2.99|P-value:9.49E-4 ID:SGTC_2342|Compound:7990637|FD-Score:3.35|P-value:2.57E-4 ID:SGTC_2375|Compound:9072683|FD-Score:-3.06|P-value:6.42E-4 ID:SGTC_2390|Compound:9097792|FD-Score:-3.15|P-value:4.74E-4 ID:SGTC_2402|Compound:5553605|FD-Score:-3.44|P-value:1.52E-4 ID:SGTC_2486|Compound:5283202|FD-Score:-3.01|P-value:7.90E-4 ID:SGTC_2520|Compound:obtusaquinone|FD-Score:5.05|P-value:7.45E-8 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:3.12|P-value:6.00E-4 ID:SGTC_2713|Compound:st079149|FD-Score:3.69|P-value:6.28E-5 ID:SGTC_2822|Compound:7994718|FD-Score:6.75|P-value:1.07E-12 ID:SGTC_2841|Compound:9004761|FD-Score:3.52|P-value:1.29E-4 ID:SGTC_2893|Compound:9048488|FD-Score:-3.11|P-value:5.45E-4 ID:SGTC_3100|Compound:9120536|FD-Score:-3.48|P-value:1.32E-4 ID:SGTC_3101|Compound:9120531|FD-Score:5.19|P-value:3.39E-8 ID:SGTC_3121|Compound:9125696|FD-Score:6.06|P-value:1.42E-10 ID:SGTC_3173|Compound:9105693|FD-Score:4.10|P-value:1.01E-5 ID:SGTC_3225|Compound:9130819|FD-Score:-3.86|P-value:2.56E-5 ID:SGTC_3254|Compound:9136651|FD-Score:9.41|P-value:5.30E-23 ID:SGTC_3300|Compound:9124615|FD-Score:-3.80|P-value:3.38E-5 ID:SGTC_66|Compound:0109-0187|FD-Score:-4.87|P-value:1.68E-7 ID:SGTC_69|Compound:0096-0274|FD-Score:-5.01|P-value:7.72E-8 ID:SGTC_74|Compound:000s-0487|FD-Score:3.70|P-value:6.03E-5 ID:SGTC_94|Compound:0334-0113|FD-Score:3.62|P-value:8.64E-5 ID:SGTC_109|Compound:0132-0036|FD-Score:-3.02|P-value:7.55E-4 ID:SGTC_168|Compound:3970-0862|FD-Score:-3.47|P-value:1.33E-4 ID:SGTC_206|Compound:4546-0025|FD-Score:-3.35|P-value:2.13E-4 ID:SGTC_337|Compound:1315-0038|FD-Score:3.01|P-value:9.09E-4 ID:SGTC_338|Compound:4055-0136|FD-Score:3.69|P-value:6.33E-5 ID:SGTC_578|Compound:3460-0051|FD-Score:3.43|P-value:1.86E-4 ID:SGTC_766|Compound:1391-0721|FD-Score:3.00|P-value:9.16E-4 ID:SGTC_1071|Compound:trifluoperazine|FD-Score:3.06|P-value:7.35E-4 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:4.27|P-value:4.50E-6 ID:SGTC_1250|Compound:0485-0349|FD-Score:4.14|P-value:8.50E-6 ID:SGTC_1293|Compound:1000-1278|FD-Score:2.99|P-value:9.68E-4 ID:SGTC_1324|Compound:1418-0026|FD-Score:3.60|P-value:9.04E-5 ID:SGTC_1381|Compound:2324-0066|FD-Score:3.32|P-value:2.81E-4 ID:SGTC_1435|Compound:4092-0789|FD-Score:3.72|P-value:5.50E-5 ID:SGTC_1527|Compound:coumarin|FD-Score:3.30|P-value:3.06E-4 ID:SGTC_1735|Compound:st034310|FD-Score:-3.13|P-value:4.99E-4 ID:SGTC_1854|Compound:st056233|FD-Score:3.58|P-value:9.86E-5 ID:SGTC_1859|Compound:st055998|FD-Score:3.43|P-value:1.83E-4 ID:SGTC_1923|Compound:st058458|FD-Score:4.11|P-value:9.83E-6 ID:SGTC_1980|Compound:st071811|FD-Score:3.06|P-value:7.49E-4 ID:SGTC_2181|Compound:6316240|FD-Score:6.25|P-value:3.75E-11 ID:SGTC_2221|Compound:6807166|FD-Score:3.86|P-value:3.07E-5 ID:SGTC_2286|Compound:7945697|FD-Score:2.99|P-value:9.49E-4 ID:SGTC_2342|Compound:7990637|FD-Score:3.35|P-value:2.57E-4 ID:SGTC_2375|Compound:9072683|FD-Score:-3.06|P-value:6.42E-4 ID:SGTC_2390|Compound:9097792|FD-Score:-3.15|P-value:4.74E-4 ID:SGTC_2402|Compound:5553605|FD-Score:-3.44|P-value:1.52E-4 ID:SGTC_2486|Compound:5283202|FD-Score:-3.01|P-value:7.90E-4 ID:SGTC_2520|Compound:obtusaquinone|FD-Score:5.05|P-value:7.45E-8 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:3.12|P-value:6.00E-4 ID:SGTC_2713|Compound:st079149|FD-Score:3.69|P-value:6.28E-5 ID:SGTC_2822|Compound:7994718|FD-Score:6.75|P-value:1.07E-12 ID:SGTC_2841|Compound:9004761|FD-Score:3.52|P-value:1.29E-4 ID:SGTC_2893|Compound:9048488|FD-Score:-3.11|P-value:5.45E-4 ID:SGTC_3100|Compound:9120536|FD-Score:-3.48|P-value:1.32E-4 ID:SGTC_3101|Compound:9120531|FD-Score:5.19|P-value:3.39E-8 ID:SGTC_3121|Compound:9125696|FD-Score:6.06|P-value:1.42E-10 ID:SGTC_3173|Compound:9105693|FD-Score:4.10|P-value:1.01E-5 ID:SGTC_3225|Compound:9130819|FD-Score:-3.86|P-value:2.56E-5 ID:SGTC_3254|Compound:9136651|FD-Score:9.41|P-value:5.30E-23 ID:SGTC_3300|Compound:9124615|FD-Score:-3.80|P-value:3.38E-5

Top fitness defect scores for YPR172W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3254 9136651 9.41 49.5 µM 5.30E-23 DNA damage response 1 2.48E-21
2 SGTC_2822 7994718 6.75 71.4 µM 1.07E-12 3 7.60E-12
3 SGTC_2181 6316240 6.25 54.3 µM 3.75E-11 4 2.01E-10
4 SGTC_3121 9125696 6.06 49.5 µM 1.42E-10 1 6.84E-10
5 SGTC_3101 9120531 5.19 49.5 µM 3.39E-8 13 1.07E-7
6 SGTC_2520 obtusaquinone 5.05 4.7 µM 7.45E-8 2 2.21E-7
7 SGTC_1135 dihydrocapsaicin 4.27 536.7 nM 4.50E-6 27 9.73E-6
8 SGTC_1250 0485-0349 4.14 40.2 µM 8.50E-6 29 1.75E-5
9 SGTC_1923 st058458 4.11 19.1 µM 9.83E-6 28 2.01E-5
10 SGTC_3173 9105693 4.10 49.5 µM 1.01E-5 18 2.06E-5
11 SGTC_2221 6807166 3.86 181.1 µM 3.07E-5 6 5.74E-5
12 SGTC_1435 4092-0789 3.72 56.7 µM 5.50E-5 plasma membrane duress 17 9.86E-5
13 SGTC_74 000s-0487 3.70 160.3 µM 6.03E-5 26 1.07E-4
14 SGTC_2713 st079149 3.69 53.4 µM 6.28E-5 30 1.11E-4
15 SGTC_338 4055-0136 3.69 114.0 µM 6.33E-5 14 1.12E-4
16 SGTC_94 0334-0113 3.62 514.8 µM 8.64E-5 30 1.50E-4
17 SGTC_1324 1418-0026 3.60 34.4 µM 9.04E-5 17 1.56E-4
18 SGTC_1854 st056233 3.58 32.9 µM 9.86E-5 amide catabolism 28 1.69E-4
19 SGTC_2841 9004761 3.52 39.0 µM 1.29E-4 amide catabolism 49 2.16E-4
20 SGTC_1859 st055998 3.43 20.0 µM 1.83E-4 40 3.00E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.111 1.12E-10 YLR414C PUN1 hom Plasma membrane protein with a role in cell wall integrity; co-localizes with Sur7p in punctate membrane patches; null mutant displays decreased thermotolerance; transcription induced upon cell wall damage and metal ion stress
0.091 1.50E-7 YGL004C RPN14 hom Proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasome regulatory particle (RP); null mutants accumulate ubiquitinated Gcn4p and display decreased 26S proteasome stability; interacts with Rpt5p
0.086 6.22E-7 YFR049W YMR31 hom Mitochondrial ribosomal protein of the small subunit, has similarity to human mitochondrial ribosomal protein MRP-S36
0.078 5.44E-6 YPR144C NOC4 het Nucleolar protein, forms a complex with Nop14p that mediates maturation and nuclear export of 40S ribosomal subunits
0.078 5.47E-6 YLL047W_d YLL047W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene RNP1
0.078 5.49E-6 YKR002W PAP1 het Poly(A) polymerase, one of three factors required for mRNA 3'-end polyadenylation, forms multiprotein complex with polyadenylation factor I (PF I), also required for mRNA nuclear export; may also polyadenylate rRNAs; required for gene looping
0.075 1.33E-5 YKR090W PXL1 hom Protein that localizes to sites of polarized growth; required for selection and/or maintenance of polarized growth sites, may modulate signaling by the GTPases Cdc42p and Rho1p; contains LIM domains and has similarity to metazoan paxillin; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.074 1.74E-5 YPL177C CUP9 hom Homeodomain-containing transcriptional repressor; regulates expression of PTR2, which encodes a major peptide transporter; imported peptides activate ubiquitin-dependent proteolysis, resulting in degradation of Cup9p and de-repression of PTR2 transcription; CUP9 has a paralog, TOS8, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.074 1.90E-5 YLR405W DUS4 hom Dihydrouridine synthase, member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus3p
0.068 9.03E-5 YER013W PRP22 het DEAH-box RNA-dependent ATPase/ATP-dependent RNA helicase, associates with lariat intermediates before the second catalytic step of splicing; mediates ATP-dependent mRNA release from the spliceosome and unwinds RNA duplexes
0.067 1.09E-4 YGR139W_d YGR139W_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.067 1.12E-4 YOL098C_p YOL098C_p hom Putative metalloprotease
0.066 1.37E-4 YDR078C SHU2 hom Component of the Shu complex, which promotes error-free DNA repair; Shu complex mediates inhibition of Srs2p function
0.065 1.48E-4 YDR182W-A_p YDR182W-A_p hom Putative protein of unknown function; identified by fungal homology and RT-PCR
0.065 1.55E-4 YMR316C-A_p YMR316C-A_p hom Protein of unknown function; mRNA identified as translated by ribosome profiling data; overlaps the verified gene DIA1/YMR316W