YPR176C / BET2

Beta subunit of Type II geranylgeranyltransferase required for vesicular transport between the endoplasmic reticulum and the Golgi; provides a membrane attachment moiety to Rab-like proteins Ypt1p and Sec4p

Zygosity: Heterozygous strain
fixedexpanded
Profile for YPR176C / BET2

Click on Significant Values for Screen Details ID:SGTC_49|Compound:0717-0965|FD-Score:2.65|P-value:6.64E-4 ID:SGTC_141|Compound:0443-0274|FD-Score:2.87|P-value:2.49E-4 ID:SGTC_289|Compound:k017-0060|FD-Score:-2.92|P-value:1.39E-4 ID:SGTC_388|Compound:3',4'-dichloroisocoumarin|FD-Score:3.37|P-value:2.13E-5 ID:SGTC_393|Compound:acivicin|FD-Score:3.01|P-value:1.31E-4 ID:SGTC_408|Compound:cantharidin|FD-Score:4.14|P-value:2.36E-7 ID:SGTC_489|Compound:paxilline|FD-Score:2.94|P-value:1.78E-4 ID:SGTC_577|Compound:r071-0003|FD-Score:-2.89|P-value:1.59E-4 ID:SGTC_659|Compound:k018-0002|FD-Score:2.60|P-value:8.36E-4 ID:SGTC_663|Compound:1486-0733|FD-Score:2.77|P-value:4.02E-4 ID:SGTC_761|Compound:k216-0224|FD-Score:3.06|P-value:1.04E-4 ID:SGTC_797|Compound:k781-0471|FD-Score:2.60|P-value:8.20E-4 ID:SGTC_798|Compound:1287-0182|FD-Score:2.60|P-value:8.07E-4 ID:SGTC_865|Compound:0488-0499|FD-Score:3.84|P-value:1.49E-6 ID:SGTC_866|Compound:0495-0101|FD-Score:5.27|P-value:6.37E-11 ID:SGTC_872|Compound:0588-0139|FD-Score:4.22|P-value:1.43E-7 ID:SGTC_873|Compound:0591-4978|FD-Score:6.55|P-value:6.04E-16 ID:SGTC_875|Compound:0709-0210|FD-Score:3.86|P-value:1.32E-6 ID:SGTC_939|Compound:1165-0479|FD-Score:5.57|P-value:5.40E-12 ID:SGTC_976|Compound:1348-1067|FD-Score:4.46|P-value:2.78E-8 ID:SGTC_987|Compound:1497-1013|FD-Score:2.97|P-value:1.56E-4 ID:SGTC_1000|Compound:4048-0884|FD-Score:2.90|P-value:2.18E-4 ID:SGTC_1045|Compound:1348-1485|FD-Score:-3.17|P-value:4.00E-5 ID:SGTC_1051|Compound:3253-3903|FD-Score:-3.05|P-value:7.45E-5 ID:SGTC_1127|Compound:asiatic acid|FD-Score:-3.27|P-value:2.45E-5 ID:SGTC_1128|Compound:3448-9350|FD-Score:-3.06|P-value:7.21E-5 ID:SGTC_1306|Compound:1185-0270|FD-Score:8.25|P-value:3.07E-24 ID:SGTC_1496|Compound:4469-0713|FD-Score:3.62|P-value:5.52E-6 ID:SGTC_1537|Compound:2',6'-dihydroxyflavanone|FD-Score:-2.49|P-value:9.39E-4 ID:SGTC_1702|Compound:st027038|FD-Score:2.70|P-value:5.38E-4 ID:SGTC_1717|Compound:st033143|FD-Score:3.60|P-value:6.05E-6 ID:SGTC_1727|Compound:st034309|FD-Score:5.76|P-value:1.00E-12 ID:SGTC_1736|Compound:st036774|FD-Score:2.61|P-value:7.86E-4 ID:SGTC_2033|Compound:5192550|FD-Score:-2.68|P-value:4.28E-4 ID:SGTC_2039|Compound:Aminomethylbenzodioxan|FD-Score:-2.60|P-value:5.86E-4 ID:SGTC_2096|Compound:5468907|FD-Score:2.57|P-value:9.44E-4 ID:SGTC_2330|Compound:7979373|FD-Score:-3.19|P-value:3.59E-5 ID:SGTC_2405|Compound:ticlatone|FD-Score:-2.54|P-value:7.69E-4 ID:SGTC_2415|Compound:st077333|FD-Score:2.79|P-value:3.60E-4 ID:SGTC_2502|Compound:avocadyne acetate|FD-Score:-3.62|P-value:3.47E-6 ID:SGTC_2532|Compound:xanthone|FD-Score:2.59|P-value:8.67E-4 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:3.52|P-value:9.59E-6 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:-3.40|P-value:1.19E-5 ID:SGTC_2688|Compound:kanamycin b|FD-Score:-4.90|P-value:6.26E-10 ID:SGTC_2795|Compound:7780010|FD-Score:3.68|P-value:3.89E-6 ID:SGTC_2800|Compound:7887935|FD-Score:-2.72|P-value:3.51E-4 ID:SGTC_2803|Compound:7707263|FD-Score:-3.44|P-value:9.76E-6 ID:SGTC_2851|Compound:9015922|FD-Score:3.52|P-value:9.24E-6 ID:SGTC_2943|Compound:9068529|FD-Score:2.58|P-value:9.10E-4 ID:SGTC_3125|Compound:9127534|FD-Score:3.75|P-value:2.58E-6 ID:SGTC_3133|Compound:9127736|FD-Score:2.77|P-value:3.94E-4 ID:SGTC_3191|Compound:9110352|FD-Score:-3.57|P-value:4.60E-6 ID:SGTC_3195|Compound:9113082|FD-Score:2.67|P-value:6.02E-4 ID:SGTC_3210|Compound:9128157|FD-Score:-3.32|P-value:1.80E-5 ID:SGTC_3345|Compound:9148410|FD-Score:2.62|P-value:7.41E-4 ID:SGTC_49|Compound:0717-0965|FD-Score:2.65|P-value:6.64E-4 ID:SGTC_141|Compound:0443-0274|FD-Score:2.87|P-value:2.49E-4 ID:SGTC_289|Compound:k017-0060|FD-Score:-2.92|P-value:1.39E-4 ID:SGTC_388|Compound:3',4'-dichloroisocoumarin|FD-Score:3.37|P-value:2.13E-5 ID:SGTC_393|Compound:acivicin|FD-Score:3.01|P-value:1.31E-4 ID:SGTC_408|Compound:cantharidin|FD-Score:4.14|P-value:2.36E-7 ID:SGTC_489|Compound:paxilline|FD-Score:2.94|P-value:1.78E-4 ID:SGTC_577|Compound:r071-0003|FD-Score:-2.89|P-value:1.59E-4 ID:SGTC_659|Compound:k018-0002|FD-Score:2.60|P-value:8.36E-4 ID:SGTC_663|Compound:1486-0733|FD-Score:2.77|P-value:4.02E-4 ID:SGTC_761|Compound:k216-0224|FD-Score:3.06|P-value:1.04E-4 ID:SGTC_797|Compound:k781-0471|FD-Score:2.60|P-value:8.20E-4 ID:SGTC_798|Compound:1287-0182|FD-Score:2.60|P-value:8.07E-4 ID:SGTC_865|Compound:0488-0499|FD-Score:3.84|P-value:1.49E-6 ID:SGTC_866|Compound:0495-0101|FD-Score:5.27|P-value:6.37E-11 ID:SGTC_872|Compound:0588-0139|FD-Score:4.22|P-value:1.43E-7 ID:SGTC_873|Compound:0591-4978|FD-Score:6.55|P-value:6.04E-16 ID:SGTC_875|Compound:0709-0210|FD-Score:3.86|P-value:1.32E-6 ID:SGTC_939|Compound:1165-0479|FD-Score:5.57|P-value:5.40E-12 ID:SGTC_976|Compound:1348-1067|FD-Score:4.46|P-value:2.78E-8 ID:SGTC_987|Compound:1497-1013|FD-Score:2.97|P-value:1.56E-4 ID:SGTC_1000|Compound:4048-0884|FD-Score:2.90|P-value:2.18E-4 ID:SGTC_1045|Compound:1348-1485|FD-Score:-3.17|P-value:4.00E-5 ID:SGTC_1051|Compound:3253-3903|FD-Score:-3.05|P-value:7.45E-5 ID:SGTC_1127|Compound:asiatic acid|FD-Score:-3.27|P-value:2.45E-5 ID:SGTC_1128|Compound:3448-9350|FD-Score:-3.06|P-value:7.21E-5 ID:SGTC_1306|Compound:1185-0270|FD-Score:8.25|P-value:3.07E-24 ID:SGTC_1496|Compound:4469-0713|FD-Score:3.62|P-value:5.52E-6 ID:SGTC_1537|Compound:2',6'-dihydroxyflavanone|FD-Score:-2.49|P-value:9.39E-4 ID:SGTC_1702|Compound:st027038|FD-Score:2.70|P-value:5.38E-4 ID:SGTC_1717|Compound:st033143|FD-Score:3.60|P-value:6.05E-6 ID:SGTC_1727|Compound:st034309|FD-Score:5.76|P-value:1.00E-12 ID:SGTC_1736|Compound:st036774|FD-Score:2.61|P-value:7.86E-4 ID:SGTC_2033|Compound:5192550|FD-Score:-2.68|P-value:4.28E-4 ID:SGTC_2039|Compound:Aminomethylbenzodioxan|FD-Score:-2.60|P-value:5.86E-4 ID:SGTC_2096|Compound:5468907|FD-Score:2.57|P-value:9.44E-4 ID:SGTC_2330|Compound:7979373|FD-Score:-3.19|P-value:3.59E-5 ID:SGTC_2405|Compound:ticlatone|FD-Score:-2.54|P-value:7.69E-4 ID:SGTC_2415|Compound:st077333|FD-Score:2.79|P-value:3.60E-4 ID:SGTC_2502|Compound:avocadyne acetate|FD-Score:-3.62|P-value:3.47E-6 ID:SGTC_2532|Compound:xanthone|FD-Score:2.59|P-value:8.67E-4 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:3.52|P-value:9.59E-6 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:-3.40|P-value:1.19E-5 ID:SGTC_2688|Compound:kanamycin b|FD-Score:-4.90|P-value:6.26E-10 ID:SGTC_2795|Compound:7780010|FD-Score:3.68|P-value:3.89E-6 ID:SGTC_2800|Compound:7887935|FD-Score:-2.72|P-value:3.51E-4 ID:SGTC_2803|Compound:7707263|FD-Score:-3.44|P-value:9.76E-6 ID:SGTC_2851|Compound:9015922|FD-Score:3.52|P-value:9.24E-6 ID:SGTC_2943|Compound:9068529|FD-Score:2.58|P-value:9.10E-4 ID:SGTC_3125|Compound:9127534|FD-Score:3.75|P-value:2.58E-6 ID:SGTC_3133|Compound:9127736|FD-Score:2.77|P-value:3.94E-4 ID:SGTC_3191|Compound:9110352|FD-Score:-3.57|P-value:4.60E-6 ID:SGTC_3195|Compound:9113082|FD-Score:2.67|P-value:6.02E-4 ID:SGTC_3210|Compound:9128157|FD-Score:-3.32|P-value:1.80E-5 ID:SGTC_3345|Compound:9148410|FD-Score:2.62|P-value:7.41E-4

Top fitness defect scores for YPR176C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1306 1185-0270 8.25 9.0 µM 3.07E-24 Golgi 2 7.92E-17 0.53
2 SGTC_873 0591-4978 6.55 488.0 µM 6.04E-16 1 2.84E-11 1.73
3 SGTC_1727 st034309 5.76 9.9 µM 1.00E-12 4 4.13E-9 0.45
4 SGTC_939 1165-0479 5.57 45.3 µM 5.40E-12 2 1.28E-8 0.92
5 SGTC_866 0495-0101 5.27 262.0 µM 6.37E-11 60S ribosome export 3 6.76E-8 0.26
6 SGTC_976 1348-1067 4.46 47.6 µM 2.78E-8 60S ribosome export 5 4.11E-6 0.35
7 SGTC_872 0588-0139 4.22 234.0 µM 1.43E-7 4 1.24E-5 0.40
8 SGTC_408 cantharidin 4.14 100.0 µM 2.36E-7 cell wall signaling 7 1.75E-5 0.01
9 SGTC_875 0709-0210 3.86 25.7 µM 1.32E-6 fatty acid desaturase (OLE1) 13 5.64E-5 0.28
10 SGTC_865 0488-0499 3.84 301.0 µM 1.49E-6 4 6.12E-5 0.33
11 SGTC_3125 9127534 3.75 49.5 µM 2.58E-6 3 8.92E-5 0.30
12 SGTC_2795 7780010 3.68 54.5 µM 3.89E-6 8 1.18E-4 0.26
13 SGTC_1496 4469-0713 3.62 57.4 µM 5.52E-6 4 1.50E-4 0.02
14 SGTC_1717 st033143 3.60 58.0 µM 6.05E-6 9 1.59E-4 0.46
15 SGTC_2851 9015922 3.52 71.4 µM 9.24E-6 10 2.13E-4 0.03
16 SGTC_2621 lithochol-11-enic acid 3.52 100.0 µM 9.59E-6 10 2.18E-4 0.04
17 SGTC_388 3',4'-dichloroisocoumarin 3.37 16.7 µM 2.13E-5 10 3.77E-4 0.01
18 SGTC_761 k216-0224 3.06 480.0 µM 1.04E-4 19 0.00112 0.12
19 SGTC_393 acivicin 3.01 6.2 µM 1.31E-4 21 0.00131 0.01
20 SGTC_987 1497-1013 2.97 404.0 µM 1.56E-4 11 0.00148 0.01

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.208 4.06E-34 YFL052W_p YFL052W_p hom Putative zinc cluster protein that contains a DNA binding domain; computational analysis suggests a role as a transcription factor; null mutant is sensitive to Calcofluor White, low osmolarity, and heat, suggesting a role for YFL052Wp in cell wall integrity
0.160 1.09E-20 YLR309C IMH1 hom Protein involved in vesicular transport, mediates transport between an endosomal compartment and the Golgi, contains a Golgi-localization (GRIP) domain that interacts with activated Arl1p-GTP to localize Imh1p to the Golgi
0.140 3.17E-16 YPR175W DPB2 het Second largest subunit of DNA polymerase II (DNA polymerase epsilon), required for maintenance of fidelity of chromosomal replication; expression peaks at the G1/S phase boundary; Cdc28p substrate
0.117 1.12E-11 YER188W_d YER188W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; large-scale analyses show mRNA expression increases under anaerobic conditions and two-hybrid interactions with Sst2p
0.115 2.09E-11 YLR190W MMR1 hom Phosphorylated protein of the mitochondrial outer membrane, localizes only to mitochondria of the bud; interacts with Myo2p to mediate mitochondrial distribution to buds; mRNA is targeted to the bud via the transport system involving She2p
0.109 2.33E-10 YAR027W UIP3 hom Putative integral membrane protein of unknown function; interacts with Ulp1p at the nuclear periphery; member of DUP240 gene family
0.109 2.93E-10 YBR150C TBS1 hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; TBS1 has a paralog, HAL9, that arose from the whole genome duplication
0.105 9.66E-10 YLR401C DUS3 hom Dihydrouridine synthase; member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus4p; contains a consensus oleate response element (ORE) in its promoter region; forms nuclear foci upon DNA replication stress
0.102 3.20E-9 YLR269C_d YLR269C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.100 6.01E-9 YJL032W_d YJL032W_d het Dubious open reading frame unlikely to encode a functional protein; overlaps 3' end of essential BET4 gene encoding the alpha subunit of Type II geranylgeranyltransferase
0.100 6.31E-9 YBR164C ARL1 hom Soluble GTPase with a role in regulation of membrane traffic; regulates potassium influx; G protein of the Ras superfamily, similar to ADP-ribosylation factor
0.099 8.06E-9 YER140W EMP65 hom ER membrane protein of unknown function; forms an ER-membrane associated protein complex with Slp1p; identified along with SLP1 in a screen for mutants defective in the unfolded protein response (UPR); proposed to function in the folding of integral membrane proteins; interacts genetically with MPS1; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.098 1.36E-8 YOR335C ALA1 het Cytoplasmic and mitochondrial alanyl-tRNA synthetase, required for protein synthesis; point mutation (cdc64-1 allele) causes cell cycle arrest at G1; lethality of null mutation is functionally complemented by human homolog
0.096 2.80E-8 YMR195W ICY1 hom Protein of unknown function, required for viability in rich media of cells lacking mitochondrial DNA; mutants have an invasive growth defect with elongated morphology; induced by amino acid starvation
0.093 7.15E-8 YIR009W MSL1 hom U2B component of U2 snRNP, involved in splicing, binds the U2 snRNA stem-loop IV in vitro but requires association of Lea1p for in vivo binding; does not contain the conserved C-terminal RNA binding domain found in other family members