YPR177C_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the 5' end of the essential PRP4 gene encoding a component of the U4/U6-U5 snRNP complex

Zygosity: Heterozygous strain
fixedexpanded
Profile for YPR177C / YPR177C

Click on Significant Values for Screen Details ID:SGTC_147|Compound:4466-0538|FD-Score:3.19|P-value:5.86E-4 ID:SGTC_481|Compound:bay k-8644|FD-Score:3.83|P-value:5.03E-5 ID:SGTC_865|Compound:0488-0499|FD-Score:-3.70|P-value:1.01E-4 ID:SGTC_1015|Compound:4130-4525|FD-Score:6.67|P-value:6.95E-12 ID:SGTC_1022|Compound:4477-0945|FD-Score:-3.50|P-value:2.22E-4 ID:SGTC_1132|Compound:3456-3614|FD-Score:-3.20|P-value:6.60E-4 ID:SGTC_1200|Compound:1643-0193|FD-Score:-3.96|P-value:3.52E-5 ID:SGTC_1203|Compound:3992-3522|FD-Score:5.30|P-value:3.95E-8 ID:SGTC_1437|Compound:4092-1038|FD-Score:3.05|P-value:9.61E-4 ID:SGTC_1747|Compound:st037496|FD-Score:3.52|P-value:1.78E-4 ID:SGTC_1938|Compound:st074717|FD-Score:-3.38|P-value:3.46E-4 ID:SGTC_1984|Compound:st072354|FD-Score:-3.69|P-value:1.09E-4 ID:SGTC_1988|Compound:st071872|FD-Score:-3.23|P-value:5.99E-4 ID:SGTC_1997|Compound:st073024|FD-Score:-3.28|P-value:5.11E-4 ID:SGTC_2025|Compound:5147754|FD-Score:-4.87|P-value:4.88E-7 ID:SGTC_2027|Compound:5150920|FD-Score:-3.44|P-value:2.84E-4 ID:SGTC_2032|Compound:5185112|FD-Score:-3.65|P-value:1.23E-4 ID:SGTC_2076|Compound:5212012|FD-Score:-3.35|P-value:3.91E-4 ID:SGTC_2341|Compound:7987486|FD-Score:-3.95|P-value:3.73E-5 ID:SGTC_2346|Compound:9031566|FD-Score:-3.20|P-value:6.75E-4 ID:SGTC_2349|Compound:9023730|FD-Score:3.05|P-value:9.70E-4 ID:SGTC_2571|Compound:chrysanthemic acid|FD-Score:5.50|P-value:1.22E-8 ID:SGTC_2607|Compound:solasodine|FD-Score:6.64|P-value:8.86E-12 ID:SGTC_2762|Compound:leflunomide|FD-Score:4.02|P-value:2.25E-5 ID:SGTC_2763|Compound:lisinopril|FD-Score:-4.42|P-value:4.54E-6 ID:SGTC_2791|Compound:5663188|FD-Score:-3.68|P-value:1.10E-4 ID:SGTC_2857|Compound:9024691|FD-Score:3.27|P-value:4.49E-4 ID:SGTC_2858|Compound:9025781|FD-Score:3.41|P-value:2.67E-4 ID:SGTC_2868|Compound:9035608|FD-Score:3.23|P-value:5.09E-4 ID:SGTC_2931|Compound:9014674|FD-Score:4.01|P-value:2.32E-5 ID:SGTC_2935|Compound:9038016|FD-Score:-5.08|P-value:1.68E-7 ID:SGTC_2944|Compound:9067346|FD-Score:3.23|P-value:5.12E-4 ID:SGTC_2962|Compound:9082311|FD-Score:3.40|P-value:2.80E-4 ID:SGTC_3080|Compound:9117754|FD-Score:3.19|P-value:5.90E-4 ID:SGTC_3217|Compound:9129673|FD-Score:3.20|P-value:5.69E-4 ID:SGTC_3301|Compound:9125354|FD-Score:3.15|P-value:6.71E-4 ID:SGTC_3313|Compound:9133968|FD-Score:-3.79|P-value:7.17E-5 ID:SGTC_147|Compound:4466-0538|FD-Score:3.19|P-value:5.86E-4 ID:SGTC_481|Compound:bay k-8644|FD-Score:3.83|P-value:5.03E-5 ID:SGTC_865|Compound:0488-0499|FD-Score:-3.70|P-value:1.01E-4 ID:SGTC_1015|Compound:4130-4525|FD-Score:6.67|P-value:6.95E-12 ID:SGTC_1022|Compound:4477-0945|FD-Score:-3.50|P-value:2.22E-4 ID:SGTC_1132|Compound:3456-3614|FD-Score:-3.20|P-value:6.60E-4 ID:SGTC_1200|Compound:1643-0193|FD-Score:-3.96|P-value:3.52E-5 ID:SGTC_1203|Compound:3992-3522|FD-Score:5.30|P-value:3.95E-8 ID:SGTC_1437|Compound:4092-1038|FD-Score:3.05|P-value:9.61E-4 ID:SGTC_1747|Compound:st037496|FD-Score:3.52|P-value:1.78E-4 ID:SGTC_1938|Compound:st074717|FD-Score:-3.38|P-value:3.46E-4 ID:SGTC_1984|Compound:st072354|FD-Score:-3.69|P-value:1.09E-4 ID:SGTC_1988|Compound:st071872|FD-Score:-3.23|P-value:5.99E-4 ID:SGTC_1997|Compound:st073024|FD-Score:-3.28|P-value:5.11E-4 ID:SGTC_2025|Compound:5147754|FD-Score:-4.87|P-value:4.88E-7 ID:SGTC_2027|Compound:5150920|FD-Score:-3.44|P-value:2.84E-4 ID:SGTC_2032|Compound:5185112|FD-Score:-3.65|P-value:1.23E-4 ID:SGTC_2076|Compound:5212012|FD-Score:-3.35|P-value:3.91E-4 ID:SGTC_2341|Compound:7987486|FD-Score:-3.95|P-value:3.73E-5 ID:SGTC_2346|Compound:9031566|FD-Score:-3.20|P-value:6.75E-4 ID:SGTC_2349|Compound:9023730|FD-Score:3.05|P-value:9.70E-4 ID:SGTC_2571|Compound:chrysanthemic acid|FD-Score:5.50|P-value:1.22E-8 ID:SGTC_2607|Compound:solasodine|FD-Score:6.64|P-value:8.86E-12 ID:SGTC_2762|Compound:leflunomide|FD-Score:4.02|P-value:2.25E-5 ID:SGTC_2763|Compound:lisinopril|FD-Score:-4.42|P-value:4.54E-6 ID:SGTC_2791|Compound:5663188|FD-Score:-3.68|P-value:1.10E-4 ID:SGTC_2857|Compound:9024691|FD-Score:3.27|P-value:4.49E-4 ID:SGTC_2858|Compound:9025781|FD-Score:3.41|P-value:2.67E-4 ID:SGTC_2868|Compound:9035608|FD-Score:3.23|P-value:5.09E-4 ID:SGTC_2931|Compound:9014674|FD-Score:4.01|P-value:2.32E-5 ID:SGTC_2935|Compound:9038016|FD-Score:-5.08|P-value:1.68E-7 ID:SGTC_2944|Compound:9067346|FD-Score:3.23|P-value:5.12E-4 ID:SGTC_2962|Compound:9082311|FD-Score:3.40|P-value:2.80E-4 ID:SGTC_3080|Compound:9117754|FD-Score:3.19|P-value:5.90E-4 ID:SGTC_3217|Compound:9129673|FD-Score:3.20|P-value:5.69E-4 ID:SGTC_3301|Compound:9125354|FD-Score:3.15|P-value:6.71E-4 ID:SGTC_3313|Compound:9133968|FD-Score:-3.79|P-value:7.17E-5

Top fitness defect scores for YPR177C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1015 4130-4525 6.67 82.0 µM 6.95E-12 60S ribosome export 3 1.25E-11 0.45
2 SGTC_2607 solasodine 6.64 47.4 µM 8.86E-12 1 1.58E-11 0.68
3 SGTC_2571 chrysanthemic acid 5.50 100.0 µM 1.22E-8 1 1.86E-8 0.99
4 SGTC_1203 3992-3522 5.30 103.0 µM 3.95E-8 5 5.89E-8 0.35
5 SGTC_2762 leflunomide 4.02 42.1 µM 2.25E-5 3 2.92E-5 0.18
6 SGTC_2931 9014674 4.01 55.7 µM 2.32E-5 6 3.00E-5 0.37
7 SGTC_481 bay k-8644 3.83 50.0 µM 5.03E-5 4 6.39E-5 0.04
8 SGTC_1747 st037496 3.52 66.6 µM 1.78E-4 14 2.20E-4 0.25
9 SGTC_2858 9025781 3.41 9.0 µM 2.67E-4 sphingolipid biosynthesis & PDR1 20 3.26E-4 0.01
10 SGTC_2962 9082311 3.40 13.2 µM 2.80E-4 19 3.42E-4 0.02
11 SGTC_2857 9024691 3.27 58.4 µM 4.49E-4 7 5.43E-4 0.10
12 SGTC_2868 9035608 3.23 32.5 µM 5.09E-4 6 6.14E-4 0.21
13 SGTC_2944 9067346 3.23 25.6 µM 5.12E-4 18 6.17E-4 0.06
14 SGTC_3217 9129673 3.20 49.5 µM 5.69E-4 22 6.85E-4 0.02
15 SGTC_147 4466-0538 3.19 29.2 µM 5.86E-4 ergosterol biosynthesis 22 7.05E-4 0.01
16 SGTC_3080 9117754 3.19 49.5 µM 5.90E-4 12 7.09E-4 0.07
17 SGTC_3301 9125354 3.15 19.8 µM 6.71E-4 7 8.04E-4 0.02
18 SGTC_1437 4092-1038 3.05 11.6 µM 9.61E-4 13 0.00114 0.03
19 SGTC_2349 9023730 3.05 187.1 µM 9.70E-4 9 0.00115 0.05
20 SGTC_2930 9013230 2.95 14.9 µM 0.00134 heme biosynthesis & mitochondrial translocase 39 0.00158 0.03

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.279 3.70E-61 YMR031C EIS1 hom Component of the eisosome required for proper eisosome assembly; similarity to Ykl050cp and Uso1p; the authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies; protein increases in abundance and relocalizes from plasma membrane to cytoplasm upon DNA replication stress
0.166 3.19E-22 YEL040W UTR2 hom Chitin transglycosylase that functions in the transfer of chitin to beta(1-6) and beta(1-3) glucans in the cell wall; similar to and functionally redundant with Crh1; glycosylphosphatidylinositol (GPI)-anchored protein localized to bud neck
0.153 5.59E-19 YOL052C SPE2 hom S-adenosylmethionine decarboxylase, required for the biosynthesis of spermidine and spermine; cells lacking Spe2p require spermine or spermidine for growth in the presence of oxygen but not when grown anaerobically
0.147 1.01E-17 YGR096W TPC1 hom Mitochondrial membrane transporter that mediates uptake of the essential cofactor thiamine pyrophosphate (ThPP) into mitochondria; expression appears to be regulated by carbon source; member of the mitochondrial carrier family
0.141 2.08E-16 YFL034C-B MOB2 het Activator of Cbk1p kinase; component of the RAM signaling network that regulates cellular polarity and morphogenesis; activation of Cbk1p facilitates the Ace2p-dependent daughter cell-specific transcription of genes involved in cell separation; similar to Mob1p
0.139 6.88E-16 YGR110W CLD1 hom Mitochondrial cardiolipin-specific phospholipase; functions upstream of Taz1p to generate monolyso-cardiolipin; transcription increases upon genotoxic stress; involved in restricting Ty1 transposition; has homology to mammalian CGI-58
0.138 8.49E-16 YDR206W EBS1 hom Protein involved in inhibition of translation and nonsense-mediated decay; interacts with cap binding protein Cdc33p and with Nam7p; localizes to P-bodies upon glucose starvation; mRNA abundance regulated by mRNA decay factors
0.136 2.92E-15 YDR143C SAN1 hom Ubiquitin-protein ligase; involved in the proteasome-dependent degradation of aberrant nuclear proteins; targets substrates with regions of exposed hydrophobicity containing 5 or more contiguous hydrophobic residues; contains intrinsically disordered regions that contribute to substrate recognition
0.131 2.93E-14 YHR182W YHR182W hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and cytoplasm; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.124 6.18E-13 YLR186W EMG1 het Methyltransferase for rRNA; catalyzes methylation of the pseudouridine residue 1191 of 18S rRNA; member of the SPOUT methyltransferase family; required for maturation of 18S rRNA and for 40S ribosomal subunit production independently of methyltransferase activity; forms homodimers; human ortholog is mutated in Bowen-Conradi syndrome, and the equivalent mutation in yeast affects Emg1p dimerization and localization but not its methyltransferase activity
0.121 2.22E-12 YGL145W TIP20 het Peripheral membrane protein required for fusion of COPI vesicles with the ER; prohibits back-fusion of COPII vesicles with the ER; forms a tethering complex with Sec39p and Dsl1p that interacts with ER SNAREs Sec20p and Use1p
0.120 2.77E-12 YGR247W CPD1 hom Cyclic nucleotide phosphodiesterase; hydrolyzes ADP-ribose 1'', 2''-cyclic phosphate to ADP-ribose 1''-phosphate; may have a role in tRNA splicing; no detectable phenotype is conferred by null mutation or by overexpression; protein abundance increases in response to DNA replication stress
0.120 3.03E-12 YML054C CYB2 hom Cytochrome b2 (L-lactate cytochrome-c oxidoreductase), component of the mitochondrial intermembrane space, required for lactate utilization; expression is repressed by glucose and anaerobic conditions
0.119 5.54E-12 YML091C RPM2 het Protein subunit of mitochondrial RNase P, has roles in nuclear transcription, cytoplasmic and mitochondrial RNA processing, and mitochondrial translation; distributed to mitochondria, cytoplasmic processing bodies, and the nucleus
0.116 1.42E-11 YER046W SPO73 hom Meiosis-specific protein of unknown function, required for spore wall formation during sporulation; dispensible for both nuclear divisions during meiosis