YPR179C / HDA3

Subunit of a possibly tetrameric trichostatin A-sensitive class II histone deacetylase complex that contains an Hda1p homodimer and an Hda2p-Hda3p heterodimer; required for the activity of the complex; has similarity to Hda2p

Zygosity: Homozygous strain
fixedexpanded
Profile for YPR179C / HDA3

Click on Significant Values for Screen Details ID:SGTC_41|Compound:0478-0632|FD-Score:4.91|P-value:3.95E-7 ID:SGTC_102|Compound:gallobenzophenone|FD-Score:3.79|P-value:7.02E-5 ID:SGTC_157|Compound:1348-1695|FD-Score:4.66|P-value:1.40E-6 ID:SGTC_159|Compound:3970-0959|FD-Score:-4.01|P-value:2.73E-5 ID:SGTC_207|Compound:4185-0010|FD-Score:3.29|P-value:4.76E-4 ID:SGTC_227|Compound:fluconazole|FD-Score:4.47|P-value:3.49E-6 ID:SGTC_257|Compound:daunorubicin|FD-Score:3.32|P-value:4.25E-4 ID:SGTC_263|Compound:alizarin|FD-Score:4.35|P-value:6.09E-6 ID:SGTC_304|Compound:1310-0298|FD-Score:-4.38|P-value:5.13E-6 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:-5.77|P-value:3.18E-9 ID:SGTC_525|Compound:k781-2675|FD-Score:-3.23|P-value:5.69E-4 ID:SGTC_532|Compound:1548-0774|FD-Score:4.26|P-value:9.36E-6 ID:SGTC_533|Compound:1222-0222|FD-Score:6.35|P-value:8.65E-11 ID:SGTC_654|Compound:1124-0271|FD-Score:3.69|P-value:1.05E-4 ID:SGTC_658|Compound:3253-0951|FD-Score:3.97|P-value:3.24E-5 ID:SGTC_781|Compound:4335-2806|FD-Score:3.80|P-value:6.65E-5 ID:SGTC_790|Compound:1575-0012|FD-Score:4.43|P-value:4.14E-6 ID:SGTC_848|Compound:0368-0089|FD-Score:3.10|P-value:9.26E-4 ID:SGTC_961|Compound:1252-1571|FD-Score:-5.38|P-value:3.16E-8 ID:SGTC_964|Compound:1287-0107|FD-Score:-4.84|P-value:5.46E-7 ID:SGTC_1023|Compound:4482-3888|FD-Score:5.08|P-value:1.64E-7 ID:SGTC_1070|Compound:indatraline|FD-Score:4.33|P-value:6.79E-6 ID:SGTC_1084|Compound:voriconazole|FD-Score:5.35|P-value:3.76E-8 ID:SGTC_1136|Compound:pergolide|FD-Score:3.12|P-value:8.64E-4 ID:SGTC_1241|Compound:0364-0022|FD-Score:-3.16|P-value:7.37E-4 ID:SGTC_1264|Compound:0783-0040|FD-Score:3.14|P-value:7.87E-4 ID:SGTC_1364|Compound:1653-0028|FD-Score:3.86|P-value:5.30E-5 ID:SGTC_1495|Compound:4469-0029|FD-Score:7.04|P-value:7.03E-13 ID:SGTC_1634|Compound:st006576|FD-Score:3.28|P-value:4.92E-4 ID:SGTC_1672|Compound:st016598|FD-Score:-3.58|P-value:1.59E-4 ID:SGTC_1677|Compound:st019204|FD-Score:-3.27|P-value:5.00E-4 ID:SGTC_1684|Compound:st024538|FD-Score:3.40|P-value:3.15E-4 ID:SGTC_1702|Compound:st027038|FD-Score:5.37|P-value:3.28E-8 ID:SGTC_1758|Compound:st042942|FD-Score:3.14|P-value:7.90E-4 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:-3.46|P-value:2.46E-4 ID:SGTC_1865|Compound:st057639|FD-Score:-3.71|P-value:9.48E-5 ID:SGTC_1884|Compound:5633444|FD-Score:-3.29|P-value:4.72E-4 ID:SGTC_2082|Compound:5219693|FD-Score:-3.51|P-value:2.04E-4 ID:SGTC_2129|Compound:girgensonine|FD-Score:3.51|P-value:2.07E-4 ID:SGTC_2166|Compound:5933061|FD-Score:3.41|P-value:2.99E-4 ID:SGTC_2173|Compound:5763948|FD-Score:3.51|P-value:2.10E-4 ID:SGTC_2365|Compound:9042475|FD-Score:3.69|P-value:1.05E-4 ID:SGTC_2406|Compound:ethylparaben|FD-Score:3.96|P-value:3.40E-5 ID:SGTC_2415|Compound:st077333|FD-Score:3.76|P-value:7.81E-5 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:3.13|P-value:8.39E-4 ID:SGTC_2612|Compound:dictamnine|FD-Score:-3.15|P-value:7.66E-4 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:-3.61|P-value:1.42E-4 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:4.37|P-value:5.67E-6 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:-3.34|P-value:3.88E-4 ID:SGTC_2628|Compound:lathosterol|FD-Score:4.42|P-value:4.43E-6 ID:SGTC_2784|Compound:7567673|FD-Score:5.13|P-value:1.27E-7 ID:SGTC_2896|Compound:9052656|FD-Score:3.70|P-value:9.98E-5 ID:SGTC_2929|Compound:9013348|FD-Score:-4.59|P-value:1.91E-6 ID:SGTC_2934|Compound:9036370|FD-Score:3.42|P-value:2.90E-4 ID:SGTC_3009|Compound:9080819|FD-Score:3.80|P-value:6.79E-5 ID:SGTC_3080|Compound:9117754|FD-Score:3.69|P-value:1.04E-4 ID:SGTC_3087|Compound:9117406|FD-Score:3.16|P-value:7.36E-4 ID:SGTC_3278|Compound:9139605|FD-Score:-3.56|P-value:1.69E-4 ID:SGTC_41|Compound:0478-0632|FD-Score:4.91|P-value:3.95E-7 ID:SGTC_102|Compound:gallobenzophenone|FD-Score:3.79|P-value:7.02E-5 ID:SGTC_157|Compound:1348-1695|FD-Score:4.66|P-value:1.40E-6 ID:SGTC_159|Compound:3970-0959|FD-Score:-4.01|P-value:2.73E-5 ID:SGTC_207|Compound:4185-0010|FD-Score:3.29|P-value:4.76E-4 ID:SGTC_227|Compound:fluconazole|FD-Score:4.47|P-value:3.49E-6 ID:SGTC_257|Compound:daunorubicin|FD-Score:3.32|P-value:4.25E-4 ID:SGTC_263|Compound:alizarin|FD-Score:4.35|P-value:6.09E-6 ID:SGTC_304|Compound:1310-0298|FD-Score:-4.38|P-value:5.13E-6 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:-5.77|P-value:3.18E-9 ID:SGTC_525|Compound:k781-2675|FD-Score:-3.23|P-value:5.69E-4 ID:SGTC_532|Compound:1548-0774|FD-Score:4.26|P-value:9.36E-6 ID:SGTC_533|Compound:1222-0222|FD-Score:6.35|P-value:8.65E-11 ID:SGTC_654|Compound:1124-0271|FD-Score:3.69|P-value:1.05E-4 ID:SGTC_658|Compound:3253-0951|FD-Score:3.97|P-value:3.24E-5 ID:SGTC_781|Compound:4335-2806|FD-Score:3.80|P-value:6.65E-5 ID:SGTC_790|Compound:1575-0012|FD-Score:4.43|P-value:4.14E-6 ID:SGTC_848|Compound:0368-0089|FD-Score:3.10|P-value:9.26E-4 ID:SGTC_961|Compound:1252-1571|FD-Score:-5.38|P-value:3.16E-8 ID:SGTC_964|Compound:1287-0107|FD-Score:-4.84|P-value:5.46E-7 ID:SGTC_1023|Compound:4482-3888|FD-Score:5.08|P-value:1.64E-7 ID:SGTC_1070|Compound:indatraline|FD-Score:4.33|P-value:6.79E-6 ID:SGTC_1084|Compound:voriconazole|FD-Score:5.35|P-value:3.76E-8 ID:SGTC_1136|Compound:pergolide|FD-Score:3.12|P-value:8.64E-4 ID:SGTC_1241|Compound:0364-0022|FD-Score:-3.16|P-value:7.37E-4 ID:SGTC_1264|Compound:0783-0040|FD-Score:3.14|P-value:7.87E-4 ID:SGTC_1364|Compound:1653-0028|FD-Score:3.86|P-value:5.30E-5 ID:SGTC_1495|Compound:4469-0029|FD-Score:7.04|P-value:7.03E-13 ID:SGTC_1634|Compound:st006576|FD-Score:3.28|P-value:4.92E-4 ID:SGTC_1672|Compound:st016598|FD-Score:-3.58|P-value:1.59E-4 ID:SGTC_1677|Compound:st019204|FD-Score:-3.27|P-value:5.00E-4 ID:SGTC_1684|Compound:st024538|FD-Score:3.40|P-value:3.15E-4 ID:SGTC_1702|Compound:st027038|FD-Score:5.37|P-value:3.28E-8 ID:SGTC_1758|Compound:st042942|FD-Score:3.14|P-value:7.90E-4 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:-3.46|P-value:2.46E-4 ID:SGTC_1865|Compound:st057639|FD-Score:-3.71|P-value:9.48E-5 ID:SGTC_1884|Compound:5633444|FD-Score:-3.29|P-value:4.72E-4 ID:SGTC_2082|Compound:5219693|FD-Score:-3.51|P-value:2.04E-4 ID:SGTC_2129|Compound:girgensonine|FD-Score:3.51|P-value:2.07E-4 ID:SGTC_2166|Compound:5933061|FD-Score:3.41|P-value:2.99E-4 ID:SGTC_2173|Compound:5763948|FD-Score:3.51|P-value:2.10E-4 ID:SGTC_2365|Compound:9042475|FD-Score:3.69|P-value:1.05E-4 ID:SGTC_2406|Compound:ethylparaben|FD-Score:3.96|P-value:3.40E-5 ID:SGTC_2415|Compound:st077333|FD-Score:3.76|P-value:7.81E-5 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:3.13|P-value:8.39E-4 ID:SGTC_2612|Compound:dictamnine|FD-Score:-3.15|P-value:7.66E-4 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:-3.61|P-value:1.42E-4 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:4.37|P-value:5.67E-6 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:-3.34|P-value:3.88E-4 ID:SGTC_2628|Compound:lathosterol|FD-Score:4.42|P-value:4.43E-6 ID:SGTC_2784|Compound:7567673|FD-Score:5.13|P-value:1.27E-7 ID:SGTC_2896|Compound:9052656|FD-Score:3.70|P-value:9.98E-5 ID:SGTC_2929|Compound:9013348|FD-Score:-4.59|P-value:1.91E-6 ID:SGTC_2934|Compound:9036370|FD-Score:3.42|P-value:2.90E-4 ID:SGTC_3009|Compound:9080819|FD-Score:3.80|P-value:6.79E-5 ID:SGTC_3080|Compound:9117754|FD-Score:3.69|P-value:1.04E-4 ID:SGTC_3087|Compound:9117406|FD-Score:3.16|P-value:7.36E-4 ID:SGTC_3278|Compound:9139605|FD-Score:-3.56|P-value:1.69E-4

Top fitness defect scores for YPR179C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1495 4469-0029 7.04 237.0 µM 7.03E-13 37 9.31E-13
2 SGTC_533 1222-0222 6.35 6.7 µM 8.65E-11 PDR1 5 1.09E-10
3 SGTC_1702 st027038 5.37 51.0 µM 3.28E-8 2 3.86E-8
4 SGTC_1084 voriconazole 5.35 435.0 nM 3.76E-8 azole & statin 9 4.42E-8
5 SGTC_2784 7567673 5.13 72.7 µM 1.27E-7 iron homeostasis 12 1.47E-7
6 SGTC_1023 4482-3888 5.08 16.0 µM 1.64E-7 TSC3-RPN4 4 1.90E-7
7 SGTC_41 0478-0632 4.91 82.6 µM 3.95E-7 12 4.53E-7
8 SGTC_157 1348-1695 4.66 65.8 µM 1.40E-6 iron homeostasis 39 1.59E-6
9 SGTC_227 fluconazole 4.47 33.5 µM 3.49E-6 azole & statin 65 3.91E-6
10 SGTC_790 1575-0012 4.43 79.1 µM 4.14E-6 TSC3-RPN4 16 4.63E-6
11 SGTC_2628 lathosterol 4.42 100.0 µM 4.43E-6 20 4.95E-6
12 SGTC_2617 dihydrotanshinone i 4.37 20.8 µM 5.67E-6 copper-dependent oxidative stress 28 6.32E-6
13 SGTC_263 alizarin 4.35 107.9 µM 6.09E-6 iron homeostasis 47 6.79E-6
14 SGTC_1070 indatraline 4.33 8.8 µM 6.79E-6 60S ribosome export 19 7.56E-6
15 SGTC_532 1548-0774 4.26 215.0 µM 9.36E-6 14 1.04E-5
16 SGTC_658 3253-0951 3.97 102.0 µM 3.24E-5 calcium & mitochondrial duress 59 3.54E-5
17 SGTC_2406 ethylparaben 3.96 405.7 µM 3.40E-5 39 3.71E-5
18 SGTC_1364 1653-0028 3.86 37.6 µM 5.30E-5 25 5.77E-5
19 SGTC_781 4335-2806 3.80 94.4 µM 6.65E-5 24 7.22E-5
20 SGTC_3009 9080819 3.80 71.4 µM 6.79E-5 22 7.37E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.113 5.26E-11 YOR174W MED4 het Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation
0.111 1.14E-10 YMR298W LIP1 het Ceramide synthase subunit; single-span ER membrane protein associated with Lag1p and Lac1p and required for ceramide synthase activity, null mutant grows extremely slowly and is defective in ceramide synthesis
0.109 2.55E-10 YJL094C KHA1 hom Putative K+/H+ antiporter with a probable role in intracellular cation homeostasis, localized to Golgi vesicles and detected in highly purified mitochondria in high-throughput studies
0.108 3.01E-10 YDR295C HDA2 hom Subunit of a possibly tetrameric trichostatin A-sensitive class II histone deacetylase complex containing an Hda1p homodimer and an Hda2p-Hda3p heterodimer; involved in telomere maintenance
0.103 2.40E-9 YJL195C_d YJL195C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL194W/CDC6
0.095 3.42E-8 YDR269C_d YDR269C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.090 2.00E-7 YER177W BMH1 hom 14-3-3 protein, major isoform; controls proteome at post-transcriptional level, binds proteins and DNA, involved in regulation of many processes including exocytosis, vesicle transport, Ras/MAPK signaling, and rapamycin-sensitive signaling; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress
0.089 2.44E-7 YCR093W CDC39 het Component of the CCR4-NOT complex, which has multiple roles in regulating mRNA levels including regulation of transcription and destabilizing mRNAs by deadenylation; basal transcription factor
0.089 2.79E-7 YML007C-A_p YML007C-A_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria
0.085 8.70E-7 YML006C GIS4 hom CAAX box containing protein of unknown function, proposed to be involved in the RAS/cAMP signaling pathway
0.085 8.93E-7 YOR304W ISW2 hom ATP-dependent DNA translocase involved in chromatin remodeling; ATPase component that, with Itc1p, forms a complex required for repression of a-specific genes, INO1, and early meiotic genes during mitotic growth
0.083 1.65E-6 YDR010C_d YDR010C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.083 1.62E-6 YGR098C ESP1 het Separase, a caspase-like cysteine protease; promotes sister chromatid separation by mediating dissociation of the cohesin Scc1p from chromatin; inhibits protein phosphatase 2A-Cdc55p to promote mitotic exit; inhibited by Pds1p; relative distribution to the nucleus increases upon DNA replication stress
0.082 1.76E-6 YOR310C NOP58 het Protein involved in pre-rRNA processing, 18S rRNA synthesis, and snoRNA synthesis; component of the small subunit processome complex, which is required for processing of pre-18S rRNA
0.082 1.90E-6 YDR270W CCC2 hom Cu(+2)-transporting P-type ATPase; required for export of copper from the cytosol into an extracytosolic compartment; has similarity to human proteins involved in Menkes and Wilsons diseases; protein abundance increases in response to DNA replication stress; affects TBSV model (+)RNA virus replication by regulating copper metabolism