YPR181C / SEC23

GTPase-activating protein, stimulates the GTPase activity of Sar1p; component of the Sec23p-Sec24p heterodimer of the COPII vesicle coat, involved in ER to Golgi transport; substrate of Ubp3/Bre5 complex; ubiquitylated by Ub-ligase Rsp5p; proteasome-mediated degradation of Sec23p is regulated by Cdc48p

Zygosity: Heterozygous strain
fixedexpanded
Profile for YPR181C / SEC23

Click on Significant Values for Screen Details ID:SGTC_71|Compound:0417-1750|FD-Score:6.73|P-value:2.79E-7 ID:SGTC_77|Compound:0828-0286|FD-Score:6.88|P-value:1.53E-7 ID:SGTC_78|Compound:0336-0123|FD-Score:5.98|P-value:4.33E-6 ID:SGTC_262|Compound:fenpropimorph|FD-Score:4.90|P-value:1.35E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:-5.62|P-value:1.44E-5 ID:SGTC_310|Compound:1273-0058|FD-Score:-5.61|P-value:1.50E-5 ID:SGTC_350|Compound:k064-0020|FD-Score:-6.52|P-value:6.12E-7 ID:SGTC_352|Compound:k048-0007|FD-Score:5.48|P-value:2.27E-5 ID:SGTC_374|Compound:0880-0231|FD-Score:-5.67|P-value:1.21E-5 ID:SGTC_431|Compound:k089-0097|FD-Score:-5.60|P-value:1.55E-5 ID:SGTC_439|Compound:amiodarone|FD-Score:4.89|P-value:1.35E-4 ID:SGTC_490|Compound:phenamil|FD-Score:-6.13|P-value:2.57E-6 ID:SGTC_692|Compound:k241-0027|FD-Score:-4.38|P-value:5.60E-4 ID:SGTC_717|Compound:1532-0246|FD-Score:4.32|P-value:6.47E-4 ID:SGTC_768|Compound:0384-0033|FD-Score:4.80|P-value:1.79E-4 ID:SGTC_832|Compound:4083-0019|FD-Score:5.92|P-value:5.28E-6 ID:SGTC_896|Compound:0964-0007|FD-Score:4.20|P-value:8.95E-4 ID:SGTC_933|Compound:2914-0560|FD-Score:6.72|P-value:2.83E-7 ID:SGTC_986|Compound:1493-0483|FD-Score:5.46|P-value:2.42E-5 ID:SGTC_1041|Compound:0206-0046|FD-Score:6.04|P-value:3.48E-6 ID:SGTC_1055|Compound:3448-0672|FD-Score:4.96|P-value:1.10E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:-4.45|P-value:4.64E-4 ID:SGTC_1480|Compound:1070-0044|FD-Score:4.18|P-value:9.31E-4 ID:SGTC_1510|Compound:1123-0200|FD-Score:4.71|P-value:2.30E-4 ID:SGTC_1602|Compound:st001878|FD-Score:-5.41|P-value:2.81E-5 ID:SGTC_1609|Compound:st001574|FD-Score:5.47|P-value:2.38E-5 ID:SGTC_1679|Compound:4130-1276|FD-Score:5.30|P-value:4.05E-5 ID:SGTC_1709|Compound:st033179|FD-Score:4.83|P-value:1.63E-4 ID:SGTC_1724|Compound:st037281|FD-Score:4.53|P-value:3.74E-4 ID:SGTC_1938|Compound:st074717|FD-Score:-5.10|P-value:7.28E-5 ID:SGTC_2012|Compound:4023501|FD-Score:-5.41|P-value:2.82E-5 ID:SGTC_2044|Compound:5102272|FD-Score:4.19|P-value:9.18E-4 ID:SGTC_2077|Compound:5212015|FD-Score:5.18|P-value:5.81E-5 ID:SGTC_2082|Compound:5219693|FD-Score:4.88|P-value:1.42E-4 ID:SGTC_2161|Compound:5662504|FD-Score:6.18|P-value:2.14E-6 ID:SGTC_2189|Compound:6047310|FD-Score:5.16|P-value:6.22E-5 ID:SGTC_2250|Compound:alverine citrate|FD-Score:4.84|P-value:1.57E-4 ID:SGTC_2319|Compound:6033012|FD-Score:5.61|P-value:1.49E-5 ID:SGTC_2448|Compound:5185112|FD-Score:5.10|P-value:7.26E-5 ID:SGTC_2453|Compound:5731132|FD-Score:4.42|P-value:5.00E-4 ID:SGTC_2458|Compound:5808907|FD-Score:-4.28|P-value:7.15E-4 ID:SGTC_2461|Compound:5755302|FD-Score:-4.45|P-value:4.64E-4 ID:SGTC_2476|Compound:5806916|FD-Score:5.14|P-value:6.60E-5 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:4.17|P-value:9.63E-4 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:6.22|P-value:1.84E-6 ID:SGTC_2640|Compound:pentamidine|FD-Score:-4.36|P-value:5.81E-4 ID:SGTC_2701|Compound:st077767|FD-Score:4.47|P-value:4.43E-4 ID:SGTC_2725|Compound:haloperidol|FD-Score:5.47|P-value:2.37E-5 ID:SGTC_2766|Compound:oltipraz|FD-Score:-5.66|P-value:1.28E-5 ID:SGTC_2776|Compound:terbinafine|FD-Score:5.79|P-value:8.06E-6 ID:SGTC_2829|Compound:7992743|FD-Score:-4.79|P-value:1.84E-4 ID:SGTC_2835|Compound:9006588|FD-Score:-7.43|P-value:1.60E-8 ID:SGTC_2991|Compound:9074669|FD-Score:4.30|P-value:6.85E-4 ID:SGTC_3048|Compound:9093155|FD-Score:-4.84|P-value:1.59E-4 ID:SGTC_3062|Compound:9077494|FD-Score:-6.92|P-value:1.32E-7 ID:SGTC_3081|Compound:9117243|FD-Score:5.66|P-value:1.27E-5 ID:SGTC_3098|Compound:9119039|FD-Score:5.79|P-value:8.24E-6 ID:SGTC_3108|Compound:9121785|FD-Score:-4.85|P-value:1.54E-4 ID:SGTC_3201|Compound:9113999|FD-Score:-6.53|P-value:5.92E-7 ID:SGTC_3203|Compound:9113543|FD-Score:-5.86|P-value:6.49E-6 ID:SGTC_3204|Compound:9114183|FD-Score:4.50|P-value:4.00E-4 ID:SGTC_3212|Compound:9128307|FD-Score:6.06|P-value:3.24E-6 ID:SGTC_3259|Compound:9138485|FD-Score:-4.98|P-value:1.05E-4 ID:SGTC_3264|Compound:9137442|FD-Score:5.75|P-value:9.34E-6 ID:SGTC_71|Compound:0417-1750|FD-Score:6.73|P-value:2.79E-7 ID:SGTC_77|Compound:0828-0286|FD-Score:6.88|P-value:1.53E-7 ID:SGTC_78|Compound:0336-0123|FD-Score:5.98|P-value:4.33E-6 ID:SGTC_262|Compound:fenpropimorph|FD-Score:4.90|P-value:1.35E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:-5.62|P-value:1.44E-5 ID:SGTC_310|Compound:1273-0058|FD-Score:-5.61|P-value:1.50E-5 ID:SGTC_350|Compound:k064-0020|FD-Score:-6.52|P-value:6.12E-7 ID:SGTC_352|Compound:k048-0007|FD-Score:5.48|P-value:2.27E-5 ID:SGTC_374|Compound:0880-0231|FD-Score:-5.67|P-value:1.21E-5 ID:SGTC_431|Compound:k089-0097|FD-Score:-5.60|P-value:1.55E-5 ID:SGTC_439|Compound:amiodarone|FD-Score:4.89|P-value:1.35E-4 ID:SGTC_490|Compound:phenamil|FD-Score:-6.13|P-value:2.57E-6 ID:SGTC_692|Compound:k241-0027|FD-Score:-4.38|P-value:5.60E-4 ID:SGTC_717|Compound:1532-0246|FD-Score:4.32|P-value:6.47E-4 ID:SGTC_768|Compound:0384-0033|FD-Score:4.80|P-value:1.79E-4 ID:SGTC_832|Compound:4083-0019|FD-Score:5.92|P-value:5.28E-6 ID:SGTC_896|Compound:0964-0007|FD-Score:4.20|P-value:8.95E-4 ID:SGTC_933|Compound:2914-0560|FD-Score:6.72|P-value:2.83E-7 ID:SGTC_986|Compound:1493-0483|FD-Score:5.46|P-value:2.42E-5 ID:SGTC_1041|Compound:0206-0046|FD-Score:6.04|P-value:3.48E-6 ID:SGTC_1055|Compound:3448-0672|FD-Score:4.96|P-value:1.10E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:-4.45|P-value:4.64E-4 ID:SGTC_1480|Compound:1070-0044|FD-Score:4.18|P-value:9.31E-4 ID:SGTC_1510|Compound:1123-0200|FD-Score:4.71|P-value:2.30E-4 ID:SGTC_1602|Compound:st001878|FD-Score:-5.41|P-value:2.81E-5 ID:SGTC_1609|Compound:st001574|FD-Score:5.47|P-value:2.38E-5 ID:SGTC_1679|Compound:4130-1276|FD-Score:5.30|P-value:4.05E-5 ID:SGTC_1709|Compound:st033179|FD-Score:4.83|P-value:1.63E-4 ID:SGTC_1724|Compound:st037281|FD-Score:4.53|P-value:3.74E-4 ID:SGTC_1938|Compound:st074717|FD-Score:-5.10|P-value:7.28E-5 ID:SGTC_2012|Compound:4023501|FD-Score:-5.41|P-value:2.82E-5 ID:SGTC_2044|Compound:5102272|FD-Score:4.19|P-value:9.18E-4 ID:SGTC_2077|Compound:5212015|FD-Score:5.18|P-value:5.81E-5 ID:SGTC_2082|Compound:5219693|FD-Score:4.88|P-value:1.42E-4 ID:SGTC_2161|Compound:5662504|FD-Score:6.18|P-value:2.14E-6 ID:SGTC_2189|Compound:6047310|FD-Score:5.16|P-value:6.22E-5 ID:SGTC_2250|Compound:alverine citrate|FD-Score:4.84|P-value:1.57E-4 ID:SGTC_2319|Compound:6033012|FD-Score:5.61|P-value:1.49E-5 ID:SGTC_2448|Compound:5185112|FD-Score:5.10|P-value:7.26E-5 ID:SGTC_2453|Compound:5731132|FD-Score:4.42|P-value:5.00E-4 ID:SGTC_2458|Compound:5808907|FD-Score:-4.28|P-value:7.15E-4 ID:SGTC_2461|Compound:5755302|FD-Score:-4.45|P-value:4.64E-4 ID:SGTC_2476|Compound:5806916|FD-Score:5.14|P-value:6.60E-5 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:4.17|P-value:9.63E-4 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:6.22|P-value:1.84E-6 ID:SGTC_2640|Compound:pentamidine|FD-Score:-4.36|P-value:5.81E-4 ID:SGTC_2701|Compound:st077767|FD-Score:4.47|P-value:4.43E-4 ID:SGTC_2725|Compound:haloperidol|FD-Score:5.47|P-value:2.37E-5 ID:SGTC_2766|Compound:oltipraz|FD-Score:-5.66|P-value:1.28E-5 ID:SGTC_2776|Compound:terbinafine|FD-Score:5.79|P-value:8.06E-6 ID:SGTC_2829|Compound:7992743|FD-Score:-4.79|P-value:1.84E-4 ID:SGTC_2835|Compound:9006588|FD-Score:-7.43|P-value:1.60E-8 ID:SGTC_2991|Compound:9074669|FD-Score:4.30|P-value:6.85E-4 ID:SGTC_3048|Compound:9093155|FD-Score:-4.84|P-value:1.59E-4 ID:SGTC_3062|Compound:9077494|FD-Score:-6.92|P-value:1.32E-7 ID:SGTC_3081|Compound:9117243|FD-Score:5.66|P-value:1.27E-5 ID:SGTC_3098|Compound:9119039|FD-Score:5.79|P-value:8.24E-6 ID:SGTC_3108|Compound:9121785|FD-Score:-4.85|P-value:1.54E-4 ID:SGTC_3201|Compound:9113999|FD-Score:-6.53|P-value:5.92E-7 ID:SGTC_3203|Compound:9113543|FD-Score:-5.86|P-value:6.49E-6 ID:SGTC_3204|Compound:9114183|FD-Score:4.50|P-value:4.00E-4 ID:SGTC_3212|Compound:9128307|FD-Score:6.06|P-value:3.24E-6 ID:SGTC_3259|Compound:9138485|FD-Score:-4.98|P-value:1.05E-4 ID:SGTC_3264|Compound:9137442|FD-Score:5.75|P-value:9.34E-6

Top fitness defect scores for YPR181C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_77 0828-0286 6.88 12.5 µM 1.53E-7 TSC3-RPN4 2 3.02E-12 1.97
2 SGTC_71 0417-1750 6.73 47.8 µM 2.79E-7 Golgi 4 8.76E-12 0.71
3 SGTC_933 2914-0560 6.72 114.0 µM 2.83E-7 2 9.00E-12 1.95
4 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 6.22 100.0 µM 1.84E-6 1 2.50E-10 0.82
5 SGTC_2161 5662504 6.18 8.5 µM 2.14E-6 tubulin folding & SWR complex 1 3.26E-10 1.81
6 SGTC_3212 9128307 6.06 49.5 µM 3.24E-6 3 6.80E-10 0.52
7 SGTC_1041 0206-0046 6.04 107.0 µM 3.48E-6 2 7.73E-10 1.17
8 SGTC_78 0336-0123 5.98 156.8 µM 4.33E-6 1 1.14E-9 0.82
9 SGTC_832 4083-0019 5.92 164.0 µM 5.28E-6 translation 10 1.62E-9 0.27
10 SGTC_2776 terbinafine 5.79 19.9 µM 8.06E-6 cell wall signaling 3 3.42E-9 0.20
11 SGTC_3098 9119039 5.79 49.5 µM 8.24E-6 Golgi 3 3.55E-9 0.83
12 SGTC_3264 9137442 5.75 49.5 µM 9.34E-6 2 4.43E-9 1.44
13 SGTC_3081 9117243 5.66 49.5 µM 1.27E-5 fatty acid desaturase (OLE1) 14 7.68E-9 0.19
14 SGTC_2319 6033012 5.61 152.6 µM 1.49E-5 tubulin folding & SWR complex 1 1.01E-8 0.95
15 SGTC_352 k048-0007 5.48 5.1 µM 2.27E-5 ERAD & cell cycle 3 2.14E-8 0.09
16 SGTC_2725 haloperidol 5.47 53.2 µM 2.37E-5 plasma membrane duress 9 2.29E-8 0.07
17 SGTC_1609 st001574 5.47 46.4 µM 2.38E-5 1 2.31E-8 1.05
18 SGTC_986 1493-0483 5.46 84.0 µM 2.42E-5 2 2.38E-8 1.50
19 SGTC_1679 4130-1276 5.30 6.7 µM 4.05E-5 Golgi 16 5.93E-8 0.51
20 SGTC_2077 5212015 5.18 200.0 µM 5.81E-5 4 1.12E-7 0.20

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.121 2.24E-12 YBR140C IRA1 het GTPase-activating protein; negatively regulates RAS by converting it from the GTP- to the GDP-bound inactive form, required for reducing cAMP levels under nutrient limiting conditions, mediates membrane association of adenylate cyclase; IRA1 has a paralog, IRA2, that arose from the whole genome duplication
0.116 1.46E-11 YDL196W_d YDL196W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame is located in promoter region of essential gene SEC31
0.107 5.84E-10 YJR105W ADO1 hom Adenosine kinase, required for the utilization of S-adenosylmethionine (AdoMet); may be involved in recycling adenosine produced through the methyl cycle
0.106 8.17E-10 YDR159W SAC3 hom Nuclear pore-associated protein; required for biogenesis of the small ribosomal subunit; component of TREX-2 complex (Sac3p-Thp1p-Sus1p-Cdc31p) involved in transcription elongation and mRNA export from the nucleus; involved in post-transcriptional tethering of active genes to the nuclear periphery and to non-nascent mRNP; similar to the human germinal center-associated nuclear protein (GANP)
0.105 9.08E-10 YJR060W CBF1 hom Dual function helix-loop-helix protein; binds the motif CACRTG present at several sites including MET gene promoters and centromere DNA element I (CDEI); affects nucleosome positioning at this motif; associates with other transcription factors such as Met4p and Isw1p to mediate transcriptional activation or repression; associates with kinetochore proteins and required for efficient chromosome segregation; protein abundance increases in response to DNA replication stress
0.105 9.62E-10 YHR007C ERG11 het Lanosterol 14-alpha-demethylase; catalyzes the C-14 demethylation of lanosterol to form 4,4''-dimethyl cholesta-8,14,24-triene-3-beta-ol in the ergosterol biosynthesis pathway; member of the cytochrome P450 family; associated and coordinately regulated with the P450 reductase Ncp1p
0.104 1.34E-9 YDL226C GCS1 hom ADP-ribosylation factor GTPase activating protein (ARF GAP), involved in ER-Golgi transport; shares functional similarity with Glo3p
0.104 1.73E-9 YAL038W CDC19 het Pyruvate kinase; functions as a homotetramer in glycolysis to convert phosphoenolpyruvate to pyruvate, the input for aerobic (TCA cycle) or anaerobic (glucose fermentation) respiration; regulated via allosteric activation by fructose bisphosphate; CDC19 has a paralog, PYK2, that arose from the whole genome duplication
0.102 3.17E-9 YDR162C NBP2 hom Protein involved in the HOG (high osmolarity glycerol) pathway; negatively regulates Hog1p by recruitment of phosphatase Ptc1p the Pbs2p-Hog1p complex; interacts with Bck1p and down regulates the cell wall integrity pathway; found in the nucleus and cytoplasm, contains an SH3 domain and a Ptc1p binding domain (PBM)
0.096 2.90E-8 YER031C YPT31 hom Rab family GTPase; involved in the exocytic pathway; mediates intra-Golgi traffic or the budding of post-Golgi vesicles from the trans-Golgi; YPT31 has a paralog, YPT32, that arose from the whole genome duplication
0.095 3.21E-8 YOL072W THP1 hom Nuclear pore-associated protein; component of TREX-2 complex (Sac3p-Thp1p-Sus1p-Cdc31p) involved in transcription elongation and mRNA export from the nucleus; involved in post-transcriptional tethering of active genes to the nuclear periphery and to non-nascent mRNP; contains a PAM domain implicated in protein-protein binding
0.095 4.21E-8 YGR289C MAL11 hom Inducible high-affinity maltose transporter (alpha-glucoside transporter); encoded in the MAL1 complex locus; broad substrate specificity that includes maltotriose; required for isomaltose utilization
0.093 6.97E-8 YJL204C RCY1 hom F-box protein involved in recycling plasma membrane proteins internalized by endocytosis; localized to sites of polarized growth
0.090 1.97E-7 YBR171W SEC66 hom Non-essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
0.088 2.94E-7 YOR319W HSH49 het U2-snRNP associated splicing factor with similarity to the mammalian splicing factor SAP49; proposed to function as a U2-snRNP assembly factor along with Hsh155p and binding partner Cus1p; contains two RNA recognition motifs (RRM)