YPR182W / SMX3

Core Sm protein Sm F; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Sme1p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm F

Zygosity: Heterozygous strain
fixedexpanded
Profile for YPR182W / SMX3

Click on Significant Values for Screen Details ID:SGTC_61|Compound:0978-8327|FD-Score:-3.62|P-value:5.12E-5 ID:SGTC_66|Compound:0109-0187|FD-Score:-4.44|P-value:8.49E-7 ID:SGTC_153|Compound:4077-0274|FD-Score:2.86|P-value:7.62E-4 ID:SGTC_154|Compound:3389-1638|FD-Score:3.27|P-value:1.52E-4 ID:SGTC_169|Compound:k015-0017|FD-Score:4.24|P-value:1.52E-6 ID:SGTC_286|Compound:k060-0067|FD-Score:3.44|P-value:7.43E-5 ID:SGTC_367|Compound:0335-0881|FD-Score:3.04|P-value:3.86E-4 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:3.40|P-value:8.71E-5 ID:SGTC_480|Compound:am 92016|FD-Score:3.68|P-value:2.43E-5 ID:SGTC_549|Compound:1661-1316|FD-Score:4.65|P-value:1.56E-7 ID:SGTC_787|Compound:4152-0075|FD-Score:2.84|P-value:8.16E-4 ID:SGTC_877|Compound:0771-0151|FD-Score:-3.10|P-value:4.38E-4 ID:SGTC_906|Compound:1165-0455|FD-Score:3.46|P-value:6.56E-5 ID:SGTC_937|Compound:3122-0005|FD-Score:-3.04|P-value:5.55E-4 ID:SGTC_957|Compound:1187-1561|FD-Score:-4.05|P-value:6.45E-6 ID:SGTC_991|Compound:3996-0057|FD-Score:-3.90|P-value:1.37E-5 ID:SGTC_1091|Compound:telmisartan|FD-Score:3.63|P-value:3.03E-5 ID:SGTC_1097|Compound:itavastatin|FD-Score:2.99|P-value:4.65E-4 ID:SGTC_1106|Compound:tegaserod maleate|FD-Score:-3.08|P-value:4.78E-4 ID:SGTC_1109|Compound:tnp00067|FD-Score:2.96|P-value:5.26E-4 ID:SGTC_1253|Compound:0550-0034|FD-Score:5.26|P-value:3.64E-9 ID:SGTC_1528|Compound:arabinosylhypoxanthine|FD-Score:3.00|P-value:4.54E-4 ID:SGTC_1627|Compound:st003713|FD-Score:2.95|P-value:5.47E-4 ID:SGTC_1821|Compound:st053465|FD-Score:3.56|P-value:4.30E-5 ID:SGTC_1844|Compound:rapamycin|FD-Score:3.05|P-value:3.78E-4 ID:SGTC_1849|Compound:st056239|FD-Score:-5.11|P-value:1.81E-8 ID:SGTC_1909|Compound:st060837|FD-Score:4.88|P-value:3.95E-8 ID:SGTC_2160|Compound:5660466|FD-Score:3.23|P-value:1.78E-4 ID:SGTC_2162|Compound:5663267|FD-Score:3.61|P-value:3.43E-5 ID:SGTC_2358|Compound:9037157|FD-Score:-3.95|P-value:1.06E-5 ID:SGTC_2366|Compound:9070441|FD-Score:2.95|P-value:5.40E-4 ID:SGTC_2368|Compound:9071271|FD-Score:4.55|P-value:2.69E-7 ID:SGTC_2392|Compound:N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide|FD-Score:-3.06|P-value:5.26E-4 ID:SGTC_2481|Compound:5478948|FD-Score:3.48|P-value:6.11E-5 ID:SGTC_2564|Compound:betulinic acid|FD-Score:3.52|P-value:5.03E-5 ID:SGTC_2570|Compound:licareol|FD-Score:-3.98|P-value:9.29E-6 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:-3.12|P-value:4.12E-4 ID:SGTC_2701|Compound:st077767|FD-Score:4.01|P-value:4.91E-6 ID:SGTC_2753|Compound:fluvastatin|FD-Score:-3.86|P-value:1.64E-5 ID:SGTC_2796|Compound:7949634|FD-Score:3.08|P-value:3.32E-4 ID:SGTC_2806|Compound:7952793|FD-Score:4.90|P-value:3.66E-8 ID:SGTC_2809|Compound:7964133|FD-Score:3.30|P-value:1.32E-4 ID:SGTC_2856|Compound:9022925|FD-Score:2.97|P-value:4.98E-4 ID:SGTC_2883|Compound:9059145|FD-Score:3.63|P-value:3.15E-5 ID:SGTC_3206|Compound:9114350|FD-Score:3.03|P-value:3.95E-4 ID:SGTC_61|Compound:0978-8327|FD-Score:-3.62|P-value:5.12E-5 ID:SGTC_66|Compound:0109-0187|FD-Score:-4.44|P-value:8.49E-7 ID:SGTC_153|Compound:4077-0274|FD-Score:2.86|P-value:7.62E-4 ID:SGTC_154|Compound:3389-1638|FD-Score:3.27|P-value:1.52E-4 ID:SGTC_169|Compound:k015-0017|FD-Score:4.24|P-value:1.52E-6 ID:SGTC_286|Compound:k060-0067|FD-Score:3.44|P-value:7.43E-5 ID:SGTC_367|Compound:0335-0881|FD-Score:3.04|P-value:3.86E-4 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:3.40|P-value:8.71E-5 ID:SGTC_480|Compound:am 92016|FD-Score:3.68|P-value:2.43E-5 ID:SGTC_549|Compound:1661-1316|FD-Score:4.65|P-value:1.56E-7 ID:SGTC_787|Compound:4152-0075|FD-Score:2.84|P-value:8.16E-4 ID:SGTC_877|Compound:0771-0151|FD-Score:-3.10|P-value:4.38E-4 ID:SGTC_906|Compound:1165-0455|FD-Score:3.46|P-value:6.56E-5 ID:SGTC_937|Compound:3122-0005|FD-Score:-3.04|P-value:5.55E-4 ID:SGTC_957|Compound:1187-1561|FD-Score:-4.05|P-value:6.45E-6 ID:SGTC_991|Compound:3996-0057|FD-Score:-3.90|P-value:1.37E-5 ID:SGTC_1091|Compound:telmisartan|FD-Score:3.63|P-value:3.03E-5 ID:SGTC_1097|Compound:itavastatin|FD-Score:2.99|P-value:4.65E-4 ID:SGTC_1106|Compound:tegaserod maleate|FD-Score:-3.08|P-value:4.78E-4 ID:SGTC_1109|Compound:tnp00067|FD-Score:2.96|P-value:5.26E-4 ID:SGTC_1253|Compound:0550-0034|FD-Score:5.26|P-value:3.64E-9 ID:SGTC_1528|Compound:arabinosylhypoxanthine|FD-Score:3.00|P-value:4.54E-4 ID:SGTC_1627|Compound:st003713|FD-Score:2.95|P-value:5.47E-4 ID:SGTC_1821|Compound:st053465|FD-Score:3.56|P-value:4.30E-5 ID:SGTC_1844|Compound:rapamycin|FD-Score:3.05|P-value:3.78E-4 ID:SGTC_1849|Compound:st056239|FD-Score:-5.11|P-value:1.81E-8 ID:SGTC_1909|Compound:st060837|FD-Score:4.88|P-value:3.95E-8 ID:SGTC_2160|Compound:5660466|FD-Score:3.23|P-value:1.78E-4 ID:SGTC_2162|Compound:5663267|FD-Score:3.61|P-value:3.43E-5 ID:SGTC_2358|Compound:9037157|FD-Score:-3.95|P-value:1.06E-5 ID:SGTC_2366|Compound:9070441|FD-Score:2.95|P-value:5.40E-4 ID:SGTC_2368|Compound:9071271|FD-Score:4.55|P-value:2.69E-7 ID:SGTC_2392|Compound:N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide|FD-Score:-3.06|P-value:5.26E-4 ID:SGTC_2481|Compound:5478948|FD-Score:3.48|P-value:6.11E-5 ID:SGTC_2564|Compound:betulinic acid|FD-Score:3.52|P-value:5.03E-5 ID:SGTC_2570|Compound:licareol|FD-Score:-3.98|P-value:9.29E-6 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:-3.12|P-value:4.12E-4 ID:SGTC_2701|Compound:st077767|FD-Score:4.01|P-value:4.91E-6 ID:SGTC_2753|Compound:fluvastatin|FD-Score:-3.86|P-value:1.64E-5 ID:SGTC_2796|Compound:7949634|FD-Score:3.08|P-value:3.32E-4 ID:SGTC_2806|Compound:7952793|FD-Score:4.90|P-value:3.66E-8 ID:SGTC_2809|Compound:7964133|FD-Score:3.30|P-value:1.32E-4 ID:SGTC_2856|Compound:9022925|FD-Score:2.97|P-value:4.98E-4 ID:SGTC_2883|Compound:9059145|FD-Score:3.63|P-value:3.15E-5 ID:SGTC_3206|Compound:9114350|FD-Score:3.03|P-value:3.95E-4

Top fitness defect scores for YPR182W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1253 0550-0034 5.26 176.0 µM 3.64E-9 1 7.05E-8 0.34
2 SGTC_2806 7952793 4.90 58.4 µM 3.66E-8 1 4.90E-7 0.56
3 SGTC_1909 st060837 4.88 51.5 µM 3.95E-8 4 5.23E-7 0.05
4 SGTC_549 1661-1316 4.65 519.0 µM 1.56E-7 3 1.65E-6 0.17
5 SGTC_2368 9071271 4.55 200.0 µM 2.69E-7 2 2.62E-6 0.64
6 SGTC_169 k015-0017 4.24 16.0 µM 1.52E-6 2 1.13E-5 0.47
7 SGTC_2701 st077767 4.01 14.7 µM 4.91E-6 8 3.01E-5 0.04
8 SGTC_480 am 92016 3.68 50.0 µM 2.43E-5 11 1.16E-4 0.02
9 SGTC_1091 telmisartan 3.63 47.6 µM 3.03E-5 4 1.39E-4 0.25
10 SGTC_2883 9059145 3.63 45.5 µM 3.15E-5 7 1.44E-4 0.01
11 SGTC_2162 5663267 3.61 200.0 µM 3.43E-5 14 1.54E-4 0.05
12 SGTC_1821 st053465 3.56 65.6 µM 4.30E-5 4 1.87E-4 0.10
13 SGTC_2564 betulinic acid 3.52 100.0 µM 5.03E-5 11 2.13E-4 0.05
14 SGTC_2481 5478948 3.48 45.2 µM 6.11E-5 PDR1 13 2.51E-4 0.22
15 SGTC_906 1165-0455 3.46 526.0 µM 6.56E-5 5 2.66E-4 0.11
16 SGTC_286 k060-0067 3.44 22.9 µM 7.43E-5 tubulin folding & SWR complex 12 2.96E-4 0.04
17 SGTC_423 5-fluorouracil 3.40 457.0 µM 8.71E-5 exosome 40 3.38E-4 0.00
18 SGTC_2809 7964133 3.30 13.0 µM 1.32E-4 60S ribosome export 18 4.81E-4 0.12
19 SGTC_154 3389-1638 3.27 511.1 µM 1.52E-4 12 5.41E-4 0.02
20 SGTC_2160 5660466 3.23 132.9 µM 1.78E-4 60S ribosome export 25 6.16E-4 0.17

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.121 1.61E-12 YLR414C PUN1 hom Plasma membrane protein with a role in cell wall integrity; co-localizes with Sur7p in punctate membrane patches; null mutant displays decreased thermotolerance; transcription induced upon cell wall damage and metal ion stress
0.108 3.83E-10 YJL058C BIT61 hom Subunit of TORC2 membrane-associated complex; involved in regulation of cell cycle-dependent actin cytoskeletal dynamics during polarized growth and cell wall integrity; BIT61 has a paralog, BIT2, that arose from the whole genome duplication
0.107 5.53E-10 YLR405W DUS4 hom Dihydrouridine synthase, member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus3p
0.104 1.84E-9 YNL062C GCD10 het Subunit of tRNA (1-methyladenosine) methyltransferase with Gcd14p, required for the modification of the adenine at position 58 in tRNAs, especially tRNAi-Met; first identified as a negative regulator of GCN4 expression
0.103 1.98E-9 YDL184C RPL41A hom Ribosomal 60S subunit protein L41A; comprises only 25 amino acids; rpl41a rpl41b double null mutant is viable; homologous to mammalian ribosomal protein L41, no bacterial homolog; RPL41A has a paralog, RPL41B, that arose from the whole genome duplication
0.102 2.72E-9 YCR088W ABP1 hom Actin-binding protein of the cortical actin cytoskeleton, important for activation of the Arp2/3 complex that plays a key role actin in cytoskeleton organization; phosphorylation within its PRR (Proline-Rich Region), mediated by Cdc28p and Pho85p, protects Abp1p from proteolysis mediated by its own PEST sequences
0.102 2.99E-9 YKL172W EBP2 het Required for 25S rRNA maturation and 60S ribosomal subunit assembly; localizes to the nucleolus and in foci along nuclear periphery; constituent of 66S pre-ribosomal particles; cooperates with Rrs1p and Mps3p to mediate telomere clustering by binding Sir4p, but is not involved in telomere tethering
0.100 7.38E-9 YGL004C RPN14 hom Proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasome regulatory particle (RP); null mutants accumulate ubiquitinated Gcn4p and display decreased 26S proteasome stability; interacts with Rpt5p
0.097 1.97E-8 YBR022W POA1 hom Phosphatase that is highly specific for ADP-ribose 1''-phosphate, a tRNA splicing metabolite; may have a role in regulation of tRNA splicing
0.096 2.79E-8 YOR252W TMA16 hom Protein of unknown function that associates with ribosomes
0.095 3.37E-8 YJL016W_p YJL016W_p hom Putative protein of unknown function; GFP-fusion protein localizes to the cytoplasm; conserved in closely related Saccharomyces species
0.095 3.70E-8 YDL078C MDH3 hom Peroxisomal malate dehydrogenase, catalyzes interconversion of malate and oxaloacetate; involved in the glyoxylate cycle
0.093 6.02E-8 YJL041W NSP1 het FG-nucleoporin component of central core of the nuclear pore complex (NPC); also part of the NPC nuclear basket; contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier; found in stable complex with Nup82p, Gle2p and two other FG-nucleoporins (Nup159p and Nup116p); also found in stable complex with Nic96p and two other FG-nucleoproteins (Nup49p and Nup57p); forms foci at the nuclear periphery upon DNA replication stress
0.092 8.85E-8 YLR263W RED1 hom Protein component of the synaptonemal complex axial elements, involved in chromosome segregation during the first meiotic division; critical for coupling checkpoint signaling to SC formation; interacts with Hop1p, Mec3p and Ddc1p
0.088 2.90E-7 YJL147C_p YJL147C_p hom Mitochondrial protein of unknown function; homozygous diploid deletion strain has a sporulation defect characterized by elevated dityrosine in the soluble fraction; expression induced by calcium shortage; YJL147W is a non-essential gene