HIPHOP chemogenomics database
YPR183W / DPM1 
Dolichol phosphate mannose (Dol-P-Man) synthase of the ER membrane, catalyzes the formation of Dol-P-Man from Dol-P and GDP-Man; required for glycosyl phosphatidylinositol membrane anchoring, O mannosylation, and protein glycosylation
Zygosity: Heterozygous strain
fixedexpanded
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Top fitness defect scores for YPR183W deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.115 | 2.40E-11 | YJR024C | MDE1 | hom | 5'-methylthioribulose-1-phosphate dehydratase; acts in the methionine salvage pathway; potential Smt3p sumoylation substrate; expression downregulated by caspofungin and deletion mutant is caspofungin resistant |
| 0.112 | 9.49E-11 | YMR147W_p | YMR147W_p | hom | Putative protein of unknown function |
| 0.111 | 1.04E-10 | YDL131W | LYS21 | hom | Homocitrate synthase isozyme; catalyzes the condensation of acetyl-CoA and alpha-ketoglutarate to form homocitrate, which is the first step in the lysine biosynthesis pathway; LYS21 has a paralog, LYS20, that arose from the whole genome duplication |
| 0.100 | 6.48E-9 | YMR272W-B_p | YMR272W-B_p | hom | Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching |
| 0.097 | 1.99E-8 | YPL011C | TAF3 | het | TFIID subunit (47 kDa), involved in promoter binding and RNA polymerase II transcription initiation |
| 0.095 | 4.15E-8 | YDR215C_d | YDR215C_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutant displays elevated sensitivity to expression of a mutant huntingtin fragment or of alpha-synuclein |
| 0.089 | 2.41E-7 | YNL249C | MPA43 | hom | Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies |
| 0.089 | 2.78E-7 | YGR259C_d | YGR259C_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF TNA1/YGR260W |
| 0.088 | 3.35E-7 | YGL049C | TIF4632 | hom | Translation initiation factor eIF4G, subunit of the mRNA cap-binding protein complex (eIF4F) that also contains eIF4E (Cdc33p); associates with the poly(A)-binding protein Pab1p, also interacts with eIF4A (Tif1p); TIF4632 has a paralog, TIF4631, that arose from the whole genome duplication |
| 0.087 | 4.84E-7 | YBR146W | MRPS9 | hom | Mitochondrial ribosomal protein of the small subunit |
| 0.086 | 5.25E-7 | YGL180W | ATG1 | hom | Protein ser/thr kinase required for vesicle formation in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; structurally required for phagophore assembly site formation; during autophagy forms a complex with Atg13p and Atg17p |
| 0.084 | 1.23E-6 | YBR157C | ICS2 | hom | Protein of unknown function; null mutation does not confer any obvious defects in growth, spore germination, viability, or carbohydrate utilization |
| 0.083 | 1.50E-6 | YNL310C | ZIM17 | het | Heat shock protein with a zinc finger motif; essential for protein import into mitochondria; may act with Pam18p to facilitate recognition and folding of imported proteins by Ssc1p (mtHSP70) in the mitochondrial matrix |
| 0.082 | 1.93E-6 | YNL043C_d | YNL043C_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YIP3/YNL044W |
| 0.082 | 2.15E-6 | YOR190W | SPR1 | hom | Sporulation-specific exo-1,3-beta-glucanase; contributes to ascospore thermoresistance |