YPR183W / DPM1

Dolichol phosphate mannose (Dol-P-Man) synthase of the ER membrane, catalyzes the formation of Dol-P-Man from Dol-P and GDP-Man; required for glycosyl phosphatidylinositol membrane anchoring, O mannosylation, and protein glycosylation

Zygosity: Heterozygous strain
fixedexpanded
Profile for YPR183W / DPM1

Click on Significant Values for Screen Details ID:SGTC_74|Compound:000s-0487|FD-Score:3.22|P-value:5.18E-4 ID:SGTC_84|Compound:0443-0269|FD-Score:3.07|P-value:9.03E-4 ID:SGTC_113|Compound:0099-0221|FD-Score:-3.16|P-value:4.24E-4 ID:SGTC_120|Compound:rhodamine 6G|FD-Score:-3.64|P-value:6.36E-5 ID:SGTC_121|Compound:0557-0495|FD-Score:-3.33|P-value:2.24E-4 ID:SGTC_360|Compound:0957-0399|FD-Score:4.00|P-value:2.18E-5 ID:SGTC_397|Compound:arbidol|FD-Score:4.12|P-value:1.26E-5 ID:SGTC_401|Compound:neomycin|FD-Score:-3.31|P-value:2.40E-4 ID:SGTC_404|Compound:fumagillin|FD-Score:3.55|P-value:1.49E-4 ID:SGTC_405|Compound:ebelactone b|FD-Score:-3.28|P-value:2.73E-4 ID:SGTC_414|Compound:piperonyl butoxide|FD-Score:5.87|P-value:8.43E-10 ID:SGTC_475|Compound:α-linolenic acid|FD-Score:-3.01|P-value:7.44E-4 ID:SGTC_479|Compound:n-linoleoylglycine|FD-Score:-3.74|P-value:4.13E-5 ID:SGTC_489|Compound:paxilline|FD-Score:4.51|P-value:1.96E-6 ID:SGTC_649|Compound:1123-0311|FD-Score:3.97|P-value:2.48E-5 ID:SGTC_674|Compound:0498-0004|FD-Score:3.36|P-value:3.05E-4 ID:SGTC_934|Compound:2950-0684|FD-Score:-3.69|P-value:5.05E-5 ID:SGTC_1487|Compound:3970-0795|FD-Score:3.11|P-value:7.80E-4 ID:SGTC_1583|Compound:clindamycin|FD-Score:3.34|P-value:3.41E-4 ID:SGTC_1677|Compound:st019204|FD-Score:3.90|P-value:3.37E-5 ID:SGTC_1715|Compound:st032160|FD-Score:-3.53|P-value:1.01E-4 ID:SGTC_1720|Compound:st037298|FD-Score:5.17|P-value:5.79E-8 ID:SGTC_1888|Compound:azatryptophan|FD-Score:3.37|P-value:3.00E-4 ID:SGTC_1975|Compound:st070967|FD-Score:3.18|P-value:6.11E-4 ID:SGTC_2104|Compound:5389443|FD-Score:3.12|P-value:7.55E-4 ID:SGTC_2105|Compound:5350118|FD-Score:3.18|P-value:6.01E-4 ID:SGTC_2137|Compound:5261020|FD-Score:3.20|P-value:5.72E-4 ID:SGTC_2149|Compound:5554786|FD-Score:3.07|P-value:8.94E-4 ID:SGTC_2160|Compound:5660466|FD-Score:4.38|P-value:3.77E-6 ID:SGTC_2163|Compound:5671233|FD-Score:-3.23|P-value:3.26E-4 ID:SGTC_2206|Compound:7254556|FD-Score:3.11|P-value:7.91E-4 ID:SGTC_2258|Compound:7960471|FD-Score:3.10|P-value:8.21E-4 ID:SGTC_2290|Compound:7904846|FD-Score:-3.24|P-value:3.19E-4 ID:SGTC_2337|Compound:9009472|FD-Score:-3.02|P-value:6.97E-4 ID:SGTC_2554|Compound:13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one|FD-Score:3.57|P-value:1.36E-4 ID:SGTC_2557|Compound:derrustone|FD-Score:4.70|P-value:7.56E-7 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:-4.55|P-value:9.06E-7 ID:SGTC_2610|Compound:ononetin|FD-Score:10.20|P-value:2.43E-26 ID:SGTC_2611|Compound:pyromycin|FD-Score:5.17|P-value:6.00E-8 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:3.37|P-value:2.98E-4 ID:SGTC_2792|Compound:7535235|FD-Score:4.27|P-value:6.41E-6 ID:SGTC_2799|Compound:7812892|FD-Score:3.39|P-value:2.77E-4 ID:SGTC_2988|Compound:9073640|FD-Score:4.79|P-value:4.75E-7 ID:SGTC_2989|Compound:9073649|FD-Score:3.70|P-value:8.00E-5 ID:SGTC_2997|Compound:9067075|FD-Score:5.50|P-value:8.39E-9 ID:SGTC_3049|Compound:9092223|FD-Score:3.44|P-value:2.32E-4 ID:SGTC_3093|Compound:9117344|FD-Score:3.33|P-value:3.42E-4 ID:SGTC_3139|Compound:9095020|FD-Score:3.96|P-value:2.65E-5 ID:SGTC_3185|Compound:9108267|FD-Score:3.17|P-value:6.30E-4 ID:SGTC_3263|Compound:9137018|FD-Score:-4.36|P-value:2.30E-6 ID:SGTC_3265|Compound:9137266|FD-Score:3.31|P-value:3.77E-4 ID:SGTC_3266|Compound:9136860|FD-Score:5.20|P-value:4.83E-8 ID:SGTC_3270|Compound:9137563|FD-Score:-3.13|P-value:4.73E-4 ID:SGTC_3272|Compound:9137413|FD-Score:-5.79|P-value:6.51E-10 ID:SGTC_3277|Compound:9138724|FD-Score:3.34|P-value:3.38E-4 ID:SGTC_74|Compound:000s-0487|FD-Score:3.22|P-value:5.18E-4 ID:SGTC_84|Compound:0443-0269|FD-Score:3.07|P-value:9.03E-4 ID:SGTC_113|Compound:0099-0221|FD-Score:-3.16|P-value:4.24E-4 ID:SGTC_120|Compound:rhodamine 6G|FD-Score:-3.64|P-value:6.36E-5 ID:SGTC_121|Compound:0557-0495|FD-Score:-3.33|P-value:2.24E-4 ID:SGTC_360|Compound:0957-0399|FD-Score:4.00|P-value:2.18E-5 ID:SGTC_397|Compound:arbidol|FD-Score:4.12|P-value:1.26E-5 ID:SGTC_401|Compound:neomycin|FD-Score:-3.31|P-value:2.40E-4 ID:SGTC_404|Compound:fumagillin|FD-Score:3.55|P-value:1.49E-4 ID:SGTC_405|Compound:ebelactone b|FD-Score:-3.28|P-value:2.73E-4 ID:SGTC_414|Compound:piperonyl butoxide|FD-Score:5.87|P-value:8.43E-10 ID:SGTC_475|Compound:α-linolenic acid|FD-Score:-3.01|P-value:7.44E-4 ID:SGTC_479|Compound:n-linoleoylglycine|FD-Score:-3.74|P-value:4.13E-5 ID:SGTC_489|Compound:paxilline|FD-Score:4.51|P-value:1.96E-6 ID:SGTC_649|Compound:1123-0311|FD-Score:3.97|P-value:2.48E-5 ID:SGTC_674|Compound:0498-0004|FD-Score:3.36|P-value:3.05E-4 ID:SGTC_934|Compound:2950-0684|FD-Score:-3.69|P-value:5.05E-5 ID:SGTC_1487|Compound:3970-0795|FD-Score:3.11|P-value:7.80E-4 ID:SGTC_1583|Compound:clindamycin|FD-Score:3.34|P-value:3.41E-4 ID:SGTC_1677|Compound:st019204|FD-Score:3.90|P-value:3.37E-5 ID:SGTC_1715|Compound:st032160|FD-Score:-3.53|P-value:1.01E-4 ID:SGTC_1720|Compound:st037298|FD-Score:5.17|P-value:5.79E-8 ID:SGTC_1888|Compound:azatryptophan|FD-Score:3.37|P-value:3.00E-4 ID:SGTC_1975|Compound:st070967|FD-Score:3.18|P-value:6.11E-4 ID:SGTC_2104|Compound:5389443|FD-Score:3.12|P-value:7.55E-4 ID:SGTC_2105|Compound:5350118|FD-Score:3.18|P-value:6.01E-4 ID:SGTC_2137|Compound:5261020|FD-Score:3.20|P-value:5.72E-4 ID:SGTC_2149|Compound:5554786|FD-Score:3.07|P-value:8.94E-4 ID:SGTC_2160|Compound:5660466|FD-Score:4.38|P-value:3.77E-6 ID:SGTC_2163|Compound:5671233|FD-Score:-3.23|P-value:3.26E-4 ID:SGTC_2206|Compound:7254556|FD-Score:3.11|P-value:7.91E-4 ID:SGTC_2258|Compound:7960471|FD-Score:3.10|P-value:8.21E-4 ID:SGTC_2290|Compound:7904846|FD-Score:-3.24|P-value:3.19E-4 ID:SGTC_2337|Compound:9009472|FD-Score:-3.02|P-value:6.97E-4 ID:SGTC_2554|Compound:13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one|FD-Score:3.57|P-value:1.36E-4 ID:SGTC_2557|Compound:derrustone|FD-Score:4.70|P-value:7.56E-7 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:-4.55|P-value:9.06E-7 ID:SGTC_2610|Compound:ononetin|FD-Score:10.20|P-value:2.43E-26 ID:SGTC_2611|Compound:pyromycin|FD-Score:5.17|P-value:6.00E-8 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:3.37|P-value:2.98E-4 ID:SGTC_2792|Compound:7535235|FD-Score:4.27|P-value:6.41E-6 ID:SGTC_2799|Compound:7812892|FD-Score:3.39|P-value:2.77E-4 ID:SGTC_2988|Compound:9073640|FD-Score:4.79|P-value:4.75E-7 ID:SGTC_2989|Compound:9073649|FD-Score:3.70|P-value:8.00E-5 ID:SGTC_2997|Compound:9067075|FD-Score:5.50|P-value:8.39E-9 ID:SGTC_3049|Compound:9092223|FD-Score:3.44|P-value:2.32E-4 ID:SGTC_3093|Compound:9117344|FD-Score:3.33|P-value:3.42E-4 ID:SGTC_3139|Compound:9095020|FD-Score:3.96|P-value:2.65E-5 ID:SGTC_3185|Compound:9108267|FD-Score:3.17|P-value:6.30E-4 ID:SGTC_3263|Compound:9137018|FD-Score:-4.36|P-value:2.30E-6 ID:SGTC_3265|Compound:9137266|FD-Score:3.31|P-value:3.77E-4 ID:SGTC_3266|Compound:9136860|FD-Score:5.20|P-value:4.83E-8 ID:SGTC_3270|Compound:9137563|FD-Score:-3.13|P-value:4.73E-4 ID:SGTC_3272|Compound:9137413|FD-Score:-5.79|P-value:6.51E-10 ID:SGTC_3277|Compound:9138724|FD-Score:3.34|P-value:3.38E-4

Top fitness defect scores for YPR183W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2610 ononetin 10.20 44.2 µM 2.43E-26 1 6.53E-25 5.33
2 SGTC_414 piperonyl butoxide 5.87 100.0 µM 8.43E-10 1 2.16E-9 1.55
3 SGTC_2997 9067075 5.50 71.4 µM 8.39E-9 unfolded protein response 10 1.88E-8 0.05
4 SGTC_3266 9136860 5.20 49.5 µM 4.83E-8 cell wall 7 9.78E-8 0.23
5 SGTC_1720 st037298 5.17 9.5 µM 5.79E-8 2 1.16E-7 0.25
6 SGTC_2611 pyromycin 5.17 23.9 µM 6.00E-8 1 1.20E-7 0.50
7 SGTC_2988 9073640 4.79 71.4 µM 4.75E-7 6 8.44E-7 0.13
8 SGTC_2557 derrustone 4.70 83.8 µM 7.56E-7 3 1.31E-6 0.60
9 SGTC_489 paxilline 4.51 115.0 µM 1.96E-6 PDR1 1 3.22E-6 0.50
10 SGTC_2160 5660466 4.38 132.9 µM 3.77E-6 60S ribosome export 10 5.98E-6 0.06
11 SGTC_2792 7535235 4.27 81.8 µM 6.41E-6 fatty acid desaturase (OLE1) 9 9.87E-6 0.36
12 SGTC_397 arbidol 4.12 50.0 µM 1.26E-5 cell wall 5 1.87E-5 0.14
13 SGTC_360 0957-0399 4.00 1.0 µM 2.18E-5 cell wall 13 3.15E-5 0.28
14 SGTC_649 1123-0311 3.97 367.0 µM 2.48E-5 endomembrane recycling 10 3.55E-5 0.23
15 SGTC_3139 9095020 3.96 49.5 µM 2.65E-5 5 3.78E-5 0.04
16 SGTC_1677 st019204 3.90 53.9 µM 3.37E-5 7 4.75E-5 0.13
17 SGTC_2989 9073649 3.70 71.4 µM 8.00E-5 15 1.08E-4 0.05
18 SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 3.57 66.7 µM 1.36E-4 5 1.78E-4 0.37
19 SGTC_404 fumagillin 3.55 50.0 µM 1.49E-4 8 1.94E-4 0.06
20 SGTC_3049 9092223 3.44 49.5 µM 2.32E-4 11 2.95E-4 0.04

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.115 2.40E-11 YJR024C MDE1 hom 5'-methylthioribulose-1-phosphate dehydratase; acts in the methionine salvage pathway; potential Smt3p sumoylation substrate; expression downregulated by caspofungin and deletion mutant is caspofungin resistant
0.112 9.49E-11 YMR147W_p YMR147W_p hom Putative protein of unknown function
0.111 1.04E-10 YDL131W LYS21 hom Homocitrate synthase isozyme; catalyzes the condensation of acetyl-CoA and alpha-ketoglutarate to form homocitrate, which is the first step in the lysine biosynthesis pathway; LYS21 has a paralog, LYS20, that arose from the whole genome duplication
0.100 6.48E-9 YMR272W-B_p YMR272W-B_p hom Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
0.097 1.99E-8 YPL011C TAF3 het TFIID subunit (47 kDa), involved in promoter binding and RNA polymerase II transcription initiation
0.095 4.15E-8 YDR215C_d YDR215C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutant displays elevated sensitivity to expression of a mutant huntingtin fragment or of alpha-synuclein
0.089 2.41E-7 YNL249C MPA43 hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.089 2.78E-7 YGR259C_d YGR259C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF TNA1/YGR260W
0.088 3.35E-7 YGL049C TIF4632 hom Translation initiation factor eIF4G, subunit of the mRNA cap-binding protein complex (eIF4F) that also contains eIF4E (Cdc33p); associates with the poly(A)-binding protein Pab1p, also interacts with eIF4A (Tif1p); TIF4632 has a paralog, TIF4631, that arose from the whole genome duplication
0.087 4.84E-7 YBR146W MRPS9 hom Mitochondrial ribosomal protein of the small subunit
0.086 5.25E-7 YGL180W ATG1 hom Protein ser/thr kinase required for vesicle formation in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; structurally required for phagophore assembly site formation; during autophagy forms a complex with Atg13p and Atg17p
0.084 1.23E-6 YBR157C ICS2 hom Protein of unknown function; null mutation does not confer any obvious defects in growth, spore germination, viability, or carbohydrate utilization
0.083 1.50E-6 YNL310C ZIM17 het Heat shock protein with a zinc finger motif; essential for protein import into mitochondria; may act with Pam18p to facilitate recognition and folding of imported proteins by Ssc1p (mtHSP70) in the mitochondrial matrix
0.082 1.93E-6 YNL043C_d YNL043C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YIP3/YNL044W
0.082 2.15E-6 YOR190W SPR1 hom Sporulation-specific exo-1,3-beta-glucanase; contributes to ascospore thermoresistance