YPR184W / GDB1

Glycogen debranching enzyme; contains glucanotranferase and alpha-1,6-amyloglucosidase activities; required for glycogen degradation; phosphorylated in mitochondria; activity is inhibited by Igd1p; protein abundance increases in response to DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YPR184W / GDB1

Click on Significant Values for Screen Details ID:SGTC_51|Compound:1013-0126|FD-Score:3.58|P-value:1.45E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:8.10|P-value:1.04E-16 ID:SGTC_169|Compound:k015-0017|FD-Score:3.69|P-value:9.42E-5 ID:SGTC_175|Compound:3793-3120|FD-Score:3.16|P-value:7.09E-4 ID:SGTC_207|Compound:4185-0010|FD-Score:5.23|P-value:5.93E-8 ID:SGTC_408|Compound:cantharidin|FD-Score:3.11|P-value:8.36E-4 ID:SGTC_600|Compound:1495-0418|FD-Score:3.15|P-value:7.21E-4 ID:SGTC_626|Compound:0214-0009|FD-Score:3.93|P-value:3.47E-5 ID:SGTC_655|Compound:k060-0012|FD-Score:3.22|P-value:5.68E-4 ID:SGTC_660|Compound:4031-1742|FD-Score:3.65|P-value:1.11E-4 ID:SGTC_663|Compound:1486-0733|FD-Score:3.63|P-value:1.19E-4 ID:SGTC_674|Compound:0498-0004|FD-Score:4.41|P-value:4.02E-6 ID:SGTC_696|Compound:1560-0013|FD-Score:4.45|P-value:3.25E-6 ID:SGTC_840|Compound:0245-0196|FD-Score:3.41|P-value:2.85E-4 ID:SGTC_844|Compound:0330-0132|FD-Score:4.96|P-value:2.60E-7 ID:SGTC_861|Compound:0443-0273|FD-Score:3.27|P-value:4.77E-4 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:6.03|P-value:4.75E-10 ID:SGTC_997|Compound:3996-0078|FD-Score:3.83|P-value:5.26E-5 ID:SGTC_1081|Compound:sertraline|FD-Score:3.49|P-value:2.12E-4 ID:SGTC_1088|Compound:bifonazole|FD-Score:3.17|P-value:6.94E-4 ID:SGTC_1094|Compound:duloxetine|FD-Score:3.42|P-value:2.70E-4 ID:SGTC_1099|Compound:5-nonyloxytryptamine|FD-Score:-3.16|P-value:5.88E-4 ID:SGTC_1132|Compound:3456-3614|FD-Score:-3.12|P-value:6.91E-4 ID:SGTC_1252|Compound:0493-0875|FD-Score:4.01|P-value:2.50E-5 ID:SGTC_1381|Compound:2324-0066|FD-Score:3.33|P-value:3.86E-4 ID:SGTC_1447|Compound:4239-0816|FD-Score:3.77|P-value:6.78E-5 ID:SGTC_1448|Compound:4255-0083|FD-Score:-3.35|P-value:3.00E-4 ID:SGTC_1451|Compound:4152-0210|FD-Score:4.10|P-value:1.64E-5 ID:SGTC_1531|Compound:st059297|FD-Score:4.29|P-value:7.08E-6 ID:SGTC_1541|Compound:2',3',6-trimethoxyflavone|FD-Score:3.31|P-value:4.15E-4 ID:SGTC_1636|Compound:st007707|FD-Score:3.38|P-value:3.20E-4 ID:SGTC_1727|Compound:st034309|FD-Score:4.06|P-value:2.03E-5 ID:SGTC_1729|Compound:st035615|FD-Score:3.38|P-value:3.12E-4 ID:SGTC_1788|Compound:fluconazole|FD-Score:3.43|P-value:2.65E-4 ID:SGTC_1797|Compound:st048695|FD-Score:3.39|P-value:3.11E-4 ID:SGTC_1851|Compound:st056236|FD-Score:-3.20|P-value:5.27E-4 ID:SGTC_1929|Compound:genistein trimethyl ether|FD-Score:3.25|P-value:5.17E-4 ID:SGTC_1977|Compound:st070720|FD-Score:4.64|P-value:1.33E-6 ID:SGTC_1992|Compound:st073643|FD-Score:-3.05|P-value:8.73E-4 ID:SGTC_1998|Compound:st075797|FD-Score:-4.14|P-value:1.15E-5 ID:SGTC_2151|Compound:5563267|FD-Score:4.75|P-value:7.42E-7 ID:SGTC_2172|Compound:5754775|FD-Score:-4.11|P-value:1.28E-5 ID:SGTC_2175|Compound:5807670|FD-Score:3.30|P-value:4.27E-4 ID:SGTC_2178|Compound:5812956|FD-Score:-3.08|P-value:7.96E-4 ID:SGTC_2179|Compound:6298986|FD-Score:5.67|P-value:4.63E-9 ID:SGTC_2185|Compound:6113692|FD-Score:4.41|P-value:4.03E-6 ID:SGTC_2274|Compound:7947094|FD-Score:-3.39|P-value:2.58E-4 ID:SGTC_2294|Compound:7971431|FD-Score:3.27|P-value:4.81E-4 ID:SGTC_2307|Compound:7538926|FD-Score:3.55|P-value:1.65E-4 ID:SGTC_2345|Compound:9052315|FD-Score:4.05|P-value:2.13E-5 ID:SGTC_2346|Compound:9031566|FD-Score:3.96|P-value:3.15E-5 ID:SGTC_2402|Compound:5553605|FD-Score:3.15|P-value:7.28E-4 ID:SGTC_2433|Compound:5607874|FD-Score:3.12|P-value:8.16E-4 ID:SGTC_2456|Compound:5770359|FD-Score:3.80|P-value:5.98E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:5.96|P-value:7.86E-10 ID:SGTC_2583|Compound:asiatic acid|FD-Score:3.85|P-value:5.01E-5 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:3.24|P-value:5.38E-4 ID:SGTC_2713|Compound:st079149|FD-Score:3.27|P-value:4.70E-4 ID:SGTC_2884|Compound:9058502|FD-Score:4.33|P-value:5.99E-6 ID:SGTC_2887|Compound:9044784|FD-Score:3.18|P-value:6.48E-4 ID:SGTC_2959|Compound:9079155|FD-Score:-5.77|P-value:1.88E-9 ID:SGTC_2966|Compound:9084041|FD-Score:3.72|P-value:8.31E-5 ID:SGTC_3126|Compound:9127922|FD-Score:3.20|P-value:6.19E-4 ID:SGTC_3135|Compound:9127742|FD-Score:-3.72|P-value:6.84E-5 ID:SGTC_3246|Compound:9135460|FD-Score:3.12|P-value:8.24E-4 ID:SGTC_3286|Compound:9117135|FD-Score:3.12|P-value:8.27E-4 ID:SGTC_3296|Compound:9122258|FD-Score:3.53|P-value:1.80E-4 ID:SGTC_51|Compound:1013-0126|FD-Score:3.58|P-value:1.45E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:8.10|P-value:1.04E-16 ID:SGTC_169|Compound:k015-0017|FD-Score:3.69|P-value:9.42E-5 ID:SGTC_175|Compound:3793-3120|FD-Score:3.16|P-value:7.09E-4 ID:SGTC_207|Compound:4185-0010|FD-Score:5.23|P-value:5.93E-8 ID:SGTC_408|Compound:cantharidin|FD-Score:3.11|P-value:8.36E-4 ID:SGTC_600|Compound:1495-0418|FD-Score:3.15|P-value:7.21E-4 ID:SGTC_626|Compound:0214-0009|FD-Score:3.93|P-value:3.47E-5 ID:SGTC_655|Compound:k060-0012|FD-Score:3.22|P-value:5.68E-4 ID:SGTC_660|Compound:4031-1742|FD-Score:3.65|P-value:1.11E-4 ID:SGTC_663|Compound:1486-0733|FD-Score:3.63|P-value:1.19E-4 ID:SGTC_674|Compound:0498-0004|FD-Score:4.41|P-value:4.02E-6 ID:SGTC_696|Compound:1560-0013|FD-Score:4.45|P-value:3.25E-6 ID:SGTC_840|Compound:0245-0196|FD-Score:3.41|P-value:2.85E-4 ID:SGTC_844|Compound:0330-0132|FD-Score:4.96|P-value:2.60E-7 ID:SGTC_861|Compound:0443-0273|FD-Score:3.27|P-value:4.77E-4 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:6.03|P-value:4.75E-10 ID:SGTC_997|Compound:3996-0078|FD-Score:3.83|P-value:5.26E-5 ID:SGTC_1081|Compound:sertraline|FD-Score:3.49|P-value:2.12E-4 ID:SGTC_1088|Compound:bifonazole|FD-Score:3.17|P-value:6.94E-4 ID:SGTC_1094|Compound:duloxetine|FD-Score:3.42|P-value:2.70E-4 ID:SGTC_1099|Compound:5-nonyloxytryptamine|FD-Score:-3.16|P-value:5.88E-4 ID:SGTC_1132|Compound:3456-3614|FD-Score:-3.12|P-value:6.91E-4 ID:SGTC_1252|Compound:0493-0875|FD-Score:4.01|P-value:2.50E-5 ID:SGTC_1381|Compound:2324-0066|FD-Score:3.33|P-value:3.86E-4 ID:SGTC_1447|Compound:4239-0816|FD-Score:3.77|P-value:6.78E-5 ID:SGTC_1448|Compound:4255-0083|FD-Score:-3.35|P-value:3.00E-4 ID:SGTC_1451|Compound:4152-0210|FD-Score:4.10|P-value:1.64E-5 ID:SGTC_1531|Compound:st059297|FD-Score:4.29|P-value:7.08E-6 ID:SGTC_1541|Compound:2',3',6-trimethoxyflavone|FD-Score:3.31|P-value:4.15E-4 ID:SGTC_1636|Compound:st007707|FD-Score:3.38|P-value:3.20E-4 ID:SGTC_1727|Compound:st034309|FD-Score:4.06|P-value:2.03E-5 ID:SGTC_1729|Compound:st035615|FD-Score:3.38|P-value:3.12E-4 ID:SGTC_1788|Compound:fluconazole|FD-Score:3.43|P-value:2.65E-4 ID:SGTC_1797|Compound:st048695|FD-Score:3.39|P-value:3.11E-4 ID:SGTC_1851|Compound:st056236|FD-Score:-3.20|P-value:5.27E-4 ID:SGTC_1929|Compound:genistein trimethyl ether|FD-Score:3.25|P-value:5.17E-4 ID:SGTC_1977|Compound:st070720|FD-Score:4.64|P-value:1.33E-6 ID:SGTC_1992|Compound:st073643|FD-Score:-3.05|P-value:8.73E-4 ID:SGTC_1998|Compound:st075797|FD-Score:-4.14|P-value:1.15E-5 ID:SGTC_2151|Compound:5563267|FD-Score:4.75|P-value:7.42E-7 ID:SGTC_2172|Compound:5754775|FD-Score:-4.11|P-value:1.28E-5 ID:SGTC_2175|Compound:5807670|FD-Score:3.30|P-value:4.27E-4 ID:SGTC_2178|Compound:5812956|FD-Score:-3.08|P-value:7.96E-4 ID:SGTC_2179|Compound:6298986|FD-Score:5.67|P-value:4.63E-9 ID:SGTC_2185|Compound:6113692|FD-Score:4.41|P-value:4.03E-6 ID:SGTC_2274|Compound:7947094|FD-Score:-3.39|P-value:2.58E-4 ID:SGTC_2294|Compound:7971431|FD-Score:3.27|P-value:4.81E-4 ID:SGTC_2307|Compound:7538926|FD-Score:3.55|P-value:1.65E-4 ID:SGTC_2345|Compound:9052315|FD-Score:4.05|P-value:2.13E-5 ID:SGTC_2346|Compound:9031566|FD-Score:3.96|P-value:3.15E-5 ID:SGTC_2402|Compound:5553605|FD-Score:3.15|P-value:7.28E-4 ID:SGTC_2433|Compound:5607874|FD-Score:3.12|P-value:8.16E-4 ID:SGTC_2456|Compound:5770359|FD-Score:3.80|P-value:5.98E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:5.96|P-value:7.86E-10 ID:SGTC_2583|Compound:asiatic acid|FD-Score:3.85|P-value:5.01E-5 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:3.24|P-value:5.38E-4 ID:SGTC_2713|Compound:st079149|FD-Score:3.27|P-value:4.70E-4 ID:SGTC_2884|Compound:9058502|FD-Score:4.33|P-value:5.99E-6 ID:SGTC_2887|Compound:9044784|FD-Score:3.18|P-value:6.48E-4 ID:SGTC_2959|Compound:9079155|FD-Score:-5.77|P-value:1.88E-9 ID:SGTC_2966|Compound:9084041|FD-Score:3.72|P-value:8.31E-5 ID:SGTC_3126|Compound:9127922|FD-Score:3.20|P-value:6.19E-4 ID:SGTC_3135|Compound:9127742|FD-Score:-3.72|P-value:6.84E-5 ID:SGTC_3246|Compound:9135460|FD-Score:3.12|P-value:8.24E-4 ID:SGTC_3286|Compound:9117135|FD-Score:3.12|P-value:8.27E-4 ID:SGTC_3296|Compound:9122258|FD-Score:3.53|P-value:1.80E-4

Top fitness defect scores for YPR184W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_58 0957-0393 8.10 9.0 µM 1.04E-16 cell wall 120 2.80E-16
2 SGTC_915 methyl methanesulfonate (MMS) 6.03 110.0 mM 4.75E-10 DNA damage response 10 7.96E-10
3 SGTC_2582 agaric acid 5.96 100.0 µM 7.86E-10 redox potentiating 162 1.30E-9
4 SGTC_2179 6298986 5.67 200.0 µM 4.63E-9 heme requiring 5 7.24E-9
5 SGTC_207 4185-0010 5.23 4.5 µM 5.93E-8 endomembrane recycling 52 8.61E-8
6 SGTC_844 0330-0132 4.96 15.3 µM 2.60E-7 8 3.61E-7
7 SGTC_2151 5563267 4.75 85.4 µM 7.42E-7 10 1.00E-6
8 SGTC_1977 st070720 4.64 65.3 µM 1.33E-6 5 1.76E-6
9 SGTC_696 1560-0013 4.45 611.0 µM 3.25E-6 15 4.20E-6
10 SGTC_674 0498-0004 4.41 451.0 µM 4.02E-6 heme requiring 15 5.17E-6
11 SGTC_2185 6113692 4.41 200.0 µM 4.03E-6 ergosterol biosynthesis 8 5.18E-6
12 SGTC_2884 9058502 4.33 52.0 µM 5.99E-6 19 7.61E-6
13 SGTC_1531 st059297 4.29 52.4 µM 7.08E-6 8 8.95E-6
14 SGTC_1451 4152-0210 4.10 104.0 µM 1.64E-5 24 2.03E-5
15 SGTC_1727 st034309 4.06 9.9 µM 2.03E-5 36 2.50E-5
16 SGTC_2345 9052315 4.05 157.4 µM 2.13E-5 19 2.61E-5
17 SGTC_1252 0493-0875 4.01 34.8 µM 2.50E-5 27 3.05E-5
18 SGTC_2346 9031566 3.96 143.8 µM 3.15E-5 Golgi 17 3.82E-5
19 SGTC_626 0214-0009 3.93 33.0 µM 3.47E-5 copper-dependent oxidative stress 21 4.20E-5
20 SGTC_2583 asiatic acid 3.85 100.0 µM 5.01E-5 41 6.00E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.205 3.13E-33 YOR231W MKK1 hom MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p; MKK1 has a paralog, MKK2, that arose from the whole genome duplication
0.203 1.09E-32 YBR260C RGD1 hom GTPase-activating protein (RhoGAP) for Rho3p and Rho4p, possibly involved in control of actin cytoskeleton organization
0.202 2.29E-32 YML103C NUP188 hom Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC organization and nucleocytoplasmic transport; homologous to human NUP188
0.185 2.66E-27 YIL160C POT1 hom 3-ketoacyl-CoA thiolase with broad chain length specificity, cleaves 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA during beta-oxidation of fatty acids
0.182 2.77E-26 YNL215W IES2 hom Protein that associates with the INO80 chromatin remodeling complex; associates with the INO80 complex under low-salt conditions; essential for growth under anaerobic conditions; protein abundance increases in response to DNA replication stress
0.180 1.05E-25 YDR205W MSC2 hom Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids
0.162 3.86E-21 YGR217W CCH1 hom Voltage-gated high-affinity calcium channel involved in calcium influx in response to some environmental stresses as well as exposure to mating pheromones; interacts and co-localizes with Mid1p, suggesting Cch1p and Mid1p function together
0.162 4.58E-21 YLR331C_d JIP3_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene MID2
0.153 4.55E-19 YAL015C NTG1 hom DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase; involved in base excision repair; acts in both nucleus and mitochondrion; creates a double-strand break at mtDNA origins that stimulates replication in response to oxidative stress; NTG1 has a paralog, NTG2, that arose from the whole genome duplication
0.152 7.42E-19 YGL178W MPT5 hom mRNA-binding protein of the PUF family; binds to the 3' UTR of specific mRNAs, including those involved in mating type switching, cell wall integrity, chronological lifespan, chromatin modification, and spindle pole body architecture; recruits the CCR4-NOT deadenylase complex to mRNAs along with Dhh1p and Dcp1p to promote deadenylation, decapping, and decay; also interacts with the Caf20p translational initiation repressor, affecting its mRNA target specificity
0.151 1.29E-18 YIL111W COX5B hom Subunit Vb of cytochrome c oxidase; cytochrome c oxidase is the terminal member of the mitochondrial inner membrane electron transport chain; Cox5Bp is predominantly expressed during anaerobic growth while its isoform Va (Cox5Ap) is expressed during aerobic growth; COX5B has a paralog, COX5A, that arose from the whole genome duplication
0.148 7.55E-18 YIL123W SIM1 hom Protein of the SUN family (Sim1p, Uth1p, Nca3p, Sun4p) that may participate in DNA replication, promoter contains SCB regulation box at -300 bp indicating that expression may be cell cycle-regulated
0.147 9.96E-18 YKL115C_d YKL115C_d hom Dubious open reading frame, unlikely to encode a protein; partially overlaps the verified gene PRR1
0.146 1.73E-17 YGR196C FYV8 hom Protein of unknown function, required for survival upon exposure to K1 killer toxin
0.146 1.78E-17 YLR412W BER1 hom Protein involved in microtubule-related processes, N-acetylation; GFP-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS; YLR412W is not an essential gene; similar to Arabidopsis SRR1 gene