YPR190C / RPC82

RNA polymerase III subunit C82

Zygosity: Heterozygous strain
fixedexpanded
Profile for YPR190C / RPC82

Click on Significant Values for Screen Details ID:SGTC_81|Compound:0411-0046|FD-Score:6.47|P-value:2.08E-10 ID:SGTC_98|Compound:0074-0023|FD-Score:-3.52|P-value:4.21E-4 ID:SGTC_104|Compound:0074-0074|FD-Score:3.76|P-value:1.31E-4 ID:SGTC_108|Compound:0509-0257|FD-Score:4.92|P-value:9.62E-7 ID:SGTC_115|Compound:0527-0192|FD-Score:5.34|P-value:1.22E-7 ID:SGTC_119|Compound:0121-0043|FD-Score:-3.47|P-value:5.12E-4 ID:SGTC_124|Compound:0136-0217|FD-Score:-3.38|P-value:6.87E-4 ID:SGTC_168|Compound:3970-0862|FD-Score:3.24|P-value:8.18E-4 ID:SGTC_181|Compound:1447-1644|FD-Score:3.67|P-value:1.86E-4 ID:SGTC_266|Compound:formosanin C|FD-Score:5.66|P-value:2.28E-8 ID:SGTC_426|Compound:0988-0037|FD-Score:3.54|P-value:2.92E-4 ID:SGTC_551|Compound:k048-0028|FD-Score:4.12|P-value:3.18E-5 ID:SGTC_558|Compound:k064-0027|FD-Score:3.24|P-value:8.16E-4 ID:SGTC_566|Compound:0958-0068|FD-Score:7.90|P-value:1.30E-14 ID:SGTC_581|Compound:0958-0271|FD-Score:-3.72|P-value:2.08E-4 ID:SGTC_586|Compound:0957-0265|FD-Score:8.11|P-value:2.67E-15 ID:SGTC_673|Compound:1082-0474|FD-Score:3.46|P-value:3.87E-4 ID:SGTC_682|Compound:0kpi-0099|FD-Score:3.60|P-value:2.34E-4 ID:SGTC_757|Compound:1066-0008|FD-Score:3.47|P-value:3.77E-4 ID:SGTC_795|Compound:0685-0265|FD-Score:3.32|P-value:6.18E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:7.80|P-value:2.67E-14 ID:SGTC_839|Compound:0122-0028|FD-Score:6.35|P-value:4.36E-10 ID:SGTC_923|Compound:1900-2434|FD-Score:4.26|P-value:1.81E-5 ID:SGTC_1008|Compound:4106-0037|FD-Score:3.26|P-value:7.73E-4 ID:SGTC_1037|Compound:k284-1091|FD-Score:5.57|P-value:3.66E-8 ID:SGTC_1057|Compound:3448-5381|FD-Score:-3.29|P-value:9.15E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:3.87|P-value:8.57E-5 ID:SGTC_1104|Compound:tacrolimus|FD-Score:-3.48|P-value:4.92E-4 ID:SGTC_1133|Compound:3473-0247|FD-Score:4.68|P-value:2.96E-6 ID:SGTC_1146|Compound:3579-1023|FD-Score:3.79|P-value:1.17E-4 ID:SGTC_1154|Compound:4088-0362|FD-Score:4.36|P-value:1.20E-5 ID:SGTC_1229|Compound:0139-0193|FD-Score:3.65|P-value:1.99E-4 ID:SGTC_1266|Compound:0828-0227|FD-Score:3.54|P-value:2.92E-4 ID:SGTC_1307|Compound:1187-1599|FD-Score:3.48|P-value:3.65E-4 ID:SGTC_1331|Compound:1472-0049|FD-Score:4.31|P-value:1.45E-5 ID:SGTC_1340|Compound:1486-1359|FD-Score:3.73|P-value:1.46E-4 ID:SGTC_1341|Compound:1486-1360|FD-Score:5.12|P-value:3.69E-7 ID:SGTC_1471|Compound:k673-0312|FD-Score:3.49|P-value:3.44E-4 ID:SGTC_1532|Compound:4',5'-dihydroxyflavone|FD-Score:4.95|P-value:8.43E-7 ID:SGTC_1542|Compound:7-hydroxy-3'-methoxyflavone|FD-Score:3.41|P-value:4.63E-4 ID:SGTC_1545|Compound:lovastatin|FD-Score:5.99|P-value:3.50E-9 ID:SGTC_1550|Compound:gossypolone|FD-Score:-4.96|P-value:1.19E-6 ID:SGTC_1554|Compound:st069299|FD-Score:-3.27|P-value:9.83E-4 ID:SGTC_1556|Compound:plumbagin|FD-Score:-4.65|P-value:4.90E-6 ID:SGTC_1627|Compound:st003713|FD-Score:4.40|P-value:1.01E-5 ID:SGTC_1781|Compound:st038725|FD-Score:3.46|P-value:3.91E-4 ID:SGTC_1824|Compound:st053723|FD-Score:-4.43|P-value:1.27E-5 ID:SGTC_1877|Compound:wortmannin|FD-Score:3.43|P-value:4.35E-4 ID:SGTC_1894|Compound:3',6'-dihydroxyflavone|FD-Score:4.04|P-value:4.38E-5 ID:SGTC_1906|Compound:st060206|FD-Score:-3.78|P-value:1.71E-4 ID:SGTC_1928|Compound:4'-methoxychalcone|FD-Score:3.96|P-value:6.21E-5 ID:SGTC_1950|Compound:st077106|FD-Score:3.61|P-value:2.31E-4 ID:SGTC_1953|Compound:st076800|FD-Score:4.97|P-value:7.46E-7 ID:SGTC_1954|Compound:st077032|FD-Score:-4.17|P-value:3.71E-5 ID:SGTC_2005|Compound:4024620|FD-Score:3.28|P-value:7.02E-4 ID:SGTC_2034|Compound:5197015|FD-Score:3.18|P-value:0.00100 ID:SGTC_2037|Compound:5169046|FD-Score:-5.01|P-value:9.61E-7 ID:SGTC_2042|Compound:p-Dimethylaminoacetophenone|FD-Score:3.95|P-value:6.48E-5 ID:SGTC_2050|Compound:5263056|FD-Score:-3.63|P-value:2.85E-4 ID:SGTC_2331|Compound:7980721|FD-Score:4.28|P-value:1.69E-5 ID:SGTC_2344|Compound:7990960|FD-Score:-3.76|P-value:1.79E-4 ID:SGTC_2351|Compound:9026858|FD-Score:4.00|P-value:5.20E-5 ID:SGTC_2370|Compound:9071495|FD-Score:3.64|P-value:2.03E-4 ID:SGTC_2373|Compound:9071805|FD-Score:5.16|P-value:2.92E-7 ID:SGTC_2376|Compound:9072922|FD-Score:-4.04|P-value:6.35E-5 ID:SGTC_2396|Compound:5342950|FD-Score:4.37|P-value:1.16E-5 ID:SGTC_2407|Compound:paclitaxel|FD-Score:3.23|P-value:8.35E-4 ID:SGTC_2411|Compound:st077133|FD-Score:7.69|P-value:5.73E-14 ID:SGTC_2418|Compound:pentamidine|FD-Score:-3.51|P-value:4.42E-4 ID:SGTC_2448|Compound:5185112|FD-Score:-3.48|P-value:4.95E-4 ID:SGTC_2467|Compound:5474540|FD-Score:3.18|P-value:9.82E-4 ID:SGTC_2522|Compound:biochanin a|FD-Score:4.72|P-value:2.39E-6 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:4.19|P-value:2.41E-5 ID:SGTC_2689|Compound:tacrolimus|FD-Score:-3.76|P-value:1.80E-4 ID:SGTC_2796|Compound:7949634|FD-Score:3.76|P-value:1.32E-4 ID:SGTC_2836|Compound:9010338|FD-Score:-3.29|P-value:9.20E-4 ID:SGTC_2890|Compound:9046729|FD-Score:4.61|P-value:4.09E-6 ID:SGTC_3007|Compound:9078383|FD-Score:3.76|P-value:1.33E-4 ID:SGTC_3019|Compound:9081971|FD-Score:3.35|P-value:5.64E-4 ID:SGTC_3074|Compound:9116018|FD-Score:3.21|P-value:9.12E-4 ID:SGTC_3103|Compound:9120822|FD-Score:4.92|P-value:9.37E-7 ID:SGTC_3106|Compound:9121286|FD-Score:3.66|P-value:1.91E-4 ID:SGTC_3117|Compound:9124945|FD-Score:3.44|P-value:4.18E-4 ID:SGTC_3217|Compound:9129673|FD-Score:3.18|P-value:9.98E-4 ID:SGTC_3296|Compound:9122258|FD-Score:-3.41|P-value:6.29E-4 ID:SGTC_3315|Compound:9136395|FD-Score:3.89|P-value:7.98E-5 ID:SGTC_3341|Compound:9147222|FD-Score:4.41|P-value:9.75E-6 ID:SGTC_3345|Compound:9148410|FD-Score:-3.34|P-value:7.93E-4 ID:SGTC_81|Compound:0411-0046|FD-Score:6.47|P-value:2.08E-10 ID:SGTC_98|Compound:0074-0023|FD-Score:-3.52|P-value:4.21E-4 ID:SGTC_104|Compound:0074-0074|FD-Score:3.76|P-value:1.31E-4 ID:SGTC_108|Compound:0509-0257|FD-Score:4.92|P-value:9.62E-7 ID:SGTC_115|Compound:0527-0192|FD-Score:5.34|P-value:1.22E-7 ID:SGTC_119|Compound:0121-0043|FD-Score:-3.47|P-value:5.12E-4 ID:SGTC_124|Compound:0136-0217|FD-Score:-3.38|P-value:6.87E-4 ID:SGTC_168|Compound:3970-0862|FD-Score:3.24|P-value:8.18E-4 ID:SGTC_181|Compound:1447-1644|FD-Score:3.67|P-value:1.86E-4 ID:SGTC_266|Compound:formosanin C|FD-Score:5.66|P-value:2.28E-8 ID:SGTC_426|Compound:0988-0037|FD-Score:3.54|P-value:2.92E-4 ID:SGTC_551|Compound:k048-0028|FD-Score:4.12|P-value:3.18E-5 ID:SGTC_558|Compound:k064-0027|FD-Score:3.24|P-value:8.16E-4 ID:SGTC_566|Compound:0958-0068|FD-Score:7.90|P-value:1.30E-14 ID:SGTC_581|Compound:0958-0271|FD-Score:-3.72|P-value:2.08E-4 ID:SGTC_586|Compound:0957-0265|FD-Score:8.11|P-value:2.67E-15 ID:SGTC_673|Compound:1082-0474|FD-Score:3.46|P-value:3.87E-4 ID:SGTC_682|Compound:0kpi-0099|FD-Score:3.60|P-value:2.34E-4 ID:SGTC_757|Compound:1066-0008|FD-Score:3.47|P-value:3.77E-4 ID:SGTC_795|Compound:0685-0265|FD-Score:3.32|P-value:6.18E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:7.80|P-value:2.67E-14 ID:SGTC_839|Compound:0122-0028|FD-Score:6.35|P-value:4.36E-10 ID:SGTC_923|Compound:1900-2434|FD-Score:4.26|P-value:1.81E-5 ID:SGTC_1008|Compound:4106-0037|FD-Score:3.26|P-value:7.73E-4 ID:SGTC_1037|Compound:k284-1091|FD-Score:5.57|P-value:3.66E-8 ID:SGTC_1057|Compound:3448-5381|FD-Score:-3.29|P-value:9.15E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:3.87|P-value:8.57E-5 ID:SGTC_1104|Compound:tacrolimus|FD-Score:-3.48|P-value:4.92E-4 ID:SGTC_1133|Compound:3473-0247|FD-Score:4.68|P-value:2.96E-6 ID:SGTC_1146|Compound:3579-1023|FD-Score:3.79|P-value:1.17E-4 ID:SGTC_1154|Compound:4088-0362|FD-Score:4.36|P-value:1.20E-5 ID:SGTC_1229|Compound:0139-0193|FD-Score:3.65|P-value:1.99E-4 ID:SGTC_1266|Compound:0828-0227|FD-Score:3.54|P-value:2.92E-4 ID:SGTC_1307|Compound:1187-1599|FD-Score:3.48|P-value:3.65E-4 ID:SGTC_1331|Compound:1472-0049|FD-Score:4.31|P-value:1.45E-5 ID:SGTC_1340|Compound:1486-1359|FD-Score:3.73|P-value:1.46E-4 ID:SGTC_1341|Compound:1486-1360|FD-Score:5.12|P-value:3.69E-7 ID:SGTC_1471|Compound:k673-0312|FD-Score:3.49|P-value:3.44E-4 ID:SGTC_1532|Compound:4',5'-dihydroxyflavone|FD-Score:4.95|P-value:8.43E-7 ID:SGTC_1542|Compound:7-hydroxy-3'-methoxyflavone|FD-Score:3.41|P-value:4.63E-4 ID:SGTC_1545|Compound:lovastatin|FD-Score:5.99|P-value:3.50E-9 ID:SGTC_1550|Compound:gossypolone|FD-Score:-4.96|P-value:1.19E-6 ID:SGTC_1554|Compound:st069299|FD-Score:-3.27|P-value:9.83E-4 ID:SGTC_1556|Compound:plumbagin|FD-Score:-4.65|P-value:4.90E-6 ID:SGTC_1627|Compound:st003713|FD-Score:4.40|P-value:1.01E-5 ID:SGTC_1781|Compound:st038725|FD-Score:3.46|P-value:3.91E-4 ID:SGTC_1824|Compound:st053723|FD-Score:-4.43|P-value:1.27E-5 ID:SGTC_1877|Compound:wortmannin|FD-Score:3.43|P-value:4.35E-4 ID:SGTC_1894|Compound:3',6'-dihydroxyflavone|FD-Score:4.04|P-value:4.38E-5 ID:SGTC_1906|Compound:st060206|FD-Score:-3.78|P-value:1.71E-4 ID:SGTC_1928|Compound:4'-methoxychalcone|FD-Score:3.96|P-value:6.21E-5 ID:SGTC_1950|Compound:st077106|FD-Score:3.61|P-value:2.31E-4 ID:SGTC_1953|Compound:st076800|FD-Score:4.97|P-value:7.46E-7 ID:SGTC_1954|Compound:st077032|FD-Score:-4.17|P-value:3.71E-5 ID:SGTC_2005|Compound:4024620|FD-Score:3.28|P-value:7.02E-4 ID:SGTC_2034|Compound:5197015|FD-Score:3.18|P-value:0.00100 ID:SGTC_2037|Compound:5169046|FD-Score:-5.01|P-value:9.61E-7 ID:SGTC_2042|Compound:p-Dimethylaminoacetophenone|FD-Score:3.95|P-value:6.48E-5 ID:SGTC_2050|Compound:5263056|FD-Score:-3.63|P-value:2.85E-4 ID:SGTC_2331|Compound:7980721|FD-Score:4.28|P-value:1.69E-5 ID:SGTC_2344|Compound:7990960|FD-Score:-3.76|P-value:1.79E-4 ID:SGTC_2351|Compound:9026858|FD-Score:4.00|P-value:5.20E-5 ID:SGTC_2370|Compound:9071495|FD-Score:3.64|P-value:2.03E-4 ID:SGTC_2373|Compound:9071805|FD-Score:5.16|P-value:2.92E-7 ID:SGTC_2376|Compound:9072922|FD-Score:-4.04|P-value:6.35E-5 ID:SGTC_2396|Compound:5342950|FD-Score:4.37|P-value:1.16E-5 ID:SGTC_2407|Compound:paclitaxel|FD-Score:3.23|P-value:8.35E-4 ID:SGTC_2411|Compound:st077133|FD-Score:7.69|P-value:5.73E-14 ID:SGTC_2418|Compound:pentamidine|FD-Score:-3.51|P-value:4.42E-4 ID:SGTC_2448|Compound:5185112|FD-Score:-3.48|P-value:4.95E-4 ID:SGTC_2467|Compound:5474540|FD-Score:3.18|P-value:9.82E-4 ID:SGTC_2522|Compound:biochanin a|FD-Score:4.72|P-value:2.39E-6 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:4.19|P-value:2.41E-5 ID:SGTC_2689|Compound:tacrolimus|FD-Score:-3.76|P-value:1.80E-4 ID:SGTC_2796|Compound:7949634|FD-Score:3.76|P-value:1.32E-4 ID:SGTC_2836|Compound:9010338|FD-Score:-3.29|P-value:9.20E-4 ID:SGTC_2890|Compound:9046729|FD-Score:4.61|P-value:4.09E-6 ID:SGTC_3007|Compound:9078383|FD-Score:3.76|P-value:1.33E-4 ID:SGTC_3019|Compound:9081971|FD-Score:3.35|P-value:5.64E-4 ID:SGTC_3074|Compound:9116018|FD-Score:3.21|P-value:9.12E-4 ID:SGTC_3103|Compound:9120822|FD-Score:4.92|P-value:9.37E-7 ID:SGTC_3106|Compound:9121286|FD-Score:3.66|P-value:1.91E-4 ID:SGTC_3117|Compound:9124945|FD-Score:3.44|P-value:4.18E-4 ID:SGTC_3217|Compound:9129673|FD-Score:3.18|P-value:9.98E-4 ID:SGTC_3296|Compound:9122258|FD-Score:-3.41|P-value:6.29E-4 ID:SGTC_3315|Compound:9136395|FD-Score:3.89|P-value:7.98E-5 ID:SGTC_3341|Compound:9147222|FD-Score:4.41|P-value:9.75E-6 ID:SGTC_3345|Compound:9148410|FD-Score:-3.34|P-value:7.93E-4

Top fitness defect scores for YPR190C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_586 0957-0265 8.11 8.2 µM 2.67E-15 cell wall 15 2.63E-16 0.17
2 SGTC_566 0958-0068 7.90 16.5 µM 1.30E-14 RSC & ERG11 3 1.45E-15 1.42
3 SGTC_800 3448-7362 7.80 155.0 µM 2.67E-14 translation 11 3.15E-15 0.03
4 SGTC_2411 st077133 7.69 39.9 µM 5.73E-14 RNA pol III & RNase P/MRP 10 7.20E-15 0.94
5 SGTC_81 0411-0046 6.47 10.0 µM 2.08E-10 18 4.95E-11 0.32
6 SGTC_839 0122-0028 6.35 230.0 µM 4.36E-10 RSC complex & mRNA processing 9 1.10E-10 0.04
7 SGTC_1545 lovastatin 5.99 49.4 µM 3.50E-9 2 1.04E-9 0.76
8 SGTC_266 formosanin C 5.66 406.0 nM 2.28E-8 sphingolipid biosynthesis & PDR1 10 7.78E-9 0.05
9 SGTC_1037 k284-1091 5.57 78.7 µM 3.66E-8 1 1.29E-8 0.91
10 SGTC_115 0527-0192 5.34 112.0 µM 1.22E-7 4 4.75E-8 0.03
11 SGTC_2373 9071805 5.16 200.0 µM 2.92E-7 1 1.21E-7 1.04
12 SGTC_1341 1486-1360 5.12 280.0 µM 3.69E-7 1 1.55E-7 0.51
13 SGTC_1953 st076800 4.97 12.1 µM 7.46E-7 3 3.31E-7 0.00
14 SGTC_1532 4',5'-dihydroxyflavone 4.95 78.7 µM 8.43E-7 Golgi 2 3.78E-7 0.58
15 SGTC_3103 9120822 4.92 49.5 µM 9.37E-7 3 4.23E-7 0.38
16 SGTC_108 0509-0257 4.92 621.1 µM 9.62E-7 10 4.35E-7 0.06
17 SGTC_2522 biochanin a 4.72 4.9 µM 2.39E-6 RNA pol III & RNase P/MRP 9 1.16E-6 0.26
18 SGTC_1133 3473-0247 4.68 50.0 µM 2.96E-6 RSC complex & mRNA processing 36 1.46E-6 0.02
19 SGTC_2890 9046729 4.61 58.4 µM 4.09E-6 Golgi 18 2.06E-6 0.12
20 SGTC_3341 9147222 4.41 25.9 µM 9.75E-6 RNA processing & uracil transport 6 5.23E-6 0.10

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.208 5.39E-34 YDL152W_d YDL152W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SAS10/YDL153C, a component of the small ribosomal subunit processosome
0.192 3.70E-29 YJL069C UTP18 het Possible U3 snoRNP protein involved in maturation of pre-18S rRNA, based on computational analysis of large-scale protein-protein interaction data
0.143 7.45E-17 YPL242C IQG1 het Essential protein required for determination of budding pattern; promotes localization of axial markers Bud4p and Cdc12p and functionally interacts with Sec3p, localizes to the contractile ring during anaphase, member of the IQGAP family; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.141 1.82E-16 YGR083C GCD2 het Delta subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression
0.141 2.62E-16 YOR260W GCD1 het Gamma subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression
0.137 1.98E-15 YPR104C FHL1 het Regulator of ribosomal protein (RP) transcription; has forkhead associated domain that binds phosphorylated proteins; recruits coactivator Ifh1p or corepressor Crf1p to RP gene promoters; also has forkhead DNA-binding domain though in vitro DNA binding assays give inconsistent results; computational analyses suggest it binds DNA directly at highly active RP genes and indirectly through Rap1p motifs at others; suppresses RNA pol III and splicing factor prp4 mutants
0.132 2.00E-14 YDL150W RPC53 het RNA polymerase III subunit C53
0.131 2.86E-14 YJL011C RPC17 het RNA polymerase III subunit C17; physically interacts with C31, C11, and TFIIIB70; may be involved in the recruitment of pol III by the preinitiation complex; protein abundance increases in response to DNA replication stress
0.128 8.21E-14 YHR205W SCH9 hom AGC family protein kinase; functional ortholog of mammalian S6 kinase; phosphorylated by Tor1p and required for TORC1-mediated regulation of ribosome biogenesis, translation initiation, and entry into G0 phase; involved in transactivation of osmostress-responsive genes; regulates G1 progression, cAPK activity and nitrogen activation of the FGM pathway; integrates nutrient signals and stress signals from sphingolipids to regulate lifespan
0.120 2.58E-12 YOR116C RPO31 het RNA polymerase III largest subunit C160, part of core enzyme; similar to bacterial beta-prime subunit and to RPA190 and RPO21
0.110 1.47E-10 YLR321C SFH1 het Component of the RSC chromatin remodeling complex; essential gene required for cell cycle progression and maintenance of proper ploidy; phosphorylated in the G1 phase of the cell cycle; Snf5p paralog
0.109 2.09E-10 YDL117W CYK3 hom SH3-domain protein located in the bud neck and cytokinetic actin ring; relocalizes from bud neck to nucleus upon DNA replication stress; activates the chitin synthase activity of Chs2p during cytokinesis; suppressor of growth and cytokinesis defects of chs2 phospho-mutants
0.104 1.65E-9 YLR424W SPP382 het Essential protein that forms a dimer with Ntr2p; also forms a trimer, with Ntr2p and Prp43p, that is involved in spliceosome disassembly; found also in a multisubunit complex with the splicing factor Clf1p; suppressor of prp38-1 mutation
0.102 2.76E-9 YDR404C RPB7 het RNA polymerase II subunit B16; forms two subunit dissociable complex with Rpb4p; involved in recruitment of 3'-end processing factors to transcribing RNA polymerase II complex and in export of mRNA to cytoplasm under stress conditions; also involved in translation initiation
0.100 6.96E-9 YNL110C NOP15 het Constituent of 66S pre-ribosomal particles, involved in 60S ribosomal subunit biogenesis; localizes to both nucleolus and cytoplasm