YPR191W / QCR2

Subunit 2 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; phosphorylated; transcription is regulated by Hap1p, Hap2p/Hap3p, and heme

Zygosity: Homozygous strain
fixedexpanded
Profile for YPR191W / QCR2

Click on Significant Values for Screen Details ID:SGTC_29|Compound:0299-0004|FD-Score:-3.54|P-value:1.78E-4 ID:SGTC_36|Compound:0335-0881|FD-Score:3.97|P-value:1.78E-5 ID:SGTC_64|Compound:000l-0018|FD-Score:5.49|P-value:6.08E-9 ID:SGTC_67|Compound:0335-0847|FD-Score:3.50|P-value:1.31E-4 ID:SGTC_70|Compound:0141-0289|FD-Score:3.42|P-value:1.77E-4 ID:SGTC_134|Compound:0269-0018|FD-Score:3.75|P-value:4.54E-5 ID:SGTC_168|Compound:3970-0862|FD-Score:3.95|P-value:1.95E-5 ID:SGTC_236|Compound:1509-0011|FD-Score:13.50|P-value:1.85E-44 ID:SGTC_275|Compound:trichlorophene|FD-Score:3.51|P-value:1.26E-4 ID:SGTC_386|Compound:1509-0011|FD-Score:4.57|P-value:1.02E-6 ID:SGTC_468|Compound:gf-109203x|FD-Score:-3.07|P-value:9.93E-4 ID:SGTC_487|Compound:nimodipine|FD-Score:-3.69|P-value:9.84E-5 ID:SGTC_490|Compound:phenamil|FD-Score:-3.65|P-value:1.16E-4 ID:SGTC_546|Compound:peri-Naphthalide|FD-Score:-3.39|P-value:3.10E-4 ID:SGTC_562|Compound:3772-2733|FD-Score:-4.70|P-value:9.56E-7 ID:SGTC_595|Compound:3909-8003|FD-Score:3.40|P-value:1.89E-4 ID:SGTC_749|Compound:1000-0129|FD-Score:4.07|P-value:1.10E-5 ID:SGTC_802|Compound:4112-3352|FD-Score:5.16|P-value:4.23E-8 ID:SGTC_832|Compound:4083-0019|FD-Score:4.13|P-value:8.52E-6 ID:SGTC_892|Compound:0929-0076|FD-Score:3.00|P-value:8.48E-4 ID:SGTC_907|Compound:3448-6986|FD-Score:3.55|P-value:1.04E-4 ID:SGTC_923|Compound:1900-2434|FD-Score:3.08|P-value:6.37E-4 ID:SGTC_965|Compound:1291-5240|FD-Score:4.19|P-value:6.54E-6 ID:SGTC_1045|Compound:1348-1485|FD-Score:3.01|P-value:8.01E-4 ID:SGTC_1079|Compound:idarubicin|FD-Score:-3.98|P-value:2.86E-5 ID:SGTC_1124|Compound:fisetin|FD-Score:3.86|P-value:2.85E-5 ID:SGTC_1216|Compound:1165-0504|FD-Score:3.00|P-value:8.45E-4 ID:SGTC_1285|Compound:0929-0069|FD-Score:3.59|P-value:8.85E-5 ID:SGTC_1451|Compound:4152-0210|FD-Score:4.73|P-value:4.39E-7 ID:SGTC_1635|Compound:st007035|FD-Score:4.29|P-value:3.92E-6 ID:SGTC_1728|Compound:st035614|FD-Score:-3.23|P-value:5.77E-4 ID:SGTC_1739|Compound:st037196|FD-Score:-3.69|P-value:9.93E-5 ID:SGTC_1741|Compound:st038134|FD-Score:-4.29|P-value:7.12E-6 ID:SGTC_1794|Compound:st048918|FD-Score:4.35|P-value:2.93E-6 ID:SGTC_1804|Compound:st050076|FD-Score:3.05|P-value:7.00E-4 ID:SGTC_1834|Compound:st055981|FD-Score:3.38|P-value:2.11E-4 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:4.48|P-value:1.56E-6 ID:SGTC_1972|Compound:st070201|FD-Score:3.49|P-value:1.32E-4 ID:SGTC_2001|Compound:4023502|FD-Score:3.13|P-value:5.35E-4 ID:SGTC_2134|Compound:5324836|FD-Score:3.70|P-value:5.68E-5 ID:SGTC_2146|Compound:5545642|FD-Score:4.25|P-value:4.80E-6 ID:SGTC_2231|Compound:micatex|FD-Score:3.84|P-value:3.13E-5 ID:SGTC_2359|Compound:9039622|FD-Score:3.25|P-value:3.44E-4 ID:SGTC_2418|Compound:pentamidine|FD-Score:3.86|P-value:2.89E-5 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:-3.90|P-value:4.01E-5 ID:SGTC_2453|Compound:5731132|FD-Score:-3.33|P-value:3.95E-4 ID:SGTC_2592|Compound:piperlongumine|FD-Score:-3.56|P-value:1.61E-4 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:-3.15|P-value:7.65E-4 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:3.02|P-value:7.74E-4 ID:SGTC_2610|Compound:ononetin|FD-Score:7.41|P-value:8.97E-15 ID:SGTC_2611|Compound:pyromycin|FD-Score:-3.73|P-value:8.27E-5 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:4.98|P-value:1.14E-7 ID:SGTC_2842|Compound:9000675|FD-Score:3.14|P-value:5.10E-4 ID:SGTC_2857|Compound:9024691|FD-Score:-4.18|P-value:1.18E-5 ID:SGTC_2881|Compound:9058953|FD-Score:4.46|P-value:1.73E-6 ID:SGTC_2950|Compound:9072895|FD-Score:3.70|P-value:5.62E-5 ID:SGTC_2996|Compound:9066192|FD-Score:2.98|P-value:8.92E-4 ID:SGTC_3217|Compound:9129673|FD-Score:-3.96|P-value:3.17E-5 ID:SGTC_3289|Compound:9119912|FD-Score:-5.63|P-value:5.47E-9 ID:SGTC_3291|Compound:9121177|FD-Score:3.71|P-value:5.39E-5 ID:SGTC_3320|Compound:9137005|FD-Score:3.46|P-value:1.53E-4 ID:SGTC_29|Compound:0299-0004|FD-Score:-3.54|P-value:1.78E-4 ID:SGTC_36|Compound:0335-0881|FD-Score:3.97|P-value:1.78E-5 ID:SGTC_64|Compound:000l-0018|FD-Score:5.49|P-value:6.08E-9 ID:SGTC_67|Compound:0335-0847|FD-Score:3.50|P-value:1.31E-4 ID:SGTC_70|Compound:0141-0289|FD-Score:3.42|P-value:1.77E-4 ID:SGTC_134|Compound:0269-0018|FD-Score:3.75|P-value:4.54E-5 ID:SGTC_168|Compound:3970-0862|FD-Score:3.95|P-value:1.95E-5 ID:SGTC_236|Compound:1509-0011|FD-Score:13.50|P-value:1.85E-44 ID:SGTC_275|Compound:trichlorophene|FD-Score:3.51|P-value:1.26E-4 ID:SGTC_386|Compound:1509-0011|FD-Score:4.57|P-value:1.02E-6 ID:SGTC_468|Compound:gf-109203x|FD-Score:-3.07|P-value:9.93E-4 ID:SGTC_487|Compound:nimodipine|FD-Score:-3.69|P-value:9.84E-5 ID:SGTC_490|Compound:phenamil|FD-Score:-3.65|P-value:1.16E-4 ID:SGTC_546|Compound:peri-Naphthalide|FD-Score:-3.39|P-value:3.10E-4 ID:SGTC_562|Compound:3772-2733|FD-Score:-4.70|P-value:9.56E-7 ID:SGTC_595|Compound:3909-8003|FD-Score:3.40|P-value:1.89E-4 ID:SGTC_749|Compound:1000-0129|FD-Score:4.07|P-value:1.10E-5 ID:SGTC_802|Compound:4112-3352|FD-Score:5.16|P-value:4.23E-8 ID:SGTC_832|Compound:4083-0019|FD-Score:4.13|P-value:8.52E-6 ID:SGTC_892|Compound:0929-0076|FD-Score:3.00|P-value:8.48E-4 ID:SGTC_907|Compound:3448-6986|FD-Score:3.55|P-value:1.04E-4 ID:SGTC_923|Compound:1900-2434|FD-Score:3.08|P-value:6.37E-4 ID:SGTC_965|Compound:1291-5240|FD-Score:4.19|P-value:6.54E-6 ID:SGTC_1045|Compound:1348-1485|FD-Score:3.01|P-value:8.01E-4 ID:SGTC_1079|Compound:idarubicin|FD-Score:-3.98|P-value:2.86E-5 ID:SGTC_1124|Compound:fisetin|FD-Score:3.86|P-value:2.85E-5 ID:SGTC_1216|Compound:1165-0504|FD-Score:3.00|P-value:8.45E-4 ID:SGTC_1285|Compound:0929-0069|FD-Score:3.59|P-value:8.85E-5 ID:SGTC_1451|Compound:4152-0210|FD-Score:4.73|P-value:4.39E-7 ID:SGTC_1635|Compound:st007035|FD-Score:4.29|P-value:3.92E-6 ID:SGTC_1728|Compound:st035614|FD-Score:-3.23|P-value:5.77E-4 ID:SGTC_1739|Compound:st037196|FD-Score:-3.69|P-value:9.93E-5 ID:SGTC_1741|Compound:st038134|FD-Score:-4.29|P-value:7.12E-6 ID:SGTC_1794|Compound:st048918|FD-Score:4.35|P-value:2.93E-6 ID:SGTC_1804|Compound:st050076|FD-Score:3.05|P-value:7.00E-4 ID:SGTC_1834|Compound:st055981|FD-Score:3.38|P-value:2.11E-4 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:4.48|P-value:1.56E-6 ID:SGTC_1972|Compound:st070201|FD-Score:3.49|P-value:1.32E-4 ID:SGTC_2001|Compound:4023502|FD-Score:3.13|P-value:5.35E-4 ID:SGTC_2134|Compound:5324836|FD-Score:3.70|P-value:5.68E-5 ID:SGTC_2146|Compound:5545642|FD-Score:4.25|P-value:4.80E-6 ID:SGTC_2231|Compound:micatex|FD-Score:3.84|P-value:3.13E-5 ID:SGTC_2359|Compound:9039622|FD-Score:3.25|P-value:3.44E-4 ID:SGTC_2418|Compound:pentamidine|FD-Score:3.86|P-value:2.89E-5 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:-3.90|P-value:4.01E-5 ID:SGTC_2453|Compound:5731132|FD-Score:-3.33|P-value:3.95E-4 ID:SGTC_2592|Compound:piperlongumine|FD-Score:-3.56|P-value:1.61E-4 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:-3.15|P-value:7.65E-4 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:3.02|P-value:7.74E-4 ID:SGTC_2610|Compound:ononetin|FD-Score:7.41|P-value:8.97E-15 ID:SGTC_2611|Compound:pyromycin|FD-Score:-3.73|P-value:8.27E-5 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:4.98|P-value:1.14E-7 ID:SGTC_2842|Compound:9000675|FD-Score:3.14|P-value:5.10E-4 ID:SGTC_2857|Compound:9024691|FD-Score:-4.18|P-value:1.18E-5 ID:SGTC_2881|Compound:9058953|FD-Score:4.46|P-value:1.73E-6 ID:SGTC_2950|Compound:9072895|FD-Score:3.70|P-value:5.62E-5 ID:SGTC_2996|Compound:9066192|FD-Score:2.98|P-value:8.92E-4 ID:SGTC_3217|Compound:9129673|FD-Score:-3.96|P-value:3.17E-5 ID:SGTC_3289|Compound:9119912|FD-Score:-5.63|P-value:5.47E-9 ID:SGTC_3291|Compound:9121177|FD-Score:3.71|P-value:5.39E-5 ID:SGTC_3320|Compound:9137005|FD-Score:3.46|P-value:1.53E-4

Top fitness defect scores for YPR191W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_236 1509-0011 13.50 5.3 µM 1.85E-44 129 5.92E-42
2 SGTC_2610 ononetin 7.41 44.2 µM 8.97E-15 1 6.43E-14
3 SGTC_64 000l-0018 5.49 272.1 µM 6.08E-9 ubiquinone biosynthesis & proteasome 94 2.00E-8
4 SGTC_802 4112-3352 5.16 742.0 µM 4.23E-8 6 1.24E-7
5 SGTC_2614 arthonioic acid 4.98 13.4 µM 1.14E-7 8 3.14E-7
6 SGTC_1451 4152-0210 4.73 104.0 µM 4.39E-7 11 1.12E-6
7 SGTC_386 1509-0011 4.57 3.1 µM 1.02E-6 121 2.48E-6
8 SGTC_1883 5-benzylidenerhodanine 4.48 20.0 µM 1.56E-6 TRP & mitochondrial translation 47 3.69E-6
9 SGTC_2881 9058953 4.46 52.0 µM 1.73E-6 11 4.06E-6
10 SGTC_1794 st048918 4.35 76.9 µM 2.93E-6 8 6.66E-6
11 SGTC_1635 st007035 4.29 42.4 µM 3.92E-6 198 8.75E-6
12 SGTC_2146 5545642 4.25 200.0 µM 4.80E-6 8 1.06E-5
13 SGTC_965 1291-5240 4.19 308.0 µM 6.54E-6 28 1.41E-5
14 SGTC_832 4083-0019 4.13 164.0 µM 8.52E-6 translation 84 1.81E-5
15 SGTC_749 1000-0129 4.07 128.0 µM 1.10E-5 amide catabolism 18 2.30E-5
16 SGTC_36 0335-0881 3.97 14.2 µM 1.78E-5 ubiquinone biosynthesis & proteasome 119 3.62E-5
17 SGTC_168 3970-0862 3.95 530.5 µM 1.95E-5 119 3.94E-5
18 SGTC_1124 fisetin 3.86 1.2 µM 2.85E-5 38 5.64E-5
19 SGTC_2418 pentamidine 3.86 31.7 µM 2.89E-5 mitochondrial processes 46 5.71E-5
20 SGTC_2231 micatex 3.84 6.8 µM 3.13E-5 20 6.16E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.442 2.57E-160 YOR330C MIP1 hom Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit
0.424 2.46E-146 YOR125C CAT5 hom Protein required for ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes; required for gluconeogenic gene activation
0.418 1.30E-141 YDR230W_d YDR230W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20
0.413 2.05E-138 YJL166W QCR8 hom Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.413 3.27E-138 YPL215W CBP3 hom Mitochondrial protein required for assembly of cytochrome bc1 complex; forms a complex with Cbp6p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
0.407 1.90E-134 YDR518W EUG1 hom Protein disulfide isomerase of the endoplasmic reticulum lumen; EUG1 has a paralog, PDI1, that arose from the whole genome duplication; function overlaps with that of Pdi1p; may interact with nascent polypeptides in the ER
0.407 4.85E-134 YMR035W IMP2 hom Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p
0.400 4.59E-129 YPL013C MRPS16 hom Mitochondrial ribosomal protein of the small subunit
0.398 1.88E-127 YER141W COX15 hom Protein required for the hydroxylation of heme O to form heme A, which is an essential prosthetic group for cytochrome c oxidase
0.397 7.23E-127 YJL023C PET130 hom Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.388 4.42E-121 YJL022W_d YJL022W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene PET130
0.388 6.41E-121 YDR375C BCS1 hom Protein translocase and chaperone required for Complex III assembly; member of the AAA ATPase family; forms a homo-oligomeric complex in the mitochondrial inner membrane that translocates the C-terminal domain of Rip1p from the matrix across the inner membrane, and then delivers it to an assembly intermediate of respiratory Complex III in an ATP-dependent reaction; also required for assembly of the Qcr10p subunit; mutations in human homolog BCS1L linked to neonatal diseases
0.386 5.68E-120 YER058W PET117 hom Protein required for assembly of cytochrome c oxidase
0.386 1.30E-119 YPL132W COX11 hom Mitochondrial inner membrane protein required for delivery of copper to the Cox1p subunit of cytochrome c oxidase; association with mitochondrial ribosomes suggests that copper delivery may occur during translation of Cox1p
0.381 2.06E-116 YDR204W COQ4 hom Protein with a role in ubiquinone (Coenzyme Q) biosynthesis, possibly functioning in stabilization of Coq7p; located on the matrix face of the mitochondrial inner membrane; component of a mitochondrial ubiquinone-synthesizing complex