YPR192W / AQY1

Spore-specific water channel that mediates the transport of water across cell membranes, developmentally controlled; may play a role in spore maturation, probably by allowing water outflow, may be involved in freeze tolerance

Zygosity: Homozygous strain
fixedexpanded
Profile for YPR192W / AQY1

Click on Significant Values for Screen Details ID:SGTC_151|Compound:3013-0144|FD-Score:2.86|P-value:8.54E-4 ID:SGTC_387|Compound:norethindrone acetate|FD-Score:-2.96|P-value:6.74E-4 ID:SGTC_421|Compound:streptovitacin|FD-Score:2.88|P-value:8.06E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:4.00|P-value:5.95E-6 ID:SGTC_669|Compound:0108-0021|FD-Score:5.41|P-value:1.60E-9 ID:SGTC_692|Compound:k241-0027|FD-Score:3.18|P-value:2.42E-4 ID:SGTC_775|Compound:4577-0580|FD-Score:-3.86|P-value:1.40E-5 ID:SGTC_824|Compound:1304-0008|FD-Score:-3.49|P-value:7.69E-5 ID:SGTC_910|Compound:3454-3003|FD-Score:5.77|P-value:1.36E-10 ID:SGTC_911|Compound:3456-4043|FD-Score:3.83|P-value:1.38E-5 ID:SGTC_912|Compound:3474-0017|FD-Score:3.49|P-value:6.52E-5 ID:SGTC_997|Compound:3996-0078|FD-Score:-3.76|P-value:2.20E-5 ID:SGTC_1009|Compound:4106-0057|FD-Score:5.03|P-value:1.82E-8 ID:SGTC_1019|Compound:4262-0212|FD-Score:-3.84|P-value:1.51E-5 ID:SGTC_1043|Compound:0916-0009|FD-Score:4.77|P-value:8.81E-8 ID:SGTC_1468|Compound:k284-1086|FD-Score:-3.56|P-value:5.59E-5 ID:SGTC_1490|Compound:4089-0339|FD-Score:3.10|P-value:3.40E-4 ID:SGTC_1491|Compound:4138-0063|FD-Score:3.12|P-value:3.10E-4 ID:SGTC_1579|Compound:chlormadinone acetate|FD-Score:2.96|P-value:5.84E-4 ID:SGTC_1586|Compound:deoxycorticosterone acetate|FD-Score:3.58|P-value:4.51E-5 ID:SGTC_1591|Compound:genipin|FD-Score:5.63|P-value:3.67E-10 ID:SGTC_1595|Compound:6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin|FD-Score:5.43|P-value:1.45E-9 ID:SGTC_1853|Compound:st056710|FD-Score:2.90|P-value:7.27E-4 ID:SGTC_1871|Compound:st057448|FD-Score:-3.17|P-value:2.97E-4 ID:SGTC_2024|Compound:5144227|FD-Score:3.69|P-value:2.66E-5 ID:SGTC_2099|Compound:5377090|FD-Score:2.84|P-value:9.06E-4 ID:SGTC_2104|Compound:5389443|FD-Score:3.55|P-value:5.01E-5 ID:SGTC_2116|Compound:5511452|FD-Score:3.78|P-value:1.75E-5 ID:SGTC_2137|Compound:5261020|FD-Score:-3.22|P-value:2.42E-4 ID:SGTC_2184|Compound:6075246|FD-Score:3.90|P-value:9.57E-6 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:3.48|P-value:6.92E-5 ID:SGTC_2528|Compound:xanthyletin|FD-Score:-3.08|P-value:4.20E-4 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:4.51|P-value:4.12E-7 ID:SGTC_2606|Compound:farnesol|FD-Score:3.56|P-value:4.73E-5 ID:SGTC_2608|Compound:thymoquinone|FD-Score:2.84|P-value:9.27E-4 ID:SGTC_2767|Compound:sibutramine|FD-Score:3.83|P-value:1.38E-5 ID:SGTC_2809|Compound:7964133|FD-Score:4.05|P-value:4.63E-6 ID:SGTC_2812|Compound:7970281|FD-Score:4.26|P-value:1.57E-6 ID:SGTC_3130|Compound:9127414|FD-Score:-4.79|P-value:9.45E-8 ID:SGTC_3134|Compound:9127454|FD-Score:-4.38|P-value:9.85E-7 ID:SGTC_3300|Compound:9124615|FD-Score:-3.68|P-value:3.29E-5 ID:SGTC_151|Compound:3013-0144|FD-Score:2.86|P-value:8.54E-4 ID:SGTC_387|Compound:norethindrone acetate|FD-Score:-2.96|P-value:6.74E-4 ID:SGTC_421|Compound:streptovitacin|FD-Score:2.88|P-value:8.06E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:4.00|P-value:5.95E-6 ID:SGTC_669|Compound:0108-0021|FD-Score:5.41|P-value:1.60E-9 ID:SGTC_692|Compound:k241-0027|FD-Score:3.18|P-value:2.42E-4 ID:SGTC_775|Compound:4577-0580|FD-Score:-3.86|P-value:1.40E-5 ID:SGTC_824|Compound:1304-0008|FD-Score:-3.49|P-value:7.69E-5 ID:SGTC_910|Compound:3454-3003|FD-Score:5.77|P-value:1.36E-10 ID:SGTC_911|Compound:3456-4043|FD-Score:3.83|P-value:1.38E-5 ID:SGTC_912|Compound:3474-0017|FD-Score:3.49|P-value:6.52E-5 ID:SGTC_997|Compound:3996-0078|FD-Score:-3.76|P-value:2.20E-5 ID:SGTC_1009|Compound:4106-0057|FD-Score:5.03|P-value:1.82E-8 ID:SGTC_1019|Compound:4262-0212|FD-Score:-3.84|P-value:1.51E-5 ID:SGTC_1043|Compound:0916-0009|FD-Score:4.77|P-value:8.81E-8 ID:SGTC_1468|Compound:k284-1086|FD-Score:-3.56|P-value:5.59E-5 ID:SGTC_1490|Compound:4089-0339|FD-Score:3.10|P-value:3.40E-4 ID:SGTC_1491|Compound:4138-0063|FD-Score:3.12|P-value:3.10E-4 ID:SGTC_1579|Compound:chlormadinone acetate|FD-Score:2.96|P-value:5.84E-4 ID:SGTC_1586|Compound:deoxycorticosterone acetate|FD-Score:3.58|P-value:4.51E-5 ID:SGTC_1591|Compound:genipin|FD-Score:5.63|P-value:3.67E-10 ID:SGTC_1595|Compound:6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin|FD-Score:5.43|P-value:1.45E-9 ID:SGTC_1853|Compound:st056710|FD-Score:2.90|P-value:7.27E-4 ID:SGTC_1871|Compound:st057448|FD-Score:-3.17|P-value:2.97E-4 ID:SGTC_2024|Compound:5144227|FD-Score:3.69|P-value:2.66E-5 ID:SGTC_2099|Compound:5377090|FD-Score:2.84|P-value:9.06E-4 ID:SGTC_2104|Compound:5389443|FD-Score:3.55|P-value:5.01E-5 ID:SGTC_2116|Compound:5511452|FD-Score:3.78|P-value:1.75E-5 ID:SGTC_2137|Compound:5261020|FD-Score:-3.22|P-value:2.42E-4 ID:SGTC_2184|Compound:6075246|FD-Score:3.90|P-value:9.57E-6 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:3.48|P-value:6.92E-5 ID:SGTC_2528|Compound:xanthyletin|FD-Score:-3.08|P-value:4.20E-4 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:4.51|P-value:4.12E-7 ID:SGTC_2606|Compound:farnesol|FD-Score:3.56|P-value:4.73E-5 ID:SGTC_2608|Compound:thymoquinone|FD-Score:2.84|P-value:9.27E-4 ID:SGTC_2767|Compound:sibutramine|FD-Score:3.83|P-value:1.38E-5 ID:SGTC_2809|Compound:7964133|FD-Score:4.05|P-value:4.63E-6 ID:SGTC_2812|Compound:7970281|FD-Score:4.26|P-value:1.57E-6 ID:SGTC_3130|Compound:9127414|FD-Score:-4.79|P-value:9.45E-8 ID:SGTC_3134|Compound:9127454|FD-Score:-4.38|P-value:9.85E-7 ID:SGTC_3300|Compound:9124615|FD-Score:-3.68|P-value:3.29E-5

Top fitness defect scores for YPR192W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_910 3454-3003 5.77 490.0 µM 1.36E-10 2 3.85E-9
2 SGTC_1591 genipin 5.63 88.4 µM 3.67E-10 mitochondrial processes 1 8.90E-9
3 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 5.43 67.5 µM 1.45E-9 15 2.84E-8
4 SGTC_669 0108-0021 5.41 26.2 µM 1.60E-9 fatty acid desaturase (OLE1) 29 3.07E-8
5 SGTC_1009 4106-0057 5.03 9.9 µM 1.82E-8 5 2.39E-7
6 SGTC_1043 0916-0009 4.77 19.3 µM 8.81E-8 8 9.03E-7
7 SGTC_2573 2',4'-dihydroxychalcone 4.51 15.0 µM 4.12E-7 30 3.32E-6
8 SGTC_2812 7970281 4.26 58.4 µM 1.57E-6 20 1.03E-5
9 SGTC_2809 7964133 4.05 13.0 µM 4.63E-6 60S ribosome export 37 2.56E-5
10 SGTC_431 k089-0097 4.00 107.0 µM 5.95E-6 iron homeostasis 40 3.16E-5
11 SGTC_2184 6075246 3.90 200.0 µM 9.57E-6 26 4.72E-5
12 SGTC_2767 sibutramine 3.83 71.5 µM 1.38E-5 22 6.42E-5
13 SGTC_911 3456-4043 3.83 236.0 µM 1.38E-5 mitochondrial processes 32 6.45E-5
14 SGTC_2116 5511452 3.78 16.9 µM 1.75E-5 17 7.85E-5
15 SGTC_2024 5144227 3.69 134.0 µM 2.66E-5 45 1.12E-4
16 SGTC_1586 deoxycorticosterone acetate 3.58 53.7 µM 4.51E-5 22 1.75E-4
17 SGTC_2606 farnesol 3.56 9.8 µM 4.73E-5 30 1.82E-4
18 SGTC_2104 5389443 3.55 200.0 µM 5.01E-5 26 1.91E-4
19 SGTC_912 3474-0017 3.49 2.2 µM 6.52E-5 37 2.39E-4
20 SGTC_2410 aloe-emodin-8-o-glycoside 3.48 46.3 µM 6.92E-5 mitochondrial processes 49 2.51E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.117 1.31E-11 YFL056C AAD6 hom Putative aryl-alcohol dehydrogenase; involved in oxidative stress response; similar to P. chrysosporium aryl-alcohol dehydrogenase; expression induced in cells treated with the mycotoxin patulin
0.113 4.40E-11 YDL133C-A RPL41B hom Ribosomal 60S subunit protein L41B; comprises only 25 amino acids; rpl41a rpl41b double null mutant is viable; homologous to mammalian ribosomal protein L41, no bacterial homolog; RPL41B has a paralog, RPL41A, that arose from the whole genome duplication
0.100 5.99E-9 YOR037W CYC2 hom Mitochondrial peripheral inner membrane protein, contains a FAD cofactor in a domain exposed in the intermembrane space; exhibits redox activity in vitro; likely participates in ligation of heme to acytochromes c and c1 (Cyc1p and Cyt1p)
0.091 1.50E-7 YPR126C_d YPR126C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.090 1.64E-7 YPR085C ASA1 het Subunit of the ASTRA complex, involved in chromatin remodeling; telomere length regulator involved in the stability or biogenesis of PIKKs such as TORC1
0.087 4.55E-7 YNL261W ORC5 het Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing
0.084 1.26E-6 YGL154C LYS5 hom Phosphopantetheinyl transferase involved in lysine biosynthesis; converts inactive apo-form of Lys2p (alpha-aminoadipate reductase) into catalytically active holo-form by posttranslational addition of phosphopantetheine
0.080 3.21E-6 YCL076W_d YCL076W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.080 3.58E-6 YAL045C_d YAL045C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; almost completely overlaps YAL044W-A
0.078 6.19E-6 YGL053W PRM8 hom Pheromone-regulated protein with 2 predicted transmembrane segments and an FF sequence, a motif involved in COPII binding; forms a complex with Prp9p in the ER; member of DUP240 gene family
0.077 7.13E-6 YDR294C DPL1 hom Dihydrosphingosine phosphate lyase, regulates intracellular levels of sphingolipid long-chain base phosphates (LCBPs), degrades phosphorylated long chain bases, prefers C16 dihydrosphingosine-l-phosphate as a substrate
0.077 8.31E-6 YBR175W SWD3 hom Essential subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; WD40 beta propeller superfamily member and ortholog of mammalian WDR5
0.077 8.41E-6 YOR018W ROD1 hom Membrane protein, binds the ubiquitin ligase Rsp5p via its 2 PY motifs; overexpression confers resistance to the GST substrate o-dinitrobenzene, zinc, and calcium; proposed to regulate the endocytosis of plasma membrane proteins; protein abundance increases in response to DNA replication stress; ROD1 has a paralog, ROG3, that arose from the whole genome duplication
0.075 1.42E-5 YEL066W HPA3 hom D-Amino acid N-acetyltransferase, catalyzes N-acetylation of D-amino acids through ordered bi-bi mechanism in which acetyl-CoA is first substrate bound and CoA is last product liberated; similar to Hpa2p, acetylates histones weakly in vitro
0.074 1.75E-5 YBR299W MAL32 hom Maltase (alpha-D-glucosidase), inducible protein involved in maltose catabolism; encoded in the MAL3 complex locus; functional in genomic reference strain S288C; hydrolyzes the disaccharides maltose, turanose, maltotriose, and sucrose