YPR194C / OPT2

Oligopeptide transporter; member of the OPT family, with potential orthologs in S. pombe and C. albicans; also plays a role in formation of mature vacuoles

Zygosity: Homozygous strain
fixedexpanded
Profile for YPR194C / OPT2

Click on Significant Values for Screen Details ID:SGTC_120|Compound:rhodamine 6G|FD-Score:3.92|P-value:8.16E-5 ID:SGTC_160|Compound:3453-0671|FD-Score:4.98|P-value:8.90E-7 ID:SGTC_465|Compound:cgp-37157|FD-Score:3.22|P-value:9.46E-4 ID:SGTC_566|Compound:0958-0068|FD-Score:3.73|P-value:1.60E-4 ID:SGTC_631|Compound:k072-0230|FD-Score:4.43|P-value:1.04E-5 ID:SGTC_661|Compound:1304-0007|FD-Score:4.49|P-value:7.91E-6 ID:SGTC_720|Compound:r052-1644|FD-Score:3.53|P-value:3.28E-4 ID:SGTC_732|Compound:3970-1727|FD-Score:3.88|P-value:9.49E-5 ID:SGTC_795|Compound:0685-0265|FD-Score:4.24|P-value:2.26E-5 ID:SGTC_811|Compound:0416-0114|FD-Score:-3.37|P-value:8.20E-4 ID:SGTC_864|Compound:0469-0573|FD-Score:3.60|P-value:2.58E-4 ID:SGTC_870|Compound:0573-2213|FD-Score:3.33|P-value:6.61E-4 ID:SGTC_876|Compound:0720-0963|FD-Score:3.68|P-value:1.94E-4 ID:SGTC_977|Compound:1348-1378|FD-Score:3.87|P-value:9.78E-5 ID:SGTC_997|Compound:3996-0078|FD-Score:3.48|P-value:3.93E-4 ID:SGTC_1010|Compound:4112-3296|FD-Score:3.28|P-value:7.73E-4 ID:SGTC_1021|Compound:4476-0760|FD-Score:3.78|P-value:1.35E-4 ID:SGTC_1026|Compound:k007-1105|FD-Score:4.84|P-value:1.66E-6 ID:SGTC_1186|Compound:1319-0216|FD-Score:3.41|P-value:5.01E-4 ID:SGTC_1213|Compound:1315-0166|FD-Score:4.45|P-value:9.31E-6 ID:SGTC_1331|Compound:1472-0049|FD-Score:3.77|P-value:1.40E-4 ID:SGTC_1341|Compound:1486-1360|FD-Score:3.39|P-value:5.31E-4 ID:SGTC_1369|Compound:1866-0067|FD-Score:-4.02|P-value:8.36E-5 ID:SGTC_1370|Compound:2001-0092|FD-Score:4.06|P-value:4.70E-5 ID:SGTC_1372|Compound:2752-0194|FD-Score:5.57|P-value:4.63E-8 ID:SGTC_1377|Compound:2944-0135|FD-Score:3.43|P-value:4.73E-4 ID:SGTC_1438|Compound:4092-1045|FD-Score:3.73|P-value:1.62E-4 ID:SGTC_1527|Compound:coumarin|FD-Score:4.53|P-value:6.58E-6 ID:SGTC_1649|Compound:st011737|FD-Score:4.57|P-value:5.66E-6 ID:SGTC_1663|Compound:st014140|FD-Score:3.46|P-value:4.20E-4 ID:SGTC_1697|Compound:st025554|FD-Score:3.39|P-value:5.39E-4 ID:SGTC_1897|Compound:st060201|FD-Score:3.44|P-value:4.47E-4 ID:SGTC_1899|Compound:st063254|FD-Score:3.92|P-value:7.94E-5 ID:SGTC_2022|Compound:5136654|FD-Score:3.56|P-value:3.04E-4 ID:SGTC_2161|Compound:5662504|FD-Score:-4.04|P-value:7.66E-5 ID:SGTC_2280|Compound:7785178|FD-Score:5.58|P-value:4.42E-8 ID:SGTC_2319|Compound:6033012|FD-Score:4.67|P-value:3.69E-6 ID:SGTC_2481|Compound:5478948|FD-Score:3.20|P-value:9.93E-4 ID:SGTC_2630|Compound:antimycin a|FD-Score:6.01|P-value:4.20E-9 ID:SGTC_2695|Compound:st077686|FD-Score:3.57|P-value:2.89E-4 ID:SGTC_2764|Compound:methyldopa|FD-Score:3.51|P-value:3.57E-4 ID:SGTC_2766|Compound:oltipraz|FD-Score:-3.75|P-value:2.22E-4 ID:SGTC_2908|Compound:7930301|FD-Score:3.52|P-value:3.40E-4 ID:SGTC_2994|Compound:9053520|FD-Score:3.95|P-value:7.15E-5 ID:SGTC_3127|Compound:9126946|FD-Score:3.26|P-value:8.15E-4 ID:SGTC_3209|Compound:9113616|FD-Score:-3.39|P-value:7.69E-4 ID:SGTC_3210|Compound:9128157|FD-Score:-9.95|P-value:2.80E-21 ID:SGTC_120|Compound:rhodamine 6G|FD-Score:3.92|P-value:8.16E-5 ID:SGTC_160|Compound:3453-0671|FD-Score:4.98|P-value:8.90E-7 ID:SGTC_465|Compound:cgp-37157|FD-Score:3.22|P-value:9.46E-4 ID:SGTC_566|Compound:0958-0068|FD-Score:3.73|P-value:1.60E-4 ID:SGTC_631|Compound:k072-0230|FD-Score:4.43|P-value:1.04E-5 ID:SGTC_661|Compound:1304-0007|FD-Score:4.49|P-value:7.91E-6 ID:SGTC_720|Compound:r052-1644|FD-Score:3.53|P-value:3.28E-4 ID:SGTC_732|Compound:3970-1727|FD-Score:3.88|P-value:9.49E-5 ID:SGTC_795|Compound:0685-0265|FD-Score:4.24|P-value:2.26E-5 ID:SGTC_811|Compound:0416-0114|FD-Score:-3.37|P-value:8.20E-4 ID:SGTC_864|Compound:0469-0573|FD-Score:3.60|P-value:2.58E-4 ID:SGTC_870|Compound:0573-2213|FD-Score:3.33|P-value:6.61E-4 ID:SGTC_876|Compound:0720-0963|FD-Score:3.68|P-value:1.94E-4 ID:SGTC_977|Compound:1348-1378|FD-Score:3.87|P-value:9.78E-5 ID:SGTC_997|Compound:3996-0078|FD-Score:3.48|P-value:3.93E-4 ID:SGTC_1010|Compound:4112-3296|FD-Score:3.28|P-value:7.73E-4 ID:SGTC_1021|Compound:4476-0760|FD-Score:3.78|P-value:1.35E-4 ID:SGTC_1026|Compound:k007-1105|FD-Score:4.84|P-value:1.66E-6 ID:SGTC_1186|Compound:1319-0216|FD-Score:3.41|P-value:5.01E-4 ID:SGTC_1213|Compound:1315-0166|FD-Score:4.45|P-value:9.31E-6 ID:SGTC_1331|Compound:1472-0049|FD-Score:3.77|P-value:1.40E-4 ID:SGTC_1341|Compound:1486-1360|FD-Score:3.39|P-value:5.31E-4 ID:SGTC_1369|Compound:1866-0067|FD-Score:-4.02|P-value:8.36E-5 ID:SGTC_1370|Compound:2001-0092|FD-Score:4.06|P-value:4.70E-5 ID:SGTC_1372|Compound:2752-0194|FD-Score:5.57|P-value:4.63E-8 ID:SGTC_1377|Compound:2944-0135|FD-Score:3.43|P-value:4.73E-4 ID:SGTC_1438|Compound:4092-1045|FD-Score:3.73|P-value:1.62E-4 ID:SGTC_1527|Compound:coumarin|FD-Score:4.53|P-value:6.58E-6 ID:SGTC_1649|Compound:st011737|FD-Score:4.57|P-value:5.66E-6 ID:SGTC_1663|Compound:st014140|FD-Score:3.46|P-value:4.20E-4 ID:SGTC_1697|Compound:st025554|FD-Score:3.39|P-value:5.39E-4 ID:SGTC_1897|Compound:st060201|FD-Score:3.44|P-value:4.47E-4 ID:SGTC_1899|Compound:st063254|FD-Score:3.92|P-value:7.94E-5 ID:SGTC_2022|Compound:5136654|FD-Score:3.56|P-value:3.04E-4 ID:SGTC_2161|Compound:5662504|FD-Score:-4.04|P-value:7.66E-5 ID:SGTC_2280|Compound:7785178|FD-Score:5.58|P-value:4.42E-8 ID:SGTC_2319|Compound:6033012|FD-Score:4.67|P-value:3.69E-6 ID:SGTC_2481|Compound:5478948|FD-Score:3.20|P-value:9.93E-4 ID:SGTC_2630|Compound:antimycin a|FD-Score:6.01|P-value:4.20E-9 ID:SGTC_2695|Compound:st077686|FD-Score:3.57|P-value:2.89E-4 ID:SGTC_2764|Compound:methyldopa|FD-Score:3.51|P-value:3.57E-4 ID:SGTC_2766|Compound:oltipraz|FD-Score:-3.75|P-value:2.22E-4 ID:SGTC_2908|Compound:7930301|FD-Score:3.52|P-value:3.40E-4 ID:SGTC_2994|Compound:9053520|FD-Score:3.95|P-value:7.15E-5 ID:SGTC_3127|Compound:9126946|FD-Score:3.26|P-value:8.15E-4 ID:SGTC_3209|Compound:9113616|FD-Score:-3.39|P-value:7.69E-4 ID:SGTC_3210|Compound:9128157|FD-Score:-9.95|P-value:2.80E-21

Top fitness defect scores for YPR194C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2630 antimycin a 6.01 100.0 µM 4.20E-9 mitochondrial processes 12 9.21E-10
2 SGTC_2280 7785178 5.58 200.0 µM 4.42E-8 2 1.22E-8
3 SGTC_1372 2752-0194 5.57 270.0 µM 4.63E-8 6 1.28E-8
4 SGTC_160 3453-0671 4.98 289.7 µM 8.90E-7 20 3.25E-7
5 SGTC_1026 k007-1105 4.84 30.6 µM 1.66E-6 ERAD & cell cycle 65 6.40E-7
6 SGTC_2319 6033012 4.67 152.6 µM 3.69E-6 tubulin folding & SWR complex 21 1.53E-6
7 SGTC_1649 st011737 4.57 51.3 µM 5.66E-6 22 2.45E-6
8 SGTC_1527 coumarin 4.53 137.0 µM 6.58E-6 12 2.89E-6
9 SGTC_661 1304-0007 4.49 33.6 µM 7.91E-6 12 3.53E-6
10 SGTC_1213 1315-0166 4.45 115.0 µM 9.31E-6 17 4.22E-6
11 SGTC_631 k072-0230 4.43 41.5 µM 1.04E-5 60S ribosome export 7 4.76E-6
12 SGTC_795 0685-0265 4.24 78.0 µM 2.26E-5 excess fatty acid 16 1.11E-5
13 SGTC_1370 2001-0092 4.06 44.6 µM 4.70E-5 29 2.47E-5
14 SGTC_2994 9053520 3.95 71.4 µM 7.15E-5 RPP1 & pyrimidine depletion 24 3.89E-5
15 SGTC_1899 st063254 3.92 59.6 µM 7.94E-5 16 4.37E-5
16 SGTC_120 rhodamine 6G 3.92 52.3 µM 8.16E-5 mitochondrial processes 33 4.50E-5
17 SGTC_732 3970-1727 3.88 52.7 µM 9.49E-5 10 5.30E-5
18 SGTC_977 1348-1378 3.87 135.0 µM 9.78E-5 24 5.48E-5
19 SGTC_1021 4476-0760 3.78 85.3 µM 1.35E-4 33 7.78E-5
20 SGTC_1331 1472-0049 3.77 76.2 µM 1.40E-4 23 8.11E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.121 2.40E-12 YGL254W FZF1 hom Transcription factor involved in sulfite metabolism; sole identified regulatory target is SSU1; overexpression suppresses sulfite-sensitivity of many unrelated mutants due to hyperactivation of SSU1, contains five zinc fingers; protein abundance increases in response to DNA replication stress
0.110 1.62E-10 YLR022C SDO1 het Essential protein involved in ribosome maturation; with Ria1p, promotes release of Tif6p from 60S ribosomal subunits in the cytoplasm so that they can assemble with 40S subunits to generate mature ribosomes; ortholog of the human protein (SBDS) responsible for autosomal recessive Shwachman-Bodian-Diamond Syndrome; highly conserved across archaea and eukaryotes
0.109 2.92E-10 YDR355C_d YDR355C_d het Dubious: Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified essential ORF SPC110/YDR356W
0.092 1.16E-7 YFL040W_p YFL040W_p hom Putative transporter, member of the sugar porter family; YFL040W is not an essential gene
0.090 1.77E-7 YHR083W SAM35 het Essential component of the sorting and assembly machinery (SAM complex or TOB complex) of the mitochondrial outer membrane, which binds precursors of beta-barrel proteins and facilitates their insertion into the outer membrane
0.089 2.31E-7 YMR136W GAT2 hom Protein containing GATA family zinc finger motifs; similar to Gln3p and Dal80p; expression repressed by leucine
0.087 5.11E-7 YDR107C TMN2 hom Protein with a role in cellular adhesion and filamentous growth; similar to Emp70p and Tmn3p; member of the evolutionarily conserved Transmembrane Nine family of proteins with nine membrane-spanning segments
0.086 6.79E-7 YMR294W JNM1 hom Component of the yeast dynactin complex, consisting of Nip100p, Jnm1p, and Arp1p; required for proper nuclear migration and spindle partitioning during mitotic anaphase B
0.085 9.06E-7 YOR081C TGL5 hom Bifunctional enzyme with triacylglycerol lipase and lysophosphatidic acid acyltransferase activity; involved in triacylglycerol mobilization; localizes to lipid particles; potential Cdc28p substrate
0.081 2.57E-6 YLR433C CNA1 hom Calcineurin A; one isoform (the other is CMP2) of the catalytic subunit of calcineurin, a Ca++/calmodulin-regulated protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is CNB1
0.080 3.67E-6 YLR131C ACE2 hom Transcription factor required for septum destruction after cytokinesis; phosphorylation by Cbk1p blocks nuclear exit during M/G1 transition, causing localization to daughter cell nuclei, and also increases Ace2p activity; phosphorylation by Cdc28p and Pho85p prevents nuclear import during cell cycle phases other than cytokinesis; part of RAM network that regulates cellular polarity and morphogenesis; ACE2 has a paralog, SWI5, that arose from the whole genome duplication
0.080 4.02E-6 YER069W ARG5,6 hom Acetylglutamate kinase and N-acetyl-gamma-glutamyl-phosphate reductase; N-acetyl-L-glutamate kinase (NAGK) catalyzes the 2nd and N-acetyl-gamma-glutamyl-phosphate reductase (NAGSA), the 3rd step in arginine biosynthesis; synthesized as a precursor which is processed in the mitochondrion to yield mature NAGK and NAGSA; enzymes form a metabolon complex with Arg2p; NAGK C-terminal domain stabilizes the enzymes, slows catalysis and is involved in feed-back inhibition by arginine
0.075 1.23E-5 YBL053W_d YBL053W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.075 1.26E-5 YGL128C CWC23 het Component of a complex containing Cef1p, putatively involved in pre-mRNA splicing; has similarity to E. coli DnaJ and other DnaJ-like proteins and to S. pombe Cwf23p
0.075 1.27E-5 YLL026W HSP104 hom Disaggregase; heat shock protein that cooperates with Ydj1p (Hsp40) and Ssa1p (Hsp70) to refold and reactivate previously denatured, aggregated proteins; responsive to stresses including: heat, ethanol, and sodium arsenite; involved in [PSI+] propagation; protein becomes more abundant and forms cytoplasmic foci in response to DNA replication stress