HIPHOP chemogenomics database

YPR195C_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain

fixedexpanded
Profile for YPR195C / YPR195C

Click on Significant Values for Screen Details

Top fitness defect scores for YPR195C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_1184	1269-1718	6.44	139.0 µM	9.73E-11		5	5.82E-11
2	SGTC_2792	7535235	5.30	81.8 µM	7.63E-8	fatty acid desaturase (OLE1)	14	5.65E-8
3	SGTC_1169	aniline yellow	4.83	25.8 µM	8.58E-7		1	6.85E-7
4	SGTC_106	0092-0003	4.78	11.6 µM	1.09E-6	copper-dependent oxidative stress	12	8.77E-7
5	SGTC_3218	9131285	4.23	49.5 µM	1.34E-5	endomembrane recycling	33	1.16E-5
6	SGTC_3325	9138760	4.16	55.2 µM	1.84E-5	Golgi	21	1.61E-5
7	SGTC_73	0327-0325	4.15	16.2 µM	1.92E-5	DNA damage response	43	1.68E-5
8	SGTC_1451	4152-0210	4.13	104.0 µM	2.03E-5		22	1.78E-5
9	SGTC_2303	7774051	4.06	200.0 µM	2.78E-5		16	2.45E-5
10	SGTC_1890	3',4',7',8'-tetrahydroxyflavone	3.94	14.9 µM	4.46E-5		12	3.99E-5
11	SGTC_2430	5571206	3.80	200.0 µM	8.07E-5		60	7.34E-5
12	SGTC_1570	verbenone	3.77	133.0 µM	8.88E-5		20	8.09E-5
13	SGTC_23	0213-0011	3.72	40.0 µM	1.07E-4	copper-dependent oxidative stress	33	9.79E-5
14	SGTC_1892	st058411	3.69	7.4 µM	1.20E-4		30	1.10E-4
15	SGTC_1919	st067113	3.69	52.3 µM	1.23E-4	TSC3-RPN4	38	1.13E-4
16	SGTC_3201	9113999	3.68	49.5 µM	1.28E-4		43	1.18E-4
17	SGTC_1705	st027868	3.62	56.3 µM	1.62E-4		17	1.50E-4
18	SGTC_2171	5739187	3.51	198.1 µM	2.35E-4	copper-dependent oxidative stress	22	2.20E-4
19	SGTC_2636	apigenin dimethyl ether	3.51	100.0 µM	2.37E-4		61	2.22E-4
20	SGTC_2341	7987486	3.50	176.7 µM	2.47E-4		32	2.31E-4

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.148	7.02E-18	YKL124W	SSH4	hom	Specificity factor required for Rsp5p-dependent ubiquitination and sorting of cargo proteins at the multivesicular body; identified as a high-copy suppressor of a SHR3 deletion, increasing steady-state levels of amino acid permeases
0.139	6.26E-16	YJR058C	APS2	hom	Small subunit of the clathrin-associated adaptor complex AP-2, which is involved in protein sorting at the plasma membrane; related to the sigma subunit of the mammalian plasma membrane clathrin-associated protein (AP-2) complex
0.121	1.69E-12	YJR153W	PGU1	hom	Endo-polygalacturonase, pectolytic enzyme that hydrolyzes the alpha-1,4-glycosidic bonds in the rhamnogalacturonan chains in pectins
0.104	1.43E-9	YLL015W	BPT1	hom	ABC type transmembrane transporter of MRP/CFTR family, found in vacuolar membrane, involved in the transport of unconjugated bilirubin and in heavy metal detoxification via glutathione conjugates, along with Ycf1p
0.103	2.18E-9	YJL200C	ACO2	hom	Putative mitochondrial aconitase isozyme; similarity to Aco1p, an aconitase required for the TCA cycle; expression induced during growth on glucose, by amino acid starvation via Gcn4p, and repressed on ethanol
0.100	6.06E-9	YNL043C_d	YNL043C_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YIP3/YNL044W
0.096	2.37E-8	YKL070W_p	YKL070W_p	hom	Putative protein of unknown function; expression induced in cells treated with mycotoxins patulin or citrinin; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.090	1.57E-7	YLL063C	AYT1	hom	Acetyltransferase; catalyzes trichothecene 3-O-acetylation, suggesting a possible role in trichothecene biosynthesis
0.090	2.06E-7	YBR261C	TAE1	hom	AdoMet-dependent proline methyltransferase; catalyzes the dimethylation of ribosomal proteins Rpl12 and Rps25 at N-terminal proline residues; has a role in protein synthesis; fusion protein localizes to the cytoplasm
0.087	5.09E-7	YBR147W	RTC2	hom	Putative vacuolar membrane transporter for cationic amino acids; likely contributes to amino acid homeostasis by exporting cationic amino acids from the vacuole; positive regulation by Lys14p suggests that lysine may be the primary substrate; member of the PQ-loop family, with seven transmembrane domains; similar to mammalian PQLC2 vacuolar transporter
0.086	6.84E-7	YOL158C	ENB1	hom	Endosomal ferric enterobactin transporter, expressed under conditions of iron deprivation; member of the major facilitator superfamily; expression is regulated by Rcs1p and affected by chloroquine treatment
0.083	1.29E-6	YJR010W	MET3	hom	ATP sulfurylase, catalyzes the primary step of intracellular sulfate activation, essential for assimilatory reduction of sulfate to sulfide, involved in methionine metabolism
0.083	1.73E-6	YDR243C	PRP28	het	RNA helicase in the DEAD-box family, involved in RNA isomerization at the 5' splice site
0.081	2.36E-6	YNL265C	IST1	hom	Protein with a positive role in the multivesicular body sorting pathway; functions and forms a complex with Did2p; recruitment to endosomes is mediated by the Vps2p-Vps24p subcomplex of ESCRT-III; also interacts with Vps4p
0.081	2.57E-6	YJL158C	CIS3	hom	Mannose-containing glycoprotein constituent of the cell wall; member of the PIR (proteins with internal repeats) family