Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
Zygosity: Homozygous strain
fixedexpanded
![]() ![]() Click on Significant Values for Screen Details |
Top fitness defect scores for YPR195C deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Correlation | pval | ORF | Gene | Zygosity | Description |
---|---|---|---|---|---|
0.148 | 7.02E-18 | YKL124W | SSH4 | hom | Specificity factor required for Rsp5p-dependent ubiquitination and sorting of cargo proteins at the multivesicular body; identified as a high-copy suppressor of a SHR3 deletion, increasing steady-state levels of amino acid permeases |
0.139 | 6.26E-16 | YJR058C | APS2 | hom | Small subunit of the clathrin-associated adaptor complex AP-2, which is involved in protein sorting at the plasma membrane; related to the sigma subunit of the mammalian plasma membrane clathrin-associated protein (AP-2) complex |
0.121 | 1.69E-12 | YJR153W | PGU1 | hom | Endo-polygalacturonase, pectolytic enzyme that hydrolyzes the alpha-1,4-glycosidic bonds in the rhamnogalacturonan chains in pectins |
0.104 | 1.43E-9 | YLL015W | BPT1 | hom | ABC type transmembrane transporter of MRP/CFTR family, found in vacuolar membrane, involved in the transport of unconjugated bilirubin and in heavy metal detoxification via glutathione conjugates, along with Ycf1p |
0.103 | 2.18E-9 | YJL200C | ACO2 | hom | Putative mitochondrial aconitase isozyme; similarity to Aco1p, an aconitase required for the TCA cycle; expression induced during growth on glucose, by amino acid starvation via Gcn4p, and repressed on ethanol |
0.100 | 6.06E-9 | YNL043C_d | YNL043C_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YIP3/YNL044W |
0.096 | 2.37E-8 | YKL070W_p | YKL070W_p | hom | Putative protein of unknown function; expression induced in cells treated with mycotoxins patulin or citrinin; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies |
0.090 | 1.57E-7 | YLL063C | AYT1 | hom | Acetyltransferase; catalyzes trichothecene 3-O-acetylation, suggesting a possible role in trichothecene biosynthesis |
0.090 | 2.06E-7 | YBR261C | TAE1 | hom | AdoMet-dependent proline methyltransferase; catalyzes the dimethylation of ribosomal proteins Rpl12 and Rps25 at N-terminal proline residues; has a role in protein synthesis; fusion protein localizes to the cytoplasm |
0.087 | 5.09E-7 | YBR147W | RTC2 | hom | Putative vacuolar membrane transporter for cationic amino acids; likely contributes to amino acid homeostasis by exporting cationic amino acids from the vacuole; positive regulation by Lys14p suggests that lysine may be the primary substrate; member of the PQ-loop family, with seven transmembrane domains; similar to mammalian PQLC2 vacuolar transporter |
0.086 | 6.84E-7 | YOL158C | ENB1 | hom | Endosomal ferric enterobactin transporter, expressed under conditions of iron deprivation; member of the major facilitator superfamily; expression is regulated by Rcs1p and affected by chloroquine treatment |
0.083 | 1.29E-6 | YJR010W | MET3 | hom | ATP sulfurylase, catalyzes the primary step of intracellular sulfate activation, essential for assimilatory reduction of sulfate to sulfide, involved in methionine metabolism |
0.083 | 1.73E-6 | YDR243C | PRP28 | het | RNA helicase in the DEAD-box family, involved in RNA isomerization at the 5' splice site |
0.081 | 2.36E-6 | YNL265C | IST1 | hom | Protein with a positive role in the multivesicular body sorting pathway; functions and forms a complex with Did2p; recruitment to endosomes is mediated by the Vps2p-Vps24p subcomplex of ESCRT-III; also interacts with Vps4p |
0.081 | 2.57E-6 | YJL158C | CIS3 | hom | Mannose-containing glycoprotein constituent of the cell wall; member of the PIR (proteins with internal repeats) family |