YPR195C_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain
fixedexpanded
Profile for YPR195C / YPR195C

Click on Significant Values for Screen Details ID:SGTC_23|Compound:0213-0011|FD-Score:3.72|P-value:1.07E-4 ID:SGTC_65|Compound:0798-0905|FD-Score:-6.92|P-value:8.93E-12 ID:SGTC_68|Compound:0986-0284|FD-Score:-3.94|P-value:7.21E-5 ID:SGTC_73|Compound:0327-0325|FD-Score:4.15|P-value:1.92E-5 ID:SGTC_77|Compound:0828-0286|FD-Score:-7.94|P-value:5.56E-15 ID:SGTC_78|Compound:0336-0123|FD-Score:-8.15|P-value:1.10E-15 ID:SGTC_106|Compound:0092-0003|FD-Score:4.78|P-value:1.09E-6 ID:SGTC_154|Compound:3389-1638|FD-Score:3.32|P-value:4.72E-4 ID:SGTC_651|Compound:3253-0966|FD-Score:3.12|P-value:9.38E-4 ID:SGTC_752|Compound:1896-0090|FD-Score:-4.16|P-value:2.87E-5 ID:SGTC_1017|Compound:4239-0030|FD-Score:-3.46|P-value:4.27E-4 ID:SGTC_1098|Compound:clofazimine|FD-Score:-4.77|P-value:1.95E-6 ID:SGTC_1108|Compound:betulinic acid|FD-Score:-3.81|P-value:1.18E-4 ID:SGTC_1113|Compound:artemisinin|FD-Score:3.45|P-value:2.96E-4 ID:SGTC_1169|Compound:aniline yellow|FD-Score:4.83|P-value:8.58E-7 ID:SGTC_1184|Compound:1269-1718|FD-Score:6.44|P-value:9.73E-11 ID:SGTC_1185|Compound:1319-0113|FD-Score:-3.58|P-value:2.83E-4 ID:SGTC_1451|Compound:4152-0210|FD-Score:4.13|P-value:2.03E-5 ID:SGTC_1484|Compound:3473-2379|FD-Score:3.25|P-value:6.02E-4 ID:SGTC_1570|Compound:verbenone|FD-Score:3.77|P-value:8.88E-5 ID:SGTC_1705|Compound:st027868|FD-Score:3.62|P-value:1.62E-4 ID:SGTC_1885|Compound:st057546|FD-Score:3.30|P-value:5.14E-4 ID:SGTC_1890|Compound:3',4',7',8'-tetrahydroxyflavone|FD-Score:3.94|P-value:4.46E-5 ID:SGTC_1892|Compound:st058411|FD-Score:3.69|P-value:1.20E-4 ID:SGTC_1919|Compound:st067113|FD-Score:3.69|P-value:1.23E-4 ID:SGTC_2059|Compound:5238311|FD-Score:3.18|P-value:7.64E-4 ID:SGTC_2105|Compound:5350118|FD-Score:-3.61|P-value:2.53E-4 ID:SGTC_2171|Compound:5739187|FD-Score:3.51|P-value:2.35E-4 ID:SGTC_2303|Compound:7774051|FD-Score:4.06|P-value:2.78E-5 ID:SGTC_2341|Compound:7987486|FD-Score:3.50|P-value:2.47E-4 ID:SGTC_2364|Compound:9055074|FD-Score:-3.72|P-value:1.66E-4 ID:SGTC_2430|Compound:5571206|FD-Score:3.80|P-value:8.07E-5 ID:SGTC_2489|Compound:cantharidin|FD-Score:3.41|P-value:3.41E-4 ID:SGTC_2535|Compound:4',4'-dimethoxydalbergione|FD-Score:-3.24|P-value:9.11E-4 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:3.51|P-value:2.37E-4 ID:SGTC_2755|Compound:lomerizine|FD-Score:-3.25|P-value:8.80E-4 ID:SGTC_2792|Compound:7535235|FD-Score:5.30|P-value:7.63E-8 ID:SGTC_2833|Compound:9001315|FD-Score:-4.99|P-value:6.64E-7 ID:SGTC_2908|Compound:7930301|FD-Score:3.26|P-value:5.77E-4 ID:SGTC_2951|Compound:9072950|FD-Score:3.46|P-value:2.90E-4 ID:SGTC_2955|Compound:9076254|FD-Score:3.32|P-value:4.72E-4 ID:SGTC_2962|Compound:9082311|FD-Score:-3.85|P-value:1.00E-4 ID:SGTC_3067|Compound:9117431|FD-Score:-3.63|P-value:2.33E-4 ID:SGTC_3201|Compound:9113999|FD-Score:3.68|P-value:1.28E-4 ID:SGTC_3218|Compound:9131285|FD-Score:4.23|P-value:1.34E-5 ID:SGTC_3304|Compound:9125678|FD-Score:-3.49|P-value:3.88E-4 ID:SGTC_3325|Compound:9138760|FD-Score:4.16|P-value:1.84E-5 ID:SGTC_3334|Compound:9142812|FD-Score:3.37|P-value:4.04E-4 ID:SGTC_23|Compound:0213-0011|FD-Score:3.72|P-value:1.07E-4 ID:SGTC_65|Compound:0798-0905|FD-Score:-6.92|P-value:8.93E-12 ID:SGTC_68|Compound:0986-0284|FD-Score:-3.94|P-value:7.21E-5 ID:SGTC_73|Compound:0327-0325|FD-Score:4.15|P-value:1.92E-5 ID:SGTC_77|Compound:0828-0286|FD-Score:-7.94|P-value:5.56E-15 ID:SGTC_78|Compound:0336-0123|FD-Score:-8.15|P-value:1.10E-15 ID:SGTC_106|Compound:0092-0003|FD-Score:4.78|P-value:1.09E-6 ID:SGTC_154|Compound:3389-1638|FD-Score:3.32|P-value:4.72E-4 ID:SGTC_651|Compound:3253-0966|FD-Score:3.12|P-value:9.38E-4 ID:SGTC_752|Compound:1896-0090|FD-Score:-4.16|P-value:2.87E-5 ID:SGTC_1017|Compound:4239-0030|FD-Score:-3.46|P-value:4.27E-4 ID:SGTC_1098|Compound:clofazimine|FD-Score:-4.77|P-value:1.95E-6 ID:SGTC_1108|Compound:betulinic acid|FD-Score:-3.81|P-value:1.18E-4 ID:SGTC_1113|Compound:artemisinin|FD-Score:3.45|P-value:2.96E-4 ID:SGTC_1169|Compound:aniline yellow|FD-Score:4.83|P-value:8.58E-7 ID:SGTC_1184|Compound:1269-1718|FD-Score:6.44|P-value:9.73E-11 ID:SGTC_1185|Compound:1319-0113|FD-Score:-3.58|P-value:2.83E-4 ID:SGTC_1451|Compound:4152-0210|FD-Score:4.13|P-value:2.03E-5 ID:SGTC_1484|Compound:3473-2379|FD-Score:3.25|P-value:6.02E-4 ID:SGTC_1570|Compound:verbenone|FD-Score:3.77|P-value:8.88E-5 ID:SGTC_1705|Compound:st027868|FD-Score:3.62|P-value:1.62E-4 ID:SGTC_1885|Compound:st057546|FD-Score:3.30|P-value:5.14E-4 ID:SGTC_1890|Compound:3',4',7',8'-tetrahydroxyflavone|FD-Score:3.94|P-value:4.46E-5 ID:SGTC_1892|Compound:st058411|FD-Score:3.69|P-value:1.20E-4 ID:SGTC_1919|Compound:st067113|FD-Score:3.69|P-value:1.23E-4 ID:SGTC_2059|Compound:5238311|FD-Score:3.18|P-value:7.64E-4 ID:SGTC_2105|Compound:5350118|FD-Score:-3.61|P-value:2.53E-4 ID:SGTC_2171|Compound:5739187|FD-Score:3.51|P-value:2.35E-4 ID:SGTC_2303|Compound:7774051|FD-Score:4.06|P-value:2.78E-5 ID:SGTC_2341|Compound:7987486|FD-Score:3.50|P-value:2.47E-4 ID:SGTC_2364|Compound:9055074|FD-Score:-3.72|P-value:1.66E-4 ID:SGTC_2430|Compound:5571206|FD-Score:3.80|P-value:8.07E-5 ID:SGTC_2489|Compound:cantharidin|FD-Score:3.41|P-value:3.41E-4 ID:SGTC_2535|Compound:4',4'-dimethoxydalbergione|FD-Score:-3.24|P-value:9.11E-4 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:3.51|P-value:2.37E-4 ID:SGTC_2755|Compound:lomerizine|FD-Score:-3.25|P-value:8.80E-4 ID:SGTC_2792|Compound:7535235|FD-Score:5.30|P-value:7.63E-8 ID:SGTC_2833|Compound:9001315|FD-Score:-4.99|P-value:6.64E-7 ID:SGTC_2908|Compound:7930301|FD-Score:3.26|P-value:5.77E-4 ID:SGTC_2951|Compound:9072950|FD-Score:3.46|P-value:2.90E-4 ID:SGTC_2955|Compound:9076254|FD-Score:3.32|P-value:4.72E-4 ID:SGTC_2962|Compound:9082311|FD-Score:-3.85|P-value:1.00E-4 ID:SGTC_3067|Compound:9117431|FD-Score:-3.63|P-value:2.33E-4 ID:SGTC_3201|Compound:9113999|FD-Score:3.68|P-value:1.28E-4 ID:SGTC_3218|Compound:9131285|FD-Score:4.23|P-value:1.34E-5 ID:SGTC_3304|Compound:9125678|FD-Score:-3.49|P-value:3.88E-4 ID:SGTC_3325|Compound:9138760|FD-Score:4.16|P-value:1.84E-5 ID:SGTC_3334|Compound:9142812|FD-Score:3.37|P-value:4.04E-4

Top fitness defect scores for YPR195C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1184 1269-1718 6.44 139.0 µM 9.73E-11 5 5.82E-11
2 SGTC_2792 7535235 5.30 81.8 µM 7.63E-8 fatty acid desaturase (OLE1) 14 5.65E-8
3 SGTC_1169 aniline yellow 4.83 25.8 µM 8.58E-7 1 6.85E-7
4 SGTC_106 0092-0003 4.78 11.6 µM 1.09E-6 copper-dependent oxidative stress 12 8.77E-7
5 SGTC_3218 9131285 4.23 49.5 µM 1.34E-5 endomembrane recycling 33 1.16E-5
6 SGTC_3325 9138760 4.16 55.2 µM 1.84E-5 Golgi 21 1.61E-5
7 SGTC_73 0327-0325 4.15 16.2 µM 1.92E-5 DNA damage response 43 1.68E-5
8 SGTC_1451 4152-0210 4.13 104.0 µM 2.03E-5 22 1.78E-5
9 SGTC_2303 7774051 4.06 200.0 µM 2.78E-5 16 2.45E-5
10 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 3.94 14.9 µM 4.46E-5 12 3.99E-5
11 SGTC_2430 5571206 3.80 200.0 µM 8.07E-5 60 7.34E-5
12 SGTC_1570 verbenone 3.77 133.0 µM 8.88E-5 20 8.09E-5
13 SGTC_23 0213-0011 3.72 40.0 µM 1.07E-4 copper-dependent oxidative stress 33 9.79E-5
14 SGTC_1892 st058411 3.69 7.4 µM 1.20E-4 30 1.10E-4
15 SGTC_1919 st067113 3.69 52.3 µM 1.23E-4 TSC3-RPN4 38 1.13E-4
16 SGTC_3201 9113999 3.68 49.5 µM 1.28E-4 43 1.18E-4
17 SGTC_1705 st027868 3.62 56.3 µM 1.62E-4 17 1.50E-4
18 SGTC_2171 5739187 3.51 198.1 µM 2.35E-4 copper-dependent oxidative stress 22 2.20E-4
19 SGTC_2636 apigenin dimethyl ether 3.51 100.0 µM 2.37E-4 61 2.22E-4
20 SGTC_2341 7987486 3.50 176.7 µM 2.47E-4 32 2.31E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.148 7.02E-18 YKL124W SSH4 hom Specificity factor required for Rsp5p-dependent ubiquitination and sorting of cargo proteins at the multivesicular body; identified as a high-copy suppressor of a SHR3 deletion, increasing steady-state levels of amino acid permeases
0.139 6.26E-16 YJR058C APS2 hom Small subunit of the clathrin-associated adaptor complex AP-2, which is involved in protein sorting at the plasma membrane; related to the sigma subunit of the mammalian plasma membrane clathrin-associated protein (AP-2) complex
0.121 1.69E-12 YJR153W PGU1 hom Endo-polygalacturonase, pectolytic enzyme that hydrolyzes the alpha-1,4-glycosidic bonds in the rhamnogalacturonan chains in pectins
0.104 1.43E-9 YLL015W BPT1 hom ABC type transmembrane transporter of MRP/CFTR family, found in vacuolar membrane, involved in the transport of unconjugated bilirubin and in heavy metal detoxification via glutathione conjugates, along with Ycf1p
0.103 2.18E-9 YJL200C ACO2 hom Putative mitochondrial aconitase isozyme; similarity to Aco1p, an aconitase required for the TCA cycle; expression induced during growth on glucose, by amino acid starvation via Gcn4p, and repressed on ethanol
0.100 6.06E-9 YNL043C_d YNL043C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YIP3/YNL044W
0.096 2.37E-8 YKL070W_p YKL070W_p hom Putative protein of unknown function; expression induced in cells treated with mycotoxins patulin or citrinin; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.090 1.57E-7 YLL063C AYT1 hom Acetyltransferase; catalyzes trichothecene 3-O-acetylation, suggesting a possible role in trichothecene biosynthesis
0.090 2.06E-7 YBR261C TAE1 hom AdoMet-dependent proline methyltransferase; catalyzes the dimethylation of ribosomal proteins Rpl12 and Rps25 at N-terminal proline residues; has a role in protein synthesis; fusion protein localizes to the cytoplasm
0.087 5.09E-7 YBR147W RTC2 hom Putative vacuolar membrane transporter for cationic amino acids; likely contributes to amino acid homeostasis by exporting cationic amino acids from the vacuole; positive regulation by Lys14p suggests that lysine may be the primary substrate; member of the PQ-loop family, with seven transmembrane domains; similar to mammalian PQLC2 vacuolar transporter
0.086 6.84E-7 YOL158C ENB1 hom Endosomal ferric enterobactin transporter, expressed under conditions of iron deprivation; member of the major facilitator superfamily; expression is regulated by Rcs1p and affected by chloroquine treatment
0.083 1.29E-6 YJR010W MET3 hom ATP sulfurylase, catalyzes the primary step of intracellular sulfate activation, essential for assimilatory reduction of sulfate to sulfide, involved in methionine metabolism
0.083 1.73E-6 YDR243C PRP28 het RNA helicase in the DEAD-box family, involved in RNA isomerization at the 5' splice site
0.081 2.36E-6 YNL265C IST1 hom Protein with a positive role in the multivesicular body sorting pathway; functions and forms a complex with Did2p; recruitment to endosomes is mediated by the Vps2p-Vps24p subcomplex of ESCRT-III; also interacts with Vps4p
0.081 2.57E-6 YJL158C CIS3 hom Mannose-containing glycoprotein constituent of the cell wall; member of the PIR (proteins with internal repeats) family