YPR197C_d

Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain
fixedexpanded
Profile for YPR197C / YPR197C

Click on Significant Values for Screen Details ID:SGTC_3|Compound:0833-0587|FD-Score:6.09|P-value:1.64E-6 ID:SGTC_5|Compound:0352-0601|FD-Score:6.03|P-value:2.03E-6 ID:SGTC_9|Compound:0092-0002|FD-Score:8.14|P-value:2.40E-10 ID:SGTC_17|Compound:0960-0276|FD-Score:5.52|P-value:1.21E-5 ID:SGTC_23|Compound:0213-0011|FD-Score:7.74|P-value:1.66E-9 ID:SGTC_25|Compound:0118-0223|FD-Score:5.38|P-value:1.98E-5 ID:SGTC_29|Compound:0299-0004|FD-Score:5.78|P-value:4.95E-6 ID:SGTC_36|Compound:0335-0881|FD-Score:5.84|P-value:4.11E-6 ID:SGTC_58|Compound:0957-0393|FD-Score:6.10|P-value:1.56E-6 ID:SGTC_63|Compound:0099-0242|FD-Score:4.95|P-value:7.91E-5 ID:SGTC_67|Compound:0335-0847|FD-Score:6.05|P-value:1.88E-6 ID:SGTC_74|Compound:000s-0487|FD-Score:5.17|P-value:3.86E-5 ID:SGTC_86|Compound:0417-1630|FD-Score:5.52|P-value:1.24E-5 ID:SGTC_103|Compound:0844-0104|FD-Score:6.40|P-value:5.07E-7 ID:SGTC_129|Compound:0088-0017|FD-Score:-4.07|P-value:8.91E-4 ID:SGTC_130|Compound:0136-0219|FD-Score:4.43|P-value:3.58E-4 ID:SGTC_131|Compound:0141-0277|FD-Score:-4.03|P-value:9.87E-4 ID:SGTC_142|Compound:0335-0849|FD-Score:16.10|P-value:2.57E-35 ID:SGTC_166|Compound:k072-0058|FD-Score:4.36|P-value:4.35E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:7.99|P-value:4.90E-10 ID:SGTC_341|Compound:1486-1430|FD-Score:7.27|P-value:1.35E-8 ID:SGTC_363|Compound:0455-0021|FD-Score:7.00|P-value:4.34E-8 ID:SGTC_433|Compound:pimozide|FD-Score:-4.26|P-value:5.31E-4 ID:SGTC_594|Compound:1487-1584|FD-Score:4.44|P-value:3.51E-4 ID:SGTC_628|Compound:1636-0253|FD-Score:4.47|P-value:3.21E-4 ID:SGTC_794|Compound:k038-0031|FD-Score:5.76|P-value:5.34E-6 ID:SGTC_859|Compound:0439-0102|FD-Score:5.09|P-value:5.00E-5 ID:SGTC_862|Compound:0452-0056|FD-Score:8.32|P-value:1.01E-10 ID:SGTC_1015|Compound:4130-4525|FD-Score:6.51|P-value:3.24E-7 ID:SGTC_1018|Compound:4259-0013|FD-Score:4.55|P-value:2.59E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:9.26|P-value:7.15E-13 ID:SGTC_1087|Compound:pterostilbene|FD-Score:7.85|P-value:9.74E-10 ID:SGTC_1294|Compound:1000-1494|FD-Score:12.50|P-value:5.15E-22 ID:SGTC_1297|Compound:1068-0111|FD-Score:5.98|P-value:2.40E-6 ID:SGTC_1309|Compound:pyrazolanthrone|FD-Score:4.69|P-value:1.71E-4 ID:SGTC_1317|Compound:1273-0028|FD-Score:11.90|P-value:4.29E-20 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:4.87|P-value:1.00E-4 ID:SGTC_1599|Compound:8-chlro-1-tetrahydronorharmanone|FD-Score:4.39|P-value:4.00E-4 ID:SGTC_1629|Compound:st005085|FD-Score:4.05|P-value:9.89E-4 ID:SGTC_1750|Compound:st081859|FD-Score:7.01|P-value:4.22E-8 ID:SGTC_1782|Compound:st039423|FD-Score:4.21|P-value:6.49E-4 ID:SGTC_1786|Compound:berberine|FD-Score:12.30|P-value:1.93E-21 ID:SGTC_1827|Compound:berberine|FD-Score:5.10|P-value:4.95E-5 ID:SGTC_1829|Compound:berberine|FD-Score:5.42|P-value:1.74E-5 ID:SGTC_1855|Compound:st056195|FD-Score:-5.02|P-value:5.73E-5 ID:SGTC_1868|Compound:st057644|FD-Score:6.18|P-value:1.15E-6 ID:SGTC_1923|Compound:st058458|FD-Score:4.49|P-value:3.04E-4 ID:SGTC_1956|Compound:st077085|FD-Score:-4.17|P-value:6.68E-4 ID:SGTC_1959|Compound:st077091|FD-Score:4.90|P-value:9.07E-5 ID:SGTC_2016|Compound:5121758|FD-Score:7.96|P-value:5.73E-10 ID:SGTC_2029|Compound:5175081|FD-Score:5.50|P-value:1.30E-5 ID:SGTC_2031|Compound:5180455|FD-Score:7.05|P-value:3.56E-8 ID:SGTC_2041|Compound:5107442|FD-Score:4.46|P-value:3.30E-4 ID:SGTC_2042|Compound:p-Dimethylaminoacetophenone|FD-Score:7.06|P-value:3.32E-8 ID:SGTC_2045|Compound:5106652|FD-Score:9.03|P-value:2.43E-12 ID:SGTC_2058|Compound:5236698|FD-Score:4.25|P-value:5.83E-4 ID:SGTC_2063|Compound:5246145|FD-Score:6.43|P-value:4.41E-7 ID:SGTC_2110|Compound:5483698|FD-Score:-4.04|P-value:9.60E-4 ID:SGTC_2127|Compound:5253358|FD-Score:4.05|P-value:9.91E-4 ID:SGTC_2154|Compound:5570129|FD-Score:4.07|P-value:9.33E-4 ID:SGTC_2178|Compound:5812956|FD-Score:4.06|P-value:9.73E-4 ID:SGTC_2302|Compound:7771753|FD-Score:6.22|P-value:9.86E-7 ID:SGTC_2326|Compound:6164455|FD-Score:-4.33|P-value:4.44E-4 ID:SGTC_2459|Compound:5811157|FD-Score:4.11|P-value:8.48E-4 ID:SGTC_2460|Compound:5552655|FD-Score:5.31|P-value:2.51E-5 ID:SGTC_2511|Compound:berberine|FD-Score:4.85|P-value:1.04E-4 ID:SGTC_2532|Compound:xanthone|FD-Score:6.05|P-value:1.89E-6 ID:SGTC_2556|Compound:citropten|FD-Score:4.58|P-value:2.37E-4 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:4.34|P-value:4.59E-4 ID:SGTC_2661|Compound:dactinomycin|FD-Score:4.42|P-value:3.68E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:-4.71|P-value:1.48E-4 ID:SGTC_2681|Compound:menadione|FD-Score:4.57|P-value:2.41E-4 ID:SGTC_2702|Compound:st077768|FD-Score:5.06|P-value:5.60E-5 ID:SGTC_2721|Compound:ifenprodil|FD-Score:4.20|P-value:6.78E-4 ID:SGTC_2751|Compound:anetholtrithion|FD-Score:6.88|P-value:7.24E-8 ID:SGTC_2757|Compound:clomiphene|FD-Score:-5.56|P-value:9.70E-6 ID:SGTC_3043|Compound:9092303|FD-Score:6.92|P-value:6.11E-8 ID:SGTC_3059|Compound:1327-0034|FD-Score:6.99|P-value:4.46E-8 ID:SGTC_3063|Compound:1327-0034|FD-Score:6.07|P-value:1.74E-6 ID:SGTC_3129|Compound:9127257|FD-Score:4.07|P-value:9.48E-4 ID:SGTC_3201|Compound:9113999|FD-Score:5.77|P-value:5.12E-6 ID:SGTC_3274|Compound:9138298|FD-Score:4.87|P-value:9.93E-5 ID:SGTC_3330|Compound:9141424|FD-Score:4.25|P-value:5.82E-4 ID:SGTC_3|Compound:0833-0587|FD-Score:6.09|P-value:1.64E-6 ID:SGTC_5|Compound:0352-0601|FD-Score:6.03|P-value:2.03E-6 ID:SGTC_9|Compound:0092-0002|FD-Score:8.14|P-value:2.40E-10 ID:SGTC_17|Compound:0960-0276|FD-Score:5.52|P-value:1.21E-5 ID:SGTC_23|Compound:0213-0011|FD-Score:7.74|P-value:1.66E-9 ID:SGTC_25|Compound:0118-0223|FD-Score:5.38|P-value:1.98E-5 ID:SGTC_29|Compound:0299-0004|FD-Score:5.78|P-value:4.95E-6 ID:SGTC_36|Compound:0335-0881|FD-Score:5.84|P-value:4.11E-6 ID:SGTC_58|Compound:0957-0393|FD-Score:6.10|P-value:1.56E-6 ID:SGTC_63|Compound:0099-0242|FD-Score:4.95|P-value:7.91E-5 ID:SGTC_67|Compound:0335-0847|FD-Score:6.05|P-value:1.88E-6 ID:SGTC_74|Compound:000s-0487|FD-Score:5.17|P-value:3.86E-5 ID:SGTC_86|Compound:0417-1630|FD-Score:5.52|P-value:1.24E-5 ID:SGTC_103|Compound:0844-0104|FD-Score:6.40|P-value:5.07E-7 ID:SGTC_129|Compound:0088-0017|FD-Score:-4.07|P-value:8.91E-4 ID:SGTC_130|Compound:0136-0219|FD-Score:4.43|P-value:3.58E-4 ID:SGTC_131|Compound:0141-0277|FD-Score:-4.03|P-value:9.87E-4 ID:SGTC_142|Compound:0335-0849|FD-Score:16.10|P-value:2.57E-35 ID:SGTC_166|Compound:k072-0058|FD-Score:4.36|P-value:4.35E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:7.99|P-value:4.90E-10 ID:SGTC_341|Compound:1486-1430|FD-Score:7.27|P-value:1.35E-8 ID:SGTC_363|Compound:0455-0021|FD-Score:7.00|P-value:4.34E-8 ID:SGTC_433|Compound:pimozide|FD-Score:-4.26|P-value:5.31E-4 ID:SGTC_594|Compound:1487-1584|FD-Score:4.44|P-value:3.51E-4 ID:SGTC_628|Compound:1636-0253|FD-Score:4.47|P-value:3.21E-4 ID:SGTC_794|Compound:k038-0031|FD-Score:5.76|P-value:5.34E-6 ID:SGTC_859|Compound:0439-0102|FD-Score:5.09|P-value:5.00E-5 ID:SGTC_862|Compound:0452-0056|FD-Score:8.32|P-value:1.01E-10 ID:SGTC_1015|Compound:4130-4525|FD-Score:6.51|P-value:3.24E-7 ID:SGTC_1018|Compound:4259-0013|FD-Score:4.55|P-value:2.59E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:9.26|P-value:7.15E-13 ID:SGTC_1087|Compound:pterostilbene|FD-Score:7.85|P-value:9.74E-10 ID:SGTC_1294|Compound:1000-1494|FD-Score:12.50|P-value:5.15E-22 ID:SGTC_1297|Compound:1068-0111|FD-Score:5.98|P-value:2.40E-6 ID:SGTC_1309|Compound:pyrazolanthrone|FD-Score:4.69|P-value:1.71E-4 ID:SGTC_1317|Compound:1273-0028|FD-Score:11.90|P-value:4.29E-20 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:4.87|P-value:1.00E-4 ID:SGTC_1599|Compound:8-chlro-1-tetrahydronorharmanone|FD-Score:4.39|P-value:4.00E-4 ID:SGTC_1629|Compound:st005085|FD-Score:4.05|P-value:9.89E-4 ID:SGTC_1750|Compound:st081859|FD-Score:7.01|P-value:4.22E-8 ID:SGTC_1782|Compound:st039423|FD-Score:4.21|P-value:6.49E-4 ID:SGTC_1786|Compound:berberine|FD-Score:12.30|P-value:1.93E-21 ID:SGTC_1827|Compound:berberine|FD-Score:5.10|P-value:4.95E-5 ID:SGTC_1829|Compound:berberine|FD-Score:5.42|P-value:1.74E-5 ID:SGTC_1855|Compound:st056195|FD-Score:-5.02|P-value:5.73E-5 ID:SGTC_1868|Compound:st057644|FD-Score:6.18|P-value:1.15E-6 ID:SGTC_1923|Compound:st058458|FD-Score:4.49|P-value:3.04E-4 ID:SGTC_1956|Compound:st077085|FD-Score:-4.17|P-value:6.68E-4 ID:SGTC_1959|Compound:st077091|FD-Score:4.90|P-value:9.07E-5 ID:SGTC_2016|Compound:5121758|FD-Score:7.96|P-value:5.73E-10 ID:SGTC_2029|Compound:5175081|FD-Score:5.50|P-value:1.30E-5 ID:SGTC_2031|Compound:5180455|FD-Score:7.05|P-value:3.56E-8 ID:SGTC_2041|Compound:5107442|FD-Score:4.46|P-value:3.30E-4 ID:SGTC_2042|Compound:p-Dimethylaminoacetophenone|FD-Score:7.06|P-value:3.32E-8 ID:SGTC_2045|Compound:5106652|FD-Score:9.03|P-value:2.43E-12 ID:SGTC_2058|Compound:5236698|FD-Score:4.25|P-value:5.83E-4 ID:SGTC_2063|Compound:5246145|FD-Score:6.43|P-value:4.41E-7 ID:SGTC_2110|Compound:5483698|FD-Score:-4.04|P-value:9.60E-4 ID:SGTC_2127|Compound:5253358|FD-Score:4.05|P-value:9.91E-4 ID:SGTC_2154|Compound:5570129|FD-Score:4.07|P-value:9.33E-4 ID:SGTC_2178|Compound:5812956|FD-Score:4.06|P-value:9.73E-4 ID:SGTC_2302|Compound:7771753|FD-Score:6.22|P-value:9.86E-7 ID:SGTC_2326|Compound:6164455|FD-Score:-4.33|P-value:4.44E-4 ID:SGTC_2459|Compound:5811157|FD-Score:4.11|P-value:8.48E-4 ID:SGTC_2460|Compound:5552655|FD-Score:5.31|P-value:2.51E-5 ID:SGTC_2511|Compound:berberine|FD-Score:4.85|P-value:1.04E-4 ID:SGTC_2532|Compound:xanthone|FD-Score:6.05|P-value:1.89E-6 ID:SGTC_2556|Compound:citropten|FD-Score:4.58|P-value:2.37E-4 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:4.34|P-value:4.59E-4 ID:SGTC_2661|Compound:dactinomycin|FD-Score:4.42|P-value:3.68E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:-4.71|P-value:1.48E-4 ID:SGTC_2681|Compound:menadione|FD-Score:4.57|P-value:2.41E-4 ID:SGTC_2702|Compound:st077768|FD-Score:5.06|P-value:5.60E-5 ID:SGTC_2721|Compound:ifenprodil|FD-Score:4.20|P-value:6.78E-4 ID:SGTC_2751|Compound:anetholtrithion|FD-Score:6.88|P-value:7.24E-8 ID:SGTC_2757|Compound:clomiphene|FD-Score:-5.56|P-value:9.70E-6 ID:SGTC_3043|Compound:9092303|FD-Score:6.92|P-value:6.11E-8 ID:SGTC_3059|Compound:1327-0034|FD-Score:6.99|P-value:4.46E-8 ID:SGTC_3063|Compound:1327-0034|FD-Score:6.07|P-value:1.74E-6 ID:SGTC_3129|Compound:9127257|FD-Score:4.07|P-value:9.48E-4 ID:SGTC_3201|Compound:9113999|FD-Score:5.77|P-value:5.12E-6 ID:SGTC_3274|Compound:9138298|FD-Score:4.87|P-value:9.93E-5 ID:SGTC_3330|Compound:9141424|FD-Score:4.25|P-value:5.82E-4

Top fitness defect scores for YPR197C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_142 0335-0849 16.10 62.7 µM 2.57E-35 ubiquinone biosynthesis & proteasome 14 7.63E-59
2 SGTC_1294 1000-1494 12.50 117.0 µM 5.15E-22 9 3.18E-36
3 SGTC_1786 berberine 12.30 21.6 µM 1.93E-21 60S ribosome export 1 3.00E-35
4 SGTC_1317 1273-0028 11.90 910.0 nM 4.29E-20 azole & statin 8 5.82E-33
5 SGTC_1083 didemethylchlorpromazine sulfoxide 9.26 707.4 nM 7.15E-13 redox potentiating 9 1.04E-20
6 SGTC_2045 5106652 9.03 78.0 µM 2.43E-12 1 8.22E-20
7 SGTC_862 0452-0056 8.32 10.2 µM 1.01E-10 azole & statin 9 4.50E-17
8 SGTC_9 0092-0002 8.14 10.4 µM 2.40E-10 3 1.96E-16
9 SGTC_310 1273-0058 7.99 1.1 µM 4.90E-10 mitochondrial stress 90 6.54E-16
10 SGTC_2016 5121758 7.96 140.0 µM 5.73E-10 redox potentiating 4 8.52E-16
11 SGTC_1087 pterostilbene 7.85 9.1 µM 9.74E-10 1 2.09E-15
12 SGTC_23 0213-0011 7.74 40.0 µM 1.66E-9 copper-dependent oxidative stress 8 5.14E-15
13 SGTC_341 1486-1430 7.27 230.0 µM 1.35E-8 2 1.76E-13
14 SGTC_2042 p-Dimethylaminoacetophenone 7.06 200.0 µM 3.32E-8 1 8.09E-13
15 SGTC_2031 5180455 7.05 200.0 µM 3.56E-8 2 9.09E-13
16 SGTC_1750 st081859 7.01 2.4 µM 4.22E-8 endomembrane recycling 87 1.21E-12
17 SGTC_363 0455-0021 7.00 3.1 µM 4.34E-8 azole & statin 23 1.27E-12
18 SGTC_3059 1327-0034 6.99 3.0 µM 4.46E-8 23 1.33E-12
19 SGTC_3043 9092303 6.92 49.5 µM 6.11E-8 1 2.26E-12
20 SGTC_2751 anetholtrithion 6.88 17.2 µM 7.24E-8 4 3.01E-12

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.315 5.12E-78 YJL193W_p YJL193W_p hom Putative protein of unknown function, predicted to encode a triose phosphate transporter subfamily member based on phylogenetic analysis; similar to YOR307C/SLY41; deletion mutant has a respiratory growth defect
0.311 4.28E-76 YPR146C_d YPR146C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.304 1.34E-72 YDR537C_d YDR537C_d hom Dubious open reading frame unlikely to encode a protein, almost completely overlaps verified ORF PAD1/YDR538W
0.300 8.25E-71 YJL155C FBP26 hom Fructose-2,6-bisphosphatase, required for glucose metabolism; protein abundance increases in response to DNA replication stress
0.297 2.30E-69 YPR198W SGE1 hom Plasma membrane multidrug transporter of the major facilitator superfamily, acts as an extrusion permease; partial multicopy suppressor of gal11 mutations
0.297 4.32E-69 YFR007W YFH7 hom Putative kinase with similarity to the phosphoribulokinase/uridine kinase/bacterial pantothenate kinase (PRK/URK/PANK) subfamily of P-loop kinases
0.294 1.00E-67 YDR181C SAS4 hom Subunit of the SAS complex (Sas2p, Sas4p, Sas5p), which acetylates free histones and nucleosomes and regulates transcriptional silencing; required for the HAT activity of Sas2p
0.290 7.50E-66 YDL183C YDL183C hom Mitochondrial inner-membrane protein thought to be involved in the formation of an active mitochondrial K+/H+ exchanger (KHE) system; non-essential gene
0.287 1.19E-64 YJR129C_p YJR129C_p hom Putative protein of unknown function; predicted S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.278 1.87E-60 YER041W YEN1 hom Holliday junction resolvase; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation; homolog of human GEN1 and has similarity to S. cerevisiae endonuclease Rth1p
0.277 3.15E-60 YLR359W ADE13 het Adenylosuccinate lyase, catalyzes two steps in the 'de novo' purine nucleotide biosynthetic pathway; expression is repressed by adenine and activated by Bas1p and Pho2p; mutations in human ortholog ADSL cause adenylosuccinase deficiency
0.273 1.38E-58 YCL014W BUD3 hom Protein involved in bud-site selection and required for axial budding pattern; localizes with septins to bud neck in mitosis and may constitute an axial landmark for next round of budding
0.253 4.08E-50 YMR127C SAS2 hom Histone acetyltransferase (HAT) catalytic subunit of the SAS complex (Sas2p-Sas4p-Sas5p), which acetylates free histones and nucleosomes and regulates transcriptional silencing; member of the MYSTacetyltransferase family
0.209 2.68E-34 YPR107C YTH1 het Essential RNA-binding component of cleavage and polyadenylation factor, contains five zinc fingers; required for pre-mRNA 3'-end processing and polyadenylation
0.200 1.39E-31 YGL093W SPC105 het Subunit of a kinetochore-microtubule binding complex with Kre28p that bridges centromeric heterochromatin and kinetochore MAPs and motors; required for sister chromatid bi-orientation and kinetochore binding of SAC components