HIPHOP chemogenomics database

YPR198W / SGE1

Plasma membrane multidrug transporter of the major facilitator superfamily, acts as an extrusion permease; partial multicopy suppressor of gal11 mutations

Zygosity: Homozygous strain

fixedexpanded
Profile for YPR198W / SGE1

Click on Significant Values for Screen Details

Top fitness defect scores for YPR198W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_363	0455-0021	13.40	3.1 µM	3.08E-28	azole & statin	5	5.84E-41
2	SGTC_1317	1273-0028	12.00	910.0 nM	5.22E-23	azole & statin	7	3.23E-33
3	SGTC_862	0452-0056	9.71	10.2 µM	8.25E-16	azole & statin	5	1.43E-22
4	SGTC_310	1273-0058	9.69	1.1 µM	8.96E-16	mitochondrial stress	46	1.61E-22
5	SGTC_182	3448-4371	8.15	550.5 µM	1.13E-11		1	1.82E-16
6	SGTC_2245	6637752	7.56	200.0 µM	2.76E-10		2	2.03E-14
7	SGTC_2422	chlorphenesin carbamate	7.32	384.2 µM	9.32E-10		1	1.22E-13
8	SGTC_2798	7813637	7.15	45.5 µM	2.17E-9		3	4.22E-13
9	SGTC_63	0099-0242	7.11	26.7 µM	2.68E-9	mitochondrial stress	17	5.77E-13
10	SGTC_130	0136-0219	6.94	337.7 µM	6.13E-9		2	1.95E-12
11	SGTC_1786	berberine	6.64	21.6 µM	2.48E-8	60S ribosome export	8	1.52E-11
12	SGTC_2511	berberine	6.59	10.5 µM	3.12E-8	60S ribosome export	3	2.13E-11
13	SGTC_1252	0493-0875	6.47	34.8 µM	5.60E-8		2	5.04E-11
14	SGTC_2603	homopterocarpin	6.34	100.0 µM	9.81E-8		3	1.15E-10
15	SGTC_3065	9113888	6.32	49.5 µM	1.07E-7		3	1.31E-10
16	SGTC_1083	didemethylchlorpromazine sulfoxide	6.17	707.4 nM	2.03E-7	redox potentiating	24	3.34E-10
17	SGTC_3338	9144300	6.08	39.6 µM	3.02E-7	Golgi	3	6.00E-10
18	SGTC_2927	9011802	6.07	47.9 µM	3.16E-7		4	6.42E-10
19	SGTC_1678	st019265	5.98	80.2 µM	4.58E-7	60S ribosome export	4	1.11E-9
20	SGTC_429	1112-0049	5.94	25.5 µM	5.56E-7	DNA damage response	12	1.47E-9

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.359	2.09E-102	YLR359W	ADE13	het	Adenylosuccinate lyase, catalyzes two steps in the 'de novo' purine nucleotide biosynthetic pathway; expression is repressed by adenine and activated by Bas1p and Pho2p; mutations in human ortholog ADSL cause adenylosuccinase deficiency
0.297	2.30E-69	YPR197C_d	YPR197C_d	hom	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.291	2.44E-66	YDR181C	SAS4	hom	Subunit of the SAS complex (Sas2p, Sas4p, Sas5p), which acetylates free histones and nucleosomes and regulates transcriptional silencing; required for the HAT activity of Sas2p
0.226	4.01E-40	YMR127C	SAS2	hom	Histone acetyltransferase (HAT) catalytic subunit of the SAS complex (Sas2p-Sas4p-Sas5p), which acetylates free histones and nucleosomes and regulates transcriptional silencing; member of the MYSTacetyltransferase family
0.172	1.24E-23	YMR154C	RIM13	hom	Calpain-like cysteine protease; involved in proteolytic activation of Rim101p in response to alkaline pH; localizes to punctate structures in alkaline conditions and in vps4 mutant; has similarity to A. nidulans palB
0.149	3.50E-18	YGR004W	PEX31	hom	Peroxisomal integral membrane protein, involved in negative regulation of peroxisome size; partially functionally redundant with Pex30p and Pex32p; probably acts at a step downstream of steps mediated by Pex28p and Pex29p
0.144	5.42E-17	YML081W	TDA9	hom	DNA-binding protein, putative transcription factor; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; null mutant is sensitive to expression of the top1-T722A allele; not an essential gene; TDA9 has a paralog, RSF2, that arose from the whole genome duplication
0.138	1.01E-15	YHR113W	APE4	hom	Cytoplasmic aspartyl aminopeptidase that may also function in the vacuole; CVT pathway cargo protein; cleaves unblocked N-terminal acidic amino acids from peptide substrates; forms a 12-subunit homo-oligomer; M18 metalloprotease family
0.126	2.30E-13	YGL045W	RIM8	hom	Protein involved in proteolytic activation of Rim101p in response to alkaline pH; interacts with ESCRT-1 subunits Stp22p and Vps28p; essential for anaerobic growth; member of the arrestin-related trafficking adaptor family
0.124	6.27E-13	YLR228C	ECM22	hom	Sterol regulatory element binding protein; regulates transcription of sterol biosynthetic genes; contains Zn[2]-Cys[6] binuclear cluster; relocates from intracellular membranes to perinuclear foci on sterol depletion; ECM22 has a paralog, UPC2, that arose from the whole genome duplication
0.121	1.67E-12	YNL081C	SWS2	hom	Putative mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S13 ribosomal protein; participates in controlling sporulation efficiency
0.121	2.12E-12	YOR213C	SAS5	hom	Subunit of the SAS complex (Sas2p, Sas4p, Sas5p), which acetylates free histones and nucleosomes and regulates transcriptional silencing; stimulates Sas2p HAT activity
0.118	7.27E-12	YOR275C	RIM20	hom	Protein involved in proteolytic activation of Rim101p in response to alkaline pH; PalA/AIP1/Alix family member; interaction with the ESCRT-III subunit Snf7p suggests a relationship between pH response and multivesicular body formation
0.117	1.01E-11	YPL061W	ALD6	hom	Cytosolic aldehyde dehydrogenase, activated by Mg2+ and utilizes NADP+ as the preferred coenzyme; required for conversion of acetaldehyde to acetate; constitutively expressed; locates to the mitochondrial outer surface upon oxidative stress
0.117	1.27E-11	YGR170W	PSD2	hom	Phosphatidylserine decarboxylase of the Golgi and vacuolar membranes, converts phosphatidylserine to phosphatidylethanolamine