YPR198W / SGE1

Plasma membrane multidrug transporter of the major facilitator superfamily, acts as an extrusion permease; partial multicopy suppressor of gal11 mutations

Zygosity: Homozygous strain
fixedexpanded
Profile for YPR198W / SGE1

Click on Significant Values for Screen Details ID:SGTC_41|Compound:0478-0632|FD-Score:4.62|P-value:7.55E-5 ID:SGTC_63|Compound:0099-0242|FD-Score:7.11|P-value:2.68E-9 ID:SGTC_74|Compound:000s-0487|FD-Score:4.87|P-value:3.20E-5 ID:SGTC_130|Compound:0136-0219|FD-Score:6.94|P-value:6.13E-9 ID:SGTC_154|Compound:3389-1638|FD-Score:4.05|P-value:4.48E-4 ID:SGTC_176|Compound:1486-1328|FD-Score:3.83|P-value:8.40E-4 ID:SGTC_182|Compound:3448-4371|FD-Score:8.15|P-value:1.13E-11 ID:SGTC_279|Compound:1273-0055|FD-Score:4.24|P-value:2.48E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:5.16|P-value:1.16E-5 ID:SGTC_310|Compound:1273-0058|FD-Score:9.69|P-value:8.96E-16 ID:SGTC_363|Compound:0455-0021|FD-Score:13.40|P-value:3.08E-28 ID:SGTC_429|Compound:1112-0049|FD-Score:5.94|P-value:5.56E-7 ID:SGTC_494|Compound:Boc-Gly-Val-Val-CHO|FD-Score:3.82|P-value:8.70E-4 ID:SGTC_630|Compound:4356-0227|FD-Score:4.09|P-value:3.98E-4 ID:SGTC_634|Compound:1611-4317|FD-Score:3.80|P-value:8.99E-4 ID:SGTC_717|Compound:1532-0246|FD-Score:3.91|P-value:6.70E-4 ID:SGTC_779|Compound:1360-0071|FD-Score:3.84|P-value:8.17E-4 ID:SGTC_862|Compound:0452-0056|FD-Score:9.71|P-value:8.25E-16 ID:SGTC_939|Compound:1165-0479|FD-Score:5.33|P-value:6.01E-6 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:6.17|P-value:2.03E-7 ID:SGTC_1155|Compound:4088-0394|FD-Score:4.05|P-value:4.50E-4 ID:SGTC_1173|Compound:0443-0020|FD-Score:4.51|P-value:1.06E-4 ID:SGTC_1213|Compound:1315-0166|FD-Score:3.77|P-value:9.75E-4 ID:SGTC_1252|Compound:0493-0875|FD-Score:6.47|P-value:5.60E-8 ID:SGTC_1297|Compound:1068-0111|FD-Score:3.81|P-value:8.84E-4 ID:SGTC_1317|Compound:1273-0028|FD-Score:12.00|P-value:5.22E-23 ID:SGTC_1340|Compound:1486-1359|FD-Score:3.90|P-value:6.84E-4 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:4.12|P-value:3.60E-4 ID:SGTC_1678|Compound:st019265|FD-Score:5.98|P-value:4.58E-7 ID:SGTC_1786|Compound:berberine|FD-Score:6.64|P-value:2.48E-8 ID:SGTC_1796|Compound:st049173|FD-Score:3.95|P-value:6.01E-4 ID:SGTC_1827|Compound:berberine|FD-Score:4.78|P-value:4.39E-5 ID:SGTC_1829|Compound:berberine|FD-Score:5.22|P-value:9.34E-6 ID:SGTC_2016|Compound:5121758|FD-Score:5.19|P-value:1.01E-5 ID:SGTC_2063|Compound:5246145|FD-Score:4.30|P-value:2.07E-4 ID:SGTC_2142|Compound:5622915|FD-Score:3.91|P-value:6.68E-4 ID:SGTC_2237|Compound:6667747|FD-Score:4.91|P-value:2.78E-5 ID:SGTC_2245|Compound:6637752|FD-Score:7.56|P-value:2.76E-10 ID:SGTC_2274|Compound:7947094|FD-Score:5.93|P-value:5.60E-7 ID:SGTC_2368|Compound:9071271|FD-Score:4.52|P-value:1.04E-4 ID:SGTC_2422|Compound:chlorphenesin carbamate|FD-Score:7.32|P-value:9.32E-10 ID:SGTC_2511|Compound:berberine|FD-Score:6.59|P-value:3.12E-8 ID:SGTC_2532|Compound:xanthone|FD-Score:4.19|P-value:2.96E-4 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:3.77|P-value:9.76E-4 ID:SGTC_2593|Compound:nobiletin|FD-Score:5.32|P-value:6.21E-6 ID:SGTC_2594|Compound:a-mangostin|FD-Score:3.98|P-value:5.37E-4 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:-4.84|P-value:3.55E-5 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:6.34|P-value:9.81E-8 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:3.78|P-value:9.56E-4 ID:SGTC_2751|Compound:anetholtrithion|FD-Score:4.55|P-value:9.41E-5 ID:SGTC_2786|Compound:7743617|FD-Score:4.06|P-value:4.28E-4 ID:SGTC_2790|Compound:5423970|FD-Score:-3.82|P-value:8.58E-4 ID:SGTC_2798|Compound:7813637|FD-Score:7.15|P-value:2.17E-9 ID:SGTC_2881|Compound:9058953|FD-Score:3.88|P-value:7.23E-4 ID:SGTC_2885|Compound:9057732|FD-Score:-5.12|P-value:1.34E-5 ID:SGTC_2927|Compound:9011802|FD-Score:6.07|P-value:3.16E-7 ID:SGTC_3065|Compound:9113888|FD-Score:6.32|P-value:1.07E-7 ID:SGTC_3245|Compound:9134821|FD-Score:5.06|P-value:1.65E-5 ID:SGTC_3250|Compound:9135583|FD-Score:4.23|P-value:2.62E-4 ID:SGTC_3260|Compound:9137109|FD-Score:4.61|P-value:7.76E-5 ID:SGTC_3330|Compound:9141424|FD-Score:4.07|P-value:4.19E-4 ID:SGTC_3338|Compound:9144300|FD-Score:6.08|P-value:3.02E-7 ID:SGTC_3339|Compound:9145883|FD-Score:-5.51|P-value:3.05E-6 ID:SGTC_3349|Compound:9149703|FD-Score:-4.58|P-value:8.62E-5 ID:SGTC_3351|Compound:9150312|FD-Score:4.73|P-value:5.16E-5 ID:SGTC_41|Compound:0478-0632|FD-Score:4.62|P-value:7.55E-5 ID:SGTC_63|Compound:0099-0242|FD-Score:7.11|P-value:2.68E-9 ID:SGTC_74|Compound:000s-0487|FD-Score:4.87|P-value:3.20E-5 ID:SGTC_130|Compound:0136-0219|FD-Score:6.94|P-value:6.13E-9 ID:SGTC_154|Compound:3389-1638|FD-Score:4.05|P-value:4.48E-4 ID:SGTC_176|Compound:1486-1328|FD-Score:3.83|P-value:8.40E-4 ID:SGTC_182|Compound:3448-4371|FD-Score:8.15|P-value:1.13E-11 ID:SGTC_279|Compound:1273-0055|FD-Score:4.24|P-value:2.48E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:5.16|P-value:1.16E-5 ID:SGTC_310|Compound:1273-0058|FD-Score:9.69|P-value:8.96E-16 ID:SGTC_363|Compound:0455-0021|FD-Score:13.40|P-value:3.08E-28 ID:SGTC_429|Compound:1112-0049|FD-Score:5.94|P-value:5.56E-7 ID:SGTC_494|Compound:Boc-Gly-Val-Val-CHO|FD-Score:3.82|P-value:8.70E-4 ID:SGTC_630|Compound:4356-0227|FD-Score:4.09|P-value:3.98E-4 ID:SGTC_634|Compound:1611-4317|FD-Score:3.80|P-value:8.99E-4 ID:SGTC_717|Compound:1532-0246|FD-Score:3.91|P-value:6.70E-4 ID:SGTC_779|Compound:1360-0071|FD-Score:3.84|P-value:8.17E-4 ID:SGTC_862|Compound:0452-0056|FD-Score:9.71|P-value:8.25E-16 ID:SGTC_939|Compound:1165-0479|FD-Score:5.33|P-value:6.01E-6 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:6.17|P-value:2.03E-7 ID:SGTC_1155|Compound:4088-0394|FD-Score:4.05|P-value:4.50E-4 ID:SGTC_1173|Compound:0443-0020|FD-Score:4.51|P-value:1.06E-4 ID:SGTC_1213|Compound:1315-0166|FD-Score:3.77|P-value:9.75E-4 ID:SGTC_1252|Compound:0493-0875|FD-Score:6.47|P-value:5.60E-8 ID:SGTC_1297|Compound:1068-0111|FD-Score:3.81|P-value:8.84E-4 ID:SGTC_1317|Compound:1273-0028|FD-Score:12.00|P-value:5.22E-23 ID:SGTC_1340|Compound:1486-1359|FD-Score:3.90|P-value:6.84E-4 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:4.12|P-value:3.60E-4 ID:SGTC_1678|Compound:st019265|FD-Score:5.98|P-value:4.58E-7 ID:SGTC_1786|Compound:berberine|FD-Score:6.64|P-value:2.48E-8 ID:SGTC_1796|Compound:st049173|FD-Score:3.95|P-value:6.01E-4 ID:SGTC_1827|Compound:berberine|FD-Score:4.78|P-value:4.39E-5 ID:SGTC_1829|Compound:berberine|FD-Score:5.22|P-value:9.34E-6 ID:SGTC_2016|Compound:5121758|FD-Score:5.19|P-value:1.01E-5 ID:SGTC_2063|Compound:5246145|FD-Score:4.30|P-value:2.07E-4 ID:SGTC_2142|Compound:5622915|FD-Score:3.91|P-value:6.68E-4 ID:SGTC_2237|Compound:6667747|FD-Score:4.91|P-value:2.78E-5 ID:SGTC_2245|Compound:6637752|FD-Score:7.56|P-value:2.76E-10 ID:SGTC_2274|Compound:7947094|FD-Score:5.93|P-value:5.60E-7 ID:SGTC_2368|Compound:9071271|FD-Score:4.52|P-value:1.04E-4 ID:SGTC_2422|Compound:chlorphenesin carbamate|FD-Score:7.32|P-value:9.32E-10 ID:SGTC_2511|Compound:berberine|FD-Score:6.59|P-value:3.12E-8 ID:SGTC_2532|Compound:xanthone|FD-Score:4.19|P-value:2.96E-4 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:3.77|P-value:9.76E-4 ID:SGTC_2593|Compound:nobiletin|FD-Score:5.32|P-value:6.21E-6 ID:SGTC_2594|Compound:a-mangostin|FD-Score:3.98|P-value:5.37E-4 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:-4.84|P-value:3.55E-5 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:6.34|P-value:9.81E-8 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:3.78|P-value:9.56E-4 ID:SGTC_2751|Compound:anetholtrithion|FD-Score:4.55|P-value:9.41E-5 ID:SGTC_2786|Compound:7743617|FD-Score:4.06|P-value:4.28E-4 ID:SGTC_2790|Compound:5423970|FD-Score:-3.82|P-value:8.58E-4 ID:SGTC_2798|Compound:7813637|FD-Score:7.15|P-value:2.17E-9 ID:SGTC_2881|Compound:9058953|FD-Score:3.88|P-value:7.23E-4 ID:SGTC_2885|Compound:9057732|FD-Score:-5.12|P-value:1.34E-5 ID:SGTC_2927|Compound:9011802|FD-Score:6.07|P-value:3.16E-7 ID:SGTC_3065|Compound:9113888|FD-Score:6.32|P-value:1.07E-7 ID:SGTC_3245|Compound:9134821|FD-Score:5.06|P-value:1.65E-5 ID:SGTC_3250|Compound:9135583|FD-Score:4.23|P-value:2.62E-4 ID:SGTC_3260|Compound:9137109|FD-Score:4.61|P-value:7.76E-5 ID:SGTC_3330|Compound:9141424|FD-Score:4.07|P-value:4.19E-4 ID:SGTC_3338|Compound:9144300|FD-Score:6.08|P-value:3.02E-7 ID:SGTC_3339|Compound:9145883|FD-Score:-5.51|P-value:3.05E-6 ID:SGTC_3349|Compound:9149703|FD-Score:-4.58|P-value:8.62E-5 ID:SGTC_3351|Compound:9150312|FD-Score:4.73|P-value:5.16E-5

Top fitness defect scores for YPR198W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_363 0455-0021 13.40 3.1 µM 3.08E-28 azole & statin 5 5.84E-41
2 SGTC_1317 1273-0028 12.00 910.0 nM 5.22E-23 azole & statin 7 3.23E-33
3 SGTC_862 0452-0056 9.71 10.2 µM 8.25E-16 azole & statin 5 1.43E-22
4 SGTC_310 1273-0058 9.69 1.1 µM 8.96E-16 mitochondrial stress 46 1.61E-22
5 SGTC_182 3448-4371 8.15 550.5 µM 1.13E-11 1 1.82E-16
6 SGTC_2245 6637752 7.56 200.0 µM 2.76E-10 2 2.03E-14
7 SGTC_2422 chlorphenesin carbamate 7.32 384.2 µM 9.32E-10 1 1.22E-13
8 SGTC_2798 7813637 7.15 45.5 µM 2.17E-9 3 4.22E-13
9 SGTC_63 0099-0242 7.11 26.7 µM 2.68E-9 mitochondrial stress 17 5.77E-13
10 SGTC_130 0136-0219 6.94 337.7 µM 6.13E-9 2 1.95E-12
11 SGTC_1786 berberine 6.64 21.6 µM 2.48E-8 60S ribosome export 8 1.52E-11
12 SGTC_2511 berberine 6.59 10.5 µM 3.12E-8 60S ribosome export 3 2.13E-11
13 SGTC_1252 0493-0875 6.47 34.8 µM 5.60E-8 2 5.04E-11
14 SGTC_2603 homopterocarpin 6.34 100.0 µM 9.81E-8 3 1.15E-10
15 SGTC_3065 9113888 6.32 49.5 µM 1.07E-7 3 1.31E-10
16 SGTC_1083 didemethylchlorpromazine sulfoxide 6.17 707.4 nM 2.03E-7 redox potentiating 24 3.34E-10
17 SGTC_3338 9144300 6.08 39.6 µM 3.02E-7 Golgi 3 6.00E-10
18 SGTC_2927 9011802 6.07 47.9 µM 3.16E-7 4 6.42E-10
19 SGTC_1678 st019265 5.98 80.2 µM 4.58E-7 60S ribosome export 4 1.11E-9
20 SGTC_429 1112-0049 5.94 25.5 µM 5.56E-7 DNA damage response 12 1.47E-9

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.359 2.09E-102 YLR359W ADE13 het Adenylosuccinate lyase, catalyzes two steps in the 'de novo' purine nucleotide biosynthetic pathway; expression is repressed by adenine and activated by Bas1p and Pho2p; mutations in human ortholog ADSL cause adenylosuccinase deficiency
0.297 2.30E-69 YPR197C_d YPR197C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.291 2.44E-66 YDR181C SAS4 hom Subunit of the SAS complex (Sas2p, Sas4p, Sas5p), which acetylates free histones and nucleosomes and regulates transcriptional silencing; required for the HAT activity of Sas2p
0.226 4.01E-40 YMR127C SAS2 hom Histone acetyltransferase (HAT) catalytic subunit of the SAS complex (Sas2p-Sas4p-Sas5p), which acetylates free histones and nucleosomes and regulates transcriptional silencing; member of the MYSTacetyltransferase family
0.172 1.24E-23 YMR154C RIM13 hom Calpain-like cysteine protease; involved in proteolytic activation of Rim101p in response to alkaline pH; localizes to punctate structures in alkaline conditions and in vps4 mutant; has similarity to A. nidulans palB
0.149 3.50E-18 YGR004W PEX31 hom Peroxisomal integral membrane protein, involved in negative regulation of peroxisome size; partially functionally redundant with Pex30p and Pex32p; probably acts at a step downstream of steps mediated by Pex28p and Pex29p
0.144 5.42E-17 YML081W TDA9 hom DNA-binding protein, putative transcription factor; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; null mutant is sensitive to expression of the top1-T722A allele; not an essential gene; TDA9 has a paralog, RSF2, that arose from the whole genome duplication
0.138 1.01E-15 YHR113W APE4 hom Cytoplasmic aspartyl aminopeptidase that may also function in the vacuole; CVT pathway cargo protein; cleaves unblocked N-terminal acidic amino acids from peptide substrates; forms a 12-subunit homo-oligomer; M18 metalloprotease family
0.126 2.30E-13 YGL045W RIM8 hom Protein involved in proteolytic activation of Rim101p in response to alkaline pH; interacts with ESCRT-1 subunits Stp22p and Vps28p; essential for anaerobic growth; member of the arrestin-related trafficking adaptor family
0.124 6.27E-13 YLR228C ECM22 hom Sterol regulatory element binding protein; regulates transcription of sterol biosynthetic genes; contains Zn[2]-Cys[6] binuclear cluster; relocates from intracellular membranes to perinuclear foci on sterol depletion; ECM22 has a paralog, UPC2, that arose from the whole genome duplication
0.121 1.67E-12 YNL081C SWS2 hom Putative mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S13 ribosomal protein; participates in controlling sporulation efficiency
0.121 2.12E-12 YOR213C SAS5 hom Subunit of the SAS complex (Sas2p, Sas4p, Sas5p), which acetylates free histones and nucleosomes and regulates transcriptional silencing; stimulates Sas2p HAT activity
0.118 7.27E-12 YOR275C RIM20 hom Protein involved in proteolytic activation of Rim101p in response to alkaline pH; PalA/AIP1/Alix family member; interaction with the ESCRT-III subunit Snf7p suggests a relationship between pH response and multivesicular body formation
0.117 1.01E-11 YPL061W ALD6 hom Cytosolic aldehyde dehydrogenase, activated by Mg2+ and utilizes NADP+ as the preferred coenzyme; required for conversion of acetaldehyde to acetate; constitutively expressed; locates to the mitochondrial outer surface upon oxidative stress
0.117 1.27E-11 YGR170W PSD2 hom Phosphatidylserine decarboxylase of the Golgi and vacuolar membranes, converts phosphatidylserine to phosphatidylethanolamine