YPR199C / ARR1

Transcriptional activator of the basic leucine zipper (bZIP) family, required for transcription of genes involved in resistance to arsenic compounds

Zygosity: Homozygous strain
fixedexpanded
Profile for YPR199C / ARR1

Click on Significant Values for Screen Details ID:SGTC_70|Compound:0141-0289|FD-Score:-5.05|P-value:3.45E-8 ID:SGTC_78|Compound:0336-0123|FD-Score:-2.97|P-value:7.41E-4 ID:SGTC_89|Compound:0302-0250|FD-Score:-3.62|P-value:5.47E-5 ID:SGTC_131|Compound:0141-0277|FD-Score:-3.70|P-value:3.79E-5 ID:SGTC_175|Compound:3793-3120|FD-Score:-2.98|P-value:7.24E-4 ID:SGTC_330|Compound:1488-0319|FD-Score:-3.83|P-value:2.10E-5 ID:SGTC_413|Compound:propylparaben|FD-Score:4.51|P-value:7.70E-7 ID:SGTC_418|Compound:lividomycin a|FD-Score:3.38|P-value:1.59E-4 ID:SGTC_566|Compound:0958-0068|FD-Score:3.63|P-value:5.62E-5 ID:SGTC_580|Compound:1123-0028|FD-Score:4.60|P-value:4.92E-7 ID:SGTC_589|Compound:1227-0070|FD-Score:4.67|P-value:3.30E-7 ID:SGTC_629|Compound:3448-6466|FD-Score:3.15|P-value:4.04E-4 ID:SGTC_731|Compound:3966-0296|FD-Score:-2.94|P-value:8.31E-4 ID:SGTC_773|Compound:4358-1457|FD-Score:3.22|P-value:3.04E-4 ID:SGTC_780|Compound:0109-0199|FD-Score:3.04|P-value:6.07E-4 ID:SGTC_818|Compound:4072-2707|FD-Score:-3.12|P-value:4.23E-4 ID:SGTC_829|Compound:1635-0120|FD-Score:3.05|P-value:5.96E-4 ID:SGTC_976|Compound:1348-1067|FD-Score:3.32|P-value:2.07E-4 ID:SGTC_1023|Compound:4482-3888|FD-Score:3.13|P-value:4.27E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:3.21|P-value:3.18E-4 ID:SGTC_1203|Compound:3992-3522|FD-Score:3.06|P-value:5.71E-4 ID:SGTC_1537|Compound:2',6'-dihydroxyflavanone|FD-Score:5.70|P-value:6.28E-10 ID:SGTC_1544|Compound:7-methoxy-4-methylcoumarin|FD-Score:5.92|P-value:1.42E-10 ID:SGTC_1547|Compound:harmine|FD-Score:8.82|P-value:2.79E-21 ID:SGTC_1633|Compound:st005664|FD-Score:3.48|P-value:1.06E-4 ID:SGTC_1636|Compound:st007707|FD-Score:5.01|P-value:4.77E-8 ID:SGTC_1637|Compound:st007924|FD-Score:3.33|P-value:1.94E-4 ID:SGTC_1638|Compound:st008370|FD-Score:4.45|P-value:1.08E-6 ID:SGTC_1681|Compound:tripelennamine|FD-Score:-3.05|P-value:5.52E-4 ID:SGTC_1775|Compound:st081588|FD-Score:2.96|P-value:8.08E-4 ID:SGTC_1887|Compound:st057648|FD-Score:3.95|P-value:1.32E-5 ID:SGTC_1943|Compound:st076331|FD-Score:-3.97|P-value:1.11E-5 ID:SGTC_1945|Compound:st075991|FD-Score:-4.44|P-value:1.05E-6 ID:SGTC_1947|Compound:st076332|FD-Score:-3.24|P-value:2.70E-4 ID:SGTC_2017|Compound:5132927|FD-Score:3.07|P-value:5.51E-4 ID:SGTC_2051|Compound:5263410|FD-Score:-4.34|P-value:1.79E-6 ID:SGTC_2171|Compound:5739187|FD-Score:-3.25|P-value:2.57E-4 ID:SGTC_2173|Compound:5763948|FD-Score:-5.57|P-value:1.34E-9 ID:SGTC_2175|Compound:5807670|FD-Score:-2.98|P-value:7.09E-4 ID:SGTC_2176|Compound:5809774|FD-Score:-3.33|P-value:1.82E-4 ID:SGTC_2181|Compound:6316240|FD-Score:-9.01|P-value:3.48E-22 ID:SGTC_2240|Compound:6690706|FD-Score:2.91|P-value:9.68E-4 ID:SGTC_2241|Compound:6772625|FD-Score:-3.20|P-value:3.14E-4 ID:SGTC_2300|Compound:7976697|FD-Score:3.26|P-value:2.58E-4 ID:SGTC_2441|Compound:5730946|FD-Score:-5.66|P-value:7.42E-10 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:7.92|P-value:1.66E-17 ID:SGTC_2606|Compound:farnesol|FD-Score:4.18|P-value:4.24E-6 ID:SGTC_2616|Compound:abietic acid|FD-Score:2.96|P-value:8.33E-4 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:-5.48|P-value:2.34E-9 ID:SGTC_2628|Compound:lathosterol|FD-Score:-4.12|P-value:5.34E-6 ID:SGTC_2789|Compound:5281112|FD-Score:-3.23|P-value:2.72E-4 ID:SGTC_2829|Compound:7992743|FD-Score:3.14|P-value:4.22E-4 ID:SGTC_2831|Compound:7999036|FD-Score:3.75|P-value:3.30E-5 ID:SGTC_2939|Compound:9044578|FD-Score:-3.73|P-value:3.34E-5 ID:SGTC_2940|Compound:9060638|FD-Score:3.45|P-value:1.21E-4 ID:SGTC_2949|Compound:9072542|FD-Score:-3.42|P-value:1.29E-4 ID:SGTC_2957|Compound:9076800|FD-Score:3.46|P-value:1.17E-4 ID:SGTC_2975|Compound:9084847|FD-Score:3.81|P-value:2.50E-5 ID:SGTC_3000|Compound:9075062|FD-Score:3.13|P-value:4.26E-4 ID:SGTC_3031|Compound:9088762|FD-Score:3.08|P-value:5.24E-4 ID:SGTC_3089|Compound:9117425|FD-Score:3.36|P-value:1.75E-4 ID:SGTC_3215|Compound:9129942|FD-Score:3.55|P-value:7.91E-5 ID:SGTC_3216|Compound:9129716|FD-Score:3.92|P-value:1.53E-5 ID:SGTC_70|Compound:0141-0289|FD-Score:-5.05|P-value:3.45E-8 ID:SGTC_78|Compound:0336-0123|FD-Score:-2.97|P-value:7.41E-4 ID:SGTC_89|Compound:0302-0250|FD-Score:-3.62|P-value:5.47E-5 ID:SGTC_131|Compound:0141-0277|FD-Score:-3.70|P-value:3.79E-5 ID:SGTC_175|Compound:3793-3120|FD-Score:-2.98|P-value:7.24E-4 ID:SGTC_330|Compound:1488-0319|FD-Score:-3.83|P-value:2.10E-5 ID:SGTC_413|Compound:propylparaben|FD-Score:4.51|P-value:7.70E-7 ID:SGTC_418|Compound:lividomycin a|FD-Score:3.38|P-value:1.59E-4 ID:SGTC_566|Compound:0958-0068|FD-Score:3.63|P-value:5.62E-5 ID:SGTC_580|Compound:1123-0028|FD-Score:4.60|P-value:4.92E-7 ID:SGTC_589|Compound:1227-0070|FD-Score:4.67|P-value:3.30E-7 ID:SGTC_629|Compound:3448-6466|FD-Score:3.15|P-value:4.04E-4 ID:SGTC_731|Compound:3966-0296|FD-Score:-2.94|P-value:8.31E-4 ID:SGTC_773|Compound:4358-1457|FD-Score:3.22|P-value:3.04E-4 ID:SGTC_780|Compound:0109-0199|FD-Score:3.04|P-value:6.07E-4 ID:SGTC_818|Compound:4072-2707|FD-Score:-3.12|P-value:4.23E-4 ID:SGTC_829|Compound:1635-0120|FD-Score:3.05|P-value:5.96E-4 ID:SGTC_976|Compound:1348-1067|FD-Score:3.32|P-value:2.07E-4 ID:SGTC_1023|Compound:4482-3888|FD-Score:3.13|P-value:4.27E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:3.21|P-value:3.18E-4 ID:SGTC_1203|Compound:3992-3522|FD-Score:3.06|P-value:5.71E-4 ID:SGTC_1537|Compound:2',6'-dihydroxyflavanone|FD-Score:5.70|P-value:6.28E-10 ID:SGTC_1544|Compound:7-methoxy-4-methylcoumarin|FD-Score:5.92|P-value:1.42E-10 ID:SGTC_1547|Compound:harmine|FD-Score:8.82|P-value:2.79E-21 ID:SGTC_1633|Compound:st005664|FD-Score:3.48|P-value:1.06E-4 ID:SGTC_1636|Compound:st007707|FD-Score:5.01|P-value:4.77E-8 ID:SGTC_1637|Compound:st007924|FD-Score:3.33|P-value:1.94E-4 ID:SGTC_1638|Compound:st008370|FD-Score:4.45|P-value:1.08E-6 ID:SGTC_1681|Compound:tripelennamine|FD-Score:-3.05|P-value:5.52E-4 ID:SGTC_1775|Compound:st081588|FD-Score:2.96|P-value:8.08E-4 ID:SGTC_1887|Compound:st057648|FD-Score:3.95|P-value:1.32E-5 ID:SGTC_1943|Compound:st076331|FD-Score:-3.97|P-value:1.11E-5 ID:SGTC_1945|Compound:st075991|FD-Score:-4.44|P-value:1.05E-6 ID:SGTC_1947|Compound:st076332|FD-Score:-3.24|P-value:2.70E-4 ID:SGTC_2017|Compound:5132927|FD-Score:3.07|P-value:5.51E-4 ID:SGTC_2051|Compound:5263410|FD-Score:-4.34|P-value:1.79E-6 ID:SGTC_2171|Compound:5739187|FD-Score:-3.25|P-value:2.57E-4 ID:SGTC_2173|Compound:5763948|FD-Score:-5.57|P-value:1.34E-9 ID:SGTC_2175|Compound:5807670|FD-Score:-2.98|P-value:7.09E-4 ID:SGTC_2176|Compound:5809774|FD-Score:-3.33|P-value:1.82E-4 ID:SGTC_2181|Compound:6316240|FD-Score:-9.01|P-value:3.48E-22 ID:SGTC_2240|Compound:6690706|FD-Score:2.91|P-value:9.68E-4 ID:SGTC_2241|Compound:6772625|FD-Score:-3.20|P-value:3.14E-4 ID:SGTC_2300|Compound:7976697|FD-Score:3.26|P-value:2.58E-4 ID:SGTC_2441|Compound:5730946|FD-Score:-5.66|P-value:7.42E-10 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:7.92|P-value:1.66E-17 ID:SGTC_2606|Compound:farnesol|FD-Score:4.18|P-value:4.24E-6 ID:SGTC_2616|Compound:abietic acid|FD-Score:2.96|P-value:8.33E-4 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:-5.48|P-value:2.34E-9 ID:SGTC_2628|Compound:lathosterol|FD-Score:-4.12|P-value:5.34E-6 ID:SGTC_2789|Compound:5281112|FD-Score:-3.23|P-value:2.72E-4 ID:SGTC_2829|Compound:7992743|FD-Score:3.14|P-value:4.22E-4 ID:SGTC_2831|Compound:7999036|FD-Score:3.75|P-value:3.30E-5 ID:SGTC_2939|Compound:9044578|FD-Score:-3.73|P-value:3.34E-5 ID:SGTC_2940|Compound:9060638|FD-Score:3.45|P-value:1.21E-4 ID:SGTC_2949|Compound:9072542|FD-Score:-3.42|P-value:1.29E-4 ID:SGTC_2957|Compound:9076800|FD-Score:3.46|P-value:1.17E-4 ID:SGTC_2975|Compound:9084847|FD-Score:3.81|P-value:2.50E-5 ID:SGTC_3000|Compound:9075062|FD-Score:3.13|P-value:4.26E-4 ID:SGTC_3031|Compound:9088762|FD-Score:3.08|P-value:5.24E-4 ID:SGTC_3089|Compound:9117425|FD-Score:3.36|P-value:1.75E-4 ID:SGTC_3215|Compound:9129942|FD-Score:3.55|P-value:7.91E-5 ID:SGTC_3216|Compound:9129716|FD-Score:3.92|P-value:1.53E-5

Top fitness defect scores for YPR199C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1547 harmine 8.82 94.2 µM 2.79E-21 ergosterol biosynthesis 8 5.79E-19
2 SGTC_2566 crystal violet carbinol 7.92 226.0 nM 1.66E-17 7 1.22E-15
3 SGTC_1544 7-methoxy-4-methylcoumarin 5.92 105.0 µM 1.42E-10 4 1.59E-9
4 SGTC_1537 2',6'-dihydroxyflavanone 5.70 78.0 µM 6.28E-10 1 5.93E-9
5 SGTC_1636 st007707 5.01 68.9 µM 4.77E-8 26 2.72E-7
6 SGTC_589 1227-0070 4.67 34.1 µM 3.30E-7 16 1.50E-6
7 SGTC_580 1123-0028 4.60 41.0 µM 4.92E-7 DNA damage response 16 2.14E-6
8 SGTC_413 propylparaben 4.51 100.0 µM 7.70E-7 amide catabolism 11 3.18E-6
9 SGTC_1638 st008370 4.45 60.6 µM 1.08E-6 ergosterol biosynthesis 24 4.28E-6
10 SGTC_2606 farnesol 4.18 9.8 µM 4.24E-6 15 1.44E-5
11 SGTC_1887 st057648 3.95 70.8 µM 1.32E-5 15 3.94E-5
12 SGTC_3216 9129716 3.92 49.5 µM 1.53E-5 RPP1 & pyrimidine depletion 25 4.49E-5
13 SGTC_2975 9084847 3.81 53.7 µM 2.50E-5 26 6.92E-5
14 SGTC_2831 7999036 3.75 19.5 µM 3.30E-5 54 8.87E-5
15 SGTC_566 0958-0068 3.63 16.5 µM 5.62E-5 RSC & ERG11 25 1.42E-4
16 SGTC_3215 9129942 3.55 49.5 µM 7.91E-5 17 1.92E-4
17 SGTC_1633 st005664 3.48 67.9 µM 1.06E-4 52 2.50E-4
18 SGTC_2957 9076800 3.46 11.5 µM 1.17E-4 31 2.72E-4
19 SGTC_2940 9060638 3.45 45.9 µM 1.21E-4 amide catabolism 45 2.81E-4
20 SGTC_418 lividomycin a 3.38 100.0 µM 1.59E-4 27 3.57E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.121 2.07E-12 YER053C-A YER053C-A hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; protein abundance increases in response to DNA replication stress
0.095 3.00E-8 YJL198W PHO90 hom Low-affinity phosphate transporter; deletion of pho84, pho87, pho89, pho90, and pho91 causes synthetic lethality; transcription independent of Pi and Pho4p activity; overexpression results in vigorous growth; PHO90 has a paralog, PHO87, that arose from the whole genome duplication
0.092 1.03E-7 YDR107C TMN2 hom Protein with a role in cellular adhesion and filamentous growth; similar to Emp70p and Tmn3p; member of the evolutionarily conserved Transmembrane Nine family of proteins with nine membrane-spanning segments
0.091 1.45E-7 YMR253C_p YMR253C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; YMR253C is not an essential gene
0.089 2.48E-7 YHR072W ERG7 het Lanosterol synthase, an essential enzyme that catalyzes the cyclization of squalene 2,3-epoxide, a step in ergosterol biosynthesis
0.088 3.52E-7 YPL061W ALD6 hom Cytosolic aldehyde dehydrogenase, activated by Mg2+ and utilizes NADP+ as the preferred coenzyme; required for conversion of acetaldehyde to acetate; constitutively expressed; locates to the mitochondrial outer surface upon oxidative stress
0.087 5.24E-7 YLR152C_p YLR152C_p hom Putative protein of unknown function; YLR152C is not an essential gene
0.086 6.79E-7 YAR050W FLO1 hom Lectin-like protein involved in flocculation, cell wall protein that binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin sensitive and heat resistant; similar to Flo5p
0.080 3.91E-6 YMR182W-A_p YMR182W-A_p hom Putative protein of unknown function
0.073 2.14E-5 YGR121W-A_p YGR121W-A_p hom Putative protein of unknown function
0.073 2.58E-5 YLR228C ECM22 hom Sterol regulatory element binding protein; regulates transcription of sterol biosynthetic genes; contains Zn[2]-Cys[6] binuclear cluster; relocates from intracellular membranes to perinuclear foci on sterol depletion; ECM22 has a paralog, UPC2, that arose from the whole genome duplication
0.073 2.59E-5 YOR255W OSW1 hom Protein involved in sporulation; required for the construction of the outer spore wall layers; required for proper localization of Spo14p
0.071 3.56E-5 YKL197C PEX1 hom AAA-peroxin that heterodimerizes with AAA-peroxin Pex6p and participates in the recycling of peroxisomal signal receptor Pex5p from the peroxisomal membrane to the cystosol; induced by oleic acid and upregulated during anaerobiosis
0.071 3.88E-5 YJR055W HIT1 hom Protein of unknown function, required for growth at high temperature
0.071 4.00E-5 YML004C GLO1 hom Monomeric glyoxalase I, catalyzes the detoxification of methylglyoxal (a by-product of glycolysis) via condensation with glutathione to produce S-D-lactoylglutathione; expression regulated by methylglyoxal levels and osmotic stress