YPR200C / ARR2

Arsenate reductase required for arsenate resistance; converts arsenate to arsenite which can then be exported from cells by Arr3p

Zygosity: Homozygous strain
fixedexpanded
Profile for YPR200C / ARR2

Click on Significant Values for Screen Details ID:SGTC_65|Compound:0798-0905|FD-Score:-3.01|P-value:5.84E-4 ID:SGTC_128|Compound:0906-2981|FD-Score:3.55|P-value:6.85E-5 ID:SGTC_130|Compound:0136-0219|FD-Score:3.67|P-value:4.03E-5 ID:SGTC_137|Compound:0438-0332|FD-Score:-3.46|P-value:9.38E-5 ID:SGTC_199|Compound:4063-0024|FD-Score:3.38|P-value:1.45E-4 ID:SGTC_335|Compound:4077-0256|FD-Score:-3.89|P-value:1.38E-5 ID:SGTC_358|Compound:0075-0058|FD-Score:-4.03|P-value:6.81E-6 ID:SGTC_375|Compound:3970-0961|FD-Score:-3.34|P-value:1.57E-4 ID:SGTC_430|Compound:0958-0115|FD-Score:-5.29|P-value:6.06E-9 ID:SGTC_442|Compound:cape|FD-Score:3.00|P-value:6.51E-4 ID:SGTC_520|Compound:3584-0023|FD-Score:4.13|P-value:4.53E-6 ID:SGTC_561|Compound:1550-0330|FD-Score:3.15|P-value:3.62E-4 ID:SGTC_742|Compound:0kpi-0133|FD-Score:-3.23|P-value:2.43E-4 ID:SGTC_893|Compound:0958-0369|FD-Score:2.99|P-value:6.78E-4 ID:SGTC_937|Compound:3122-0005|FD-Score:2.90|P-value:9.31E-4 ID:SGTC_992|Compound:3909-8734|FD-Score:4.29|P-value:2.00E-6 ID:SGTC_999|Compound:4022-0066|FD-Score:-3.53|P-value:7.13E-5 ID:SGTC_1003|Compound:4049-0218|FD-Score:-3.20|P-value:2.75E-4 ID:SGTC_1062|Compound:mesoridazine|FD-Score:2.96|P-value:7.36E-4 ID:SGTC_1066|Compound:ketoconazole|FD-Score:3.56|P-value:6.68E-5 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:4.21|P-value:3.10E-6 ID:SGTC_1303|Compound:1160-0052|FD-Score:3.07|P-value:4.92E-4 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:3.06|P-value:5.18E-4 ID:SGTC_1722|Compound:st034304|FD-Score:-3.42|P-value:1.13E-4 ID:SGTC_1730|Compound:st033808|FD-Score:4.12|P-value:4.95E-6 ID:SGTC_1777|Compound:st045864|FD-Score:-3.78|P-value:2.25E-5 ID:SGTC_1828|Compound:st055811|FD-Score:-3.89|P-value:1.39E-5 ID:SGTC_1833|Compound:st055984|FD-Score:-3.44|P-value:1.03E-4 ID:SGTC_1912|Compound:st060209|FD-Score:3.39|P-value:1.39E-4 ID:SGTC_1914|Compound:st062367|FD-Score:5.83|P-value:1.91E-10 ID:SGTC_2010|Compound:4012422|FD-Score:2.98|P-value:6.83E-4 ID:SGTC_2112|Compound:5488546|FD-Score:2.92|P-value:8.79E-4 ID:SGTC_2132|Compound:5317594|FD-Score:-2.87|P-value:9.83E-4 ID:SGTC_2389|Compound:9091542|FD-Score:2.97|P-value:7.11E-4 ID:SGTC_2392|Compound:N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide|FD-Score:2.96|P-value:7.44E-4 ID:SGTC_2404|Compound:5161160|FD-Score:-2.99|P-value:6.31E-4 ID:SGTC_2408|Compound:sulbentine|FD-Score:-5.31|P-value:5.36E-9 ID:SGTC_2503|Compound:beta-caryophyllene alcohol|FD-Score:-2.88|P-value:9.53E-4 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:2.99|P-value:6.69E-4 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:2.98|P-value:6.84E-4 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:-3.27|P-value:2.12E-4 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:-3.12|P-value:3.81E-4 ID:SGTC_2628|Compound:lathosterol|FD-Score:3.00|P-value:6.42E-4 ID:SGTC_2661|Compound:dactinomycin|FD-Score:4.06|P-value:6.52E-6 ID:SGTC_2763|Compound:lisinopril|FD-Score:3.66|P-value:4.25E-5 ID:SGTC_2806|Compound:7952793|FD-Score:4.41|P-value:1.08E-6 ID:SGTC_2842|Compound:9000675|FD-Score:-3.16|P-value:3.28E-4 ID:SGTC_2880|Compound:9042983|FD-Score:3.93|P-value:1.21E-5 ID:SGTC_2890|Compound:9046729|FD-Score:3.44|P-value:1.12E-4 ID:SGTC_2983|Compound:9022671|FD-Score:3.10|P-value:4.45E-4 ID:SGTC_3054|Compound:9094397|FD-Score:3.09|P-value:4.52E-4 ID:SGTC_3060|Compound:1327-0027|FD-Score:3.73|P-value:3.07E-5 ID:SGTC_3203|Compound:9113543|FD-Score:3.91|P-value:1.32E-5 ID:SGTC_3211|Compound:9128781|FD-Score:3.50|P-value:8.61E-5 ID:SGTC_3281|Compound:9140613|FD-Score:3.32|P-value:1.86E-4 ID:SGTC_3294|Compound:9122953|FD-Score:3.19|P-value:3.06E-4 ID:SGTC_3306|Compound:9127676|FD-Score:-2.99|P-value:6.35E-4 ID:SGTC_65|Compound:0798-0905|FD-Score:-3.01|P-value:5.84E-4 ID:SGTC_128|Compound:0906-2981|FD-Score:3.55|P-value:6.85E-5 ID:SGTC_130|Compound:0136-0219|FD-Score:3.67|P-value:4.03E-5 ID:SGTC_137|Compound:0438-0332|FD-Score:-3.46|P-value:9.38E-5 ID:SGTC_199|Compound:4063-0024|FD-Score:3.38|P-value:1.45E-4 ID:SGTC_335|Compound:4077-0256|FD-Score:-3.89|P-value:1.38E-5 ID:SGTC_358|Compound:0075-0058|FD-Score:-4.03|P-value:6.81E-6 ID:SGTC_375|Compound:3970-0961|FD-Score:-3.34|P-value:1.57E-4 ID:SGTC_430|Compound:0958-0115|FD-Score:-5.29|P-value:6.06E-9 ID:SGTC_442|Compound:cape|FD-Score:3.00|P-value:6.51E-4 ID:SGTC_520|Compound:3584-0023|FD-Score:4.13|P-value:4.53E-6 ID:SGTC_561|Compound:1550-0330|FD-Score:3.15|P-value:3.62E-4 ID:SGTC_742|Compound:0kpi-0133|FD-Score:-3.23|P-value:2.43E-4 ID:SGTC_893|Compound:0958-0369|FD-Score:2.99|P-value:6.78E-4 ID:SGTC_937|Compound:3122-0005|FD-Score:2.90|P-value:9.31E-4 ID:SGTC_992|Compound:3909-8734|FD-Score:4.29|P-value:2.00E-6 ID:SGTC_999|Compound:4022-0066|FD-Score:-3.53|P-value:7.13E-5 ID:SGTC_1003|Compound:4049-0218|FD-Score:-3.20|P-value:2.75E-4 ID:SGTC_1062|Compound:mesoridazine|FD-Score:2.96|P-value:7.36E-4 ID:SGTC_1066|Compound:ketoconazole|FD-Score:3.56|P-value:6.68E-5 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:4.21|P-value:3.10E-6 ID:SGTC_1303|Compound:1160-0052|FD-Score:3.07|P-value:4.92E-4 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:3.06|P-value:5.18E-4 ID:SGTC_1722|Compound:st034304|FD-Score:-3.42|P-value:1.13E-4 ID:SGTC_1730|Compound:st033808|FD-Score:4.12|P-value:4.95E-6 ID:SGTC_1777|Compound:st045864|FD-Score:-3.78|P-value:2.25E-5 ID:SGTC_1828|Compound:st055811|FD-Score:-3.89|P-value:1.39E-5 ID:SGTC_1833|Compound:st055984|FD-Score:-3.44|P-value:1.03E-4 ID:SGTC_1912|Compound:st060209|FD-Score:3.39|P-value:1.39E-4 ID:SGTC_1914|Compound:st062367|FD-Score:5.83|P-value:1.91E-10 ID:SGTC_2010|Compound:4012422|FD-Score:2.98|P-value:6.83E-4 ID:SGTC_2112|Compound:5488546|FD-Score:2.92|P-value:8.79E-4 ID:SGTC_2132|Compound:5317594|FD-Score:-2.87|P-value:9.83E-4 ID:SGTC_2389|Compound:9091542|FD-Score:2.97|P-value:7.11E-4 ID:SGTC_2392|Compound:N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide|FD-Score:2.96|P-value:7.44E-4 ID:SGTC_2404|Compound:5161160|FD-Score:-2.99|P-value:6.31E-4 ID:SGTC_2408|Compound:sulbentine|FD-Score:-5.31|P-value:5.36E-9 ID:SGTC_2503|Compound:beta-caryophyllene alcohol|FD-Score:-2.88|P-value:9.53E-4 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:2.99|P-value:6.69E-4 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:2.98|P-value:6.84E-4 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:-3.27|P-value:2.12E-4 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:-3.12|P-value:3.81E-4 ID:SGTC_2628|Compound:lathosterol|FD-Score:3.00|P-value:6.42E-4 ID:SGTC_2661|Compound:dactinomycin|FD-Score:4.06|P-value:6.52E-6 ID:SGTC_2763|Compound:lisinopril|FD-Score:3.66|P-value:4.25E-5 ID:SGTC_2806|Compound:7952793|FD-Score:4.41|P-value:1.08E-6 ID:SGTC_2842|Compound:9000675|FD-Score:-3.16|P-value:3.28E-4 ID:SGTC_2880|Compound:9042983|FD-Score:3.93|P-value:1.21E-5 ID:SGTC_2890|Compound:9046729|FD-Score:3.44|P-value:1.12E-4 ID:SGTC_2983|Compound:9022671|FD-Score:3.10|P-value:4.45E-4 ID:SGTC_3054|Compound:9094397|FD-Score:3.09|P-value:4.52E-4 ID:SGTC_3060|Compound:1327-0027|FD-Score:3.73|P-value:3.07E-5 ID:SGTC_3203|Compound:9113543|FD-Score:3.91|P-value:1.32E-5 ID:SGTC_3211|Compound:9128781|FD-Score:3.50|P-value:8.61E-5 ID:SGTC_3281|Compound:9140613|FD-Score:3.32|P-value:1.86E-4 ID:SGTC_3294|Compound:9122953|FD-Score:3.19|P-value:3.06E-4 ID:SGTC_3306|Compound:9127676|FD-Score:-2.99|P-value:6.35E-4

Top fitness defect scores for YPR200C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1914 st062367 5.83 72.6 µM 1.91E-10 4 2.83E-9
2 SGTC_2806 7952793 4.41 58.4 µM 1.08E-6 12 5.15E-6
3 SGTC_992 3909-8734 4.29 162.0 µM 2.00E-6 10 8.81E-6
4 SGTC_1135 dihydrocapsaicin 4.21 536.7 nM 3.10E-6 29 1.29E-5
5 SGTC_520 3584-0023 4.13 682.0 µM 4.53E-6 22 1.79E-5
6 SGTC_1730 st033808 4.12 45.1 µM 4.95E-6 25 1.93E-5
7 SGTC_2661 dactinomycin 4.06 13.0 µM 6.52E-6 redox potentiating 16 2.46E-5
8 SGTC_2880 9042983 3.93 58.4 µM 1.21E-5 fatty acid desaturase (OLE1) 27 4.23E-5
9 SGTC_3203 9113543 3.91 49.5 µM 1.32E-5 30 4.56E-5
10 SGTC_3060 1327-0027 3.73 12.5 µM 3.07E-5 39 9.49E-5
11 SGTC_130 0136-0219 3.67 337.7 µM 4.03E-5 29 1.20E-4
12 SGTC_2763 lisinopril 3.66 49.3 µM 4.25E-5 15 1.26E-4
13 SGTC_1066 ketoconazole 3.56 628.0 nM 6.68E-5 34 1.87E-4
14 SGTC_128 0906-2981 3.55 13.4 µM 6.85E-5 23 1.91E-4
15 SGTC_3211 9128781 3.50 49.5 µM 8.61E-5 88 2.33E-4
16 SGTC_2890 9046729 3.44 58.4 µM 1.12E-4 Golgi 34 2.93E-4
17 SGTC_1912 st060209 3.39 90.8 µM 1.39E-4 56 3.55E-4
18 SGTC_199 4063-0024 3.38 41.6 µM 1.45E-4 13 3.69E-4
19 SGTC_3281 9140613 3.32 49.5 µM 1.86E-4 RPP1 & pyrimidine depletion 40 4.56E-4
20 SGTC_3294 9122953 3.19 26.3 µM 3.06E-4 tubulin folding & SWR complex 57 7.06E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.104 1.79E-9 YBR041W FAT1 hom Very long chain fatty acyl-CoA synthetase and long chain fatty acid transporter; activates imported fatty acids with a preference for very long lengths (C20-C26); has a separate function in the transport of long chain fatty acids
0.099 1.02E-8 YHR093W_d AHT1_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; multicopy suppressor of glucose transport defects, likely due to the presence of an HXT4 regulatory element in the region
0.092 9.38E-8 YGR122C-A_d YGR122C-A_d hom Dubious open reading frame unlikely to encode a functional protein, similar to YLR334C and YOL106W
0.091 1.36E-7 YLR193C UPS1 hom Phosphatidic acid transfer protein; plays a role in phospholipid metabolism by transporting phosphatidic acid from the outer to the inner mitochondrial membrane; localizes to the mitochondrial intermembrane space; null mutant has altered cardiolipin and phosphatidic acid levels; ortholog of human PRELI
0.090 1.97E-7 YKL074C MUD2 hom Protein involved in early pre-mRNA splicing; component of the pre-mRNA-U1 snRNP complex, the commitment complex; interacts with Msl5p/BBP splicing factor and Sub2p; similar to metazoan splicing factor U2AF65
0.088 3.21E-7 YNL253W TEX1 hom Protein involved in mRNA export, component of the transcription export (TREX) complex
0.087 4.45E-7 YLR036C_p YLR036C_p hom Putative protein of unknown function predicted to have transmembrane domains; interacts with HSP90 by yeast two-hybrid analysis; YLR036C is not an essential protein
0.085 7.24E-7 YER069W ARG5,6 hom Acetylglutamate kinase and N-acetyl-gamma-glutamyl-phosphate reductase; N-acetyl-L-glutamate kinase (NAGK) catalyzes the 2nd and N-acetyl-gamma-glutamyl-phosphate reductase (NAGSA), the 3rd step in arginine biosynthesis; synthesized as a precursor which is processed in the mitochondrion to yield mature NAGK and NAGSA; enzymes form a metabolon complex with Arg2p; NAGK C-terminal domain stabilizes the enzymes, slows catalysis and is involved in feed-back inhibition by arginine
0.080 3.21E-6 YBR012C_d YBR012C_d hom Dubious open reading frame, unlikely to encode a functional protein; expression induced by iron-regulated transcriptional activator Aft2p
0.080 3.80E-6 YLR221C RSA3 hom Protein with a likely role in ribosomal maturation, required for accumulation of wild-type levels of large (60S) ribosomal subunits; binds to the helicase Dbp6p in pre-60S ribosomal particles in the nucleolus
0.079 4.04E-6 YJL074C SMC3 het Subunit of the multiprotein cohesin complex required for sister chromatid cohesion in mitotic cells; also required, with Rec8p, for cohesion and recombination during meiosis; phylogenetically conserved SMC chromosomal ATPase family member
0.078 6.97E-6 YDR400W URH1 hom Uridine nucleosidase (uridine-cytidine N-ribohydrolase), cleaves N-glycosidic bonds in nucleosides; involved in the pyrimidine salvage and nicotinamide riboside salvage pathways
0.077 8.59E-6 YMR096W SNZ1 hom Protein involved in vitamin B6 biosynthesis; member of a stationary phase-induced gene family; coregulated with SNO1; interacts with Sno1p and with Yhr198p, perhaps as a multiprotein complex containing other Snz and Sno proteins
0.073 2.05E-5 YER005W YND1 hom Apyrase with wide substrate specificity, helps prevent inhibition of glycosylation by hydrolyzing nucleoside tri- and diphosphates that inhibit glycotransferases; partially redundant with Gda1p; mediates adenovirus E4orf4-induced toxicity
0.073 2.15E-5 YDL225W SHS1 hom Component of the septin ring that is required for cytokinesis; septins are GTP-binding proteins that assemble into rod-like hetero-oligomers that can associate with other rods to form filaments; septin rings at the mother-bud neck act as scaffolds for recruiting cell division factors and as barriers to prevent diffusion of specific proteins; undergoes sumoylation and phosphorylation during mitosis; protein abundance increases in response to DNA replication stress