HIPHOP chemogenomics database

YAL013W / DEP1

Transcriptional modulator involved in regulation of structural phospholipid biosynthesis genes and metabolically unrelated genes, as well as maintenance of telomeres, mating efficiency, and sporulation

Zygosity: Homozygous strain

fixedexpanded
Profile for YAL013W / DEP1

Click on Significant Values for Screen Details

Top fitness defect scores for YAL013W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_358	0075-0058	7.82	9.4 µM	1.48E-15		5	2.72E-15
2	SGTC_22	0964-0034	6.46	14.5 µM	3.49E-11	unfolded protein response	14	5.14E-11
3	SGTC_577	r071-0003	5.81	38.6 µM	2.29E-9	fatty acid desaturase (OLE1)	18	3.08E-9
4	SGTC_710	3448-4187	5.53	58.0 µM	1.25E-8	fatty acid desaturase (OLE1)	21	1.62E-8
5	SGTC_513	4245-1575	5.27	41.7 µM	5.48E-8	unfolded protein response	66	6.89E-8
6	SGTC_2399	5884133	4.96	200.0 µM	2.90E-7	cell wall signaling	42	3.52E-7
7	SGTC_142	0335-0849	4.76	62.7 µM	8.30E-7	ubiquinone biosynthesis & proteasome	93	9.87E-7
8	SGTC_1132	3456-3614	4.65	2.5 µM	1.39E-6	tubulin folding & SWR complex	22	1.64E-6
9	SGTC_959	1222-0044	4.56	107.0 µM	2.17E-6		10	2.53E-6
10	SGTC_938	3126-1755	4.47	342.0 µM	3.36E-6		7	3.88E-6
11	SGTC_2924	9010168	4.34	62.8 µM	6.32E-6	cell wall signaling	27	7.21E-6
12	SGTC_663	1486-0733	4.30	13.9 µM	7.50E-6	cell wall signaling	43	8.54E-6
13	SGTC_2009	4012297	4.25	12.1 µM	9.58E-6	cell wall signaling	53	1.09E-5
14	SGTC_2007	4011539	4.20	71.8 µM	1.20E-5	cell wall signaling	49	1.35E-5
15	SGTC_367	0335-0881	4.19	7.1 µM	1.26E-5	ubiquinone biosynthesis & proteasome	67	1.42E-5
16	SGTC_158	k038-0087	4.17	26.4 µM	1.34E-5	ubiquinone biosynthesis & proteasome	127	1.51E-5
17	SGTC_36	0335-0881	4.14	14.2 µM	1.55E-5	ubiquinone biosynthesis & proteasome	113	1.74E-5
18	SGTC_2613	3',4'-dimethoxydalbergione	4.05	24.6 µM	2.34E-5		21	2.60E-5
19	SGTC_1228	0124-0032	3.83	52.5 µM	5.83E-5		20	6.38E-5
20	SGTC_1996	st072960	3.75	66.8 µM	8.09E-5		19	8.81E-5

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.212	2.14E-35	YBR260C	RGD1	hom	GTPase-activating protein (RhoGAP) for Rho3p and Rho4p, possibly involved in control of actin cytoskeleton organization
0.182	1.84E-26	YHR079C	IRE1	hom	Serine-threonine kinase and endoribonuclease; transmembrane protein that mediates the unfolded protein response (UPR) by regulating Hac1p synthesis through HAC1 mRNA splicing; Kar2p binds inactive Ire1p and releases from it upon ER stress
0.179	1.20E-25	YMR263W	SAP30	hom	Subunit of a histone deacetylase complex, along with Rpd3p and Sin3p, that is involved in silencing at telomeres, rDNA, and silent mating-type loci; involved in telomere maintenance
0.166	4.82E-22	YNL322C	KRE1	hom	Cell wall glycoprotein involved in beta-glucan assembly; serves as a K1 killer toxin membrane receptor
0.166	5.31E-22	YBR095C	RXT2	hom	Subunit of the histone deacetylase Rpd3L complex; possibly involved in cell fusion and invasive growth
0.164	1.36E-21	YMR238W	DFG5	hom	Putative mannosidase, essential glycosylphosphatidylinositol (GPI)-anchored membrane protein required for cell wall biogenesis in bud formation, involved in filamentous growth, homologous to Dcw1p
0.163	1.86E-21	YAL053W	FLC2	hom	Putative FAD transporter; required for uptake of FAD into endoplasmic reticulum; involved in cell wall maintenance; FLC2 has a paralog, YOR365C, that arose from the whole genome duplication
0.162	4.22E-21	YAL056C-A_d	YAL056C-A_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.157	5.39E-20	YGR196C	FYV8	hom	Protein of unknown function, required for survival upon exposure to K1 killer toxin
0.148	8.06E-18	YMR200W	ROT1	het	Molecular chaperone involved in protein folding in the ER; mutation causes defects in cell wall synthesis and in lysis of autophagic bodies, suppresses tor2 mutations, and is synthetically lethal with kar2-1 and with rot2 mutations; involved in N-linked glycosylation and O-mannosylation
0.145	2.61E-17	YJL095W	BCK1	hom	Mitogen-activated protein (MAP) kinase kinase kinase acting in the protein kinase C signaling pathway, which controls cell integrity; upon activation by Pkc1p phosphorylates downstream kinases Mkk1p and Mkk2p
0.143	1.03E-16	YER019C-A	SBH2	hom	Ssh1p-Sss1p-Sbh2p complex component, involved in protein translocation into the endoplasmic reticulum; homologous to Sbh1p
0.141	2.91E-16	YHR030C	SLT2	hom	Serine/threonine MAP kinase; involved in regulating maintenance of cell wall integrity, progression through the cell cycle, and nuclear mRNA retention in heat shock; required for mitophagy and pexophagy; affects recruitment of mitochondria to the phagophore assembly site (PAS); regulated by the PKC1-mediated signaling pathway
0.139	5.40E-16	YBR229C	ROT2	hom	Glucosidase II catalytic subunit required for normal cell wall synthesis; mutations in rot2 suppress tor2 mutations, and are synthetically lethal with rot1 mutations
0.139	5.43E-16	YKR042W	UTH1	hom	Protein involved in cell wall biogenesis; required for mitochondrial autophagy; mitochondrial outer membrane and cell wall localized SUN family member; involved in the oxidative stress response, life span during starvation, and cell death; UTH1 has a paralog, NCA3, that arose from the whole genome duplication