YAL014C / SYN8

Endosomal SNARE related to mammalian syntaxin 8

Zygosity: Homozygous strain
fixedexpanded
Profile for YAL014C / SYN8

Click on Significant Values for Screen Details ID:SGTC_42|Compound:0133-0086|FD-Score:2.79|P-value:9.04E-4 ID:SGTC_131|Compound:0141-0277|FD-Score:-3.67|P-value:3.40E-5 ID:SGTC_164|Compound:4100-3994|FD-Score:2.78|P-value:9.50E-4 ID:SGTC_277|Compound:nystatin|FD-Score:3.05|P-value:3.32E-4 ID:SGTC_278|Compound:4092-0821|FD-Score:4.33|P-value:7.81E-7 ID:SGTC_280|Compound:3448-3607|FD-Score:3.81|P-value:1.15E-5 ID:SGTC_282|Compound:k297-0036|FD-Score:2.97|P-value:4.63E-4 ID:SGTC_308|Compound:4092-1169|FD-Score:3.13|P-value:2.42E-4 ID:SGTC_341|Compound:1486-1430|FD-Score:3.55|P-value:3.82E-5 ID:SGTC_346|Compound:4513-0042|FD-Score:5.66|P-value:1.85E-10 ID:SGTC_359|Compound:0081-0058|FD-Score:5.12|P-value:6.95E-9 ID:SGTC_372|Compound:0155-0182|FD-Score:3.19|P-value:1.86E-4 ID:SGTC_416|Compound:estradiol valerate|FD-Score:2.91|P-value:5.81E-4 ID:SGTC_520|Compound:3584-0023|FD-Score:-2.98|P-value:6.41E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-3.21|P-value:2.56E-4 ID:SGTC_890|Compound:0929-0006|FD-Score:-3.19|P-value:2.74E-4 ID:SGTC_1128|Compound:3448-9350|FD-Score:-3.92|P-value:1.03E-5 ID:SGTC_1132|Compound:3456-3614|FD-Score:3.38|P-value:8.25E-5 ID:SGTC_1426|Compound:4048-4480|FD-Score:3.38|P-value:8.53E-5 ID:SGTC_1505|Compound:k297-0037|FD-Score:3.00|P-value:4.06E-4 ID:SGTC_1571|Compound:st070080|FD-Score:-3.27|P-value:2.03E-4 ID:SGTC_1584|Compound:6-fluoro-dl-tryptophan|FD-Score:3.81|P-value:1.12E-5 ID:SGTC_1642|Compound:st009582|FD-Score:4.21|P-value:1.47E-6 ID:SGTC_1710|Compound:st031758|FD-Score:-3.26|P-value:2.10E-4 ID:SGTC_1712|Compound:st032288|FD-Score:5.50|P-value:5.58E-10 ID:SGTC_1886|Compound:st057356|FD-Score:3.21|P-value:1.77E-4 ID:SGTC_1898|Compound:st060199|FD-Score:3.77|P-value:1.35E-5 ID:SGTC_1948|Compound:st076329|FD-Score:2.94|P-value:5.15E-4 ID:SGTC_1989|Compound:st071868|FD-Score:3.44|P-value:6.29E-5 ID:SGTC_1997|Compound:st073024|FD-Score:2.87|P-value:6.70E-4 ID:SGTC_2271|Compound:7849410|FD-Score:-2.90|P-value:8.73E-4 ID:SGTC_2273|Compound:7815444|FD-Score:4.84|P-value:3.89E-8 ID:SGTC_2278|Compound:7948257|FD-Score:3.50|P-value:4.97E-5 ID:SGTC_2337|Compound:9009472|FD-Score:-3.53|P-value:6.55E-5 ID:SGTC_2360|Compound:9040895|FD-Score:2.85|P-value:7.33E-4 ID:SGTC_2366|Compound:9070441|FD-Score:4.06|P-value:3.30E-6 ID:SGTC_2392|Compound:N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide|FD-Score:2.83|P-value:7.79E-4 ID:SGTC_2407|Compound:paclitaxel|FD-Score:4.74|P-value:7.27E-8 ID:SGTC_2522|Compound:biochanin a|FD-Score:3.73|P-value:1.68E-5 ID:SGTC_2524|Compound:avocatin b|FD-Score:2.99|P-value:4.27E-4 ID:SGTC_2525|Compound:harmine|FD-Score:2.92|P-value:5.65E-4 ID:SGTC_2583|Compound:asiatic acid|FD-Score:3.53|P-value:4.37E-5 ID:SGTC_2794|Compound:7785382|FD-Score:3.41|P-value:7.48E-5 ID:SGTC_2861|Compound:9024595|FD-Score:3.29|P-value:1.22E-4 ID:SGTC_2992|Compound:9074591|FD-Score:-3.10|P-value:4.05E-4 ID:SGTC_3211|Compound:9128781|FD-Score:-3.66|P-value:3.67E-5 ID:SGTC_42|Compound:0133-0086|FD-Score:2.79|P-value:9.04E-4 ID:SGTC_131|Compound:0141-0277|FD-Score:-3.67|P-value:3.40E-5 ID:SGTC_164|Compound:4100-3994|FD-Score:2.78|P-value:9.50E-4 ID:SGTC_277|Compound:nystatin|FD-Score:3.05|P-value:3.32E-4 ID:SGTC_278|Compound:4092-0821|FD-Score:4.33|P-value:7.81E-7 ID:SGTC_280|Compound:3448-3607|FD-Score:3.81|P-value:1.15E-5 ID:SGTC_282|Compound:k297-0036|FD-Score:2.97|P-value:4.63E-4 ID:SGTC_308|Compound:4092-1169|FD-Score:3.13|P-value:2.42E-4 ID:SGTC_341|Compound:1486-1430|FD-Score:3.55|P-value:3.82E-5 ID:SGTC_346|Compound:4513-0042|FD-Score:5.66|P-value:1.85E-10 ID:SGTC_359|Compound:0081-0058|FD-Score:5.12|P-value:6.95E-9 ID:SGTC_372|Compound:0155-0182|FD-Score:3.19|P-value:1.86E-4 ID:SGTC_416|Compound:estradiol valerate|FD-Score:2.91|P-value:5.81E-4 ID:SGTC_520|Compound:3584-0023|FD-Score:-2.98|P-value:6.41E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-3.21|P-value:2.56E-4 ID:SGTC_890|Compound:0929-0006|FD-Score:-3.19|P-value:2.74E-4 ID:SGTC_1128|Compound:3448-9350|FD-Score:-3.92|P-value:1.03E-5 ID:SGTC_1132|Compound:3456-3614|FD-Score:3.38|P-value:8.25E-5 ID:SGTC_1426|Compound:4048-4480|FD-Score:3.38|P-value:8.53E-5 ID:SGTC_1505|Compound:k297-0037|FD-Score:3.00|P-value:4.06E-4 ID:SGTC_1571|Compound:st070080|FD-Score:-3.27|P-value:2.03E-4 ID:SGTC_1584|Compound:6-fluoro-dl-tryptophan|FD-Score:3.81|P-value:1.12E-5 ID:SGTC_1642|Compound:st009582|FD-Score:4.21|P-value:1.47E-6 ID:SGTC_1710|Compound:st031758|FD-Score:-3.26|P-value:2.10E-4 ID:SGTC_1712|Compound:st032288|FD-Score:5.50|P-value:5.58E-10 ID:SGTC_1886|Compound:st057356|FD-Score:3.21|P-value:1.77E-4 ID:SGTC_1898|Compound:st060199|FD-Score:3.77|P-value:1.35E-5 ID:SGTC_1948|Compound:st076329|FD-Score:2.94|P-value:5.15E-4 ID:SGTC_1989|Compound:st071868|FD-Score:3.44|P-value:6.29E-5 ID:SGTC_1997|Compound:st073024|FD-Score:2.87|P-value:6.70E-4 ID:SGTC_2271|Compound:7849410|FD-Score:-2.90|P-value:8.73E-4 ID:SGTC_2273|Compound:7815444|FD-Score:4.84|P-value:3.89E-8 ID:SGTC_2278|Compound:7948257|FD-Score:3.50|P-value:4.97E-5 ID:SGTC_2337|Compound:9009472|FD-Score:-3.53|P-value:6.55E-5 ID:SGTC_2360|Compound:9040895|FD-Score:2.85|P-value:7.33E-4 ID:SGTC_2366|Compound:9070441|FD-Score:4.06|P-value:3.30E-6 ID:SGTC_2392|Compound:N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide|FD-Score:2.83|P-value:7.79E-4 ID:SGTC_2407|Compound:paclitaxel|FD-Score:4.74|P-value:7.27E-8 ID:SGTC_2522|Compound:biochanin a|FD-Score:3.73|P-value:1.68E-5 ID:SGTC_2524|Compound:avocatin b|FD-Score:2.99|P-value:4.27E-4 ID:SGTC_2525|Compound:harmine|FD-Score:2.92|P-value:5.65E-4 ID:SGTC_2583|Compound:asiatic acid|FD-Score:3.53|P-value:4.37E-5 ID:SGTC_2794|Compound:7785382|FD-Score:3.41|P-value:7.48E-5 ID:SGTC_2861|Compound:9024595|FD-Score:3.29|P-value:1.22E-4 ID:SGTC_2992|Compound:9074591|FD-Score:-3.10|P-value:4.05E-4 ID:SGTC_3211|Compound:9128781|FD-Score:-3.66|P-value:3.67E-5

Top fitness defect scores for YAL014C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_346 4513-0042 5.66 7.2 µM 1.85E-10 azole & statin 15 7.63E-9
2 SGTC_1712 st032288 5.50 53.4 µM 5.58E-10 calcium & mitochondrial duress 91 1.90E-8
3 SGTC_359 0081-0058 5.12 15.9 µM 6.95E-9 60S ribosome export 17 1.53E-7
4 SGTC_2273 7815444 4.84 169.1 µM 3.89E-8 11 6.35E-7
5 SGTC_2407 paclitaxel 4.74 400.0 µM 7.27E-8 19 1.07E-6
6 SGTC_278 4092-0821 4.33 23.9 µM 7.81E-7 plasma membrane duress 32 7.58E-6
7 SGTC_1642 st009582 4.21 77.7 µM 1.47E-6 RPP1 & pyrimidine depletion 11 1.28E-5
8 SGTC_2366 9070441 4.06 60.6 µM 3.30E-6 26 2.50E-5
9 SGTC_1584 6-fluoro-dl-tryptophan 3.81 90.0 µM 1.12E-5 mitochondrial processes 17 6.85E-5
10 SGTC_280 3448-3607 3.81 3.0 µM 1.15E-5 60S ribosome export 11 7.04E-5
11 SGTC_1898 st060199 3.77 18.6 µM 1.35E-5 21 8.01E-5
12 SGTC_2522 biochanin a 3.73 4.9 µM 1.68E-5 RNA pol III & RNase P/MRP 16 9.59E-5
13 SGTC_341 1486-1430 3.55 230.0 µM 3.82E-5 31 1.89E-4
14 SGTC_2583 asiatic acid 3.53 100.0 µM 4.37E-5 51 2.12E-4
15 SGTC_2278 7948257 3.50 134.3 µM 4.97E-5 39 2.36E-4
16 SGTC_1989 st071868 3.44 50.2 µM 6.29E-5 22 2.86E-4
17 SGTC_2794 7785382 3.41 27.3 µM 7.48E-5 56 3.30E-4
18 SGTC_1132 3456-3614 3.38 2.5 µM 8.25E-5 tubulin folding & SWR complex 83 3.58E-4
19 SGTC_1426 4048-4480 3.38 71.7 µM 8.53E-5 60S ribosome export 32 3.68E-4
20 SGTC_2861 9024595 3.29 19.5 µM 1.22E-4 8 4.95E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.141 2.46E-16 YKL046C DCW1 hom Putative mannosidase, GPI-anchored membrane protein required for cell wall biosynthesis in bud formation;homologous to Dfg5p
0.138 8.26E-16 YGR082W TOM20 het Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; acts as a receptor for incoming precursor proteins
0.133 8.53E-15 YJR017C ESS1 het Peptidylprolyl-cis/trans-isomerase (PPIase); specific for phosphorylated serine and threonine residues N-terminal to proline; regulates phosphorylation of the RNAP II large subunit (Rpo21p) C-terminal domain (CTD); associates with phospho-Ser5 form of RNAP II in vivo; regulates phosphorylation of Ser7 within CTD; present along entire coding length of genes; represses initiation of CUTs; required for efficient termination of mRNA transcription and trimethylation of histone H3
0.133 9.40E-15 YKL051W SFK1 hom Plasma membrane protein that may act together with or upstream of Stt4p to generate normal levels of the essential phospholipid PI4P, at least partially mediates proper localization of Stt4p to the plasma membrane
0.128 8.92E-14 YOR004W UTP23 het Component of the small subunit processome, involved in 40S ribosomal subunit biogenesis; interacts with snR30 and is required for dissociation of snR30 from large pre-ribosomal particles; has homology to PINc domain protein Fcf1p, although the PINc domain of Utp23p is not required for function; essential protein
0.122 1.25E-12 YGL203C KEX1 hom Protease involved in the processing of killer toxin and alpha factor precursor; cleaves Lys and Arg residues from the C-terminus of peptides and proteins
0.116 1.64E-11 YNL009W IDP3 hom Peroxisomal NADP-dependent isocitrate dehydrogenase; catalyzes oxidation of isocitrate to alpha-ketoglutarate with the formation of NADP(H+), required for growth on unsaturated fatty acids; IDP3 has a paralog, IDP2, that arose from the whole genome duplication
0.108 3.28E-10 YNL086W_p SNN1_p hom Putative protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; green fluorescent protein (GFP)-fusion protein localizes to endosomes
0.108 3.49E-10 YJL082W IML2 hom Protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress; IML2 has a paralog, YKR018C, that arose from the whole genome duplication
0.102 3.29E-9 YJL083W TAX4 hom EH domain-containing protein; involved in regulating phosphatidylinositol 4,5-bisphosphate levels and autophagy; Irs4p and Tax4p bind and activate the PtdIns phosphatase Inp51p; Irs4p and Tax4p are involved in localizing Atg17p to the PAS; TAX4 has a paralog, IRS4, that arose from the whole genome duplication
0.101 4.72E-9 YDR443C SSN2 hom Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; required for stable association of Srb10p-Srb11p kinase; essential for transcriptional regulation
0.101 4.87E-9 YDR357C_p CNL1_p hom Protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; null mutant is sensitive to drug inducing secretion of vacuolar cargo; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.101 5.47E-9 YFR052W RPN12 het Subunit of the 19S regulatory particle of the 26S proteasome lid; synthetically lethal with RPT1, which is an ATPase component of the 19S regulatory particle; physically interacts with Nob1p and Rpn3p; protein abundance increases in response to DNA replication stress
0.098 1.09E-8 YIL170W HXT12 hom Possible pseudogene in strain S288C; YIL170W/HXT12 and the adjacent ORF, YIL171W, together encode a non-functional member of the hexose transporter family
0.096 2.43E-8 YER157W COG3 het Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments