YAL037W_p

Putative protein of unknown function; YAL037W has a paralog, YOR342C, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YAL037W / YAL037W

Click on Significant Values for Screen Details ID:SGTC_24|Compound:0417-1663|FD-Score:3.50|P-value:3.43E-4 ID:SGTC_127|Compound:0180-0333|FD-Score:3.53|P-value:3.14E-4 ID:SGTC_341|Compound:1486-1430|FD-Score:-4.67|P-value:2.63E-6 ID:SGTC_344|Compound:k064-0035|FD-Score:4.29|P-value:1.63E-5 ID:SGTC_421|Compound:streptovitacin|FD-Score:4.66|P-value:3.07E-6 ID:SGTC_440|Compound:fluspirilene|FD-Score:4.22|P-value:2.12E-5 ID:SGTC_454|Compound:lyso-paf C-16|FD-Score:3.73|P-value:1.53E-4 ID:SGTC_533|Compound:1222-0222|FD-Score:-4.54|P-value:4.72E-6 ID:SGTC_535|Compound:2293-4129|FD-Score:-4.69|P-value:2.35E-6 ID:SGTC_539|Compound:4859-0462|FD-Score:-3.99|P-value:4.84E-5 ID:SGTC_592|Compound:k241-0073|FD-Score:3.41|P-value:4.71E-4 ID:SGTC_702|Compound:1488-0190|FD-Score:3.36|P-value:5.78E-4 ID:SGTC_735|Compound:3076-0345|FD-Score:3.39|P-value:5.12E-4 ID:SGTC_763|Compound:3453-1109|FD-Score:3.69|P-value:1.73E-4 ID:SGTC_902|Compound:1120-0002|FD-Score:3.69|P-value:1.74E-4 ID:SGTC_969|Compound:1313-0238|FD-Score:5.87|P-value:6.04E-9 ID:SGTC_1087|Compound:pterostilbene|FD-Score:3.64|P-value:2.12E-4 ID:SGTC_1171|Compound:0368-0077|FD-Score:3.45|P-value:4.22E-4 ID:SGTC_1217|Compound:1183-1422|FD-Score:-3.59|P-value:2.30E-4 ID:SGTC_1387|Compound:3342-1166|FD-Score:3.32|P-value:6.53E-4 ID:SGTC_1418|Compound:3966-3099|FD-Score:-3.64|P-value:1.92E-4 ID:SGTC_1419|Compound:3993-2473|FD-Score:4.51|P-value:6.15E-6 ID:SGTC_1483|Compound:3453-0561|FD-Score:4.42|P-value:9.23E-6 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:5.82|P-value:8.07E-9 ID:SGTC_1683|Compound:st010134|FD-Score:3.20|P-value:9.87E-4 ID:SGTC_1691|Compound:st019933|FD-Score:-3.34|P-value:5.49E-4 ID:SGTC_2008|Compound:4012253|FD-Score:3.66|P-value:1.98E-4 ID:SGTC_2267|Compound:7931562|FD-Score:-3.82|P-value:9.49E-5 ID:SGTC_2359|Compound:9039622|FD-Score:-3.44|P-value:3.90E-4 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:4.43|P-value:8.65E-6 ID:SGTC_2630|Compound:antimycin a|FD-Score:-3.26|P-value:7.32E-4 ID:SGTC_2834|Compound:9001755|FD-Score:-4.24|P-value:1.77E-5 ID:SGTC_2841|Compound:9004761|FD-Score:-3.87|P-value:7.90E-5 ID:SGTC_2894|Compound:9048625|FD-Score:3.52|P-value:3.20E-4 ID:SGTC_3007|Compound:9078383|FD-Score:3.26|P-value:8.05E-4 ID:SGTC_3061|Compound:glucosamine|FD-Score:5.23|P-value:1.92E-7 ID:SGTC_3144|Compound:9087057|FD-Score:-6.13|P-value:1.14E-9 ID:SGTC_3188|Compound:9110789|FD-Score:3.25|P-value:8.25E-4 ID:SGTC_3204|Compound:9114183|FD-Score:3.67|P-value:1.88E-4 ID:SGTC_3223|Compound:9129970|FD-Score:7.42|P-value:3.03E-13 ID:SGTC_3224|Compound:9130643|FD-Score:-6.80|P-value:1.70E-11 ID:SGTC_3274|Compound:9138298|FD-Score:3.70|P-value:1.71E-4 ID:SGTC_24|Compound:0417-1663|FD-Score:3.50|P-value:3.43E-4 ID:SGTC_127|Compound:0180-0333|FD-Score:3.53|P-value:3.14E-4 ID:SGTC_341|Compound:1486-1430|FD-Score:-4.67|P-value:2.63E-6 ID:SGTC_344|Compound:k064-0035|FD-Score:4.29|P-value:1.63E-5 ID:SGTC_421|Compound:streptovitacin|FD-Score:4.66|P-value:3.07E-6 ID:SGTC_440|Compound:fluspirilene|FD-Score:4.22|P-value:2.12E-5 ID:SGTC_454|Compound:lyso-paf C-16|FD-Score:3.73|P-value:1.53E-4 ID:SGTC_533|Compound:1222-0222|FD-Score:-4.54|P-value:4.72E-6 ID:SGTC_535|Compound:2293-4129|FD-Score:-4.69|P-value:2.35E-6 ID:SGTC_539|Compound:4859-0462|FD-Score:-3.99|P-value:4.84E-5 ID:SGTC_592|Compound:k241-0073|FD-Score:3.41|P-value:4.71E-4 ID:SGTC_702|Compound:1488-0190|FD-Score:3.36|P-value:5.78E-4 ID:SGTC_735|Compound:3076-0345|FD-Score:3.39|P-value:5.12E-4 ID:SGTC_763|Compound:3453-1109|FD-Score:3.69|P-value:1.73E-4 ID:SGTC_902|Compound:1120-0002|FD-Score:3.69|P-value:1.74E-4 ID:SGTC_969|Compound:1313-0238|FD-Score:5.87|P-value:6.04E-9 ID:SGTC_1087|Compound:pterostilbene|FD-Score:3.64|P-value:2.12E-4 ID:SGTC_1171|Compound:0368-0077|FD-Score:3.45|P-value:4.22E-4 ID:SGTC_1217|Compound:1183-1422|FD-Score:-3.59|P-value:2.30E-4 ID:SGTC_1387|Compound:3342-1166|FD-Score:3.32|P-value:6.53E-4 ID:SGTC_1418|Compound:3966-3099|FD-Score:-3.64|P-value:1.92E-4 ID:SGTC_1419|Compound:3993-2473|FD-Score:4.51|P-value:6.15E-6 ID:SGTC_1483|Compound:3453-0561|FD-Score:4.42|P-value:9.23E-6 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:5.82|P-value:8.07E-9 ID:SGTC_1683|Compound:st010134|FD-Score:3.20|P-value:9.87E-4 ID:SGTC_1691|Compound:st019933|FD-Score:-3.34|P-value:5.49E-4 ID:SGTC_2008|Compound:4012253|FD-Score:3.66|P-value:1.98E-4 ID:SGTC_2267|Compound:7931562|FD-Score:-3.82|P-value:9.49E-5 ID:SGTC_2359|Compound:9039622|FD-Score:-3.44|P-value:3.90E-4 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:4.43|P-value:8.65E-6 ID:SGTC_2630|Compound:antimycin a|FD-Score:-3.26|P-value:7.32E-4 ID:SGTC_2834|Compound:9001755|FD-Score:-4.24|P-value:1.77E-5 ID:SGTC_2841|Compound:9004761|FD-Score:-3.87|P-value:7.90E-5 ID:SGTC_2894|Compound:9048625|FD-Score:3.52|P-value:3.20E-4 ID:SGTC_3007|Compound:9078383|FD-Score:3.26|P-value:8.05E-4 ID:SGTC_3061|Compound:glucosamine|FD-Score:5.23|P-value:1.92E-7 ID:SGTC_3144|Compound:9087057|FD-Score:-6.13|P-value:1.14E-9 ID:SGTC_3188|Compound:9110789|FD-Score:3.25|P-value:8.25E-4 ID:SGTC_3204|Compound:9114183|FD-Score:3.67|P-value:1.88E-4 ID:SGTC_3223|Compound:9129970|FD-Score:7.42|P-value:3.03E-13 ID:SGTC_3224|Compound:9130643|FD-Score:-6.80|P-value:1.70E-11 ID:SGTC_3274|Compound:9138298|FD-Score:3.70|P-value:1.71E-4

Top fitness defect scores for YAL037W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3223 9129970 7.42 49.5 µM 3.03E-13 1 6.06E-14
2 SGTC_969 1313-0238 5.87 134.0 µM 6.04E-9 mitochondrial processes 7 2.14E-9
3 SGTC_1565 sinapyl alcohol 5.82 95.1 µM 8.07E-9 2 2.91E-9
4 SGTC_3061 glucosamine 5.23 200.0 µM 1.92E-7 2 8.33E-8
5 SGTC_421 streptovitacin 4.66 30.0 mM 3.07E-6 11 1.56E-6
6 SGTC_1419 3993-2473 4.51 62.6 µM 6.15E-6 8 3.25E-6
7 SGTC_2613 3',4'-dimethoxydalbergione 4.43 24.6 µM 8.65E-6 13 4.67E-6
8 SGTC_1483 3453-0561 4.42 55.9 µM 9.23E-6 14 5.00E-6
9 SGTC_344 k064-0035 4.29 6.4 µM 1.63E-5 60S ribosome export 19 9.13E-6
10 SGTC_440 fluspirilene 4.22 35.1 µM 2.12E-5 9 1.20E-5
11 SGTC_454 lyso-paf C-16 3.73 6.7 µM 1.53E-4 23 9.75E-5
12 SGTC_3274 9138298 3.70 49.5 µM 1.71E-4 26 1.10E-4
13 SGTC_763 3453-1109 3.69 128.0 µM 1.73E-4 24 1.11E-4
14 SGTC_902 1120-0002 3.69 2.1 µM 1.74E-4 azole & statin 55 1.12E-4
15 SGTC_3204 9114183 3.67 49.5 µM 1.88E-4 41 1.21E-4
16 SGTC_2008 4012253 3.66 172.0 µM 1.98E-4 33 1.28E-4
17 SGTC_1087 pterostilbene 3.64 9.1 µM 2.12E-4 35 1.38E-4
18 SGTC_127 0180-0333 3.53 59.1 µM 3.14E-4 mitochondrial response to ROS 63 2.08E-4
19 SGTC_2894 9048625 3.52 32.5 µM 3.20E-4 22 2.12E-4
20 SGTC_24 0417-1663 3.50 219.0 µM 3.43E-4 30 2.28E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.117 1.06E-11 YKL024C URA6 het Uridylate kinase, catalyzes the seventh enzymatic step in the de novo biosynthesis of pyrimidines, converting uridine monophosphate (UMP) into uridine-5'-diphosphate (UDP)
0.112 7.03E-11 YER006W NUG1 het GTPase that associates with nuclear 60S pre-ribosomes, required for export of 60S ribosomal subunits from the nucleus
0.092 8.12E-8 YPR111W DBF20 hom Ser/Thr kinase involved in late nuclear division, one of the mitotic exit network (MEN) proteins; necessary for the execution of cytokinesis; also plays a role in regulating the stability of SWI5 and CLB2 mRNAs
0.084 1.11E-6 YKL202W_d YKL202W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.082 2.28E-6 YAL044C GCV3 hom H subunit of the mitochondrial glycine decarboxylase complex, required for the catabolism of glycine to 5,10-methylene-THF; also required for all protein lipoylation; expression is regulated by levels of 5,10-methylene-THF
0.076 1.02E-5 YMR213W CEF1 het Essential splicing factor; associated with Prp19p and the spliceosome, contains an N-terminal c-Myb DNA binding motif necessary for cell viability but not for Prp19p association, evolutionarily conserved and homologous to S. pombe Cdc5p
0.073 2.19E-5 YBR005W RCR1 hom Protein of the ER membrane involved in cell wall chitin deposition; may function in the endosomal-vacuolar trafficking pathway, helping determine whether plasma membrane proteins are degraded or routed to the plasma membrane; RCR1 has a paralog, RCR2, that arose from the whole genome duplication
0.072 2.74E-5 YLR307W CDA1 hom Chitin deacetylase, together with Cda2p involved in the biosynthesis ascospore wall component, chitosan; required for proper rigidity of the ascospore wall
0.070 4.65E-5 YLR064W PER33 hom Protein that localizes to the endoplasmic reticulum; also associates with the nuclear pore complex; deletion extends chronological lifespan; highly conserved across species, orthologous to human TMEM33 and paralogous to Pom33p; protein abundance increases in response to DNA replication stress
0.069 6.57E-5 YLR196W PWP1 het Protein with WD-40 repeats involved in rRNA processing; associates with trans-acting ribosome biogenesis factors; similar to beta-transducin superfamily
0.067 9.26E-5 YPL107W_p YPL107W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YPL107W is not an essential gene
0.066 1.17E-4 YFL027C GYP8 hom GTPase-activating protein for yeast Rab family members; Ypt1p is the preferred in vitro substrate but also acts on Sec4p, Ypt31p and Ypt32p; involved in the regulation of ER to Golgi vesicle transport
0.065 1.65E-4 YNL016W PUB1 hom Poly (A)+ RNA-binding protein; abundant mRNP-component protein that binds mRNA and is required for stability of many mRNAs; component of glucose deprivation induced stress granules, involved in P-body-dependent granule assembly; protein abundance increases in response to DNA replication stress
0.065 1.67E-4 YDR057W YOS9 hom ER quality-control lectin; integral subunit of the HRD ligase; binds to glycans with terminal alpha-1,6 linked mannose on misfolded N-glycosylated proteins and participates in targeting proteins to ERAD; member of the OS-9 protein family
0.064 2.32E-4 YMR012W CLU1 hom eIF3 component of unknown function; deletion causes defects in mitochondrial organization but not in growth or translation initiation, can rescue cytokinesis and mitochondrial organization defects of the Dictyostelium cluA- mutant