YAL045C_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; almost completely overlaps YAL044W-A

Zygosity: Homozygous strain
fixedexpanded
Profile for YAL045C / YAL045C

Click on Significant Values for Screen Details ID:SGTC_164|Compound:4100-3994|FD-Score:3.15|P-value:3.00E-4 ID:SGTC_313|Compound:3474-0040|FD-Score:-3.14|P-value:3.66E-4 ID:SGTC_360|Compound:0957-0399|FD-Score:4.30|P-value:1.41E-6 ID:SGTC_361|Compound:000s-0510|FD-Score:3.19|P-value:2.51E-4 ID:SGTC_527|Compound:4476-4215|FD-Score:3.98|P-value:7.35E-6 ID:SGTC_532|Compound:1548-0774|FD-Score:2.86|P-value:8.98E-4 ID:SGTC_630|Compound:4356-0227|FD-Score:-3.29|P-value:2.03E-4 ID:SGTC_645|Compound:0845-0943|FD-Score:3.52|P-value:6.25E-5 ID:SGTC_669|Compound:0108-0021|FD-Score:3.23|P-value:2.17E-4 ID:SGTC_907|Compound:3448-6986|FD-Score:3.59|P-value:4.61E-5 ID:SGTC_910|Compound:3454-3003|FD-Score:3.26|P-value:1.90E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-4.99|P-value:3.82E-8 ID:SGTC_1177|Compound:0983-0204|FD-Score:3.27|P-value:1.81E-4 ID:SGTC_1332|Compound:1480-0653|FD-Score:3.24|P-value:2.03E-4 ID:SGTC_1681|Compound:tripelennamine|FD-Score:-4.33|P-value:1.55E-6 ID:SGTC_1802|Compound:st050112|FD-Score:-2.99|P-value:6.61E-4 ID:SGTC_1804|Compound:st050076|FD-Score:3.76|P-value:2.08E-5 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-4.26|P-value:2.26E-6 ID:SGTC_2071|Compound:5230951|FD-Score:-3.69|P-value:3.66E-5 ID:SGTC_2112|Compound:5488546|FD-Score:-3.68|P-value:3.83E-5 ID:SGTC_2167|Compound:5876490|FD-Score:3.24|P-value:2.05E-4 ID:SGTC_2293|Compound:7624732|FD-Score:-3.75|P-value:2.81E-5 ID:SGTC_2295|Compound:7971645|FD-Score:3.92|P-value:9.90E-6 ID:SGTC_2361|Compound:9034121|FD-Score:3.48|P-value:7.38E-5 ID:SGTC_2405|Compound:ticlatone|FD-Score:-4.25|P-value:2.43E-6 ID:SGTC_2593|Compound:nobiletin|FD-Score:-2.97|P-value:7.07E-4 ID:SGTC_2602|Compound:kawain|FD-Score:4.05|P-value:5.14E-6 ID:SGTC_2605|Compound:digitonin|FD-Score:3.26|P-value:1.86E-4 ID:SGTC_2629|Compound:bisabolol|FD-Score:3.49|P-value:7.01E-5 ID:SGTC_2635|Compound:hydroquinidine|FD-Score:-3.45|P-value:1.03E-4 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:-2.95|P-value:7.85E-4 ID:SGTC_2813|Compound:7971799|FD-Score:2.93|P-value:6.83E-4 ID:SGTC_3313|Compound:9133968|FD-Score:2.97|P-value:5.91E-4 ID:SGTC_164|Compound:4100-3994|FD-Score:3.15|P-value:3.00E-4 ID:SGTC_313|Compound:3474-0040|FD-Score:-3.14|P-value:3.66E-4 ID:SGTC_360|Compound:0957-0399|FD-Score:4.30|P-value:1.41E-6 ID:SGTC_361|Compound:000s-0510|FD-Score:3.19|P-value:2.51E-4 ID:SGTC_527|Compound:4476-4215|FD-Score:3.98|P-value:7.35E-6 ID:SGTC_532|Compound:1548-0774|FD-Score:2.86|P-value:8.98E-4 ID:SGTC_630|Compound:4356-0227|FD-Score:-3.29|P-value:2.03E-4 ID:SGTC_645|Compound:0845-0943|FD-Score:3.52|P-value:6.25E-5 ID:SGTC_669|Compound:0108-0021|FD-Score:3.23|P-value:2.17E-4 ID:SGTC_907|Compound:3448-6986|FD-Score:3.59|P-value:4.61E-5 ID:SGTC_910|Compound:3454-3003|FD-Score:3.26|P-value:1.90E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-4.99|P-value:3.82E-8 ID:SGTC_1177|Compound:0983-0204|FD-Score:3.27|P-value:1.81E-4 ID:SGTC_1332|Compound:1480-0653|FD-Score:3.24|P-value:2.03E-4 ID:SGTC_1681|Compound:tripelennamine|FD-Score:-4.33|P-value:1.55E-6 ID:SGTC_1802|Compound:st050112|FD-Score:-2.99|P-value:6.61E-4 ID:SGTC_1804|Compound:st050076|FD-Score:3.76|P-value:2.08E-5 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-4.26|P-value:2.26E-6 ID:SGTC_2071|Compound:5230951|FD-Score:-3.69|P-value:3.66E-5 ID:SGTC_2112|Compound:5488546|FD-Score:-3.68|P-value:3.83E-5 ID:SGTC_2167|Compound:5876490|FD-Score:3.24|P-value:2.05E-4 ID:SGTC_2293|Compound:7624732|FD-Score:-3.75|P-value:2.81E-5 ID:SGTC_2295|Compound:7971645|FD-Score:3.92|P-value:9.90E-6 ID:SGTC_2361|Compound:9034121|FD-Score:3.48|P-value:7.38E-5 ID:SGTC_2405|Compound:ticlatone|FD-Score:-4.25|P-value:2.43E-6 ID:SGTC_2593|Compound:nobiletin|FD-Score:-2.97|P-value:7.07E-4 ID:SGTC_2602|Compound:kawain|FD-Score:4.05|P-value:5.14E-6 ID:SGTC_2605|Compound:digitonin|FD-Score:3.26|P-value:1.86E-4 ID:SGTC_2629|Compound:bisabolol|FD-Score:3.49|P-value:7.01E-5 ID:SGTC_2635|Compound:hydroquinidine|FD-Score:-3.45|P-value:1.03E-4 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:-2.95|P-value:7.85E-4 ID:SGTC_2813|Compound:7971799|FD-Score:2.93|P-value:6.83E-4 ID:SGTC_3313|Compound:9133968|FD-Score:2.97|P-value:5.91E-4

Top fitness defect scores for YAL045C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_360 0957-0399 4.30 1.0 µM 1.41E-6 cell wall 36 8.48E-6
2 SGTC_2602 kawain 4.05 100.0 µM 5.14E-6 22 2.56E-5
3 SGTC_527 4476-4215 3.98 268.0 µM 7.35E-6 PDR1 33 3.47E-5
4 SGTC_2295 7971645 3.92 200.0 µM 9.90E-6 21 4.49E-5
5 SGTC_1804 st050076 3.76 49.1 µM 2.08E-5 19 8.46E-5
6 SGTC_907 3448-6986 3.59 75.5 µM 4.61E-5 38 1.67E-4
7 SGTC_645 0845-0943 3.52 5.4 µM 6.25E-5 60S ribosome export 17 2.17E-4
8 SGTC_2629 bisabolol 3.49 100.0 µM 7.01E-5 34 2.39E-4
9 SGTC_2361 9034121 3.48 116.0 µM 7.38E-5 RSC complex & mRNA processing 32 2.50E-4
10 SGTC_1177 0983-0204 3.27 23.6 µM 1.81E-4 32 5.38E-4
11 SGTC_2605 digitonin 3.26 300.0 nM 1.86E-4 61 5.51E-4
12 SGTC_910 3454-3003 3.26 490.0 µM 1.90E-4 40 5.62E-4
13 SGTC_1332 1480-0653 3.24 17.5 µM 2.03E-4 TSC3-RPN4 37 5.94E-4
14 SGTC_2167 5876490 3.24 200.0 µM 2.05E-4 66 6.00E-4
15 SGTC_669 0108-0021 3.23 26.2 µM 2.17E-4 fatty acid desaturase (OLE1) 135 6.28E-4
16 SGTC_361 000s-0510 3.19 1.4 µM 2.51E-4 67 7.12E-4
17 SGTC_164 4100-3994 3.15 89.6 µM 3.00E-4 77 8.29E-4
18 SGTC_3313 9133968 2.97 57.0 µM 5.91E-4 38 0.00148
19 SGTC_2813 7971799 2.93 71.4 µM 6.83E-4 69 0.00168
20 SGTC_532 1548-0774 2.86 215.0 µM 8.98E-4 66 0.00212

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.318 1.01E-79 YBL036C YBL036C hom Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS
0.204 9.42E-33 YER030W CHZ1 hom Histone chaperone for Htz1p/H2A-H2B dimer; required for the stabilization of the Chz1p-Htz1-H2B complex; has overlapping function with Nap1p; null mutant displays weak sensitivity to MMS and benomyl; contains a highly conserved CHZ motif; protein abundance increases in response to DNA replication stress
0.198 5.35E-31 YMR095C SNO1 hom Protein of unconfirmed function, involved in pyridoxine metabolism; expression is induced during stationary phase; forms a putative glutamine amidotransferase complex with Snz1p, with Sno1p serving as the glutaminase
0.179 1.65E-25 YDL174C DLD1 hom D-lactate dehydrogenase, oxidizes D-lactate to pyruvate, transcription is heme-dependent, repressed by glucose, and derepressed in ethanol or lactate; located in the mitochondrial inner membrane
0.174 3.67E-24 YDR122W KIN1 hom Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; closely related to Kin2p
0.173 4.61E-24 YBR083W TEC1 hom Transcription factor targeting filamentation genes and Ty1 expression; Ste12p activation of most filamentation gene promoters depends on Tec1p and Tec1p transcriptional activity is dependent on its association with Ste12p; binds to TCS elements upstream of filamentation genes, which are regulated by Tec1p/Ste12p/Dig1p complex; competes with Dig2p for binding to Ste12p/Dig1p; positive regulator of chronological life span; TEA/ATTS DNA-binding domain family member
0.167 2.10E-22 YLL012W YEH1 hom Steryl ester hydrolase, one of three gene products (Yeh1p, Yeh2p, Tgl1p) responsible for steryl ester hydrolase activity and involved in sterol homeostasis; localized to lipid particle membranes
0.167 2.65E-22 YLR288C MEC3 hom DNA damage and meiotic pachytene checkpoint protein; subunit of a heterotrimeric complex (Rad17p-Mec3p-Ddc1p) that forms a sliding clamp, loaded onto partial duplex DNA by a clamp loader complex; homolog of human and S. pombe Hus1
0.165 8.09E-22 YER064C VHR2 hom Non-essential nuclear protein; null mutation has global effects on transcription; VHR2 has a paralog, VHR1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress
0.164 9.21E-22 YOR037W CYC2 hom Mitochondrial peripheral inner membrane protein, contains a FAD cofactor in a domain exposed in the intermembrane space; exhibits redox activity in vitro; likely participates in ligation of heme to acytochromes c and c1 (Cyc1p and Cyt1p)
0.163 2.12E-21 YER060W-A FCY22 hom Putative purine-cytosine permease, very similar to Fcy2p but cannot substitute for its function
0.161 4.99E-21 YKL099C UTP11 het Subunit of U3-containing Small Subunit (SSU) processome complex involved in production of 18S rRNA and assembly of small ribosomal subunit
0.160 1.13E-20 YDL110C TMA17 hom Protein of unknown function that associates with ribosomes; heterozygous deletion demonstrated increases in chromosome instability in a rad9 deletion background; protein abundance is decreased upon intracellular iron depletion
0.156 1.05E-19 YGR097W ASK10 hom Component of RNA polymerase II holoenzyme; phosphorylated in response to oxidative stress; has a role in destruction of Ssn8p; proposed to function in activation of the glycerol channel Fps1p; ASK10 has a paralog, RGC1, that arose from the whole genome duplication
0.153 5.00E-19 YBL015W ACH1 hom Protein with CoA transferase activity, particularly for CoASH transfer from succinyl-CoA to acetate; has minor acetyl-CoA-hydrolase activity; phosphorylated; required for acetate utilization and for diploid pseudohyphal growth