YAL051W / OAF1

Oleate-activated transcription factor; acts alone and as a heterodimer with Pip2p; activates genes involved in beta-oxidation of fatty acids and peroxisome organization and biogenesis; OAF1 has a paralog, PIP2, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YAL051W / OAF1

Click on Significant Values for Screen Details ID:SGTC_103|Compound:0844-0104|FD-Score:11.70|P-value:1.24E-35 ID:SGTC_270|Compound:tamoxifen|FD-Score:3.77|P-value:3.17E-5 ID:SGTC_353|Compound:1988-1175|FD-Score:3.13|P-value:4.47E-4 ID:SGTC_402|Compound:epigallocatechin gallate|FD-Score:-2.89|P-value:9.94E-4 ID:SGTC_432|Compound:NS 1619|FD-Score:2.94|P-value:9.00E-4 ID:SGTC_440|Compound:fluspirilene|FD-Score:4.66|P-value:3.71E-7 ID:SGTC_462|Compound:ag-879|FD-Score:-2.98|P-value:7.21E-4 ID:SGTC_472|Compound:calcifediol|FD-Score:3.19|P-value:3.55E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:3.00|P-value:7.21E-4 ID:SGTC_605|Compound:1315-0399|FD-Score:3.15|P-value:4.11E-4 ID:SGTC_609|Compound:0986-0026|FD-Score:4.83|P-value:1.41E-7 ID:SGTC_616|Compound:4092-0450|FD-Score:2.97|P-value:8.12E-4 ID:SGTC_621|Compound:3584-0052|FD-Score:5.31|P-value:8.24E-9 ID:SGTC_631|Compound:k072-0230|FD-Score:3.79|P-value:2.85E-5 ID:SGTC_997|Compound:3996-0078|FD-Score:-2.91|P-value:9.34E-4 ID:SGTC_1053|Compound:3366-3204|FD-Score:-3.81|P-value:2.40E-5 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:4.32|P-value:2.22E-6 ID:SGTC_1161|Compound:k007-0610|FD-Score:3.83|P-value:2.38E-5 ID:SGTC_1512|Compound:0259-0544|FD-Score:-3.10|P-value:4.59E-4 ID:SGTC_1513|Compound:0337-0559|FD-Score:-3.37|P-value:1.58E-4 ID:SGTC_1581|Compound:himbacine|FD-Score:-3.10|P-value:4.71E-4 ID:SGTC_1610|Compound:st001799|FD-Score:3.68|P-value:4.68E-5 ID:SGTC_1682|Compound:st012968|FD-Score:-3.71|P-value:3.68E-5 ID:SGTC_1685|Compound:st024049|FD-Score:3.19|P-value:3.63E-4 ID:SGTC_1829|Compound:berberine|FD-Score:2.96|P-value:8.58E-4 ID:SGTC_1892|Compound:st058411|FD-Score:3.36|P-value:1.79E-4 ID:SGTC_1985|Compound:st071382|FD-Score:-2.99|P-value:6.97E-4 ID:SGTC_1990|Compound:st072050|FD-Score:-3.80|P-value:2.51E-5 ID:SGTC_1991|Compound:st073000|FD-Score:3.57|P-value:7.47E-5 ID:SGTC_1993|Compound:st073995|FD-Score:5.00|P-value:5.31E-8 ID:SGTC_2075|Compound:5212009|FD-Score:3.24|P-value:2.89E-4 ID:SGTC_2148|Compound:5546263|FD-Score:-3.67|P-value:4.53E-5 ID:SGTC_2150|Compound:5556613|FD-Score:-2.91|P-value:9.40E-4 ID:SGTC_2157|Compound:5649910|FD-Score:-2.99|P-value:7.07E-4 ID:SGTC_2183|Compound:6420625|FD-Score:-3.47|P-value:1.06E-4 ID:SGTC_2307|Compound:7538926|FD-Score:3.07|P-value:5.62E-4 ID:SGTC_2318|Compound:6029776|FD-Score:6.36|P-value:6.83E-12 ID:SGTC_2379|Compound:9035213|FD-Score:3.94|P-value:1.46E-5 ID:SGTC_2476|Compound:5806916|FD-Score:3.41|P-value:1.48E-4 ID:SGTC_2533|Compound:agelasine|FD-Score:3.40|P-value:1.56E-4 ID:SGTC_2574|Compound:2',4'-dihydroxychalcone|FD-Score:-3.44|P-value:1.20E-4 ID:SGTC_2576|Compound:guaiol|FD-Score:3.10|P-value:5.06E-4 ID:SGTC_2780|Compound:5215298|FD-Score:3.88|P-value:1.89E-5 ID:SGTC_2782|Compound:7736369|FD-Score:3.03|P-value:6.53E-4 ID:SGTC_2786|Compound:7743617|FD-Score:3.14|P-value:4.25E-4 ID:SGTC_2814|Compound:7977482|FD-Score:3.01|P-value:7.06E-4 ID:SGTC_2880|Compound:9042983|FD-Score:3.12|P-value:4.68E-4 ID:SGTC_2977|Compound:9011197|FD-Score:-3.72|P-value:3.56E-5 ID:SGTC_3073|Compound:9114972|FD-Score:3.60|P-value:6.60E-5 ID:SGTC_3090|Compound:9117696|FD-Score:4.15|P-value:5.24E-6 ID:SGTC_3136|Compound:9095672|FD-Score:-3.21|P-value:3.05E-4 ID:SGTC_3141|Compound:9094609|FD-Score:-3.12|P-value:4.29E-4 ID:SGTC_3235|Compound:9132602|FD-Score:4.43|P-value:1.25E-6 ID:SGTC_103|Compound:0844-0104|FD-Score:11.70|P-value:1.24E-35 ID:SGTC_270|Compound:tamoxifen|FD-Score:3.77|P-value:3.17E-5 ID:SGTC_353|Compound:1988-1175|FD-Score:3.13|P-value:4.47E-4 ID:SGTC_402|Compound:epigallocatechin gallate|FD-Score:-2.89|P-value:9.94E-4 ID:SGTC_432|Compound:NS 1619|FD-Score:2.94|P-value:9.00E-4 ID:SGTC_440|Compound:fluspirilene|FD-Score:4.66|P-value:3.71E-7 ID:SGTC_462|Compound:ag-879|FD-Score:-2.98|P-value:7.21E-4 ID:SGTC_472|Compound:calcifediol|FD-Score:3.19|P-value:3.55E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:3.00|P-value:7.21E-4 ID:SGTC_605|Compound:1315-0399|FD-Score:3.15|P-value:4.11E-4 ID:SGTC_609|Compound:0986-0026|FD-Score:4.83|P-value:1.41E-7 ID:SGTC_616|Compound:4092-0450|FD-Score:2.97|P-value:8.12E-4 ID:SGTC_621|Compound:3584-0052|FD-Score:5.31|P-value:8.24E-9 ID:SGTC_631|Compound:k072-0230|FD-Score:3.79|P-value:2.85E-5 ID:SGTC_997|Compound:3996-0078|FD-Score:-2.91|P-value:9.34E-4 ID:SGTC_1053|Compound:3366-3204|FD-Score:-3.81|P-value:2.40E-5 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:4.32|P-value:2.22E-6 ID:SGTC_1161|Compound:k007-0610|FD-Score:3.83|P-value:2.38E-5 ID:SGTC_1512|Compound:0259-0544|FD-Score:-3.10|P-value:4.59E-4 ID:SGTC_1513|Compound:0337-0559|FD-Score:-3.37|P-value:1.58E-4 ID:SGTC_1581|Compound:himbacine|FD-Score:-3.10|P-value:4.71E-4 ID:SGTC_1610|Compound:st001799|FD-Score:3.68|P-value:4.68E-5 ID:SGTC_1682|Compound:st012968|FD-Score:-3.71|P-value:3.68E-5 ID:SGTC_1685|Compound:st024049|FD-Score:3.19|P-value:3.63E-4 ID:SGTC_1829|Compound:berberine|FD-Score:2.96|P-value:8.58E-4 ID:SGTC_1892|Compound:st058411|FD-Score:3.36|P-value:1.79E-4 ID:SGTC_1985|Compound:st071382|FD-Score:-2.99|P-value:6.97E-4 ID:SGTC_1990|Compound:st072050|FD-Score:-3.80|P-value:2.51E-5 ID:SGTC_1991|Compound:st073000|FD-Score:3.57|P-value:7.47E-5 ID:SGTC_1993|Compound:st073995|FD-Score:5.00|P-value:5.31E-8 ID:SGTC_2075|Compound:5212009|FD-Score:3.24|P-value:2.89E-4 ID:SGTC_2148|Compound:5546263|FD-Score:-3.67|P-value:4.53E-5 ID:SGTC_2150|Compound:5556613|FD-Score:-2.91|P-value:9.40E-4 ID:SGTC_2157|Compound:5649910|FD-Score:-2.99|P-value:7.07E-4 ID:SGTC_2183|Compound:6420625|FD-Score:-3.47|P-value:1.06E-4 ID:SGTC_2307|Compound:7538926|FD-Score:3.07|P-value:5.62E-4 ID:SGTC_2318|Compound:6029776|FD-Score:6.36|P-value:6.83E-12 ID:SGTC_2379|Compound:9035213|FD-Score:3.94|P-value:1.46E-5 ID:SGTC_2476|Compound:5806916|FD-Score:3.41|P-value:1.48E-4 ID:SGTC_2533|Compound:agelasine|FD-Score:3.40|P-value:1.56E-4 ID:SGTC_2574|Compound:2',4'-dihydroxychalcone|FD-Score:-3.44|P-value:1.20E-4 ID:SGTC_2576|Compound:guaiol|FD-Score:3.10|P-value:5.06E-4 ID:SGTC_2780|Compound:5215298|FD-Score:3.88|P-value:1.89E-5 ID:SGTC_2782|Compound:7736369|FD-Score:3.03|P-value:6.53E-4 ID:SGTC_2786|Compound:7743617|FD-Score:3.14|P-value:4.25E-4 ID:SGTC_2814|Compound:7977482|FD-Score:3.01|P-value:7.06E-4 ID:SGTC_2880|Compound:9042983|FD-Score:3.12|P-value:4.68E-4 ID:SGTC_2977|Compound:9011197|FD-Score:-3.72|P-value:3.56E-5 ID:SGTC_3073|Compound:9114972|FD-Score:3.60|P-value:6.60E-5 ID:SGTC_3090|Compound:9117696|FD-Score:4.15|P-value:5.24E-6 ID:SGTC_3136|Compound:9095672|FD-Score:-3.21|P-value:3.05E-4 ID:SGTC_3141|Compound:9094609|FD-Score:-3.12|P-value:4.29E-4 ID:SGTC_3235|Compound:9132602|FD-Score:4.43|P-value:1.25E-6

Top fitness defect scores for YAL051W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_103 0844-0104 11.70 51.8 µM 1.24E-35 ERAD & cell cycle 20 9.75E-32
2 SGTC_2318 6029776 6.36 164.0 µM 6.83E-12 4 9.92E-11
3 SGTC_621 3584-0052 5.31 32.1 µM 8.24E-9 9 5.36E-8
4 SGTC_1993 st073995 5.00 70.8 µM 5.31E-8 7 2.80E-7
5 SGTC_609 0986-0026 4.83 86.3 µM 1.41E-7 calcium & mitochondrial duress 15 6.66E-7
6 SGTC_440 fluspirilene 4.66 35.1 µM 3.71E-7 5 1.57E-6
7 SGTC_3235 9132602 4.43 49.5 µM 1.25E-6 13 4.64E-6
8 SGTC_1083 didemethylchlorpromazine sulfoxide 4.32 707.4 nM 2.22E-6 redox potentiating 59 7.73E-6
9 SGTC_3090 9117696 4.15 49.5 µM 5.24E-6 13 1.66E-5
10 SGTC_2379 9035213 3.94 200.0 µM 1.46E-5 22 4.13E-5
11 SGTC_2780 5215298 3.88 71.4 µM 1.89E-5 41 5.19E-5
12 SGTC_1161 k007-0610 3.83 110.0 µM 2.38E-5 ERAD & cell cycle 126 6.36E-5
13 SGTC_631 k072-0230 3.79 41.5 µM 2.85E-5 60S ribosome export 20 7.49E-5
14 SGTC_270 tamoxifen 3.77 5.5 µM 3.17E-5 NEO1 36 8.22E-5
15 SGTC_1610 st001799 3.68 48.1 µM 4.68E-5 17 1.16E-4
16 SGTC_3073 9114972 3.60 49.5 µM 6.60E-5 60S ribosome export 19 1.58E-4
17 SGTC_1991 st073000 3.57 8.9 µM 7.47E-5 NEO1 94 1.76E-4
18 SGTC_2476 5806916 3.41 10.5 µM 1.48E-4 29 3.24E-4
19 SGTC_2533 agelasine 3.40 13.7 µM 1.56E-4 ERG2 74 3.39E-4
20 SGTC_1892 st058411 3.36 7.4 µM 1.79E-4 48 3.85E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.323 1.41E-82 YDL148C NOP14 het Nucleolar protein, forms a complex with Noc4p that mediates maturation and nuclear export of 40S ribosomal subunits; also present in the small subunit processome complex, which is required for processing of pre-18S rRNA
0.235 3.04E-43 YOL065C INP54 hom Phosphatidylinositol 4,5-bisphosphate 5-phosphatase with a role in secretion, localizes to the endoplasmic reticulum via the C-terminal tail; lacks the Sac1 domain and proline-rich region found in the other 3 INP proteins
0.219 1.32E-37 YOR363C PIP2 hom Autoregulatory oleate-specific transcriptional activator of peroxisome proliferation, contains Zn(2)-Cys(6) cluster domain, forms heterodimer with Oaf1p, binds oleate response elements (OREs), activates beta-oxidation genes; PIP2 has a paralog, OAF1, that arose from the whole genome duplication
0.196 2.00E-30 YER041W YEN1 hom Holliday junction resolvase; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation; homolog of human GEN1 and has similarity to S. cerevisiae endonuclease Rth1p
0.191 5.17E-29 YDL126C CDC48 het AAA ATPase involved in multiple processes; subunit of polyubiquitin-selective segregase complex involved in ERAD, cell wall integrity during heat stress, mitotic spindle disassembly; subunit of complex involved in mitochondria-associated degradation; role in mobilizing membrane bound transcription factors by regulated ubiquitin/proteasome-dependent processing; roles in macroautophagy, PMN, RAD, ribophagy, and homotypic ER membrane fusion; functional ortholog of human p97/VCP
0.191 7.79E-29 YDL122W UBP1 hom Ubiquitin-specific protease that removes ubiquitin from ubiquitinated proteins; cleaves at the C terminus of ubiquitin fusions irrespective of their size; capable of cleaving polyubiquitin chains
0.186 1.24E-27 YDR186C YDR186C hom Putative protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.186 1.39E-27 YNL179C_d YNL179C_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; deletion in cyr1 mutant results in loss of stress resistance
0.183 8.36E-27 YPL117C IDI1 het Isopentenyl diphosphate:dimethylallyl diphosphate isomerase (IPP isomerase), catalyzes an essential activation step in the isoprenoid biosynthetic pathway; required for viability
0.182 1.80E-26 YMR052W FAR3 hom Protein of unknown function; involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far7p, Far8p, Far9p, Far10p, and Far11p; localizes to the endoplasmic reticulum; protein abundance increases in response to DNA replication stress
0.182 1.96E-26 YMR029C FAR8 hom Protein involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far3p, Far7p, Far9p, Far10p, and Far11p
0.176 9.66E-25 YNL149C PGA2 het Essential protein required for maturation of Gas1p and Pho8p; involved in protein trafficking; GFP-fusion protein localizes to the ER and YFP-fusion protein to the nuclear envelope-ER network; null mutants have a cell separation defect
0.173 6.11E-24 YMR276W DSK2 hom Nuclear-enriched ubiquitin-like polyubiquitin-binding protein; required for spindle pole body (SPB) duplication and for transit through the G2/M phase of the cell cycle; involved in proteolysis; interacts with the proteasome; protein abundance increases in response to DNA replication stress
0.170 4.50E-23 YML105C SEC65 het Subunit of the signal recognition particle (SRP), involved in protein targeting to the ER; interacts with Srp54p; homolog of mammalian SRP19
0.170 4.27E-23 YER084W_p YER084W_p hom Protein of unknown function; expressed at both mRNA and protein levels