YAL060W / BDH1

NAD-dependent (R,R)-butanediol dehydrogenase, catalyzes oxidation of (R,R)-2,3-butanediol to (3R)-acetoin, oxidation of meso-butanediol to (3S)-acetoin, and reduction of acetoin; enhances use of 2,3-butanediol as an aerobic carbon source

Zygosity: Homozygous strain
fixedexpanded
Profile for YAL060W / BDH1

Click on Significant Values for Screen Details ID:SGTC_162|Compound:k030-0015|FD-Score:3.79|P-value:1.26E-4 ID:SGTC_166|Compound:k072-0058|FD-Score:-4.71|P-value:2.67E-6 ID:SGTC_406|Compound:estrone|FD-Score:3.33|P-value:6.53E-4 ID:SGTC_474|Compound:dl-dihydrosphingosine|FD-Score:4.00|P-value:5.49E-5 ID:SGTC_497|Compound:capsazepine|FD-Score:-3.33|P-value:6.33E-4 ID:SGTC_544|Compound:k015-0020|FD-Score:3.31|P-value:6.85E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-4.23|P-value:2.16E-5 ID:SGTC_878|Compound:0828-0289|FD-Score:-4.51|P-value:6.47E-6 ID:SGTC_1100|Compound:amiodarone|FD-Score:3.24|P-value:8.70E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-7.85|P-value:1.67E-14 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:-3.52|P-value:3.35E-4 ID:SGTC_1152|Compound:3909-8331|FD-Score:3.70|P-value:1.76E-4 ID:SGTC_1240|Compound:0356-0016|FD-Score:3.75|P-value:1.47E-4 ID:SGTC_1242|Compound:0402-0103|FD-Score:7.27|P-value:1.05E-12 ID:SGTC_1244|Compound:0416-0015|FD-Score:-5.46|P-value:6.62E-8 ID:SGTC_1251|Compound:0490-5699|FD-Score:6.34|P-value:4.36E-10 ID:SGTC_1290|Compound:0986-0249|FD-Score:-3.34|P-value:6.13E-4 ID:SGTC_1303|Compound:1160-0052|FD-Score:-5.12|P-value:3.79E-7 ID:SGTC_1316|Compound:1272-0050|FD-Score:-3.34|P-value:6.28E-4 ID:SGTC_1505|Compound:k297-0037|FD-Score:-3.42|P-value:4.73E-4 ID:SGTC_1563|Compound:conessine|FD-Score:3.52|P-value:3.32E-4 ID:SGTC_1738|Compound:st035555|FD-Score:3.36|P-value:5.91E-4 ID:SGTC_1741|Compound:st038134|FD-Score:4.61|P-value:4.25E-6 ID:SGTC_1878|Compound:temozolomide|FD-Score:3.23|P-value:9.13E-4 ID:SGTC_2103|Compound:5378138|FD-Score:3.85|P-value:9.79E-5 ID:SGTC_2121|Compound:5257820|FD-Score:4.16|P-value:2.93E-5 ID:SGTC_2272|Compound:7805186|FD-Score:5.05|P-value:5.41E-7 ID:SGTC_2325|Compound:6158266|FD-Score:-3.86|P-value:9.36E-5 ID:SGTC_2338|Compound:7999974|FD-Score:3.86|P-value:9.69E-5 ID:SGTC_2442|Compound:5158906|FD-Score:4.26|P-value:1.88E-5 ID:SGTC_2451|Compound:5856223|FD-Score:-5.92|P-value:5.24E-9 ID:SGTC_2452|Compound:5863136|FD-Score:-5.82|P-value:9.01E-9 ID:SGTC_2563|Compound:tomatine|FD-Score:5.75|P-value:1.39E-8 ID:SGTC_2568|Compound:diosmetin|FD-Score:4.54|P-value:5.83E-6 ID:SGTC_2602|Compound:kawain|FD-Score:3.98|P-value:6.06E-5 ID:SGTC_2692|Compound:st077426|FD-Score:3.67|P-value:1.94E-4 ID:SGTC_2693|Compound:st077581|FD-Score:3.28|P-value:7.71E-4 ID:SGTC_2862|Compound:9027634|FD-Score:-3.37|P-value:5.60E-4 ID:SGTC_2876|Compound:9059903|FD-Score:4.31|P-value:1.58E-5 ID:SGTC_3014|Compound:9081533|FD-Score:3.87|P-value:9.34E-5 ID:SGTC_3018|Compound:9082602|FD-Score:3.49|P-value:3.66E-4 ID:SGTC_3332|Compound:9141069|FD-Score:-4.04|P-value:4.69E-5 ID:SGTC_162|Compound:k030-0015|FD-Score:3.79|P-value:1.26E-4 ID:SGTC_166|Compound:k072-0058|FD-Score:-4.71|P-value:2.67E-6 ID:SGTC_406|Compound:estrone|FD-Score:3.33|P-value:6.53E-4 ID:SGTC_474|Compound:dl-dihydrosphingosine|FD-Score:4.00|P-value:5.49E-5 ID:SGTC_497|Compound:capsazepine|FD-Score:-3.33|P-value:6.33E-4 ID:SGTC_544|Compound:k015-0020|FD-Score:3.31|P-value:6.85E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-4.23|P-value:2.16E-5 ID:SGTC_878|Compound:0828-0289|FD-Score:-4.51|P-value:6.47E-6 ID:SGTC_1100|Compound:amiodarone|FD-Score:3.24|P-value:8.70E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-7.85|P-value:1.67E-14 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:-3.52|P-value:3.35E-4 ID:SGTC_1152|Compound:3909-8331|FD-Score:3.70|P-value:1.76E-4 ID:SGTC_1240|Compound:0356-0016|FD-Score:3.75|P-value:1.47E-4 ID:SGTC_1242|Compound:0402-0103|FD-Score:7.27|P-value:1.05E-12 ID:SGTC_1244|Compound:0416-0015|FD-Score:-5.46|P-value:6.62E-8 ID:SGTC_1251|Compound:0490-5699|FD-Score:6.34|P-value:4.36E-10 ID:SGTC_1290|Compound:0986-0249|FD-Score:-3.34|P-value:6.13E-4 ID:SGTC_1303|Compound:1160-0052|FD-Score:-5.12|P-value:3.79E-7 ID:SGTC_1316|Compound:1272-0050|FD-Score:-3.34|P-value:6.28E-4 ID:SGTC_1505|Compound:k297-0037|FD-Score:-3.42|P-value:4.73E-4 ID:SGTC_1563|Compound:conessine|FD-Score:3.52|P-value:3.32E-4 ID:SGTC_1738|Compound:st035555|FD-Score:3.36|P-value:5.91E-4 ID:SGTC_1741|Compound:st038134|FD-Score:4.61|P-value:4.25E-6 ID:SGTC_1878|Compound:temozolomide|FD-Score:3.23|P-value:9.13E-4 ID:SGTC_2103|Compound:5378138|FD-Score:3.85|P-value:9.79E-5 ID:SGTC_2121|Compound:5257820|FD-Score:4.16|P-value:2.93E-5 ID:SGTC_2272|Compound:7805186|FD-Score:5.05|P-value:5.41E-7 ID:SGTC_2325|Compound:6158266|FD-Score:-3.86|P-value:9.36E-5 ID:SGTC_2338|Compound:7999974|FD-Score:3.86|P-value:9.69E-5 ID:SGTC_2442|Compound:5158906|FD-Score:4.26|P-value:1.88E-5 ID:SGTC_2451|Compound:5856223|FD-Score:-5.92|P-value:5.24E-9 ID:SGTC_2452|Compound:5863136|FD-Score:-5.82|P-value:9.01E-9 ID:SGTC_2563|Compound:tomatine|FD-Score:5.75|P-value:1.39E-8 ID:SGTC_2568|Compound:diosmetin|FD-Score:4.54|P-value:5.83E-6 ID:SGTC_2602|Compound:kawain|FD-Score:3.98|P-value:6.06E-5 ID:SGTC_2692|Compound:st077426|FD-Score:3.67|P-value:1.94E-4 ID:SGTC_2693|Compound:st077581|FD-Score:3.28|P-value:7.71E-4 ID:SGTC_2862|Compound:9027634|FD-Score:-3.37|P-value:5.60E-4 ID:SGTC_2876|Compound:9059903|FD-Score:4.31|P-value:1.58E-5 ID:SGTC_3014|Compound:9081533|FD-Score:3.87|P-value:9.34E-5 ID:SGTC_3018|Compound:9082602|FD-Score:3.49|P-value:3.66E-4 ID:SGTC_3332|Compound:9141069|FD-Score:-4.04|P-value:4.69E-5

Top fitness defect scores for YAL060W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1242 0402-0103 7.27 60.1 µM 1.05E-12 6 1.78E-13
2 SGTC_1251 0490-5699 6.34 265.0 µM 4.36E-10 8 1.12E-10
3 SGTC_2563 tomatine 5.75 8.5 µM 1.39E-8 11 4.52E-9
4 SGTC_2272 7805186 5.05 180.0 µM 5.41E-7 cell wall signaling 10 2.26E-7
5 SGTC_1741 st038134 4.61 10.2 µM 4.25E-6 17 2.04E-6
6 SGTC_2568 diosmetin 4.54 100.0 µM 5.83E-6 16 2.86E-6
7 SGTC_2876 9059903 4.31 26.0 µM 1.58E-5 4 8.28E-6
8 SGTC_2442 5158906 4.26 48.5 µM 1.88E-5 13 1.00E-5
9 SGTC_2121 5257820 4.16 149.6 µM 2.93E-5 9 1.60E-5
10 SGTC_474 dl-dihydrosphingosine 4.00 5.0 µM 5.49E-5 26 3.13E-5
11 SGTC_2602 kawain 3.98 100.0 µM 6.06E-5 28 3.48E-5
12 SGTC_3014 9081533 3.87 49.5 µM 9.34E-5 11 5.52E-5
13 SGTC_2338 7999974 3.86 200.0 µM 9.69E-5 25 5.75E-5
14 SGTC_2103 5378138 3.85 10.0 µM 9.79E-5 19 5.81E-5
15 SGTC_162 k030-0015 3.79 37.8 µM 1.26E-4 iron homeostasis 24 7.60E-5
16 SGTC_1240 0356-0016 3.75 42.1 µM 1.47E-4 mitochondrial response to ROS 42 8.95E-5
17 SGTC_1152 3909-8331 3.70 15.9 µM 1.76E-4 14 1.09E-4
18 SGTC_2692 st077426 3.67 47.7 µM 1.94E-4 29 1.20E-4
19 SGTC_1563 conessine 3.52 56.1 µM 3.32E-4 29 2.14E-4
20 SGTC_3018 9082602 3.49 49.5 µM 3.66E-4 59 2.37E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.239 9.40E-45 YFL063W_d YFL063W_d hom Dubious open reading frame, based on available experimental and comparative sequence data
0.229 3.03E-41 YDL110C TMA17 hom Protein of unknown function that associates with ribosomes; heterozygous deletion demonstrated increases in chromosome instability in a rad9 deletion background; protein abundance is decreased upon intracellular iron depletion
0.220 3.31E-38 YBR262C AIM5 hom Mitochondrial inner membrane protein; subunit of the mitochondrial inner membrane organizing system (MitOS, MICOS, or MINOS), a scaffold-like structure on the intermembrane space side of the inner membrane which has a role in the maintenance of crista junctions and inner membrane architecture
0.219 1.22E-37 YLR353W BUD8 hom Protein involved in bud-site selection; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern, and bud at the proximal pole
0.217 6.30E-37 YBL036C YBL036C hom Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS
0.200 1.18E-31 YLR016C PML1 hom Subunit of the RES complex, which is required for nuclear retention of unspliced pre-mRNAs; acts in the same pathway as Pml39p and Mlp1p
0.200 1.22E-31 YDR122W KIN1 hom Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; closely related to Kin2p
0.195 4.21E-30 YOR298C-A MBF1 hom Transcriptional coactivator; bridges the DNA-binding region of Gcn4p and TATA-binding protein Spt15p; suppressor of frameshift mutations; protein abundance increases in response to DNA replication stress
0.195 5.50E-30 YER067C-A_d YER067C-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YER067W
0.194 7.54E-30 YKL179C COY1 hom Golgi membrane protein with similarity to mammalian CASP; genetic interactions with GOS1 (encoding a Golgi snare protein) suggest a role in Golgi function
0.188 5.24E-28 YLR205C HMX1 hom ER localized heme oxygenase, involved in heme degradation during iron starvation and in the oxidative stress response; expression is regulated by AFT1 and oxidative stress; relocates to the perinuclear region in the presence of oxidants
0.188 5.43E-28 YBL066C SEF1 hom Putative transcription factor, has homolog in Kluyveromyces lactis
0.188 5.64E-28 YBL015W ACH1 hom Protein with CoA transferase activity, particularly for CoASH transfer from succinyl-CoA to acetate; has minor acetyl-CoA-hydrolase activity; phosphorylated; required for acetate utilization and for diploid pseudohyphal growth
0.186 1.84E-27 YDR210W_p YDR210W_p hom Predicted tail-anchored plasma membrane protein containing a conserved CYSTM module; related proteins in other organisms may be involved in response to stress; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
0.186 2.18E-27 YKL220C FRE2 hom Ferric reductase and cupric reductase, reduces siderophore-bound iron and oxidized copper prior to uptake by transporters; expression induced by low iron levels but not by low copper levels