YAL061W_p / BDH2

Putative medium-chain alcohol dehydrogenase with similarity to BDH1; transcription induced by constitutively active PDR1 and PDR3

Zygosity: Homozygous strain
fixedexpanded
Profile for YAL061W / BDH2

Click on Significant Values for Screen Details ID:SGTC_6|Compound:0844-0013|FD-Score:2.96|P-value:3.95E-4 ID:SGTC_16|Compound:erodoxin|FD-Score:-2.93|P-value:6.63E-4 ID:SGTC_67|Compound:0335-0847|FD-Score:2.74|P-value:9.49E-4 ID:SGTC_130|Compound:0136-0219|FD-Score:2.86|P-value:5.91E-4 ID:SGTC_165|Compound:k038-0023|FD-Score:-4.72|P-value:9.83E-8 ID:SGTC_166|Compound:k072-0058|FD-Score:-6.34|P-value:1.25E-12 ID:SGTC_363|Compound:0455-0021|FD-Score:-3.58|P-value:4.20E-5 ID:SGTC_633|Compound:0437-0093|FD-Score:-2.93|P-value:6.66E-4 ID:SGTC_640|Compound:3381-0960|FD-Score:3.52|P-value:3.43E-5 ID:SGTC_692|Compound:k241-0027|FD-Score:3.46|P-value:4.51E-5 ID:SGTC_750|Compound:4073-0104|FD-Score:-3.44|P-value:7.99E-5 ID:SGTC_775|Compound:4577-0580|FD-Score:-4.57|P-value:2.43E-7 ID:SGTC_776|Compound:4476-4378|FD-Score:3.28|P-value:1.04E-4 ID:SGTC_782|Compound:0083-0095|FD-Score:-5.86|P-value:4.96E-11 ID:SGTC_785|Compound:1270-0111|FD-Score:-4.29|P-value:1.16E-6 ID:SGTC_791|Compound:1348-1292|FD-Score:-3.23|P-value:1.98E-4 ID:SGTC_796|Compound:1234-0020|FD-Score:-3.04|P-value:4.28E-4 ID:SGTC_812|Compound:4251-0442|FD-Score:3.22|P-value:1.35E-4 ID:SGTC_893|Compound:0958-0369|FD-Score:2.72|P-value:9.93E-4 ID:SGTC_898|Compound:1000-0849|FD-Score:2.84|P-value:6.40E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-7.05|P-value:3.07E-15 ID:SGTC_1290|Compound:0986-0249|FD-Score:-4.17|P-value:2.21E-6 ID:SGTC_1448|Compound:4255-0083|FD-Score:2.87|P-value:5.62E-4 ID:SGTC_1459|Compound:k035-0031|FD-Score:-3.48|P-value:6.56E-5 ID:SGTC_1615|Compound:st002656|FD-Score:-3.42|P-value:8.59E-5 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-2.88|P-value:8.04E-4 ID:SGTC_2097|Compound:5376186|FD-Score:2.75|P-value:8.98E-4 ID:SGTC_2103|Compound:5378138|FD-Score:3.04|P-value:2.90E-4 ID:SGTC_2118|Compound:5526350|FD-Score:-3.08|P-value:3.64E-4 ID:SGTC_2270|Compound:7924575|FD-Score:2.89|P-value:5.24E-4 ID:SGTC_2336|Compound:9001819|FD-Score:3.13|P-value:1.96E-4 ID:SGTC_2344|Compound:7990960|FD-Score:-2.89|P-value:7.89E-4 ID:SGTC_2354|Compound:9060492|FD-Score:-2.90|P-value:7.62E-4 ID:SGTC_2357|Compound:9067248|FD-Score:-4.56|P-value:2.59E-7 ID:SGTC_2393|Compound:9031399|FD-Score:10.40|P-value:7.26E-32 ID:SGTC_2396|Compound:5342950|FD-Score:3.66|P-value:1.80E-5 ID:SGTC_2397|Compound:5161689|FD-Score:-3.89|P-value:9.62E-6 ID:SGTC_2398|Compound:5228213|FD-Score:3.06|P-value:2.58E-4 ID:SGTC_2400|Compound:5203494|FD-Score:-10.40|P-value:2.40E-31 ID:SGTC_2425|Compound:5628681|FD-Score:2.81|P-value:7.13E-4 ID:SGTC_2568|Compound:diosmetin|FD-Score:2.96|P-value:3.88E-4 ID:SGTC_2757|Compound:clomiphene|FD-Score:2.76|P-value:8.68E-4 ID:SGTC_2830|Compound:7992007|FD-Score:-2.96|P-value:5.87E-4 ID:SGTC_2832|Compound:7992762|FD-Score:-3.45|P-value:7.54E-5 ID:SGTC_2834|Compound:9001755|FD-Score:-3.44|P-value:7.85E-5 ID:SGTC_2851|Compound:9015922|FD-Score:3.01|P-value:3.19E-4 ID:SGTC_2993|Compound:9054257|FD-Score:-3.35|P-value:1.19E-4 ID:SGTC_3165|Compound:9101544|FD-Score:3.11|P-value:2.17E-4 ID:SGTC_3218|Compound:9131285|FD-Score:2.76|P-value:8.79E-4 ID:SGTC_3265|Compound:9137266|FD-Score:3.33|P-value:8.24E-5 ID:SGTC_3272|Compound:9137413|FD-Score:-2.92|P-value:6.84E-4 ID:SGTC_6|Compound:0844-0013|FD-Score:2.96|P-value:3.95E-4 ID:SGTC_16|Compound:erodoxin|FD-Score:-2.93|P-value:6.63E-4 ID:SGTC_67|Compound:0335-0847|FD-Score:2.74|P-value:9.49E-4 ID:SGTC_130|Compound:0136-0219|FD-Score:2.86|P-value:5.91E-4 ID:SGTC_165|Compound:k038-0023|FD-Score:-4.72|P-value:9.83E-8 ID:SGTC_166|Compound:k072-0058|FD-Score:-6.34|P-value:1.25E-12 ID:SGTC_363|Compound:0455-0021|FD-Score:-3.58|P-value:4.20E-5 ID:SGTC_633|Compound:0437-0093|FD-Score:-2.93|P-value:6.66E-4 ID:SGTC_640|Compound:3381-0960|FD-Score:3.52|P-value:3.43E-5 ID:SGTC_692|Compound:k241-0027|FD-Score:3.46|P-value:4.51E-5 ID:SGTC_750|Compound:4073-0104|FD-Score:-3.44|P-value:7.99E-5 ID:SGTC_775|Compound:4577-0580|FD-Score:-4.57|P-value:2.43E-7 ID:SGTC_776|Compound:4476-4378|FD-Score:3.28|P-value:1.04E-4 ID:SGTC_782|Compound:0083-0095|FD-Score:-5.86|P-value:4.96E-11 ID:SGTC_785|Compound:1270-0111|FD-Score:-4.29|P-value:1.16E-6 ID:SGTC_791|Compound:1348-1292|FD-Score:-3.23|P-value:1.98E-4 ID:SGTC_796|Compound:1234-0020|FD-Score:-3.04|P-value:4.28E-4 ID:SGTC_812|Compound:4251-0442|FD-Score:3.22|P-value:1.35E-4 ID:SGTC_893|Compound:0958-0369|FD-Score:2.72|P-value:9.93E-4 ID:SGTC_898|Compound:1000-0849|FD-Score:2.84|P-value:6.40E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-7.05|P-value:3.07E-15 ID:SGTC_1290|Compound:0986-0249|FD-Score:-4.17|P-value:2.21E-6 ID:SGTC_1448|Compound:4255-0083|FD-Score:2.87|P-value:5.62E-4 ID:SGTC_1459|Compound:k035-0031|FD-Score:-3.48|P-value:6.56E-5 ID:SGTC_1615|Compound:st002656|FD-Score:-3.42|P-value:8.59E-5 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-2.88|P-value:8.04E-4 ID:SGTC_2097|Compound:5376186|FD-Score:2.75|P-value:8.98E-4 ID:SGTC_2103|Compound:5378138|FD-Score:3.04|P-value:2.90E-4 ID:SGTC_2118|Compound:5526350|FD-Score:-3.08|P-value:3.64E-4 ID:SGTC_2270|Compound:7924575|FD-Score:2.89|P-value:5.24E-4 ID:SGTC_2336|Compound:9001819|FD-Score:3.13|P-value:1.96E-4 ID:SGTC_2344|Compound:7990960|FD-Score:-2.89|P-value:7.89E-4 ID:SGTC_2354|Compound:9060492|FD-Score:-2.90|P-value:7.62E-4 ID:SGTC_2357|Compound:9067248|FD-Score:-4.56|P-value:2.59E-7 ID:SGTC_2393|Compound:9031399|FD-Score:10.40|P-value:7.26E-32 ID:SGTC_2396|Compound:5342950|FD-Score:3.66|P-value:1.80E-5 ID:SGTC_2397|Compound:5161689|FD-Score:-3.89|P-value:9.62E-6 ID:SGTC_2398|Compound:5228213|FD-Score:3.06|P-value:2.58E-4 ID:SGTC_2400|Compound:5203494|FD-Score:-10.40|P-value:2.40E-31 ID:SGTC_2425|Compound:5628681|FD-Score:2.81|P-value:7.13E-4 ID:SGTC_2568|Compound:diosmetin|FD-Score:2.96|P-value:3.88E-4 ID:SGTC_2757|Compound:clomiphene|FD-Score:2.76|P-value:8.68E-4 ID:SGTC_2830|Compound:7992007|FD-Score:-2.96|P-value:5.87E-4 ID:SGTC_2832|Compound:7992762|FD-Score:-3.45|P-value:7.54E-5 ID:SGTC_2834|Compound:9001755|FD-Score:-3.44|P-value:7.85E-5 ID:SGTC_2851|Compound:9015922|FD-Score:3.01|P-value:3.19E-4 ID:SGTC_2993|Compound:9054257|FD-Score:-3.35|P-value:1.19E-4 ID:SGTC_3165|Compound:9101544|FD-Score:3.11|P-value:2.17E-4 ID:SGTC_3218|Compound:9131285|FD-Score:2.76|P-value:8.79E-4 ID:SGTC_3265|Compound:9137266|FD-Score:3.33|P-value:8.24E-5 ID:SGTC_3272|Compound:9137413|FD-Score:-2.92|P-value:6.84E-4

Top fitness defect scores for YAL061W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature		Screen
Rank
Screen
P-value
1 SGTC_2393 9031399 10.40 185.9 µM 7.26E-32 RNA processing & uracil transport 2 8.37E-26
2 SGTC_2396 5342950 3.66 42.8 µM 1.80E-5 RSC complex & mRNA processing 56 1.28E-4
3 SGTC_640 3381-0960 3.52 37.1 µM 3.43E-5 25 2.15E-4
4 SGTC_692 k241-0027 3.46 77.8 µM 4.51E-5 19 2.68E-4
5 SGTC_3265 9137266 3.33 49.5 µM 8.24E-5 22 4.35E-4
6 SGTC_776 4476-4378 3.28 112.0 µM 1.04E-4 ERG2 42 5.24E-4
7 SGTC_812 4251-0442 3.22 148.0 µM 1.35E-4 24 6.47E-4
8 SGTC_2336 9001819 3.13 198.7 µM 1.96E-4 heme biosynthesis & mitochondrial translocase 89 8.74E-4
9 SGTC_3165 9101544 3.11 49.5 µM 2.17E-4 32 9.48E-4
10 SGTC_2398 5228213 3.06 48.8 µM 2.58E-4 iron homeostasis 101 0.00109
11 SGTC_2103 5378138 3.04 10.0 µM 2.90E-4 56 0.00120
12 SGTC_2851 9015922 3.01 71.4 µM 3.19E-4 91 0.00129
13 SGTC_2568 diosmetin 2.96 100.0 µM 3.88E-4 73 0.00152
14 SGTC_6 0844-0013 2.96 19.8 µM 3.95E-4 218 0.00154
15 SGTC_2270 7924575 2.89 90.9 µM 5.24E-4 RPP1 & pyrimidine depletion 71 0.00193
16 SGTC_1448 4255-0083 2.87 152.0 µM 5.62E-4 ERG2 70 0.00204
17 SGTC_130 0136-0219 2.86 337.7 µM 5.91E-4 77 0.00213
18 SGTC_898 1000-0849 2.84 28.3 µM 6.40E-4 39 0.00227
19 SGTC_2425 5628681 2.81 7.8 µM 7.13E-4 92 0.00247
20 SGTC_2757 clomiphene 2.76 4.2 µM 8.68E-4 fatty acid desaturase (OLE1) 121 0.00290

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.326 8.83E-84 YKL220C FRE2 hom Ferric reductase and cupric reductase, reduces siderophore-bound iron and oxidized copper prior to uptake by transporters; expression induced by low iron levels but not by low copper levels
0.304 6.85E-73 YBR118W TEF2 hom Translational elongation factor EF-1 alpha; also encoded by TEF1; functions in the binding reaction of aminoacyl-tRNA (AA-tRNA) to ribosomes; may also have a role in tRNA re-export from the nucleus; TEF2 has a paralog, TEF1, that arose from the whole genome duplication
0.254 1.13E-50 YLR326W_p YLR326W_p hom Putative protein of unknown function, predicted to be palmitoylated
0.231 8.13E-42 YKL140W TGL1 hom Steryl ester hydrolase, one of three gene products (Yeh1p, Yeh2p, Tgl1p) responsible for steryl ester hydrolase activity and involved in sterol homeostasis; localized to lipid particle membranes
0.227 1.26E-40 YKL122C SRP21 het Subunit of the signal recognition particle (SRP), which functions in protein targeting to the endoplasmic reticulum membrane; not found in mammalian SRP; forms a pre-SRP structure in the nucleolus that is translocated to the cytoplasm
0.210 7.11E-35 YBR262C AIM5 hom Mitochondrial inner membrane protein; subunit of the mitochondrial inner membrane organizing system (MitOS, MICOS, or MINOS), a scaffold-like structure on the intermembrane space side of the inner membrane which has a role in the maintenance of crista junctions and inner membrane architecture
0.209 1.63E-34 YKL179C COY1 hom Golgi membrane protein with similarity to mammalian CASP; genetic interactions with GOS1 (encoding a Golgi snare protein) suggest a role in Golgi function
0.203 1.78E-32 YFL063W_d YFL063W_d hom Dubious open reading frame, based on available experimental and comparative sequence data
0.195 3.17E-30 YBL036C YBL036C hom Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS
0.188 4.10E-28 YOR298C-A MBF1 hom Transcriptional coactivator; bridges the DNA-binding region of Gcn4p and TATA-binding protein Spt15p; suppressor of frameshift mutations; protein abundance increases in response to DNA replication stress
0.186 2.00E-27 YLR353W BUD8 hom Protein involved in bud-site selection; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern, and bud at the proximal pole
0.181 4.79E-26 YCR102W-A_d YCR102W-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.177 5.12E-25 YDR139C RUB1 hom Ubiquitin-like protein with similarity to mammalian NEDD8; conjugation (neddylation) substrates include the cullins Cdc53p, Rtt101p, and Cul3p; activated by Ula1p and Uba3p (E1 enzyme pair); conjugation mediated by Ubc12p (E2 enzyme)
0.172 9.47E-24 YJR048W CYC1 hom Cytochrome c, isoform 1; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration; CYC1 has a paralog, CYC7, that arose from the whole genome duplication
0.170 3.48E-23 YOR208W PTP2 hom Phosphotyrosine-specific protein phosphatase involved in the inactivation of mitogen-activated protein kinase (MAPK) during osmolarity sensing; dephosporylates Hog1p MAPK and regulates its localization; localized to the nucleus