YAL068C / PAU8

Protein of unknown function, member of the seripauperin multigene family encoded mainly in subtelomeric regions

Zygosity: Homozygous strain
fixedexpanded
Profile for YAL068C / PAU8

Click on Significant Values for Screen Details ID:SGTC_27|Compound:0485-0001|FD-Score:2.87|P-value:6.75E-4 ID:SGTC_126|Compound:0417-1624|FD-Score:-2.98|P-value:4.17E-4 ID:SGTC_181|Compound:1447-1644|FD-Score:4.11|P-value:2.20E-6 ID:SGTC_182|Compound:3448-4371|FD-Score:4.65|P-value:1.02E-7 ID:SGTC_378|Compound:3970-0959|FD-Score:2.87|P-value:6.79E-4 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:-4.75|P-value:5.32E-8 ID:SGTC_768|Compound:0384-0033|FD-Score:-2.80|P-value:8.56E-4 ID:SGTC_855|Compound:0428-0020|FD-Score:2.88|P-value:6.39E-4 ID:SGTC_870|Compound:0573-2213|FD-Score:-3.95|P-value:4.89E-6 ID:SGTC_879|Compound:0831-1030|FD-Score:-4.40|P-value:4.12E-7 ID:SGTC_916|Compound:4466-0038|FD-Score:3.16|P-value:2.06E-4 ID:SGTC_931|Compound:2812-0076|FD-Score:-2.93|P-value:5.10E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-4.38|P-value:4.66E-7 ID:SGTC_1118|Compound:chelidonine|FD-Score:2.90|P-value:5.96E-4 ID:SGTC_1192|Compound:1488-0095|FD-Score:-3.27|P-value:1.26E-4 ID:SGTC_1194|Compound:1488-0194|FD-Score:2.80|P-value:8.68E-4 ID:SGTC_1269|Compound:0831-0796|FD-Score:2.83|P-value:7.74E-4 ID:SGTC_1314|Compound:1222-0010|FD-Score:-3.88|P-value:6.99E-6 ID:SGTC_1317|Compound:1273-0028|FD-Score:-2.94|P-value:5.04E-4 ID:SGTC_1382|Compound:3002-2117|FD-Score:3.19|P-value:1.85E-4 ID:SGTC_1721|Compound:st082152|FD-Score:-4.58|P-value:1.52E-7 ID:SGTC_1724|Compound:st037281|FD-Score:-3.38|P-value:7.78E-5 ID:SGTC_1875|Compound:nocodazole|FD-Score:2.78|P-value:9.52E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.67|P-value:1.95E-5 ID:SGTC_2107|Compound:5363541|FD-Score:2.85|P-value:7.18E-4 ID:SGTC_2121|Compound:5257820|FD-Score:3.24|P-value:1.50E-4 ID:SGTC_2264|Compound:7948757|FD-Score:-3.79|P-value:1.10E-5 ID:SGTC_2274|Compound:7947094|FD-Score:-2.79|P-value:9.06E-4 ID:SGTC_2291|Compound:7917025|FD-Score:-3.73|P-value:1.51E-5 ID:SGTC_2303|Compound:7774051|FD-Score:5.31|P-value:1.52E-9 ID:SGTC_2469|Compound:5655019|FD-Score:2.88|P-value:6.51E-4 ID:SGTC_2551|Compound:apiole|FD-Score:3.10|P-value:2.62E-4 ID:SGTC_2629|Compound:bisabolol|FD-Score:2.91|P-value:5.80E-4 ID:SGTC_3034|Compound:9090421|FD-Score:3.07|P-value:3.07E-4 ID:SGTC_3157|Compound:9099274|FD-Score:3.35|P-value:8.95E-5 ID:SGTC_3272|Compound:9137413|FD-Score:-3.21|P-value:1.65E-4 ID:SGTC_27|Compound:0485-0001|FD-Score:2.87|P-value:6.75E-4 ID:SGTC_126|Compound:0417-1624|FD-Score:-2.98|P-value:4.17E-4 ID:SGTC_181|Compound:1447-1644|FD-Score:4.11|P-value:2.20E-6 ID:SGTC_182|Compound:3448-4371|FD-Score:4.65|P-value:1.02E-7 ID:SGTC_378|Compound:3970-0959|FD-Score:2.87|P-value:6.79E-4 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:-4.75|P-value:5.32E-8 ID:SGTC_768|Compound:0384-0033|FD-Score:-2.80|P-value:8.56E-4 ID:SGTC_855|Compound:0428-0020|FD-Score:2.88|P-value:6.39E-4 ID:SGTC_870|Compound:0573-2213|FD-Score:-3.95|P-value:4.89E-6 ID:SGTC_879|Compound:0831-1030|FD-Score:-4.40|P-value:4.12E-7 ID:SGTC_916|Compound:4466-0038|FD-Score:3.16|P-value:2.06E-4 ID:SGTC_931|Compound:2812-0076|FD-Score:-2.93|P-value:5.10E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-4.38|P-value:4.66E-7 ID:SGTC_1118|Compound:chelidonine|FD-Score:2.90|P-value:5.96E-4 ID:SGTC_1192|Compound:1488-0095|FD-Score:-3.27|P-value:1.26E-4 ID:SGTC_1194|Compound:1488-0194|FD-Score:2.80|P-value:8.68E-4 ID:SGTC_1269|Compound:0831-0796|FD-Score:2.83|P-value:7.74E-4 ID:SGTC_1314|Compound:1222-0010|FD-Score:-3.88|P-value:6.99E-6 ID:SGTC_1317|Compound:1273-0028|FD-Score:-2.94|P-value:5.04E-4 ID:SGTC_1382|Compound:3002-2117|FD-Score:3.19|P-value:1.85E-4 ID:SGTC_1721|Compound:st082152|FD-Score:-4.58|P-value:1.52E-7 ID:SGTC_1724|Compound:st037281|FD-Score:-3.38|P-value:7.78E-5 ID:SGTC_1875|Compound:nocodazole|FD-Score:2.78|P-value:9.52E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.67|P-value:1.95E-5 ID:SGTC_2107|Compound:5363541|FD-Score:2.85|P-value:7.18E-4 ID:SGTC_2121|Compound:5257820|FD-Score:3.24|P-value:1.50E-4 ID:SGTC_2264|Compound:7948757|FD-Score:-3.79|P-value:1.10E-5 ID:SGTC_2274|Compound:7947094|FD-Score:-2.79|P-value:9.06E-4 ID:SGTC_2291|Compound:7917025|FD-Score:-3.73|P-value:1.51E-5 ID:SGTC_2303|Compound:7774051|FD-Score:5.31|P-value:1.52E-9 ID:SGTC_2469|Compound:5655019|FD-Score:2.88|P-value:6.51E-4 ID:SGTC_2551|Compound:apiole|FD-Score:3.10|P-value:2.62E-4 ID:SGTC_2629|Compound:bisabolol|FD-Score:2.91|P-value:5.80E-4 ID:SGTC_3034|Compound:9090421|FD-Score:3.07|P-value:3.07E-4 ID:SGTC_3157|Compound:9099274|FD-Score:3.35|P-value:8.95E-5 ID:SGTC_3272|Compound:9137413|FD-Score:-3.21|P-value:1.65E-4

Top fitness defect scores for YAL068C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2303 7774051 5.31 200.0 µM 1.52E-9 8 5.62E-8
2 SGTC_182 3448-4371 4.65 550.5 µM 1.02E-7 15 1.67E-6
3 SGTC_181 1447-1644 4.11 8.1 µM 2.20E-6 endomembrane recycling 31 1.98E-5
4 SGTC_3157 9099274 3.35 49.5 µM 8.95E-5 33 3.98E-4
5 SGTC_2121 5257820 3.24 149.6 µM 1.50E-4 29 6.06E-4
6 SGTC_1382 3002-2117 3.19 298.0 µM 1.85E-4 32 7.18E-4
7 SGTC_916 4466-0038 3.16 42.0 nM 2.06E-4 cell wall 122 7.81E-4
8 SGTC_2551 apiole 3.10 73.9 µM 2.62E-4 27 9.52E-4
9 SGTC_3034 9090421 3.07 49.5 µM 3.07E-4 60S ribosome export 25 0.00108
10 SGTC_2629 bisabolol 2.91 100.0 µM 5.80E-4 79 0.00182
11 SGTC_1118 chelidonine 2.90 707.5 nM 5.96E-4 65 0.00186
12 SGTC_855 0428-0020 2.88 25.0 µM 6.39E-4 Golgi 60 0.00196
13 SGTC_2469 5655019 2.88 90.8 µM 6.51E-4 71 0.00199
14 SGTC_27 0485-0001 2.87 32.6 µM 6.75E-4 RPP1 & pyrimidine depletion 33 0.00205
15 SGTC_378 3970-0959 2.87 8.3 µM 6.79E-4 62 0.00206
16 SGTC_2107 5363541 2.85 170.2 µM 7.18E-4 47 0.00216
17 SGTC_1269 0831-0796 2.83 3.0 µM 7.74E-4 60S ribosome export 52 0.00230
18 SGTC_1194 1488-0194 2.80 225.0 µM 8.68E-4 95 0.00252
19 SGTC_1875 nocodazole 2.78 6.0 µM 9.52E-4 tubulin folding & SWR complex 98 0.00272
20 SGTC_612 0302-0167 2.77 22.4 µM 0.00101 copper-dependent oxidative stress 115 0.00284

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.207 1.00E-33 YER030W CHZ1 hom Histone chaperone for Htz1p/H2A-H2B dimer; required for the stabilization of the Chz1p-Htz1-H2B complex; has overlapping function with Nap1p; null mutant displays weak sensitivity to MMS and benomyl; contains a highly conserved CHZ motif; protein abundance increases in response to DNA replication stress
0.200 1.45E-31 YOR012W_p YOR012W_p hom Putative protein of unknown function
0.192 2.65E-29 YLR401C DUS3 hom Dihydrouridine synthase; member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus4p; contains a consensus oleate response element (ORE) in its promoter region; forms nuclear foci upon DNA replication stress
0.173 4.65E-24 YBL036C YBL036C hom Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS
0.172 1.02E-23 YIL089W YIL089W hom Protein of unknown function found in the ER and vacuole lumen; overexpression of YIL089W affects endocytic protein trafficking
0.157 6.57E-20 YER064C VHR2 hom Non-essential nuclear protein; null mutation has global effects on transcription; VHR2 has a paralog, VHR1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress
0.156 8.94E-20 YGL096W TOS8 hom Homeodomain-containing protein and putative transcription factor; found associated with chromatin; target of SBF transcription factor; induced during meiosis and under cell-damaging conditions; TOS8 has a paralog, CUP9, that arose from the whole genome duplication
0.155 1.39E-19 YDR044W HEM13 het Coproporphyrinogen III oxidase, an oxygen requiring enzyme that catalyzes the sixth step in the heme biosynthetic pathway; transcription is repressed by oxygen and heme (via Rox1p and Hap1p)
0.154 3.34E-19 YDL138W RGT2 hom Plasma membrane high glucose sensor that regulates glucose transport; contains 12 predicted transmembrane segments and a long C-terminal tail required for induction of hexose transporters; RGT2 has a paralog, SNF3, that arose from the whole genome duplication
0.148 6.40E-18 YGR097W ASK10 hom Component of RNA polymerase II holoenzyme; phosphorylated in response to oxidative stress; has a role in destruction of Ssn8p; proposed to function in activation of the glycerol channel Fps1p; ASK10 has a paralog, RGC1, that arose from the whole genome duplication
0.146 1.79E-17 YOR163W DDP1 hom Polyphosphate phosphatase; hydrolyzes diphosphorylated inositol polyphosphates and diadenosine polyphosphates; high specificity for diadenosine hexa- and pentaphosphates; contains endopolyphosphatase activity with a high affinity for polyphosphates, an activity also observed for its human DIPP homologs; possesses mRNA decapping activity; nudix hydrolase family member; protein abundance increases in response to DNA replication stress
0.139 5.32E-16 YLR346C_p YLR346C_p hom Putative protein of unknown function found in mitochondria; expression is regulated by transcription factors involved in pleiotropic drug resistance, Pdr1p and Yrr1p; YLR346C is not an essential gene
0.139 7.68E-16 YCL076W_d YCL076W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.138 9.05E-16 YGR025W_d YGR025W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.136 2.47E-15 YDR122W KIN1 hom Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; closely related to Kin2p