YAR018C / KIN3

Nonessential serine/threonine protein kinase; possible role in DNA damage response

Zygosity: Homozygous strain
fixedexpanded
Profile for YAR018C / KIN3

Click on Significant Values for Screen Details ID:SGTC_501|Compound:nsc-95397|FD-Score:4.22|P-value:3.51E-5 ID:SGTC_616|Compound:4092-0450|FD-Score:-3.80|P-value:1.49E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:-3.25|P-value:9.69E-4 ID:SGTC_713|Compound:1488-1073|FD-Score:3.30|P-value:9.54E-4 ID:SGTC_930|Compound:2810-3379|FD-Score:3.41|P-value:6.72E-4 ID:SGTC_1026|Compound:k007-1105|FD-Score:3.51|P-value:4.86E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:-6.27|P-value:1.23E-9 ID:SGTC_1156|Compound:4092-0367|FD-Score:4.35|P-value:2.09E-5 ID:SGTC_1248|Compound:0469-0687|FD-Score:3.69|P-value:2.55E-4 ID:SGTC_1434|Compound:4073-0095|FD-Score:3.32|P-value:8.81E-4 ID:SGTC_1460|Compound:k062-0059|FD-Score:3.45|P-value:5.80E-4 ID:SGTC_1472|Compound:k841-0093|FD-Score:3.59|P-value:3.62E-4 ID:SGTC_1513|Compound:0337-0559|FD-Score:-3.90|P-value:1.00E-4 ID:SGTC_1688|Compound:st021091|FD-Score:-4.10|P-value:4.80E-5 ID:SGTC_1700|Compound:st030840|FD-Score:3.61|P-value:3.45E-4 ID:SGTC_1827|Compound:berberine|FD-Score:-3.29|P-value:8.60E-4 ID:SGTC_1835|Compound:st008666|FD-Score:4.01|P-value:7.81E-5 ID:SGTC_1884|Compound:5633444|FD-Score:3.37|P-value:7.51E-4 ID:SGTC_2282|Compound:7944268|FD-Score:-4.49|P-value:9.48E-6 ID:SGTC_2358|Compound:9037157|FD-Score:-4.29|P-value:2.16E-5 ID:SGTC_2379|Compound:9035213|FD-Score:3.72|P-value:2.27E-4 ID:SGTC_2385|Compound:9074692|FD-Score:3.66|P-value:2.81E-4 ID:SGTC_2398|Compound:5228213|FD-Score:4.00|P-value:8.22E-5 ID:SGTC_2407|Compound:paclitaxel|FD-Score:3.62|P-value:3.27E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:-4.70|P-value:3.82E-6 ID:SGTC_2589|Compound:lobaric acid|FD-Score:3.79|P-value:1.78E-4 ID:SGTC_2809|Compound:7964133|FD-Score:3.56|P-value:4.06E-4 ID:SGTC_2856|Compound:9022925|FD-Score:-5.24|P-value:3.07E-7 ID:SGTC_2858|Compound:9025781|FD-Score:-7.39|P-value:1.12E-12 ID:SGTC_2929|Compound:9013348|FD-Score:8.32|P-value:1.87E-15 ID:SGTC_2940|Compound:9060638|FD-Score:-3.88|P-value:1.10E-4 ID:SGTC_3052|Compound:9092717|FD-Score:5.20|P-value:4.66E-7 ID:SGTC_3212|Compound:9128307|FD-Score:3.83|P-value:1.53E-4 ID:SGTC_501|Compound:nsc-95397|FD-Score:4.22|P-value:3.51E-5 ID:SGTC_616|Compound:4092-0450|FD-Score:-3.80|P-value:1.49E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:-3.25|P-value:9.69E-4 ID:SGTC_713|Compound:1488-1073|FD-Score:3.30|P-value:9.54E-4 ID:SGTC_930|Compound:2810-3379|FD-Score:3.41|P-value:6.72E-4 ID:SGTC_1026|Compound:k007-1105|FD-Score:3.51|P-value:4.86E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:-6.27|P-value:1.23E-9 ID:SGTC_1156|Compound:4092-0367|FD-Score:4.35|P-value:2.09E-5 ID:SGTC_1248|Compound:0469-0687|FD-Score:3.69|P-value:2.55E-4 ID:SGTC_1434|Compound:4073-0095|FD-Score:3.32|P-value:8.81E-4 ID:SGTC_1460|Compound:k062-0059|FD-Score:3.45|P-value:5.80E-4 ID:SGTC_1472|Compound:k841-0093|FD-Score:3.59|P-value:3.62E-4 ID:SGTC_1513|Compound:0337-0559|FD-Score:-3.90|P-value:1.00E-4 ID:SGTC_1688|Compound:st021091|FD-Score:-4.10|P-value:4.80E-5 ID:SGTC_1700|Compound:st030840|FD-Score:3.61|P-value:3.45E-4 ID:SGTC_1827|Compound:berberine|FD-Score:-3.29|P-value:8.60E-4 ID:SGTC_1835|Compound:st008666|FD-Score:4.01|P-value:7.81E-5 ID:SGTC_1884|Compound:5633444|FD-Score:3.37|P-value:7.51E-4 ID:SGTC_2282|Compound:7944268|FD-Score:-4.49|P-value:9.48E-6 ID:SGTC_2358|Compound:9037157|FD-Score:-4.29|P-value:2.16E-5 ID:SGTC_2379|Compound:9035213|FD-Score:3.72|P-value:2.27E-4 ID:SGTC_2385|Compound:9074692|FD-Score:3.66|P-value:2.81E-4 ID:SGTC_2398|Compound:5228213|FD-Score:4.00|P-value:8.22E-5 ID:SGTC_2407|Compound:paclitaxel|FD-Score:3.62|P-value:3.27E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:-4.70|P-value:3.82E-6 ID:SGTC_2589|Compound:lobaric acid|FD-Score:3.79|P-value:1.78E-4 ID:SGTC_2809|Compound:7964133|FD-Score:3.56|P-value:4.06E-4 ID:SGTC_2856|Compound:9022925|FD-Score:-5.24|P-value:3.07E-7 ID:SGTC_2858|Compound:9025781|FD-Score:-7.39|P-value:1.12E-12 ID:SGTC_2929|Compound:9013348|FD-Score:8.32|P-value:1.87E-15 ID:SGTC_2940|Compound:9060638|FD-Score:-3.88|P-value:1.10E-4 ID:SGTC_3052|Compound:9092717|FD-Score:5.20|P-value:4.66E-7 ID:SGTC_3212|Compound:9128307|FD-Score:3.83|P-value:1.53E-4

Top fitness defect scores for YAR018C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature		Screen
Rank
Screen
P-value
1 SGTC_2929 9013348 8.32 24.6 µM 1.87E-15 2 4.24E-17
2 SGTC_3052 9092717 5.20 49.5 µM 4.66E-7 5 9.87E-8
3 SGTC_1156 4092-0367 4.35 4.9 µM 2.09E-5 11 6.84E-6
4 SGTC_501 nsc-95397 4.22 161.0 µM 3.51E-5 10 1.22E-5
5 SGTC_1835 st008666 4.01 49.2 µM 7.81E-5 23 2.98E-5
6 SGTC_2398 5228213 4.00 48.8 µM 8.22E-5 iron homeostasis 36 3.15E-5
7 SGTC_3212 9128307 3.83 49.5 µM 1.53E-4 47 6.32E-5
8 SGTC_2589 lobaric acid 3.79 100.0 µM 1.78E-4 27 7.46E-5
9 SGTC_2379 9035213 3.72 200.0 µM 2.27E-4 28 9.77E-5
10 SGTC_1248 0469-0687 3.69 58.6 µM 2.55E-4 37 1.11E-4
11 SGTC_2385 9074692 3.66 200.0 µM 2.81E-4 54 1.24E-4
12 SGTC_2407 paclitaxel 3.62 400.0 µM 3.27E-4 49 1.47E-4
13 SGTC_1700 st030840 3.61 7.9 µM 3.45E-4 PDR1 26 1.56E-4
14 SGTC_1472 k841-0093 3.59 193.0 µM 3.62E-4 26 1.64E-4
15 SGTC_2809 7964133 3.56 13.0 µM 4.06E-4 60S ribosome export 54 1.87E-4
16 SGTC_1026 k007-1105 3.51 30.6 µM 4.86E-4 ERAD & cell cycle 118 2.28E-4
17 SGTC_1460 k062-0059 3.45 9.2 µM 5.80E-4 Golgi 28 2.78E-4
18 SGTC_930 2810-3379 3.41 265.0 µM 6.72E-4 23 3.27E-4
19 SGTC_1884 5633444 3.37 25.0 µM 7.51E-4 redox potentiating 82 3.70E-4
20 SGTC_1434 4073-0095 3.32 163.0 µM 8.81E-4 21 4.42E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.117 9.46E-12 YLR367W RPS22B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S15A and bacterial S8; RPS22B has a paralog, RPS22A, that arose from the whole genome duplication
0.103 2.35E-9 YOR329C SCD5 het Protein required for normal actin organization and endocytosis; targeting subunit for protein phosphatase type 1; undergoes Crm1p-dependent nuclear-cytoplasmic shuttling; multicopy suppressor of clathrin deficiency
0.092 9.86E-8 YDR317W HIM1 hom Protein of unknown function involved in DNA repair
0.091 1.47E-7 YDL110C TMA17 hom Protein of unknown function that associates with ribosomes; heterozygous deletion demonstrated increases in chromosome instability in a rad9 deletion background; protein abundance is decreased upon intracellular iron depletion
0.089 2.30E-7 YNL214W PEX17 hom Peroxisomal membrane peroxin and subunit of the docking complex that facilitates the import of peroxisomal matrix proteins; required for peroxisome biogenesis
0.088 3.06E-7 YKL218C SRY1 hom 3-hydroxyaspartate dehydratase, deaminates L-threo-3-hydroxyaspartate to form oxaloacetate and ammonia; required in the presence of hydroxyaspartate; highly similar to mouse serine racemase (Srr) but has no serine racemase activity
0.088 3.11E-7 YGR173W RBG2 hom Protein with a role in translation; forms a complex with Gir2p; has similarity to mammalian developmentally regulated GTP-binding protein
0.087 4.03E-7 YDR097C MSH6 hom Protein required for mismatch repair in mitosis and meiosis, forms a complex with Msh2p to repair both single-base & insertion-deletion mispairs; also involved in interstrand cross-link repair; potentially phosphorylated by Cdc28p
0.084 1.10E-6 YKL082C RRP14 het Essential protein, constituent of 66S pre-ribosomal particles; interacts with proteins involved in ribosomal biogenesis and cell polarity; member of the SURF-6 family
0.084 1.21E-6 YDR525W_d API2_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 26% of ORF overlaps the dubious ORF YDR524C-A; insertion mutation in a cdc34-2 mutant background causes altered bud morphology
0.084 1.25E-6 YDR210W_p YDR210W_p hom Predicted tail-anchored plasma membrane protein containing a conserved CYSTM module; related proteins in other organisms may be involved in response to stress; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
0.083 1.43E-6 YDR088C SLU7 het RNA splicing factor, required for ATP-independent portion of 2nd catalytic step of spliceosomal RNA splicing; interacts with Prp18p; contains zinc knuckle domain
0.082 1.77E-6 YMR016C SOK2 hom Nuclear protein that negatively regulates pseudohyphal differentiation; plays a regulatory role in the cyclic AMP (cAMP)-dependent protein kinase (PKA) signal transduction pathway; SOK2 has a paralog, PHD1, that arose from the whole genome duplication
0.082 1.84E-6 YOR064C YNG1 hom Subunit of the NuA3 histone acetyltransferase complex that acetylates histone H3; contains PHD finger domain that interacts with methylated histone H3, has similarity to the human tumor suppressor ING1
0.080 3.98E-6 YPL005W AEP3 hom Protein that may facilitate use of unformylated tRNA-Met in mitochondrial translation initiation; localized to the matrix face of the mitochondrial inner membrane; stabilizes the bicistronic AAP1-ATP6 mRNA