YAR020C / PAU7

Member of the seripauperin multigene family, active during alcoholic fermentation, regulated by anaerobiosis, inhibited by oxygen, repressed by heme

Zygosity: Homozygous strain
fixedexpanded
Profile for YAR020C / PAU7

Click on Significant Values for Screen Details ID:SGTC_94|Compound:0334-0113|FD-Score:3.37|P-value:3.10E-4 ID:SGTC_479|Compound:n-linoleoylglycine|FD-Score:3.10|P-value:8.38E-4 ID:SGTC_672|Compound:1441-0018|FD-Score:3.15|P-value:6.90E-4 ID:SGTC_777|Compound:1315-0167|FD-Score:3.85|P-value:4.70E-5 ID:SGTC_938|Compound:3126-1755|FD-Score:-4.57|P-value:1.44E-6 ID:SGTC_945|Compound:3381-0768|FD-Score:4.19|P-value:1.03E-5 ID:SGTC_990|Compound:3985-0011|FD-Score:3.08|P-value:9.00E-4 ID:SGTC_1117|Compound:retinoic acid|FD-Score:3.06|P-value:9.74E-4 ID:SGTC_1314|Compound:1222-0010|FD-Score:3.67|P-value:9.58E-5 ID:SGTC_1345|Compound:1488-0192|FD-Score:3.35|P-value:3.37E-4 ID:SGTC_1451|Compound:4152-0210|FD-Score:3.98|P-value:2.64E-5 ID:SGTC_1456|Compound:k015-0012|FD-Score:6.85|P-value:1.62E-12 ID:SGTC_1458|Compound:k015-0034|FD-Score:4.33|P-value:5.47E-6 ID:SGTC_1504|Compound:k297-0033|FD-Score:3.10|P-value:8.24E-4 ID:SGTC_1519|Compound:esterone|FD-Score:3.64|P-value:1.09E-4 ID:SGTC_1726|Compound:st035556|FD-Score:3.53|P-value:1.74E-4 ID:SGTC_1760|Compound:st045453|FD-Score:3.28|P-value:4.40E-4 ID:SGTC_1771|Compound:st048882|FD-Score:4.41|P-value:3.70E-6 ID:SGTC_1779|Compound:st039427|FD-Score:3.88|P-value:4.05E-5 ID:SGTC_1793|Compound:st048256|FD-Score:4.24|P-value:8.28E-6 ID:SGTC_1957|Compound:st077035|FD-Score:4.22|P-value:9.24E-6 ID:SGTC_1960|Compound:st011366|FD-Score:3.64|P-value:1.09E-4 ID:SGTC_1968|Compound:st069590|FD-Score:5.52|P-value:9.85E-9 ID:SGTC_1969|Compound:st069479|FD-Score:-5.56|P-value:6.14E-9 ID:SGTC_1971|Compound:st069429|FD-Score:-5.83|P-value:1.21E-9 ID:SGTC_1998|Compound:st075797|FD-Score:3.13|P-value:7.49E-4 ID:SGTC_2038|Compound:4100038|FD-Score:3.57|P-value:1.46E-4 ID:SGTC_2050|Compound:5263056|FD-Score:-3.05|P-value:8.67E-4 ID:SGTC_2070|Compound:5230947|FD-Score:3.17|P-value:6.46E-4 ID:SGTC_2097|Compound:5376186|FD-Score:3.78|P-value:6.23E-5 ID:SGTC_2108|Compound:5365811|FD-Score:3.78|P-value:6.34E-5 ID:SGTC_2374|Compound:9071832|FD-Score:3.13|P-value:7.49E-4 ID:SGTC_2397|Compound:5161689|FD-Score:3.75|P-value:6.94E-5 ID:SGTC_2464|Compound:5717415|FD-Score:4.21|P-value:9.68E-6 ID:SGTC_2585|Compound:alliin|FD-Score:-4.55|P-value:1.56E-6 ID:SGTC_2652|Compound:actinonin|FD-Score:3.86|P-value:4.51E-5 ID:SGTC_2815|Compound:7968870|FD-Score:-4.16|P-value:9.96E-6 ID:SGTC_2864|Compound:9034755|FD-Score:3.09|P-value:8.77E-4 ID:SGTC_2900|Compound:5328528|FD-Score:-3.45|P-value:2.03E-4 ID:SGTC_3056|Compound:9094900|FD-Score:-3.87|P-value:3.62E-5 ID:SGTC_3102|Compound:9121669|FD-Score:4.15|P-value:1.24E-5 ID:SGTC_3103|Compound:9120822|FD-Score:3.08|P-value:8.83E-4 ID:SGTC_3109|Compound:9122853|FD-Score:3.47|P-value:2.11E-4 ID:SGTC_3111|Compound:9122088|FD-Score:-3.14|P-value:6.40E-4 ID:SGTC_3116|Compound:9124943|FD-Score:-3.12|P-value:6.81E-4 ID:SGTC_3139|Compound:9095020|FD-Score:-3.09|P-value:7.59E-4 ID:SGTC_3265|Compound:9137266|FD-Score:-3.15|P-value:6.17E-4 ID:SGTC_3278|Compound:9139605|FD-Score:-3.41|P-value:2.34E-4 ID:SGTC_94|Compound:0334-0113|FD-Score:3.37|P-value:3.10E-4 ID:SGTC_479|Compound:n-linoleoylglycine|FD-Score:3.10|P-value:8.38E-4 ID:SGTC_672|Compound:1441-0018|FD-Score:3.15|P-value:6.90E-4 ID:SGTC_777|Compound:1315-0167|FD-Score:3.85|P-value:4.70E-5 ID:SGTC_938|Compound:3126-1755|FD-Score:-4.57|P-value:1.44E-6 ID:SGTC_945|Compound:3381-0768|FD-Score:4.19|P-value:1.03E-5 ID:SGTC_990|Compound:3985-0011|FD-Score:3.08|P-value:9.00E-4 ID:SGTC_1117|Compound:retinoic acid|FD-Score:3.06|P-value:9.74E-4 ID:SGTC_1314|Compound:1222-0010|FD-Score:3.67|P-value:9.58E-5 ID:SGTC_1345|Compound:1488-0192|FD-Score:3.35|P-value:3.37E-4 ID:SGTC_1451|Compound:4152-0210|FD-Score:3.98|P-value:2.64E-5 ID:SGTC_1456|Compound:k015-0012|FD-Score:6.85|P-value:1.62E-12 ID:SGTC_1458|Compound:k015-0034|FD-Score:4.33|P-value:5.47E-6 ID:SGTC_1504|Compound:k297-0033|FD-Score:3.10|P-value:8.24E-4 ID:SGTC_1519|Compound:esterone|FD-Score:3.64|P-value:1.09E-4 ID:SGTC_1726|Compound:st035556|FD-Score:3.53|P-value:1.74E-4 ID:SGTC_1760|Compound:st045453|FD-Score:3.28|P-value:4.40E-4 ID:SGTC_1771|Compound:st048882|FD-Score:4.41|P-value:3.70E-6 ID:SGTC_1779|Compound:st039427|FD-Score:3.88|P-value:4.05E-5 ID:SGTC_1793|Compound:st048256|FD-Score:4.24|P-value:8.28E-6 ID:SGTC_1957|Compound:st077035|FD-Score:4.22|P-value:9.24E-6 ID:SGTC_1960|Compound:st011366|FD-Score:3.64|P-value:1.09E-4 ID:SGTC_1968|Compound:st069590|FD-Score:5.52|P-value:9.85E-9 ID:SGTC_1969|Compound:st069479|FD-Score:-5.56|P-value:6.14E-9 ID:SGTC_1971|Compound:st069429|FD-Score:-5.83|P-value:1.21E-9 ID:SGTC_1998|Compound:st075797|FD-Score:3.13|P-value:7.49E-4 ID:SGTC_2038|Compound:4100038|FD-Score:3.57|P-value:1.46E-4 ID:SGTC_2050|Compound:5263056|FD-Score:-3.05|P-value:8.67E-4 ID:SGTC_2070|Compound:5230947|FD-Score:3.17|P-value:6.46E-4 ID:SGTC_2097|Compound:5376186|FD-Score:3.78|P-value:6.23E-5 ID:SGTC_2108|Compound:5365811|FD-Score:3.78|P-value:6.34E-5 ID:SGTC_2374|Compound:9071832|FD-Score:3.13|P-value:7.49E-4 ID:SGTC_2397|Compound:5161689|FD-Score:3.75|P-value:6.94E-5 ID:SGTC_2464|Compound:5717415|FD-Score:4.21|P-value:9.68E-6 ID:SGTC_2585|Compound:alliin|FD-Score:-4.55|P-value:1.56E-6 ID:SGTC_2652|Compound:actinonin|FD-Score:3.86|P-value:4.51E-5 ID:SGTC_2815|Compound:7968870|FD-Score:-4.16|P-value:9.96E-6 ID:SGTC_2864|Compound:9034755|FD-Score:3.09|P-value:8.77E-4 ID:SGTC_2900|Compound:5328528|FD-Score:-3.45|P-value:2.03E-4 ID:SGTC_3056|Compound:9094900|FD-Score:-3.87|P-value:3.62E-5 ID:SGTC_3102|Compound:9121669|FD-Score:4.15|P-value:1.24E-5 ID:SGTC_3103|Compound:9120822|FD-Score:3.08|P-value:8.83E-4 ID:SGTC_3109|Compound:9122853|FD-Score:3.47|P-value:2.11E-4 ID:SGTC_3111|Compound:9122088|FD-Score:-3.14|P-value:6.40E-4 ID:SGTC_3116|Compound:9124943|FD-Score:-3.12|P-value:6.81E-4 ID:SGTC_3139|Compound:9095020|FD-Score:-3.09|P-value:7.59E-4 ID:SGTC_3265|Compound:9137266|FD-Score:-3.15|P-value:6.17E-4 ID:SGTC_3278|Compound:9139605|FD-Score:-3.41|P-value:2.34E-4

Top fitness defect scores for YAR020C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1456 k015-0012 6.85 13.0 µM 1.62E-12 3 3.78E-12
2 SGTC_1968 st069590 5.52 43.6 µM 9.85E-9 4 1.68E-8
3 SGTC_1771 st048882 4.41 4.2 µM 3.70E-6 RPP1 & pyrimidine depletion 11 5.14E-6
4 SGTC_1458 k015-0034 4.33 6.3 µM 5.47E-6 11 7.50E-6
5 SGTC_1793 st048256 4.24 72.2 µM 8.28E-6 2 1.12E-5
6 SGTC_1957 st077035 4.22 62.4 µM 9.24E-6 11 1.24E-5
7 SGTC_2464 5717415 4.21 7.7 µM 9.68E-6 11 1.30E-5
8 SGTC_945 3381-0768 4.19 11.3 µM 1.03E-5 endomembrane recycling 29 1.38E-5
9 SGTC_3102 9121669 4.15 49.5 µM 1.24E-5 6 1.65E-5
10 SGTC_1451 4152-0210 3.98 104.0 µM 2.64E-5 25 3.43E-5
11 SGTC_1779 st039427 3.88 55.0 µM 4.05E-5 31 5.18E-5
12 SGTC_2652 actinonin 3.86 100.0 µM 4.51E-5 4 5.76E-5
13 SGTC_777 1315-0167 3.85 517.0 µM 4.70E-5 Golgi 28 5.99E-5
14 SGTC_2097 5376186 3.78 200.0 µM 6.23E-5 24 7.86E-5
15 SGTC_2108 5365811 3.78 200.0 µM 6.34E-5 17 7.99E-5
16 SGTC_2397 5161689 3.75 200.0 µM 6.94E-5 43 8.73E-5
17 SGTC_1314 1222-0010 3.67 41.1 µM 9.58E-5 15 1.19E-4
18 SGTC_1519 esterone 3.64 74.0 µM 1.09E-4 DNA intercalators 25 1.35E-4
19 SGTC_1960 st011366 3.64 51.8 µM 1.09E-4 15 1.35E-4
20 SGTC_2038 4100038 3.57 31.0 µM 1.46E-4 plasma membrane duress 66 1.79E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.100 6.56E-9 YOR193W PEX27 hom Peripheral peroxisomal membrane protein involved in controlling peroxisome size and number, interacts with homologous protein Pex25p
0.095 4.03E-8 YIR004W DJP1 hom Cytosolic J-domain-containing protein, required for peroxisomal protein import and involved in peroxisome assembly, homologous to E. coli DnaJ
0.093 6.63E-8 YLL025W PAU17 hom Protein of unknown function, member of the seripauperin multigene family encoded mainly in subtelomeric regions; YLL025W is not an essential gene
0.093 7.00E-8 YNL065W AQR1 hom Plasma membrane transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; confers resistance to short-chain monocarboxylic acids and quinidine; involved in the excretion of excess amino acids; AQR1 has a paralog, QDR1, that arose from the whole genome duplication; relocalizes from plasma membrane to cytoplasm upon DNA replication stress
0.088 3.55E-7 YPR167C MET16 hom 3'-phosphoadenylsulfate reductase, reduces 3'-phosphoadenylyl sulfate to adenosine-3',5'-bisphosphate and free sulfite using reduced thioredoxin as cosubstrate, involved in sulfate assimilation and methionine metabolism
0.087 3.94E-7 YDR153C ENT5 hom Protein containing an N-terminal epsin-like domain involved in clathrin recruitment and traffic between the Golgi and endosomes; associates with the clathrin adaptor Gga2p, clathrin adaptor complex AP-1, and clathrin
0.087 4.25E-7 YGL181W GTS1 hom Protein involved in Arf3p regulation and in transcription regulation; localizes to the nucleus and to endocytic patches; contains an N-terminal Zn-finger and ArfGAP homology domain, a C-terminal glutamine-rich region, and a UBA (ubiquitin associated) domain; gts1 mutations affect budding, cell size, heat tolerance, sporulation, life span, ultradian rhythms, endocytosis; expression oscillates in a pattern similar to metabolic oscillations
0.086 6.29E-7 YKR040C_d YKR040C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YKR041W
0.086 6.65E-7 YHR108W GGA2 hom Protein that interacts with and regulates Arf1p and Arf2p in a GTP-dependent manner to facilitate traffic through the late Golgi; binds phosphatidylinositol 4-phosphate, which plays a role in TGN localization; has homology to gamma-adaptin
0.083 1.55E-6 YLL005C SPO75 hom Meiosis-specific protein of unknown function, required for spore wall formation during sporulation; dispensable for both nuclear divisions during meiosis
0.079 4.48E-6 YCL023C_d YCL023C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF KCC4
0.079 4.74E-6 YML100W-A_p YML100W-A_p hom Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
0.077 8.06E-6 YDR061W_p YDR061W_p hom Protein with similarity to ATP-binding cassette (ABC) transporter family members; lacks predicted membrane-spanning regions; transcriptionally activated by Yrm1p along with genes involved in multidrug resistance
0.077 9.03E-6 YNL200C YNL200C hom NADHX epimerase; catalyzes isomerization of (R)- and (S)-NADHX; homologous to AIBP in mammals and the N- terminal domain of YjeF in E.coli; enzyme is widespread in eukaryotes, prokaryotes and archaea; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.075 1.36E-5 YLR046C_p YLR046C_p hom Putative membrane protein; member of the fungal lipid-translocating exporter (LTE) family of proteins; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance