YAR027W / UIP3

Putative integral membrane protein of unknown function; interacts with Ulp1p at the nuclear periphery; member of DUP240 gene family

Zygosity: Homozygous strain
fixedexpanded
Profile for YAR027W / UIP3

Click on Significant Values for Screen Details ID:SGTC_181|Compound:1447-1644|FD-Score:3.06|P-value:9.44E-4 ID:SGTC_422|Compound:cantharidin|FD-Score:3.22|P-value:5.26E-4 ID:SGTC_866|Compound:0495-0101|FD-Score:4.52|P-value:2.21E-6 ID:SGTC_878|Compound:0828-0289|FD-Score:3.51|P-value:1.79E-4 ID:SGTC_1016|Compound:4226-1401|FD-Score:3.44|P-value:2.37E-4 ID:SGTC_1233|Compound:0325-0408|FD-Score:3.10|P-value:8.23E-4 ID:SGTC_1267|Compound:0828-0272|FD-Score:3.69|P-value:8.69E-5 ID:SGTC_1274|Compound:0865-0114|FD-Score:3.68|P-value:9.30E-5 ID:SGTC_1289|Compound:0976-0073|FD-Score:3.53|P-value:1.66E-4 ID:SGTC_1347|Compound:1493-0251|FD-Score:3.16|P-value:6.52E-4 ID:SGTC_1509|Compound:1326-1131|FD-Score:3.49|P-value:1.94E-4 ID:SGTC_1735|Compound:st034310|FD-Score:-3.78|P-value:6.06E-5 ID:SGTC_1823|Compound:3-hydroxy-2-naphthoic acid|FD-Score:3.41|P-value:2.64E-4 ID:SGTC_1829|Compound:berberine|FD-Score:3.32|P-value:3.72E-4 ID:SGTC_1831|Compound:st055328|FD-Score:3.22|P-value:5.34E-4 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:-3.90|P-value:3.77E-5 ID:SGTC_1978|Compound:st071761|FD-Score:3.22|P-value:5.38E-4 ID:SGTC_2343|Compound:7990716|FD-Score:3.40|P-value:2.77E-4 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:4.26|P-value:7.60E-6 ID:SGTC_2788|Compound:5282734|FD-Score:3.13|P-value:7.41E-4 ID:SGTC_3039|Compound:9090270|FD-Score:-3.21|P-value:5.55E-4 ID:SGTC_181|Compound:1447-1644|FD-Score:3.06|P-value:9.44E-4 ID:SGTC_422|Compound:cantharidin|FD-Score:3.22|P-value:5.26E-4 ID:SGTC_866|Compound:0495-0101|FD-Score:4.52|P-value:2.21E-6 ID:SGTC_878|Compound:0828-0289|FD-Score:3.51|P-value:1.79E-4 ID:SGTC_1016|Compound:4226-1401|FD-Score:3.44|P-value:2.37E-4 ID:SGTC_1233|Compound:0325-0408|FD-Score:3.10|P-value:8.23E-4 ID:SGTC_1267|Compound:0828-0272|FD-Score:3.69|P-value:8.69E-5 ID:SGTC_1274|Compound:0865-0114|FD-Score:3.68|P-value:9.30E-5 ID:SGTC_1289|Compound:0976-0073|FD-Score:3.53|P-value:1.66E-4 ID:SGTC_1347|Compound:1493-0251|FD-Score:3.16|P-value:6.52E-4 ID:SGTC_1509|Compound:1326-1131|FD-Score:3.49|P-value:1.94E-4 ID:SGTC_1735|Compound:st034310|FD-Score:-3.78|P-value:6.06E-5 ID:SGTC_1823|Compound:3-hydroxy-2-naphthoic acid|FD-Score:3.41|P-value:2.64E-4 ID:SGTC_1829|Compound:berberine|FD-Score:3.32|P-value:3.72E-4 ID:SGTC_1831|Compound:st055328|FD-Score:3.22|P-value:5.34E-4 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:-3.90|P-value:3.77E-5 ID:SGTC_1978|Compound:st071761|FD-Score:3.22|P-value:5.38E-4 ID:SGTC_2343|Compound:7990716|FD-Score:3.40|P-value:2.77E-4 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:4.26|P-value:7.60E-6 ID:SGTC_2788|Compound:5282734|FD-Score:3.13|P-value:7.41E-4 ID:SGTC_3039|Compound:9090270|FD-Score:-3.21|P-value:5.55E-4

Top fitness defect scores for YAR027W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature		Screen
Rank
Screen
P-value
1 SGTC_866 0495-0101 4.52 262.0 µM 2.21E-6 60S ribosome export 8 3.12E-6
2 SGTC_2621 lithochol-11-enic acid 4.26 100.0 µM 7.60E-6 17 1.03E-5
3 SGTC_1267 0828-0272 3.69 9.5 µM 8.69E-5 27 1.10E-4
4 SGTC_1274 0865-0114 3.68 173.0 µM 9.30E-5 32 1.18E-4
5 SGTC_1289 0976-0073 3.53 69.1 µM 1.66E-4 20 2.07E-4
6 SGTC_878 0828-0289 3.51 13.7 µM 1.79E-4 65 2.22E-4
7 SGTC_1509 1326-1131 3.49 80.0 µM 1.94E-4 22 2.40E-4
8 SGTC_1016 4226-1401 3.44 38.0 µM 2.37E-4 RNA pol III & RNase P/MRP 34 2.91E-4
9 SGTC_1823 3-hydroxy-2-naphthoic acid 3.41 106.0 µM 2.64E-4 32 3.24E-4
10 SGTC_2343 7990716 3.40 14.8 µM 2.77E-4 37 3.39E-4
11 SGTC_1829 berberine 3.32 14.4 µM 3.72E-4 60S ribosome export 33 4.51E-4
12 SGTC_422 cantharidin 3.22 155.0 µM 5.26E-4 cell wall signaling 89 6.32E-4
13 SGTC_1831 st055328 3.22 12.0 µM 5.34E-4 heme biosynthesis & mitochondrial translocase 55 6.41E-4
14 SGTC_1978 st071761 3.22 42.0 µM 5.38E-4 TSC3-RPN4 32 6.46E-4
15 SGTC_1347 1493-0251 3.16 600.0 nM 6.52E-4 mitochondrial response to ROS 43 7.79E-4
16 SGTC_2788 5282734 3.13 71.4 µM 7.41E-4 94 8.81E-4
17 SGTC_1233 0325-0408 3.10 14.2 µM 8.23E-4 52 9.76E-4
18 SGTC_181 1447-1644 3.06 8.1 µM 9.44E-4 endomembrane recycling 69 0.00112
19 SGTC_1628 st004252 3.03 77.7 µM 0.00104 66 0.00122
20 SGTC_2079 5212404 3.00 121.0 µM 0.00117 43 0.00137

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.109 2.33E-10 YPR176C BET2 het Beta subunit of Type II geranylgeranyltransferase required for vesicular transport between the endoplasmic reticulum and the Golgi; provides a membrane attachment moiety to Rab-like proteins Ypt1p and Sec4p
0.107 5.22E-10 YFR017C IGD1 hom Cytoplasmic protein that inhibits Gdb1p glycogen debranching activity; required for normal intracellular accumulation of glycogen; phosphorylated in vivo; expression increases during wine fermentation; protein abundance increases in response to DNA replication stress; IGD1 has a paralog, YOL024W, that arose from the whole genome duplication
0.103 2.19E-9 YOR111W_p YOR111W_p hom Putative protein of unknown function
0.100 7.20E-9 YDL105W NSE4 het Component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair
0.097 1.77E-8 YOL149W DCP1 het Subunit of the Dcp1p-Dcp2p decapping enzyme complex; decapping complex removes the 5' cap structure from mRNAs prior to their degradation; enhances the activity of catalytic subunit Dcp2p; regulated by DEAD box protein Dhh1p; forms cytoplasmic foci upon DNA replication stress
0.096 2.27E-8 YIL051C MMF1 het Mitochondrial protein required for transamination of isoleucine but not of valine or leucine; may regulate specificity of branched-chain transaminases Bat1p and Bat2p; interacts genetically with mitochondrial ribosomal protein genes
0.093 6.80E-8 YFR036W CDC26 hom Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition
0.090 1.73E-7 YIL140W AXL2 hom Integral plasma membrane protein required for axial budding in haploid cells, localizes to the incipient bud site and bud neck; glycosylated by Pmt4p; potential Cdc28p substrate
0.088 3.54E-7 YNL230C ELA1 hom Elongin A; F-box protein that forms a heterodimer with Elc1p and is required for ubiquitin-dependent degradation of the RNA Polymerase II subunit Rpo21p; subunit of the Elongin-Cullin-Socs (ECS) ligase complex
0.087 4.55E-7 YMR210W YMR210W hom Putative acyltransferase with similarity to Eeb1p and Eht1p, has a minor role in medium-chain fatty acid ethyl ester biosynthesis; may be involved in lipid metabolism and detoxification
0.086 5.57E-7 YLL034C RIX7 het Putative ATPase of the AAA family, required for export of pre-ribosomal large subunits from the nucleus; distributed between the nucleolus, nucleoplasm, and nuclear periphery depending on growth conditions
0.083 1.30E-6 YNL191W DUG3 hom Component of glutamine amidotransferase (GATase II); forms a complex with Dug2p to degrade glutathione (GSH) and other peptides containing a gamma-glu-X bond in an alternative pathway to GSH degradation by gamma-glutamyl transpeptidase (Ecm38p)
0.083 1.51E-6 YOR186W_p YOR186W_p hom Putative protein of unknown function; proper regulation of expression during heat stress is sphingolipid-dependent; YOR186W has a paralog, YLR297W, that arose from the whole genome duplication
0.081 2.66E-6 YGR053C_p YGR053C_p hom Putative protein of unknown function
0.081 2.83E-6 YML038C YMD8 hom Putative nucleotide sugar transporter, has similarity to Vrg4p